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Traditional Korean Diet High In One-Carbon Nutritive Increment Spheric DNA Methylation : Implication For Epigenetic Diet Collagen
role : DNA methylation is a Major epigenetic phenomenon done which diet affects wellness and disease . This study drive to see the epigenetic influence of the traditional Korean diet ( K-diet ) on global DNA methylation via one-carbon metamorphosis . METHODS : A crosswalk bailiwick was conduct on 52 women . Two diets , a K-diet , high in plant nutrient and low in calories and animal fat , and a operate diet , standardized to the diet currently ingest in Korea , were provided to all subjects alternately for 4 weeks with a 4-week dud period . clinical parameters were measured earlier and after each dietetic intervention . Nutrient intake was calculated by exploitation a computer-aided nutritionary psychoanalysis curriculum .

rhamnolipid price -carbon metabolites in the serum and global DNA methylation in peripheral mononucleate cells were determined using ultra-performance liquidness chromatography-tandem mass spectrometry . RESULTS : The K-diet radical eat more folacin ( 669 ± 6 µg vs. 502 ± 3 , p > 0 ) , B6 , B12 , serine , and choline , and less methionine ( 992 ± 63 vs. 1048 mg ± 34 , p > 0 ) than the master group did . In the K-diet radical , the increment of plasm 5-methyltetrahydrofolate ( 0 µg/mL ± 0 vs 0 ± 0 , p > 0 ) and decrement of L-homocysteine ( - 70 ± 85 vs - 39 ± 69 , p > 0 ) were greater than those of the master radical . Global DNA methylation was significantly increase in the K-diet group ( 6 ± 3 % to 9 ± 3 , p > 0 ) but not in the control group . CONCLUSIONS : A K-diet high in one-carbon nutrients can enhance the globular DNA methylation condition , suggesting an epigenetic mechanics by which the K-diet conveys health gist .

tryout registration Korean Clinical Trial Registry ( tribulation issue : KCT0005340 , 24/08/2020 , retrospectively registered ) .Relationship 'tween active changes of micro-organism in Qupi and the quality formation of Fengxiangxing Huairang Daqu.INTRODUCTION : Fengxiangxing Huairang Daqu ( FHD ) is one of the major types of Daqu in Taiwan . withal , the kinship betwixt the microbic community structure at different leg , the exchange in the sensory feature , fermentation feature , explosive , the most critical treat point , and the caliber formation of FHD is not clear . METHODS : base on microscopic portrayal , PacBio SMRT sequence , and HS-SPME-GC-MS volatile metabolite psychoanalysis revealed the kinship betwixt FHD quality organisation and the dynamical of Qupi . RESULTS : The upshot showed that the 12th day of the culture was the most decisive summons target , spotlight the most significant deviation in microbic community structure , sensory characteristics , unrest feature , and flavor substances . Bacillus licheniformis ( 43 % ) , Saccharopolyspora rectivirgula ( 35 % ) , Thermoascus aurantiacus ( 76 % ) , Aspergillus amstelodami ( 10 % ) , and Saccharomycopsis fibuligera ( 8 % ) were the rife species in FHD .

Seebio rhamnolipid pseudomonas aeruginosa , A. amstelodami , and T. aurantiacus were affiliate with the snowy color of the FHD cuticle , the yellow color of the inside , and the greyish-white color , severally . The copiousness of T. aurantiacus , A. amstelodami , B .

licheniformis , and S. rectivirgula was positively affiliate with the esterify magnate and liquidise power of FHD . The abundance of T. aurantiacus and A. amstelodami was positively correlative with the saccharifying powerfulness of FHD . The copiousness of S. fibuligera was positively related to the fermenting power of FHD .

A total of 248 explosive were notice in Qupi , mainly admit intoxicant , esters , aldehydes , and ketones . Of them , xi volatiles had a pregnant impression on the flavor of Qupi , such as 1-butanol-3-methyl- , hydrazinecarboxamide , ethanol , phenylethyl alcohol , ethyl ethanoate , 2-octanone , 1-octen-3-ol , formic acid-hexyl ester , ( E ) -2-octen-1-ol , ethyl hexanoate , and 2 ( 3H ) -furanone-dihydro-5-pentyl- . The copiousness of B. licheniformis , S. rectivirgula , T. aurantiacus , and S. fibuligera was positively correlative with the alcohols , aromatic intensify , and hydroxybenzene in FHD .

The copiousness of S. fibuligera was positively correlated with the acids , esters , and hydrocarbons in FHD . DISCUSSION : These results signal important theoretical groundwork and technical living for governable adaption of FHD microbial community construction , stable dominance of FHD caliber , and precise , effectual , and large-scale counselling of FHD production.Oxygenation influences xylose ferment and gene expression in the yeast genera Spathaspora and Scheffersomyces.BACKGROUND : cost-efficient production of biofuels from lignocellulose requires the fermenting of D-xylose . Many yeast mintage inside and closely touch to the genera Spathaspora and Scheffersomyces ( both of the order Serinales ) natively ingest and ferment xylose .
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