Notes

Shape-Restrained Modeling involving Protein-Small-Molecule Buildings with good Indecisiveness Pushed DOCKing.
Comorbidities such as GDM/type 2 DM, PIH, PROM, APH and jaundice were similar in both groups and statistically non-significant, whereas association of anaemia and hypothyroidism were statistically significant (p<0.05) in the positive group. A single maternal death was reported in the positive group. There was an increase in Caesarean section (p=0.002) with higher incidence of preterm births and lowbirth weights in the positive group. Only 3 babies tested positive for COVID-19, so vertical transmission probability was low. Overall, all babies were healthy and the majority of women were discharged without any complications.

There was no significant effect of the infection on maternal and fetal outcomes, but further studies and long-term follow-up is needed to look for any delayed effects on the babies and mothers.
There was no significant effect of the infection on maternal and fetal outcomes, but further studies and long-term follow-up is needed to look for any delayed effects on the babies and mothers.
The enforced restrictions, including physical isolation and school lockdowns after the outbreak of the COVID-19 pandemic, have brought about anxiety and uncertainty the younger generation.

The main objective is to analyse the everyday challenges faced by adolescents in Poland during the time of social isolation in the COVID-19 pandemic.

A nationwide, online survey of adolescents aged 11-18 (N=2408) was conducted in April 2020. Quantitative and qualitative analyses were undertaken. Differences in the everyday challenges experienced during the COVID-19 pandemic connected with gender, age and place of residence were analysed.

Girls were significantly more likely than boys to perceive the limitations in contacts with others (friends and family) and the concerns about the health of relatives as a big difficulty. Among the youngest students (11-12 years of age), the lack of contact with friends and family and worries about their health and the fear of infection ranked higher than for other students. For the oldest (17-18) the lack of private time and space and not being able to meet one's boyfriend/ girlfriend were the most troublesome. The necessity to stay at home and the inconvenience resulting from the lack of outdoor exercise were ranked higher by urban students than by students living in rural areas.

When planning campaigns in the near future to support the mental health of adolescents in the context of the pandemic it is recommended to include especially the youngest adolescents and those living in small and medium-sized cities.
When planning campaigns in the near future to support the mental health of adolescents in the context of the pandemic it is recommended to include especially the youngest adolescents and those living in small and medium-sized cities.A historical review of the development of hip arthroplasty is made. The work was divided into five stages bioarthroplastic, pre-alloarthroplastic, early development of endoprosthetic alloarthroplasty, transitional stage and contemporary alloarthroplasty. The most important documentary history was located in relation to the events that marked milestones in its development from the end of the 19th century to the present time. The purpose of this manuscript was to make a reflective analysis analyzing what have been its successes, its failures and the lessons it has left us. Likewise, it was considered transcendent not only to review its historical development, but also to locate ourselves in the present and towards where we should direct our efforts to continue innovating this therapeutic resource, taking advantage of the lessons of the past and the attitudes of the present and the route to the future. Given the length of the manuscript, it was divided into parts. In this first part, we will review from the bioarthroplastic stage to the current arthroplastic stage.
Carpal dislocations and fracture-dislocations are uncommon injuries and represent approximately 5-7% of all wrist injuries, or about 10% of all carpal injuries. Multiple treatments are proposed to treat these injuries. The aim of our paper is to review the evidence about the treatment of lesser arc perilunate dislocations and to assess the results of the different therapeutic methods.

A systematic review was carried out through the electronic search engines PubMed, Bireme and Timbó. The search reached a total of 898 articles, according to the inclusion and exclusion criteria, 16 works were selected to carry out our systematic bibliographic review.

The majority of the studies analyzed are retrospective case series studies, level of evidence IV. Our results are based on the extraction of data only from minor arc lesions of said works. Five subgroups were performed according to the type of treatment to analyze the results.

The different therapeutic methods were analyzed and clinical, functional and radiographic parameters were compared during follow-up.

There are no significant differences, in terms of the scores used, between closed reduction and percutaneous fixation or open reduction and ligament repair.
There are no significant differences, in terms of the scores used, between closed reduction and percutaneous fixation or open reduction and ligament repair.Injuries in the metatarsophalangeal joint complex of the hallux are seen with greater frequency in athletes, their importance lies in the functional limitation it generates. Early diagnosis and treatment can reduce the sequelae, however, the recognition of chronic lesions and with it the implementation of adequate therapeutic management generate improvements in quality of life. This document records a case of inveterate dislocation of the metatarsophalangeal joint of the hallux of more than one year of evolution with involvement of the intersesamoid ligament which was corrected with arthrodesis achieving immediate satisfactory results, in the medium and long term with the subsequent functional recovery and total reduction of pain.
The Single Assessment Numeric Evaluation (SANE) score is a brief method of evaluating patients' perception of the shoulder joint and has proven high correlation with other outcome measures that are more lengthy and time-consuming in daily practice. The SANE score to date has not been validated in Spanish.

To translate, adapt, and validate the SANE score in Spanish.

An initial translation and counter-translation was conducted by two bilingual evaluators and an official translator. Content validity was evaluated by a group of experts in shoulder surgery. The criteria validity was determined by determining correlation with the previously translated and validated ASES score. Reliability of the test was determined.

113 patients were evaluated, with an average age of 53.6 being 56% female. The most frequent diagnosis was rotator cuff syndrome in 78.6% followed by frozen shoulder, glenohumeral and acromioclavicular osteoarthritis and shoulder instability and acromioclavicular dislocation. Correlation between the SANE and ASES results was 0.699. selleck inhibitor The test was highly reliable with an intraclass correlation coefficient of 0.86.

The SANE score is a valid and reliable patient centered outcome measure that has a good correlation with other previously validated scores in Spanish that are less practical. We present a translated valid version of the SANE score in Spanish that can be used as a patient reported outcome measure for shoulder pathologies.
The SANE score is a valid and reliable patient centered outcome measure that has a good correlation with other previously validated scores in Spanish that are less practical. We present a translated valid version of the SANE score in Spanish that can be used as a patient reported outcome measure for shoulder pathologies.Comprehensive geriatric assessment impacts on the preservation of functionality , affecting the quality of life of the patient. Low muscle mass, expressed as low grip strength, is a common condition that has shown great utility in predicting mortality, days of hospital stay, and early mobilization.
To describe the usefulness of grip strength as a predictor of functional loss in patients older than 60 years with hip fracture.

A prospective, observational, analytical, longitudinal cohort study in 60-year-old hospitalized patients with hip fracture, the grip strength was evaluated with a hydraulic dynamometer at admission and after surgery, with a follow-up at 30 days.

The patients presented a significant decrease in grip strength at admission compared to grip strength at discharge (20.79 ± 4.75 vs. 15.45 ± 4.17 respectively). When evaluating muscle strength, it was found that those patients with functional loss had a higher score of grip strength at admission (21.42 ± 5.26, p = 0.04), and grip strength at discharge (16.14 ± 4.52 p = 0.013). For each day of hospital stay, 0.493 kg of muscle strength decreases.

There is a positive correlation between the days of hospital stay with the decrease in muscle strength in addition to a positive correlation between the Barthel score and grip strength, which proposes that this parameter is an important factor to evaluate in the adult functionality approach.
There is a positive correlation between the days of hospital stay with the decrease in muscle strength in addition to a positive correlation between the Barthel score and grip strength, which proposes that this parameter is an important factor to evaluate in the adult functionality approach.
The aim of this study was to describe the epidemiology and to estimate the direct medical costs of hip fracture among elderly patients in Mexico.

An observational, cross sectional and retrospective study was undertaken. Hospital discharge and surgical procedures for the period 2013-2018 were the databases used for the analysis, and obtained from General Directorate of Health Information. Variables included were sex, federal entity, age, year of discharge, and fracture type according to the CIE-10; and also, the supplies needed for the surgical procedures.

A total of 16,829 patients with hip fracture were discharge, 69% were women, and the mean for age was 79 years old and for the hospital stay length was nine days. The most frequent fracture type was the femur neck with 77% and the average medical costs was USD$45,122,228.00.

Falling risks increase with age, especially in patients among 80-89 years of age, hence, is expected that this type of pathology increases in the following years. The medical costs for treatment of hip fracture represents an economic impact on health services. For that reason, the implementation of prevention strategies, risk of falling for example, is the one of most efficient approach.
Falling risks increase with age, especially in patients among 80-89 years of age, hence, is expected that this type of pathology increases in the following years. The medical costs for treatment of hip fracture represents an economic impact on health services. For that reason, the implementation of prevention strategies, risk of falling for example, is the one of most efficient approach.
Osteoarthritis in Mexico is one of the ten most frequent causes of disability. Early diagnosis and detection of risk factors are determinant for treatment. The institutional organization establishes therapeutic guidelines according to each level of care, but effective management is not achieved.

A prospective, pilot, interventional, clinical study was conducted, which included patients diagnosed with different degrees of knee osteoarthritis in the first, second and third level of care, with an integrative model that includes a group of professionals for the intervention of nutritional, physiotherapeutic, social and psychological evaluation from the first level.

The intervention of a multidisciplinary care group allows a correct evaluation and assignment of the level of care, optimizing human and material resources. The participation of different disciplines in nutrition, psychology, social work, physiotherapy and rehabilitation modifies the global lifestyle by involving the patients themselves in their treatment.
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