Notes

Pan-cancer evaluation shows a good immunological position and prognostic probable of PXN inside individual cancer malignancy.
Quantum emitters in diamond are leading optically accessible solid-state qubits. Among these, Group IV-vacancy defect centers have attracted great interest as coherent and stable optical interfaces to long-lived spin states. Theory indicates that their inversion symmetry provides first-order insensitivity to stray electric fields, a common limitation for optical coherence in any host material. Here we experimentally quantify this electric field dependence via an external electric field applied to individual tin-vacancy (SnV) centers in diamond. These measurements reveal that the permanent electric dipole moment and polarizability are at least 4 orders of magnitude smaller than for the diamond nitrogen vacancy (NV) centers, representing the first direct measurement of the inversion symmetry protection of a Group IV defect in diamond. Moreover, we show that by modulating the electric-field-induced dipole we can use the SnV as a nanoscale probe of local electric field noise, and we employ this technique to highlight the effect of spectral diffusion on the SnV.Data from the Voyager probes have provided us with the first measurement of cosmic ray intensities at MeV energies, an energy range that had previously not been explored. Simple extrapolations of models that fit data at GeV energies, e.g., from AMS-02, however, fail to reproduce the Voyager data in that the predicted intensities are too high. Oftentimes, this discrepancy is addressed by adding a break to the source spectrum or the diffusion coefficient in an ad hoc fashion, with a convincing physical explanation yet to be provided. Here, we argue that the discrete nature of cosmic ray sources, which is usually ignored, is instead a more likely explanation. We model the distribution of intensities expected from a statistical model of discrete sources and show that its expectation value is not representative but has a spectral shape different from that for a typical configuration of sources. The Voyager proton and electron data are however compatible with the median of the intensity distribution.We demonstrate superresolution optical sensing of the size of the wave packet of a single trapped ion. Our method extends the well-known ground state depletion (GSD) technique to the coherent regime. Here, we use a hollow beam to strongly saturate a coherently driven dipole-forbidden transition around a subdiffraction limited area at its center and observe state dependent fluorescence. By spatially scanning this laser beam over a single trapped ^40Ca^+ ion, we are able to measure the wave packet sizes of cooled ions. Using a depletion beam waist of 4.2(1)  μm we reach a spatial resolution which allows us to determine a wave packet size of 39(9) nm for a near ground state cooled ion. This value matches an independently deduced value of 32(2) nm, calculated from resolved sideband spectroscopy measurements. Finally, we discuss the ultimate resolution limits of our adapted GSD imaging technique in view of applications to direct quantum wave packet imaging.We study the dynamics of a driven non-Hermitian superconducting qubit which is perturbed by quantum jumps between energy levels, a purely quantum effect with no classical correspondence. The quantum jumps mix the qubit states leading to decoherence. We observe that this decoherence rate is enhanced near the exceptional point, owing to the cube-root topology of the non-Hermitian eigenenergies. Together with the effect of non-Hermitian gain or loss, quantum jumps can also lead to a breakdown of adiabatic evolution under the slow-driving limit. Our study shows the critical role of quantum jumps in generalizing the applications of classical non-Hermitian systems to open quantum systems for sensing and control.Dynamic states offer extended possibilities to control the properties of quantum matter. Recent efforts are focused on studying the ordered states which appear exclusively under the time-dependent drives. Here, we demonstrate a class of systems which feature dynamic spin-triplet superconducting order stimulated by the alternating electric field. The effect is based on the interplay of ferromagnetism, interfacial spin-orbital coupling, and the condensate motion driven by the field, which converts hidden static p-wave order, produced by the joint action of the ferromagnetism and the spin-orbital coupling, into dynamic s-wave equal-spin-triplet correlations. We demonstrate that the critical current of Josephson junctions hosting these states is proportional to the electromagnetic power, supplied either by the external irradiation or by the ac current source. Based on these unusual properties we propose the scheme of a Josephson transistor which can be switched by the ac voltage and demonstrates an even-numbered sequence of Shapiro steps. Combining the photoactive Josephson junctions with recently discovered Josephson phase batteries we find photomagnetic SQUID devices which can generate spontaneous magnetic fields while being exposed to irradiation.Organic salts represent an ideal experimental playground for studying the interplay between magnetic and charge degrees of freedom, which has culminated in the discovery of several spin-liquid candidates such as κ-(ET)_2Cu_2(CN)_3 (κ-Cu). Recent theoretical studies indicate the possibility of chiral spin liquids stabilized by ring exchange, but the parent states with chiral magnetic order have not been observed in this material family. In this Letter, we discuss the properties of the recently synthesized κ-(BETS)_2Mn[N(CN)_2]_3 (κ-Mn). Based on analysis of specific heat, magnetic torque, and NMR measurements combined with ab initio calculations, we identify a spin-vortex crystal order. These observations definitively confirm the importance of ring exchange in these materials and support the proposed chiral spin-liquid scenario for triangular lattice organics.The existence of a transition from a clogged to an unclogged state has been recently proposed for the flow of macroscopic particles through bottlenecks in systems as diverse as colloidal suspensions, granular matter, or live beings. Here, we experimentally demonstrate that, for vibrated granular media, such a transition genuinely exists, and we characterize it as a function of the outlet size and vibration intensity. We confirm the suitability of the "flowing parameter" as the order parameter, and we find out that the rescaled maximum acceleration of the system should be replaced as the control parameter by a dimensionless velocity that can be seen as the square root of the ratio between kinetic and potential energy. In all the investigated scenarios, we observe that, for a critical value of this control parameter S_c, there seems to be a continuous transition to an unclogged state. The data can be rescaled with this critical value, which, as expected, decreases with the orifice size D. This leads to a phase diagram in the S-D plane in which clogging appears as a concave surface.Quantum state tomography (QST) is a challenging task in intermediate-scale quantum devices. Here, we apply conditional generative adversarial networks (CGANs) to QST. In the CGAN framework, two dueling neural networks, a generator and a discriminator, learn multimodal models from data. We augment a CGAN with custom neural-network layers that enable conversion of output from any standard neural network into a physical density matrix. To reconstruct the density matrix, the generator and discriminator networks train each other on data using standard gradient-based methods. We demonstrate that our QST-CGAN reconstructs optical quantum states with high fidelity, using orders of magnitude fewer iterative steps, and less data, than both accelerated projected-gradient-based and iterative maximum-likelihood estimation. We also show that the QST-CGAN can reconstruct a quantum state in a single evaluation of the generator network if it has been pretrained on similar quantum states.Symmetries play a major role in identifying topological phases of matter and in establishing a direct connection between protected edge states and topological bulk invariants via the bulk-boundary correspondence. selleck chemicals One-dimensional lattices are deemed to be protected by chiral symmetry, exhibiting quantized Zak phases and protected edge states, but not for all cases. Here, we experimentally realize an extended Su-Schrieffer-Heeger model with broken chiral symmetry by engineering one-dimensional zigzag photonic lattices, where the long-range hopping breaks chiral symmetry but ensures the existence of inversion symmetry. By the averaged mean displacement method, we detect topological invariants directly in the bulk through the continuous-time quantum walk of photons. Our results demonstrate that inversion symmetry protects the quantized Zak phase but edge states can disappear in the topological nontrivial phase, thus breaking the conventional bulk-boundary correspondence. Our photonic lattice provides a useful platform to study the interplay among topological phases, symmetries, and the bulk-boundary correspondence.We consider the nonequilibrium orbital dynamics of spin-polarized ultracold fermions in the first excited band of an optical lattice. A specific lattice depth and filling configuration is designed to allow the p_x and p_y excited orbital degrees of freedom to act as a pseudospin. Starting from the full Hamiltonian for p-wave interactions in a periodic potential, we derive an extended Hubbard-type model that describes the anisotropic lattice dynamics of the excited orbitals at low energy. We then show how dispersion engineering can provide a viable route to realizing collective behavior driven by p-wave interactions. In particular, Bragg dressing and lattice depth can reduce single-particle dispersion rates, such that a collective many-body gap is opened with only moderate Feshbach enhancement of p-wave interactions. Physical insight into the emergent gap-protected collective dynamics is gained by projecting the Hamiltonian into the Dicke manifold, yielding a one-axis twisting model for the orbital pseudospin that can be probed using conventional Ramsey-style interferometry. Experimentally realistic protocols to prepare and measure the many-body dynamics are discussed, including the effects of band relaxation, particle loss, spin-orbit coupling, and doping.A search for new phenomena is presented in final states with two leptons and one or no b-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full run-2 proton-proton collision dataset recorded at a center-of-mass energy of sqrt[s]=13  TeV by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 139  fb^-1. No significant deviation from the expected background is observed in the data. Inspired by the B-meson decay anomalies, a four-fermion contact interaction between two quarks (b, s) and two leptons (ee or μμ) is used as a benchmark signal model, which is characterized by the energy scale and coupling, Λ and g_*, respectively. Contact interactions with Λ/g_* lower than 2.0 (2.4) TeV are excluded for electrons (muons) at the 95% confidence level, still far below the value that is favored by the B-meson decay anomalies. Model-independent limits are set as a function of the minimum dilepton invariant mass, which allow the results to be reinterpreted in various signal scenarios.
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