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Hemorheological Way of Increase Perfusion involving Red Blood vessels Tissue with Reduced Deformability Using Drag-Reducing Plastic (In Vitro Review).
Over a decade ago, a multidrug-resistant nosocomial fungus Candida auris emerged worldwide and has since become a significant challenge for clinicians and microbiologists across the globe. A resilient pathogen, C. learn more auris survives harsh disinfectants, desiccation and high-saline environments. It readily colonizes the inanimate environment, susceptible patients and causes invasive infections that exact a high toll. Prone to misidentification by conventional microbiology techniques, C. auris rapidly acquires multiple genetic determinants that confer multidrug resistance. Whole-genome sequencing has identified four distinct clades of C. auris, and possibly a fifth one, in circulation. Even as our understanding of this formidable pathogen grows, the nearly simultaneous emergence of its distinct clades in different parts of the world, followed by their rapid global spread, remains largely unexplained. We contend that certain host-pathogen-environmental factors have been evolving along adverse trajectories for the last few decades, especially in regions where C. auris originally appeared, until these factors possibly reached a tipping point to compel the evolution, emergence and spread of C. auris. Comparative genomics has helped identify several resistance mechanisms in C. auris that are analogous to those seen in other Candida species, but they fail to fully explain how high-level resistance rapidly develops in this yeast. A better understanding of these unresolved aspects is essential not only for the effective management of C. auris patients, hospital outbreaks and its global spread but also for forecasting and tackling novel resistant pathogens that might emerge in the future. In this review, we discuss the emergence, spread and resistance of C. auris, and propose future investigations to tackle this resilient pathogen.A group of four psychrotrophic bacterial strains was isolated on James Ross Island (Antarctica) in 2013. All isolates, originating from different soil samples, were collected from the ice-free northern part of the island. They were rod-shaped, Gram-stain-negative, and produced moderately slimy red-pink pigmented colonies on R2A agar. A polyphasic taxonomic approach based on 16S rRNA gene sequencing, whole-genome sequencing, MALDI-TOF MS, rep-PCR analyses, chemotaxonomic methods and extensive biotyping was used to clarify the taxonomic position of these isolates. Phylogenetic analysis based on 16S rRNA gene sequences showed that the isolates belonged to the genus Hymenobacter. The closest relative was Hymenobacter humicola CCM 8763T, exhibiting 98.3 and 98.9% 16S rRNA pairwise similarity with the reference isolates P5342T and P5252T, respectively. Average nucleotide identity, digital DNA-DNA hybridization and core gene distances calculated from the whole-genome sequencing data confirmed that P5252T and P5342T represent two distinct Hymenobacter species. The menaquinone systems of both strains contained MK-7 as the major respiratory quinone. The predominant polar lipids for both strains were phosphatidylethanolamine and one unidentified glycolipid. The major components in the cellular fatty acid composition were summed feature 3 (C161 ω7c/C161ω6c), C161ω5c, summed feature 4 (anteiso-C171 B/iso-C171 I), anteiso-C150 and iso-C15 0 for all isolates. Based on the obtained results, two novel species are proposed, for which the names Hymenobacter terrestris sp. nov. (type strain P5252T=CCM 8765T=LMG 31495T) and Hymenobacter lapidiphilus sp. nov. (type strain P5342T=CCM 8764T=LMG 30613T) are suggested.Lee and Schwarz made considerable theoretical advances in the psychology of cleansing by proposing that cleaning actions might serve as separation procedures between two psychological entities. Here, we propose that the effectiveness of the separation process may be modulated by the available amount of executive resources, and that separation may operate as a load-dependent resetting procedure.Lee and Schwarz interpret meta-analytic research and replication studies as providing evidence for the robustness of cleansing effects. We argue that the currently available evidence is unconvincing because (a) publication bias and the opportunistic use of researcher degrees of freedom appear to have inflated meta-analytic effect size estimates, and (b) preregistered replications failed to find any evidence of cleansing effects.Lee and Schwarz suggest grounded procedures of separation as a mechanism for embodied cleansing. We compare this process to other mechanisms in grounded cognition and suggest a broader conceptualization that allows integration into general cognitive models of social behavior. Specifically, separation will be understood as a mindset of completed avoidance resulting in high abstraction and openness to new experiences.We link cleansing effects to contemporary cognitive theories via an account of event representation (intersecting object histories) that provides an explicit, neurally plausible mechanism for encoding objects (e.g., the self) and their associations (with other entities) across time. It explains separation as resulting from weakening associations between the self in the present and the self in the past.Cleansing (separation) inductions reduce the impact of negative and positive reactions, whereas connection manipulations magnify them. We suggest that grounded procedures can produce these effects by affecting the perceived validity of thoughts. In accord with the self-validation theory, we also note the importance of considering how moderators, such as the meaning of the action and the timing of inductions, affect outcomes.Lee and Schwarz propose grounded procedures of separation as a domain-general mechanism underlying cleansing effects. One strong test of domain generality is to investigate the ontogenetic origins of a process. Here, we argue that the developmental evidence provides weak support for a domain-general grounded procedures account. Instead, it is likely that distinct separation procedures develop uniquely for different content domains.Lee and Schwarz (L&S) suggest that separation is the grounded procedure underlying cleansing effects in different psychological domains. Here, we interpret L&S's account from a hierarchical view of cognition that considers the influence of physical properties and sensorimotor constraints on mental representations. This approach allows theoretical integration and generalization of L&S's account to the domain of formal quantitative reasoning.The model presented by Lee and Schwarz provides a novel explanation for the elementary mechanisms of psychological cleansing. I argue that the model could be extended to account for complex instances of psychological cleansing where the grounded procedures are not isolated and the opposing motives of separation and connection are entangled in a strategic interplay.This commentary provides an interpretation of the effects of grounded procedures in terms of the goal-generalization processes involved in coping with negative feelings and identifies some implications that might not yet have been considered.To understand the consequences of cleansing, Lee and Schwarz favor a grounded procedures perspective over recently developed disgust theory. We believe that this position stems from three errors (1) interpreting cleansing effects as broader than they are; (2) not detailing the proximate mechanisms underlying disgust; and (3) not detailing adaptive function versus system byproducts when developing the grounded procedures perspective.Lee and Schwarz propose that grounded procedures can also be related to connection rather than separation. Drawing on consumer behavior research, we point to different grounded procedures of connection - in terms of the motor actions involved, their salient properties, and their motivational conditions - and discuss how procedures of separation may be affected by the procedures of connection that precede them.According to Lee and Schwarz, the sensorimotor experience of cleansing involves separating one physical entity from another and grounds mental separation of one psychological entity from another. We propose that cleansing effects may result from symbolic cognition. Instead of viewing abstract meanings as emerging from concrete physical acts of cleansing, this physical act may be appended with pre-existing, symbolic meaning.Our commentators explore the operation of grounded procedures across all levels of analysis in the behavioral sciences, from mental to social, developmental, and evolutionary/functional. Building on them, we offer two integrative principles for systematic effects of grounded procedures to occur. We discuss theoretical topics at each level of analysis, address methodological recommendations, and highlight further extensions of grounded procedures.While Lee and Schwarz propose grounded procedures of separation as an explanation for physical cleansing in various domains (e.g., washing one's hands), we suggest that separation can also account for behavioral cleansing aimed at washing consciences and polishing reputations. We discuss this extension in terms of degrees of behavioral cleansing, motivations, and intentions behind cleansing, and social settings.In this commentary we outline perceptual control theory and suggest this as a fruitful way for Lee and Schwarz (L&S) to fully embody their account of cleansing behavior. Moreover, we take issue with the command control approach that L&S have taken seeing this as an unnecessary cognitive commitment within an embodied model of cleansing behavior.We propose that cleansing behaviors and other acts of separation or connection have more powerful effects when they are grounded in shared practices - in a shared reality. We conceptualize sensorimotor and shared reality effects as synergistic. Most potent should be physical behaviors performed collectively as a shared practice (e.g., communal bathing), grounded both in sensorimotor experience and in shared reality.The pattern of data underlying the successful replications of cleansing effects is improbable and most consistent with selective reporting. Moreover, the meta-analytic approach presented by Lee and Schwarz is likely to find an effect even if none existed. Absent more robust evidence, there is no need to develop a theoretical account of grounded procedures.We propose that the metaphor of cleansing was a by-product of modernization processes. Based on cultural and historical evidence, we claim that the activation of cleansing metaphor triggered positive associations in times when separation was a positively regarded element of human culture and agriculture, but it should not exert the same effect in times when separation became culturally anachronistic.The hypothesis of grounded procedures of separation predicts accentuated effects in individuals with psychiatric disorders, for example, obsessive-compulsive disorders with washing compulsion. This could provide a vantage point for understanding cognitive processes related to specific disorders. However, fully exploring it requires updated experimental designs, including extensive control conditions, exclusion of alternative explanations, internal replications, and parametric variation to strengthen internal validity.
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