Notes

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The circular intensity differential scattering (CIDS), i.e. the normalized Mueller matrix element -S14/S11, can be used to detect the helical structures of DNA molecules in biological systems, however, no CIDS measurement from single particles has been reported to date. We report an innovative method for measuring CIDS phase functions from single particles individually flowing through a scattering laser beam. CIDS signals were obtained from polystyrene latex (PSL) microspheres with or without coating of DNA molecules, tryptophan particles, and aggregates of B. subtilis spores, at the size of 3 μm in diameter. Preliminary results show that this method is able to measure CIDS phase function in tens of microseconds from single particles, and has the ability to identify particles containing biological molecules.Harnessing the power and flexibility of radiolabeled molecules, Cerenkov luminescence tomography (CLT) provides a novel technique for non-invasive visualisation and quantification of viable tumour cells in a living organism. However, owing to the photon scattering effect and the ill-posed inverse problem, CLT still suffers from insufficient spatial resolution and shape recovery in various preclinical applications. In this study, we proposed a total variation constrained graph manifold learning (TV-GML) strategy for achieving accurate spatial location, dual-source resolution, and tumour morphology. TV-GML integrates the isotropic total variation term and dynamic graph Laplacian constraint to make a trade-off between edge preservation and piecewise smooth region reconstruction. Meanwhile, the tetrahedral mesh-Cartesian grid pair method based on the k-nearest neighbour, and the adaptive and composite Barzilai-Borwein method, were proposed to ensure global super linear convergence of the solution of TV-GML. The comparison results of both simulation experiments and in vivo experiments further indicated that TV-GML achieved superior reconstruction performance in terms of location accuracy, dual-source resolution, shape recovery capability, robustness, and in vivo practicability. Significance We believe that this novel method will be beneficial to the application of CLT for quantitative analysis and morphological observation of various preclinical applications and facilitate the development of the theory of solving inverse problem.An approach to generating frequency-tunable biphase and quadriphase coded pulse signals without background interference based on a polarization division multiplexing dual-parallel Mach-Zehnder modulator (PDM-DPMZM) is presented and demonstrated. Two ternary baseband code sequences are separately encoded into a pair of orthogonal optical carriers by exploiting a polyphase encoder on the basis of the principle of vector modulation, which in turn can be mapped to the phase shifts of the generated phase coded waveforms after the balanced detection. The frequency tunability can also be achieved by controlling the bias voltage of the associated modulator, so that the carrier frequency can be tuned to either fundamental or doubled frequency. Additionally, by designing different phase codes, the generated pulse signals can be conveniently switched between the quadriphase and biphase coding waveforms. The major advantage of the proposed approach is that four phase shifts can be obtained by simply adjusting the polarity of the ternary code sequences, overcoming the power-dependent limitation of the previous work. A proof-of-principle experiment is conducted to assess the feasibility of the proposed approach built on the Barker code and Frank code phase coded pulse signals generation. Experimental results show the phase coded pulse signals at 12 and 24 GHz carrier frequency are well behaved in terms of peak-to-sidelobe ratio (PSR), range-Doppler coupling and Doppler tolerance.The use of the new CYTOP (Cyclized Transparent Optical Polymer) fibres for the inscription of optical structures and the detection of different parameters has started to gain importance in the past decade. This work presents the design, simulation and manufacture of a CYTOP-based surrounding refractive index sensor for aqueous solutions, given its high sensitivity in the range 1.315 - 1.333 (at 1550 nm wavelength). The structure is based on a bent and polished fibre (in order to increase its sensitivity), the polished area being the surface on which a diffraction grating is inscribed with a femtosecond laser. The interaction of the field propagated by the fibre with the grating causes diffraction of certain orders towards the outside, depending, among other things, on the refractive index of the fluid. In addition to a maximum sensitivity of -208.8 nm/RIU and a remarkable insensitivity to temperature, it offers a spectral fingerprint of each sensed fluid.A Mach-Zehnder interferometer assisted ring resonator configuration (MARC)-based multiplexed photonic sensor with a large measurement range is experimentally demonstrated. The presented MARC sensor consists of a balanced Mach-Zehnder interferometer and a ring resonator acting as a sensing component. It produces transmission responses with unique spectral signatures, which depend on the physical angular separation between the through port and the drop port waveguides. These unique spectral signatures enhance the effective free spectral range of ring resonators. Hence MARC sensors with a large measurement range are realized. We experimentally demonstrated that the measurement range from the MARC with 135° angular separation is 8x larger than a standard ring resonator. Ruxolitinib Moreover, by utilizing the MARC, we distinguished the responses from two and three ring resonators multiplexed together. These results verify proof-of-principle for the MARC-based sensors. This inexpensive compact multipurpose device holds promise for numerous applications.Nonlinear crystalline ridge waveguides, e.g., lithium niobate-on-insulator ridge waveguides, feature high index contrast and strong optical confinement, thus dramatically enhancing nonlinear interaction and facilitating various nonlinear effects. Here, we experimentally demonstrate efficient second-harmonic generation (SHG) and cascaded fourth-harmonic generation (FHG) in a periodically poled lithium niobate (PPLN) ridge waveguide pumped with pulsed laser at the quasi-phase matching (QPM) wavelength, as well as simultaneous SHG and cascaded third-harmonic generation (THG) waves when pumped at the non-QPM wavelength. Furthermore, the ridge waveguide achieves an efficient single-pass SHG conversion efficiency of picosecond pulsed laser at ∼62%. These results may be beneficial for on-chip nonlinear frequency conversion.A scheme for ion-based high-harmonic generation from water window to keV x-ray is investigated. He1+ ions with 54.42-eV ionization potential extend the harmonic cutoff energy to 1 keV. The transverse selective-zoning method of quasi-phase-matching is utilized to overcome the severe plasma dispersion in a highly ionized medium. The calculated conversion efficiency reaches about 15% of the perfect phase-matching condition. Wavelength tunability is achieved by incorporating a programmable spatial-light modulator to control the quasi-phase-matching pattern.The demand for high-speed and highly efficient optical communication techniques has been rapidly growing due to the ever-increasing volume of data traffic. As well as the digital coherent communication used for core and metro networks, intensity modulation and direct detection (IM-DD) are still promising schemes in intra/inter data centers thanks to their low latency, high reliability, and good cost performance. In this work, we study a microresonator-based frequency comb as a potential light source for future IM-DD optical systems where applications may include replacing individual stabilized lasers with a continuous laser driven microresonator. Regarding comb line powers and spectral intervals, we compare a modulation instability comb and a soliton microcomb and provide a quantitative analysis with regard to telecom applications. Our experimental demonstration achieved a forward error correction (FEC) free operation of bit-error rate (BER) less then 10-9 with a 1.45 Tbps capacity using a total of 145 lines over the entire C-band and revealed the possibility of soliton microcomb-based ultra-dense wavelength division multiplexing (WDM) with a simple, cost-effective IM-DD scheme, with a view to future practical use in data centers.Efficient control of the phase and polarization of light is of significant importance in modern optics and photonics. However, traditional methods are often accompanied with cascaded and bulky designs that cannot fulfill the ongoing demand for further integrations. Here, a single-layered metasurface composed of nonvolatile phase-change material Ge2Sb2Se4Te1 (GSST) is proposed with tunable spin-orbit interactions in subwavelength scale. According to the spin-dependent destructive or constructive interference, asymmetric transmission for circularly polarized incidence (extinction ratio > 81) can be achieved when GSST is in an amorphous state. Moreover, when GSST changes to crystalline state, reversed chiral transmission (extinction ratio > 121) can be observed due to the existence of intrinsic chirality. In addition, as the average cross-polarized transmitted amplitude is larger than 85%, arbitrary wavefront manipulations can be achieved in both states simultaneously based on the theory of Pancharatnam-Berry phase. As a proof of concept, several functional metasurface devices are designed and characterized to further demonstrate the validation of our design methodology. It is believed that these multifunctional devices with ultrahigh compactness are promising for various applications including chiroptical spectroscopy, EM communication, chiral imaging, and information encryption.Pinpoint damage is the main type of bulk damage in potassium dihydrogen phosphate (KDP) crystals in high-power lasers. Using time-resolved microimaging, we observed the complete dynamic evolution of pinpoint damage in a KDP crystal. We analyzed changes in the patterns of dark zones formed by decreasing probe transmittance in transient images throughout the process. The mechanical properties of stress waves in KDP crystals were further studied by a depolarized shadowgraph experiment and theoretical simulation. The dynamic evolution of mechanical stress waves was observed, and the correlation between mechanical failure due to stress waves and the static characteristic damage morphology was established.We theoretically investigate the nonlinear dynamics of an optomechanical system, where the system consists of N identical mechanical oscillators individually coupled to a common cavity field. We find that the optomechanical nonlinearity can be enhanced N times through theoretical analysis and numerical simulation in such a system. This leads to the power thresholds to observe the nonlinear behaviors (bistable, period-doubling, and chaotic dynamics) being reduced to 1/N. In addition, we find that changing the sign (positive or negative) of the coupling strength partly does not affect the threshold of driving power for generating corresponding nonlinear phenomena. Our work may provide a way to engineer optomechanical devices with a lower threshold, which has potential applications in implementing secret information processing and optical sensing.
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