Notes

Produced by a templating process at the molecular level, MIPs are capable of recognizing and binding target molecules with similar specificity and selectivity to their natural analogues
One of the main challenges in MIP sensor development is the miniaturization of MIP structures and their interfacing with the transducer or with a microchip. Photostructuring appears thereby as one of the most suitable methods for patterning MIPs at the micro and nano scale, directly on the transducer surface. In the present review, a general overview on MIPs in biosensing applications is given, and the photopolymerization and photopatterning of MIPs are particularly described.Photochemistry of framework-supported M(diimine)(CO)3X complexes in three-dimensional lithium carboxylate metal-organic frameworks: monitoring the The structures and photochemical behaviour of two new metal-organic frameworks (MOFs) are reported. Photolyzable Acid Precursor of Re(2,2'-bipy-5,5'-dicarboxylic acid)(CO)3Cl or Mn(2,2'-bipy-5,5'-dicarboxylic acid)(CO)3Br with LiCl or LiBr, respectively, produces single crystals of Li2(DMF)2 [(2,2'-bipy-5,5'-dicarboxylate)Re(CO)3Cl]n ( RELI: ) or Li2(DMF)2[(2,2'-bipy-5,5'-dicarboxylate)Mn(CO)3Br]n ( MNLI: ). The structures formed by the two MOFs comprise one-dimensional chains of carboxylate-bridged Li(I) cations that are cross-linked by units of Re(2,2'-bipy-5,5'-dicarboxylate)(CO)3Cl ( RELI: ) or Mn(2,2'-bipy-5,5'- dicarboxylate)(CO)3Br ( MNLI: ).

The photophysical and photochemical behaviour of both RELI: and MNLI: are probed. The rhenium-containing MOF, RELI: , exhibits luminescence and the excited state behaviour, as established by time-resolved infrared measurements, is closer in behaviour to that of unsubstituted [Re(bipy)(CO)3Cl] rather than a related MOF where the Li(I) cations are replaced by Mn(II) cations. These observations are further supported by density functional theory calculations. Upon excitation MNLI: forms a dicarbonyl species which rapidly recombines with the dissociated CO, in a fashion consistent with the majority of the photoejected CO not escaping the MOF channels.This article is part of the themed issue 'Coordination polymers and metal-organic frameworks: Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.Penn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.(12)Kinghorn Cancer Centre, Garvan Institute for Medical Research, Darlinghurst, Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC).

Here, we explore approaches to target CCNE1-amplified cancers and potential strategies to overcome resistance to targeted agents.Experimental Design: To examine dependency on CDK2 in CCNE1-amplified HGSC, we utilized siRNA and conditional shRNA gene suppression, and chemical inhibition using dinaciclib, a small-molecule CDK2 inhibitor. High-throughput compound screening was used to identify selective synergistic drug combinations, as well as combinations that may overcome drug resistance. An observed relationship between CCNE1 and the AKT pathway was further explored in genomic data from primary tumors, and functional studies in fallopian tube secretory cells.Results: We validate CDK2 as a therapeutic target by demonstrating selective sensitivity to gene suppression. However, we found that dinaciclib did not trigger amplicon-dependent sensitivity in a panel of HGSC cell lines. A high-throughput compound screen identified synergistic combinations in CCNE1-amplified HGSC, including dinaciclib and AKT inhibitors.

Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 and AKT2 Overexpression of Cyclin E1 and AKT isoforms, in addition to mutant TP53, imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of HGSC.Conclusions: These findings suggest a specific dependency of CCNE1-amplified tumors for AKT activity, and point to a novel combination of dinaciclib and AKT inhibitors that may ©2016 American Association for Cancer Research.interest were disclosed by the other authors.Photochemical [2 + 2] polymerization of metal-organic gels of a rigid and angular diene with silver-salts of diverse anions: selective dye-sorption and Two similar types of dienes, one rigid and the other flexible, were explored for their gel formation abilities with Ag(i) salts. The rigid and angular dienes have shown an exceptional ability for gel formation with silver salts of nitrate, triflate, tetrafluoro borate and hexafluorophosphate. These metal-organic gels (MOGs) and their xerogels are found to have an excellent ability to undergo the photochemical [2 + 2] polymerization reaction upon irradiation. The reactions were monitored, and the products were characterized via1H NMR and MALDI-TOF analyses.

Further, the solid-state luminescence behaviour and the selective dye-sorption of the gels have been explored before and after the photo-polymerization reaction.Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child Columbia University, 722 W. 168th St., New York, NY 10032, USA; Columbia Center for Children's Environmental Health, Columbia University, 722 W. 168th St.
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