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Based on this classification, the choice for an empirical antibiotic therapy is made. The spectrum of pathogens should therefore be limited in order to use antibiotics with a narrow spectrum of activity and little collateral damage if possible, thus, preventing both the development of resistance and complications. CONCLUSIONS Adequate empirical antibiotic therapy and prophylaxis in line with guidelines is based on the clinical classification and risk factors.OBJECTIVES Indian agriculture is mostly dependent on monsoon. Poor and irregular rainfall may result in crop failure and food shortage among the vulnerable population. This study examined the variations in drought condition and its association with under age 5 child malnutrition across the districts of India. METHODS Using remote sensing and National Family Health Survey (NFHS-4) data, univariate Moran's I and bivariate local indicator of spatial autocorrelation (LISA) maps were generated to assess the spatial autocorrelation and clustering. To empirically check the association, we applied multivariate ordinary least square and spatial autoregressive models. RESULTS The study identified highly significant spatial dependence of drought followed by underweight, stunting, and wasting. Bivariate LISA maps showed negative spatial autocorrelation between drought and child malnutrition. Regression results suggest agricultural drought is substantially associated with stunting. An increasing value of drought showed statistical association with the decreasing (β = - 8.251; p value  less then  0.05) prevalence rate of child stunting across India. CONCLUSIONS This study provides evidence of child undernutrition attributable to drought condition, which will further improve the knowledge of human vulnerability and adaptability in the climatic context.OBJECTIVE The respiratory severity score (RSS) has been demonstrated to be associated with the oxygenation index in intubated newborn infants. We aimed to evaluate the usefulness of RSS with regard to birthweight (BW) in preterm infants for predicting an association with future pulmonary hypertension (PH). METHODS Preterm infants with 18 h (OR 4.907, 95% CI 1.436-16.765, p = 0.011). CONCLUSION RSS/kg is a potential marker associated with the development of PH. Future studies could verify its usefulness as a reliable surrogate for predicting respiratory morbidity in clinical settings. © The Author(s) [2020]. Published by Oxford University Press. All rights reserved. For permissions, please email [email protected] To investigate metabolic features that may predispose to GCA in a nested case-control study. METHODS Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N = 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. RESULTS A total of 76 cases with a confirmed incident diagnosis of GCA (61% female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (s.d. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (s.d. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (s.d. SN-38 overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. CONCLUSION Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology.BACKGROUND Activation of mitogen-activated protein kinase phosphatase-1 (MKP-1), a dual-specificity protein phosphatase, regulates mitogen-activated protein kinase signaling. C-Jun N-terminal kinase (JNK) and p38 are activated in cisplatin-induced renal injury. However, the change of MKP-1 expression in cisplatin-induced renal injury and the regulatory effect of sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide-dependent deacetylase, on MKP-1 remains unknown. METHODS To address these issues, we used constitutional Sirt2 knockout (KO) mice, transgenic (TG) mice with increased expression of SIRT2 specifically in proximal tubular epithelial cellsand wild-type (WT) mice. Cisplatin nephrotoxicity was induced by intraperitoneal injection of cisplatin. RESULTS MKP-1 expression in the kidney was decreased after cisplatin treatment. Cisplatin-induced downregulation of MKP-1 was reversed in Sirt2 KO mice kidney and further decreased in Sirt2 TG mice kidney. We observed similar phenomenon with SIRT2-knockdown or SIRT2-overexpressed tubular epithelial cells. Phosphorylation of p38 and JNK, a downstream signal pathway of MKP-1, increased in WT mice kidney following treatment with cisplatin. A decrease in SIRT2 suppressed cisplatin-induced phosphorylation of p38 and JNK in kidney and tubular epithelial cells. Overexpression of SIRT2 further increased phosphorylation of p38 and JNK in kidney and tubular epithelial cells. Acetylation of MKP-1 was significantly increased in SIRT2-knockdown cells and decreased in SIRT2-overexpressed cells after cisplatin stimulation. Sirt2 KO mice and Sirt2 TG mice showed amelioration and aggravation of renal injury, apoptosis, necroptosis and inflammation induced by cisplatin. CONCLUSION Our data show that SIRT2 is associated with cisplatin-induced renal injury through regulation of MKP-1 expression. © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
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