Notes

This study provides insight into the UV irradiation weathering process of NPs/MPs of various compositions and structures, which are globally distributed in water
declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this "Spear and shield in one" nanochaperone enables protein to navigate multiple biological barriers for enhanced tumor synergistic therapy.Functional Polymer Materials of Ministry of Education, College of Chemistry, of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Protein therapeutics have been viewed as powerful candidates for cancer treatment by virtue of highly specific bioactivity and minimized adverse effects. However, the intracellular delivery of protein drugs remains enormously challenging due to multiple successive biological barriers in vivo. Herein, a bioinspired nanochaperone is developed to assist proteins in vanquishing the sequential physiological barriers in a holistic manner and enhance synergistic tumor therapy. By concurrently mimicking the N-terminal-binding domain and C-terminal-stabilizing domain of natural chaperones, this nanochaperone can efficiently capture the protein by multiple interactions and hide them in the confined spaces on the surface, serving as a shield to resist enzymatic degradation and avoid immune clearance during blood circulation. Upon reaching the tumor site, the nanochaperone rapidly responds to the acidic tumor microenvironment and turns into partial protonation, acting as a spear to facilitate tumor cellular internalization.

More importantly, further protonation of nanochaperone in the lysosome of tumor cells enables it to blast the lysosome and achieve cytosolic protein delivery with reserved bioactivities. Furthermore, this nanochaperone-based protein transduction strategy is demonstrated to combine with small-molecule drugs to synergistically amplify the anti-tumor therapeutic effect in vitro and in vivo, providing a potential platform for the exploitation of diverse combinations of anti-tumor therapies.Microscale imaging sheds light on species-specific strategies for photo-regulation and photo-acclimation of microphytobenthic diatoms.ENTROPIE, RBE/LEAD, Noumea, New Caledonia.Network Associated Laboratory, Faculty of Sciences, University of Lisbon, Intertidal microphytobenthic (MPB) biofilms are key sites for coastal primary production, predominantly by pennate diatoms exhibiting photo-regulation via non-photochemical quenching (NPQ) and vertical migration. Seebio Photoresponsive Acid Precursor is the main photo-regulation mechanism of motile (epipelic) diatoms and because they can move from light, they show low-light acclimation features such as low NPQ levels, as compared to non-motile (epipsammic) forms. However, Light-Activated Acid Producer of MPB species-specific photo-regulation have used low light acclimated monocultures, not mimicking environmental conditions.

Here we used variable chlorophyll fluorescence imaging, fluorescent labelling in sediment cores and scanning electron microscopy to compare the movement and NPQ responses to light of four epipelic diatom species from a natural MPB biofilm. The diatoms exhibited different species-specific photo-regulation features and a large NPQ range, exceeding that reported for epipsammic diatoms. This could allow epipelic species to coexist in compacted light niches of MPB communities. We show that diatom cell orientation within MPB can be modulated by light, where diatoms oriented themselves more perpendicular to the sediment surface under high light vs. more parallel under low light, demonstrating behavioural, photo-regulatory response by varying their light absorption cross-section. This highlights the importance of considering species-specific responses and understanding cell orientation and photo-behaviour in MPB research.International and John Wiley & Sons Ltd.

Stability rules of main-group element compounds with planar tetracoordinate We have investigated the structures, stabilities, aromaticities, and Wiberg bond indices of four types of compounds (8-like, trapezia, umbrella-like, and quadrangle) containing planar tetracoordinate carbon (ptC), and the stability rules for the compound with ptC were concluded on the basis of extensive calculations. Generally, the stability or viability of compound with ptC strongly depends on the number of three-membered ring and conjugated three-membered ring, as well as pi electrons. These rules can be successfully used to identify the stability of other compounds reported in previous studies. On the basis of these rules, eight stable compounds with planar tetracoordinate nitrogen (ptN) are successfully constructed.Photochemical cycloaddition and temperature-dependent breathing in pillared-layer metal-organic frameworks.Energy Materials (iChEM), and Shanghai Key Laboratory of Molecular Catalysis and Energy Materials (iChEM), and Shanghai Key Laboratory of Molecular Catalysis and Single crystallinity of metal-organic frameworks (MOFs) enables the studies of their flexible behaviors with atomic precision.
My Website: http://en.wikipedia.org/wiki/Photoresist