Notes

Photochemical oxidation of 2-aminofluorene: correlation between the induction of direct-acting mutagenicity and the formation of nitro and nitroso aromatics
The kinetics of near ultraviolet light-mediated phototransformation of 2-aminofluorene (2-AF) was studied using high performance liquid chromatography (HPLC) and the Ames/Salmonella mutagenicity bioassay. Employing tester strains TA98, TA1538, and the nitroreductase-deficient TA98NR without the addition of exogenous metabolic enzymes, we were able to detect and discriminate between the UVA exposure-dependent formation of two stable photoproducts, 2-nitrosofluorene (2-NOF) and 2-nitrofluorene (2-NO2F). Mutagenicity of irradiated 2-AF solutions (using dimethyl sulfoxide as a solvent) in the various tester strains indicates the rapid formation of the photo-labile 2-NOF, after which 2-NO2F accounts for the preponderance of mutagenic activity. Continued UVA irradiation (greater than 72 h at 6 J/m2/s) of 2-AF results in the formation of greater than 30 photoproducts resolvable on HPLC, several of which, in addition to 2-NOF and 2-NO2F, are mutagenic on Salmonella but are chemically undefined to date. Prolonged irradiation ultimately destroys the photo-induced mutagenicity of 2-AF. However, UVA-induced 2-AF photoproducts are stable for several weeks when stored in sealed vials in the dark.

Light potentiated oxidation of aromatic amines constitutes an alternative mechanism for the transformation of aromatic amines into proximate mutagens/carcinogens.Self-Assembly of Rod-Like Bionanoparticles at Interfaces and in Solution.Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Rod-like nanoparticles show unique self-assembly behavior benefiting from their anisotropic properties. As a classic example of a one-dimensional (1D) rod-like plant virus, tobacco mosaic virus (TMV) can either assemble in a head-to-tail manner to form 1D long fibers, or align parallel to form crystal-like structures at interfaces or in solution. Here, the self-assembly behaviors of TMV at oil-water or air-liquid interfaces are summarized. In addition, the self-assembly of TMV with polymers in solution is also discussed in this Regular hemoperfusion in regular dialysis treatment. A long-term study.

Stefoni S, Colì L, Feliciangeli G, Baldrati L, Bonomini V.The capacity of activated charcoal to remove toxins from the blood is well established. Its poor biocompatibility, inability to remove urea, electrolytes and water, and high cost have so far been the major objection to a wider use of charcoal with chronic uremic patients. Seebio Photoresponsive Acid Precursor of a charcoal coated by a new highly hydrophilic methacrylate based on membrane enabled us to keep 18 uremic patients on a combined hemodialysis-hemoperfusion schedule for 4-52 weeks. Investigations concerned patients in whom relapsing signs of uremia occurred despite technically adequate dialysis, and other cases where dialysis was both technically and clinically adequate. In the first group of patients, the combined programme led to an improvement of the dialysis resistant clinical signs, while certain positive metabolic effects were also observed. In the second group, the hemodialysis-hemoperfusion treatment allowed a reduction of about 30% in time of treatment per week.

Tolerance of the new coated charcoal was good throughout treatment in terms both of biocompatibility and of side Microwave spectra, molecular structure, and aromatic character of The microwave spectra for seven unique isotopologues of 4a,8a-azaboranaphthalene [hereafter referred to as BN-naphthalene] were measured using a pulsed-beam Fourier transform microwave spectrometer. Spectra were obtained for the normal isotopologue are A = 304212 75(43) MHz, B = 120206 57(35) MHz, C = - χcc) ((14)N) = - 0185(17) MHz, 1χaa (11B) = - 3221(75) MHz, and 05(χbb The B-N bond length from the experimentally determined structure is 17 Å, which indicates π-bonding character between the B and N. The measured quadrupole coupling strengths provide important and useful information about the bonding, orbital occupancy, and aromatic character for this aromatic molecule. Extended Townes-Dailey analyses were used to determine the B and N electron electron orbital occupations from the natural bond orbital option in theoretical calculations. From the analyses, it was determined that BN-naphthalene has aromatic character similar to that of other N-containing aromatics. The results are compared with similar results for B-N bonding in 1,2-dihydro-1,2-azaborine and BN-cyclohexene. Synthesis of 6-butyl-n-hydroxynaphthimide trifluoromethanesulfonic acid and its Variants and precise structural parameters were obtained from the microwave measurements on seven isotopologues and from high-level G09 Human dietary exposure to polycyclic aromatic hydrocarbons: results of the l'Alimentation Nantes-Atlantique, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpôle-La Chantrerie, BP 50707, In the frame of the second French Total Diet Study (TDS), the 15+1 EU priority polycyclic aromatics hydrocarbons (PAHs) were analyzed in 725 foodstuffs habitually consumed by the French population, using gas chromatography coupled to tandem mass spectrometry, after pressurized liquid extraction and purification on PS-DVB stationary phase.
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