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Kurt Schneider introduced in the definition of the first-rank symptoms (FRS) the criterion that, where unequivocally present, the FRS are always psychological primaries and irreducible. This criterion, grounded on 'phenomenology' (description of subjective experiences), cannot be applied, according to Schneider, to delusions, either two-stage FRS delusional perception, or second-rank delusional notions. The Schneider's key criterion was neglected since the initial adoption of the 'Schneider's FRS' in the subsequent international literature (e.g. PSE, RDC, DSM, and ICD). The 'Schneider's FRS' (e.g. WAY-100635 thought insertion, thought withdrawal, passivity, and influence) were persistently equivocated as 'delusions', in spite of the Schneider's FRS exclusion criterion. The internationally equivocated 'Schneider's FRS' (only homonymous of the original 'Schneider's FRS'), were eliminated in the DSM-5 and de-emphasized in ICD-11. However, the diagnostic value of the original 'Schneider's FRS', assessed on the basis of the strict compliance with the Schneider's criterion for their definition, was never determined. The 'damnatio memoriae' of the original Schneider's FRS may be premature. The definition and assessment of the 'experienced' symptoms of schizophrenia, only directly observed and reported by the patients, represent a specific, crucial, irreplaceable domain of psychopathology, to be carefully distinguished from the domain of the 'behavioral' symptoms observed by the clinician. Contemporary psychopathology research is aware of the absolute need for psychiatry to enhance precision and exactness in the definition of the experienced symptoms of schizophrenia, through the formulation of unequivocal inclusion and exclusion criteria (descriptive micro-psychopathology), in order to determine their value in research and care.Background Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2) to assess its change after antidepressant treatment. Methods A total of 460 patients with a current MDE in a context of major depressive disorder (MDD) were compared to 895 HC for NOS activity (L-Cit/L-Arg plasma ratio). L-Arg and L-Cit plasma levels were measured using a MS-based liquid chromatography method. Depressed patients were assessed at baseline, and after 3 and 6 months of antidepressant treatment for depression severity and clinical response. Results Depressed patients had a lower NOS activity than HC at baseline [0.31 ± 0.09 v. 0.38 ± 0.12; 95% confidence interval (CI) -0.084 to -0.062, p less then 0.0001]. Lower NOS activity at baseline predicted a higher response rate [odds ratio (OR) = 29.20; 95% CI 1.58-536.37; p = 0.023]. NOS activity in depressed patients increased significantly up to 0.34 ± 0.08 after antidepressant treatment (Est = 0.0034; 95% CI 0.0002-0.0067; p = 0.03). Conclusions Depressed patients have a decreased NOS activity that improves after antidepressant treatment and predicts drug response. NOS activity may be a promising biomarker for MDE in a context of MDD.Objective Patulous Eustachian tube appears to be caused by a concave defect in the anterolateral wall of the tubal valve of the Eustachian tube. This study aimed to compare the clinical features of patulous Eustachian tube patients with or without a defect in the anterolateral wall of the tubal valve. Methods Sixty-six patients with a patulous Eustachian tube completed a questionnaire, which was evaluated alongside endoscopic findings of the tympanic membrane, nasal cavity and Eustachian tube orifice. Results Females were more frequently diagnosed with a patulous Eustachian tube, but the valve defect was more common in males (p = 0.007). The ratio of patulous Eustachian tube patients with or without defects in the anterolateral wall of the tubal valve was 1.61. Weight loss in the previous six months and being refractory to conservative management were significantly associated with the defect (p = 0.035 and 0.037, respectively). Symptom severity was significantly higher in patients with the defect. Conclusion Patulous Eustachian tube patients without a defect in the anterolateral wall of the tubal valve can be non-surgically treated more often than those with the defect. Identification of the defect could assist in making treatment decisions for patulous Eustachian tube patients.Background Disease trajectories of patients with anxiety disorders are highly diverse and approximately 60% remain chronically ill. The ability to predict disease course in individual patients would enable personalized management of these patients. This study aimed to predict recovery from anxiety disorders within 2 years applying a machine learning approach. Methods In total, 887 patients with anxiety disorders (panic disorder, generalized anxiety disorder, agoraphobia, or social phobia) were selected from a naturalistic cohort study. A wide array of baseline predictors (N = 569) from five domains (clinical, psychological, sociodemographic, biological, lifestyle) were used to predict recovery from anxiety disorders and recovery from all common mental disorders (CMDs anxiety disorders, major depressive disorder, dysthymia, or alcohol dependency) at 2-year follow-up using random forest classifiers (RFCs). Results At follow-up, 484 patients (54.6%) had recovered from anxiety disorders. RFCs achieved a cross-validated area-under-the-receiving-operator-characteristic-curve (AUC) of 0.67 when using the combination of all predictor domains (sensitivity 62.0%, specificity 62.8%) for predicting recovery from anxiety disorders. Classification of recovery from CMDs yielded an AUC of 0.70 (sensitivity 64.6%, specificity 62.3%) when using all domains. In both cases, the clinical domain alone provided comparable performances. Feature analysis showed that prediction of recovery from anxiety disorders was primarily driven by anxiety features, whereas recovery from CMDs was primarily driven by depression features. Conclusions The current study showed moderate performance in predicting recovery from anxiety disorders over a 2-year follow-up for individual patients and indicates that anxiety features are most indicative for anxiety improvement and depression features for improvement in general.For culture models of primary cells of the human nasal mucosa, monocultures with epithelial cells (EC) are used as well as co-cultures with EC and fibroblasts (FB). Well-differentiated models of the respiratory nasal epithelium can be used for ecogenotoxicological assessments, for experiments on host-pathogen interactions or tissue engineering. However, long-term cultivation and repeated passaging may induce a loss of DNA integrity or cell functionality. The aim of this study was to evaluate these parameters in test systems created from primary nasal mucosa cells Enzymatic and sequential cell isolation from nasal tissue was performed. EC monocultures and compartment-separated EC-FB co-cultures were cultivated over three passages under air-liquid interface conditions. DNA stability and regenerative capacity at DNA and chromosomal level as well as proliferation and cell differentiation were examined. Both methods showed equivalent levels of DNA stability and regenerative capacity over all passages. Sequential growth of the co-culture provided higher cell purity while enzymatic cell harvest was associated with FB contamination in EC culture. Mucociliary differentiation were verified with electron microscopy in both methods. Functionality measured by lipopolysaccharide stimulation of interleukins was constant over long-term cultivation. Our data confirm DNA stability in long-term cell cultivation as well as functional integrity in both culture methods. Sequential cell isolation should be favoured over enzymatic isolation due to higher culture purity.Although most theoretical and policy approaches treat criminal behavior and child maltreatment as different issues, we examine the prevalence of those involved in both the criminal justice system and child protective services as perpetrators, assessing how several criminal career characteristics differ between dual-system and single-system offenders. Using longitudinal cohort data from the Queensland Cross-Sector Research Collaboration (QCRC), we found that while dual-system-involved offenders made up only 4% of the population, their proportion was much higher among those with a delinquent history, especially among females (males = 21%, females = 38%). Those involved with both systems were more serious offenders and child maltreatment perpetrators with respect to the number and versatility of system contacts. These findings suggest involvement in both the criminal justice and child welfare systems are part of an underlying vulnerability or predisposition toward antisocial behavior and represent an important overlap of service delivery that must be managed effectively.There has been an increasing interest in cross-cultural risk assessment over the past 5 years. Much of this has been driven by concerns that particular risk instruments may be biased against, or ill-suited to, non-White offending populations. A growing body of work has asserted that unique cultural-specific risk factors and experiences may not be adequately considered within current risk assessment frameworks which have led to calls to culturally alter/remodel risk instruments. While recognising the importance of generalizable risk instruments, this article outlines a number of realities that cross-cultural risk assessment researchers must contend with before embarking on projects to alter instruments. With specific regard to structured professional judgement risk instruments, the article notes that efforts to culturally amend instruments, could paradoxically reduce accuracy and increase bias.Despite the large societal and personal cost associated with the detainment of juvenile offenders in residential facilities, little is known about the factors that contribute to youth behavior while incarcerated. One factor that may be of importance to maintaining security within facilities and improving rehabilitation efforts is youth's perceptions of correctional staff, namely, youth's perceptions of positive staff characteristics (e.g., friendliness; helpfulness) and staff behavior toward youth (e.g., fair punishments). Accordingly, the current study used the National Survey of Youth in Custody across two cohorts to better understand youth perceptions about staff by examining rates of these perceptions within juvenile detention centers nationwide. Furthermore, given the overrepresentation of marginalized groups in the justice system, systematic differences in youth's perceptions about staff were evaluated based on demographic characteristics, including age, race, sex, and sexual orientation, to better understand how these characteristics influence youth perceptions. Results suggested several significant differences based on demographic characteristics, with the most prominent and consistent differences associated with race and age, with Black youth and older youth having the least positive views of staff. Interestingly, non-heterosexual youth were more likely to view staff characteristics as positive than heterosexual youth. Implications of findings are discussed.
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