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The truly amazing Imitator: Hidden Neurosyphilis Uncovered Following Start of the Immunosuppressive Drug Secukinumab.
Misinformation and lack of understanding of memory loss, dementia and brain health are barriers to dementia risk reduction and timely health seeking behaviour. Online video technology for health promotion has been popularised with the increase in online networks, improved access to technology, and the rise of online health seeking behaviour. However, an understanding of the efficacy of this technology in the context of brain health awareness in older adults is lacking. This research explored whether three short brain health animations could reduce worry, impart new knowledge, and promote behavioural change in older adults.
Participants (8,179) completed an online survey pre- and post-engagement with three animated films.

Level of worry significantly decreased, and over half of the participants indicated that they intended to change their behaviour after watching the videos. The majority of participants indicated they had learned something new from the videos, and found the videos enjoyable. Regression analysis described how participants who reported learning from the videos were more likely to report behavioural change. In addition, enjoyment significantly predicated outcomes of learning and behaviour change.

our research suggests that short animated brain health films are effective in educating the public about memory, attention and brain health, may motivate people to make changes in lifestyle, and possibly reduce stigma towards dementia.
our research suggests that short animated brain health films are effective in educating the public about memory, attention and brain health, may motivate people to make changes in lifestyle, and possibly reduce stigma towards dementia.
We aimed to determine if treatment of male sexual partners of women with recurrent BV with oral metronidazole twice daily for 7 days (i.e. multi-dose metronidazole) significantly decreased BV recurrence rates in the female.

This was a multi-center, two-arm, double-blinded, placebo-controlled study. Women with recurrent BV and a current diagnosis of BV by Amsel and Nugent were enrolled. Multi-dose metronidazole for 7 days was dispensed to women. Male partners were randomized to placebo versus multi-dose metronidazole for 7 days and asked to refrain from unprotected sex for 14 days. Female follow-up visits were conducted at day 21 and 8 and 16 weeks. Male follow-up visits occurred at days 14-21. BV cure was defined as 0-2 Amsel criteria and Nugent score 0-6 in the female partner with the primary endpoint at 16 weeks.

Two-hundred fourteen couples were enrolled. In the intent-to-treat population, there was no significant difference between treatment arms for the primary outcome. BV treatment failure occurred in 81% and 80% of women in the metronidazole and placebo arms through the third follow-up visit, respectively (p>0.999). However, women whose male partners were adherent to study medication were less likely to fail treatment (adjusted relative risk (ARR)=0.85; 95% CI 0.73-0.99; p=0.035). This finding persisted in post-hoc comparisons in the metronidazole arm.

Overall, this study did not find that male partner treatment with multi-dose metronidazole significantly reduces BV recurrence in female partners although women whose partners were adherent to multi-dose metronidazole were less likely to fail treatment.
Overall, this study did not find that male partner treatment with multi-dose metronidazole significantly reduces BV recurrence in female partners although women whose partners were adherent to multi-dose metronidazole were less likely to fail treatment.Inorganic ions such as phosphate, are essential nutrients required for a broad spectrum of cellular functions and regulation. During infection, pathogens must obtain inorganic phosphate (Pi) from the host. Despite the essentiality of phosphate for all forms of life, how the intracellular parasite Toxoplasma gondii acquires Pi from the host cell is still unknown. In this study, we demonstrated that Toxoplasma actively internalizes exogenous Pi by exploiting a gradient of Na+ ions to drive Pi uptake across the plasma membrane. The Na+-dependent phosphate transport mechanism is electrogenic and functionally coupled to a cipargarmin sensitive Na+-H+-ATPase. Toxoplasma expresses one transmembrane Pi transporter harboring PHO4 binding domains that typify the PiT Family. This transporter named TgPiT, localizes to the plasma membrane, the inward buds of the endosomal organelles termed VAC, and many cytoplasmic vesicles. Upon Pi limitation in the medium, TgPiT is more abundant at the plasma membrane. We genetically ablated the PiT gene, and ΔTgPiT parasites are impaired in importing Pi and synthesizing polyphosphates. Interestingly, ΔTgPiT parasites accumulate 4-times more acidocalcisomes, storage organelles for phosphate molecules, as compared to parental parasites. In addition, these mutants have a reduced cell volume, enlarged VAC organelles, defects in calcium storage and a slightly alkaline pH. Overall, these mutants exhibit severe growth defects and have reduced acute virulence in mice. this website In survival mode, ΔTgPiT parasites upregulate several genes, including those encoding enzymes that cleave or transfer phosphate groups from phosphometabolites, transporters and ions exchangers localized to VAC or acidocalcisomes. Taken together, these findings point to a critical role of TgPiT for Pi supply for Toxoplasma and also for protection against osmotic stresses.Scholars traditionally receive career credit for a paper based on where in the author list they appear, but position in an author list often carries little information about what the contribution of each researcher was. "Contributorship" refers to a movement to formally document the nature of each researcher's contribution to a project. We discuss the emerging CRediT standard for documenting contributions and describe a web-based app and R package called tenzing that is designed to facilitate its use. tenzing can make it easier for researchers on a project to plan and record their planned contributions and to document those contributions in a journal article.
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