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Proc Univariate data=adlb_ntest normal;
Var aval ;
Qqplot aval;
By avisit;
where avisit in ("Baseline" "Month 6");
/* output out =test;*/
Run;
Shapiro Wilk. Slect min(pvalue)
o If Shapiro-Wilk test p-value is < 0.05 (Not Normal) for the Baseline and Month 6/LOCF,
then do a log transformation of the data
for the primary and secondary analysis and all Observered Cases Months and use the table below.
if pmin < 0.05 then do;
aval = 1000*aval;
if aval eq 0 then aval =5;
log_aval = log(aval);
end;
if avisit eq "Baseline" then output base_log;
else output pbase_log;
run;
Ods output statistics=stats /*(keep=variable lowerclmean upperclmean)conflimits=conf*/ ttests=t_res(keep=variable Probt) ;
Proc Ttest data=log_both h0=0 ci=equal alpha=0.05;
Var log_chg;
where avisit ne "Baseline";
Run;
ods exclude none;
ods listing close;
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