Notes

Looking at the outcome associated with E-Government on Business Interpersonal Obligation Functionality: The Mediating Effect of Necessary Corporate and business Interpersonal Responsibility Plan, Corruption, and Information and Communication Technologies Improvement In the COVID era.
Heart failure (HF) and diabetes mellitus (DM) frequently coexist, with a prevalence of DM of 35-40% in patients with HF, independent of the level of impairment of the ejection fraction (EF). Furthermore, DM is considered a strong independent risk factor for the progression of HF with either preserved or reduced EF and is associated with poor prognosis. The ability of neprilysin inhibitors to elevate levels of biologically active natriuretic peptides has made them a potential therapeutic approach in HF. In the Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) trial, a dual-acting angiotensin-receptor-neprilysin inhibitor, sacubitril/valsartan was superior to enalapril in reducing the risks of death and HF hospitalization in patients with HF with reduced EF. In addition, in a post-hoc analysis of this trial, among patients with DM, treatment with sacubitril/valsartan resulted in improved glycemic control compared with enalapril. Also, ttients with DM, are needed to further clarify beneficial metabolic properties of sacubitril/valsartan.Although there are undeniable advantages of treatment of the inflammatory bowel diseases, Crohn's disease, and ulcerative colitis, with biological agents, the increased susceptibility to tuberculosis should not be ignored. Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis complex which includes M. tuberculosis, M. bovis, and M. africanum. Primary tuberculosis is uncommon in the setting of inflammatory bowel disease reactivation of latent tuberculosis is of greater concern. Consequently, latent infection should be excluded in patients who qualify for immunosuppressive treatments. Apart from the review of the literature, this article also presents three cases of different patterns of tuberculosis that occurred during treatment with infliximab, adalimumab, or vedolizumab. The first case reports a case of tuberculosis presenting as right middle lobe pneumonia. The second case featured miliary tuberculosis of the lungs with involvement of the mediastinal lymph nodes, liver, and spleen. The third patient developed a tuberculoma of the right parietal lobe and tuberculous meningitis. It is important to reiterate that every patient qualifying for a biologic agent should undergo testing to accurately identify latent tuberculosis, as well as precise monitoring for the possible development of one of the various forms or patterns of tuberculosis during treatment.
Parkinson's disease psychosis (PDP) is a common, nonmotor symptom of Parkinson's disease (PD), which may affect up to 60% of patients and is associated with impaired quality of life, increased healthcare costs, and nursing home placement, among other adverse outcomes. Characteristic symptoms of PDP include illusions; visual, auditory, tactile, and olfactory hallucinations; and delusions. PDP symptoms typically progress over its course from being mild, infrequent, and often untroubling to complex, sometimes constant, and potentially highly disturbing. PDP has traditionally been treated with atypical antipsychotics (e.g., clozapine and quetiapine) although these are not approved for this indication and clozapine requires frequent white blood cell count monitoring due to the risk of agranulocytosis. Pimavanserin is a newer atypical antipsychotic with highly selective binding to serotonergic receptors, no evidence for worsening motor symptoms in PD, and no need for white blood cell count monitoring. It is currebradykinesia, and dyskinesia), although they may also have adverse effects that contribute to symptoms of PDP.
These scenarios provide multiple insights regarding PDP management and the role of pimavanserin. Effective treatment of PDP may reduce disturbing symptoms of psychosis, thus improving patient function and quality of life. see more In addition, effective pharmacotherapy for PDP may also facilitate the use of other medications needed to treat neurological symptoms of PD (e.g., tremor, bradykinesia, and dyskinesia), although they may also have adverse effects that contribute to symptoms of PDP.
Self-management strategies are important in healthcare for people with Parkinson's to improve daily living. There is limited evidence on effectiveness in Parkinson's, and the active components of effective self-management strategies are uncertain. This review aims to identify and synthesise the qualitative evidence regarding the experiences of self-management components by people with Parkinson's and their carers.

MEDLINE, PsycINFO, Embase, Web of Science, and CINAHL were searched from inception to July 8, 2020, for qualitative research concerning self-management for people with Parkinson's. Data were coded and thematically synthesised using NVivo.
. Of 9547 search results, six papers were included in the final thematic synthesis. The studies reviewed consisted of 147 participants 104 were people with Parkinson's and 43 were carers. Seven main themes were derived concerning self-management of people with Parkinson's (1) medication management, (2) physical exercise, (3) self-monitoring techniques, (4) ps The studies reviewed consisted of 147 participants 104 were people with Parkinson's and 43 were carers. Seven main themes were derived concerning self-management of people with Parkinson's (1) medication management, (2) physical exercise, (3) self-monitoring techniques, (4) psychological strategies, (5) maintaining independence, (6) encouraging social engagement, and (7) providing knowledge and information. These components should be incorporated as relevant strategies and techniques and should be specific as well as tailored to different stages of the disease. Discussion. Self-management programmes for people with Parkinson's should include the seven themes presented as part of this review and pay particular attention to presenting relevant information and skills as they relate to different stages of the disease. link2 Tailoring information and social engagement were two components that required specific attention in order to engage people with Parkinson's effectively.Parkinson's disease (PD) is typically well recognized by its characteristic motor symptoms (e.g., bradykinesia, rigidity, and tremor). The cognitive symptoms of PD are increasingly being acknowledged by clinicians and researchers alike. However, PD also involves a host of emotional and communicative changes which can cause major disruptions to social functioning. These incude problems producing emotional facial expressions (i.e., facial masking) and emotional speech (i.e., dysarthria), as well as difficulties recognizing the verbal and nonverbal emotional cues of others. These social symptoms of PD can result in severe negative social consequences, including stigma, dehumanization, and loneliness, which might affect quality of life to an even greater extent than more well-recognized motor or cognitive symptoms. It is, therefore, imperative that researchers and clinicans become aware of these potential social symptoms and their negative effects, in order to properly investigate and manage the socioemotional aspects of PD. link3 This narrative review provides an examination of the current research surrounding some of the most common social symptoms of PD and their related social consequences and argues that proactively and adequately addressing these issues might improve disease outcomes.
Stroke is a public health problem in Ethiopia. Despite the high prevalence of stroke in Ethiopia, there is a paucity of data with regard to drug treatment, treatment outcome, and risk factors of poor treatment outcome of stroke. Hence, this study is aimed at assessing treatment outcome and its determinants among patients admitted to stroke unit of Jimma University Medical Center (JUMC).

A two-year hospital-based retrospective cross-sectional study was employed to analyze the medical records of patients admitted with stroke to stroke unit of Jimma University Medical Centre from February 1
, 2016 to March 30
, 2018. Data was entered by Epidata manager version 4.0.2 and analyzed by SPSS version 24. Multivariable logistic regression analysis with the backward stepwise approach was done to identify independent predictors of poor treatment outcome of stroke. Variables with
value less than 0.05 were considered as statically significant determinants of poor treatment outcome.

Of 220 patients with stroke adly admission should be delivered particularly for patients who have risk factors of stroke (cardiovascular diseases).
Substantial numbers of stroke patients had poor treatment outcomes. Elderly patients, patients diagnosed with hemorrhagic stroke, patients with comorbidity, and those with delayed hospital admission were more likely to have poor treatment outcome. Hence, frequent monitoring and care should be given for the aforementioned patients. Awareness creation on the importance of early admission should be delivered particularly for patients who have risk factors of stroke (cardiovascular diseases).Sheep and goat pox is highly contagious viral infection of sheep and goats caused by the genus Capripox virus. Clinically, the disease is characterized by fever, macules developing into papules, and necrotic lesions in the skin and nodular lesions in internal organs. In Ethiopia, there are seroprevalence epidemiological studies on the disease. However, the spatiotemporal clustering of sheep and goat pox incidence has not been investigated. A retrospective study design using the outbreak reported data from Kombolcha Regional Laboratory for the years from September 2013 to December 2019 was performed to determine the temporal and spatial distribution of sheep and goat pox outbreaks. A total of 663 sheep and goat pox disease outbreaks were reported in all major parts of Eastern Amhara region between 2013 and 2019. In this period, sheep and goat pox was reported in all administrative zones of Eastern Amhara region (n = 5). The average incidence of sheep and goat pox outbreaks at the district level was 8.61 per 7 years. The incidence differed between areas, being the lowest in hot dry month and highest in warm and cold moist months. Sheep and goat pox outbreaks generally have a peak in November followed by August and a low in May. There is a significant difference in the occurrence of sheep and goat pox disease outbreaks between months and years (p less then 0.001). The forecast for the period 2020-2026 revealed that a high number of sheep and goat pox disease outbreaks will occur than the previous one. Therefore, all stakeholders should work cooperatively to combat this disease occurrence, and there should be capacity development for participatory disease search, risk analysis, laboratory diagnosis, and information management in order to respond properly to outbreak of sheep and goat pox disease; thereby, it enhances the prevention and control the disease.A gray target can appear lighter or darker depending on its surrounding spatial context. We examined the effect of exposure time on three such examples (simultaneous lightness contrast, dungeon illusion, and the two-room arrangement), finding very different results with exposure time as brief as 15 ms the simultaneous lightness contrast was much stronger, the effect of the dungeon illusion was reversed, and the lightness difference between the two isoluminant patches in the two-room arrangement disappeared. These suggest that local luminance ratios dominate lightness perception in a brief flash.
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