Notes

Beneficial potential of biologics within prurigo nodularis.
Blunder diagnosis design produced utilizing a multi-task convolutional neurological circle within patient-specific quality peace of mind for volumetric-modulated arc remedy.
For the logical form of ylide-substituted phosphines regarding precious metal(i)-catalysis: from non-active to ppm-level catalysis.
05). The quality of life of patients in group B after operation was better than that in group A (
<0.05). There was no marked difference in VAS scores between groups.

Etomidate has better anesthetic effect than propofol in lung adenocarcinoma resection, leading to better stabilization of the vital signs of patients and it also has higher safety.
Etomidate has better anesthetic effect than propofol in lung adenocarcinoma resection, leading to better stabilization of the vital signs of patients and it also has higher safety.
To explore the regulation of miR-125a-5p in hepatocellular carcinoma (HCC) and its mechanisms.

By transfecting a miR-125a-5p sequence and an interfering sequence of miR-125a-5p-s into human HCC cell lines HCC-LM3 and HepG2, miR-125a-5p-related levels were assesed by Western blot. The abilities of cell proliferation and migration were assessed by cell culture and Transwell assay, respectively.

HepG2 cells showed increased miR-125a-5p levels compared with HCC-LM3 cells (
< 0.01). However, compared with QZG cells, the level of miR-125a-5p in HepG2 and HCC-LM3 cells was down-regulated. Compared with miR-125a-5p groups, miR-125a-5p-s groups showed increased colony formation rate and mobility (P < 0.01). After being transfected with miR-125a-5p, the transformation factor 2β (TRA2β) and mRNA levels were decreased, whereas 5p-s expression was increased (
< 0.01). Inhibition of TRA2β by small interfering RNA (siRNA) diminished the ability of cells.

miR-125a-5p inhibits the invasive capacity of HCC cells through targeting the TRA2β pathway.
miR-125a-5p inhibits the invasive capacity of HCC cells through targeting the TRA2β pathway.
To explore the application effect of standardized clinical skills instruction video based on QR code management in clinical teaching to promote the information reform and innovation of clinical teaching and seek a new practice method with a higher teaching efficiency.

A total of 150 clinical, medical-technical, and nursing interns who completed their internship in our hospital by June 2021 after being enrolled in 2020 were assigned to the experimental group, and 84 interns who completed their internship by June 2020 after being recruited in 2019 were retrospectively included in the control group. The experimental group received standardized clinical skills instruction videos based on QR code management to clinical teaching, while the control group was given the traditional teaching method. The costs of teaching models, materials management, and human resources in the clinical skills center that were eventually consumed by the two groups were counted, and the satisfaction of the interns and teachers towardndent learning, which promotes the information reform and innovation of clinical hospital teaching based on the integration of multimedia teaching and network learning and provides a novel practice method with a higher effect for clinical hospital teaching.
The standardized clinical skills instruction video based on QR code management can realize the synchronization of classroom teaching and network teaching and the decentralized network-independent learning, which promotes the information reform and innovation of clinical hospital teaching based on the integration of multimedia teaching and network learning and provides a novel practice method with a higher effect for clinical hospital teaching.
To investigate the efficacy of faecal microbiota transplantation (FMT) in the treatment of ulcerative colitis (UC) and its effect on gastrointestinal motility (GM) and immune function.

A retrospective cohort study was conducted on 47 UC patients. The patients were divided into an observation group (n=17, treated with FMT) and a control group (n=30, treated with conventional treatment) according to the treatment regimen. In the observation group, FMT was used to treat colonic lesions by transplanting colonic bacteria fluid from healthy people. Clinical efficacy, immune function, level of inflammatory factors and gastrointestinal function of the two groups were observed before and after treatment.

The total response rates of observation group was 94.12%, which was higher than that of control group (70.00%; P<0.05). After treatment, the contents of CD3+, CD4+ T cells and CD4+/CD8+ ratio were increased, while the content of CD8+ T cells was decreased in both groups compared with those before treatment (ament of UC, which may be related to the improvement of immune function, alleviation of inflammatory response and promotion of GM recovery.
To explore the influencing factors of rehabilitation treatment effect in patients with first-episode stroke and provide a theoretical basis for clinical practice.

The clinical data of patients with first-episode stroke who received rehabilitation treatment in our hospital from January 2015 to January 2019 were collected and analyzed retrospectively. The Modified Barthel Index (MBI) and Frenchay Activity Scale (FAS) were used to evaluate the rehabilitation treatment effect. Spearman rank correlation analysis was carried out to investigate the relationship between the data characteristics and rehabilitation treatment effect, and univariate and multivariate logistic regression analyses were conducted to explore the independent factors influencing the rehabilitation treatment effect in the first-episode stroke group.

In this study, 786 cases of 873 patients with first-episode stroke were included, with an effective inclusion rate of 90.0%. Univariate analysis showed that MBI and FAS scores were statisticall, and family environment score could independently affect MBI and FAS scores of patients with stroke (all
<0.05).

Age, the number of residual symptoms, depression status, attitude towards rehabilitation treatment, starting time of rehabilitation treatment, rehabilitation treatment duration, and family environment score are independent factors for rehabilitation treatment effect in patients with first-episode stroke.
Age, the number of residual symptoms, depression status, attitude towards rehabilitation treatment, starting time of rehabilitation treatment, rehabilitation treatment duration, and family environment score are independent factors for rehabilitation treatment effect in patients with first-episode stroke.
To evaluate the clinical efficacy of probiotics and dietary fiber combined with pinaverium bromide in the treatment of irritable bowel syndrome (IBS) and its effect on intestinal flora.

As a prospective study, 180 patients with IBS hospitalized in the gastroenterology department of our hospital from January 2018 to January 2021 were selected and assigned to Group A, Group B, or Group C using the random number table method, with 60 cases in each group. Patients in Group A received conventional treatment with pinaverium bromide tablets. Those in Group B were given bifid triple viable combined with pinaverium bromide, and those in Group C were given bifid triple viable and dietary fiber combined with pinaverium bromide. The treatment spanned 4 weeks. The treatment efficacy, degree of symptom improvement, quality of life, adverse effects, and changes in intestinal flora were compared among the three groups.

The total treatment efficacy was significantly higher in Group C compared with Group A (χ
=8.711, P=with pinaverium bromide can significantly improve clinical efficacy, shorten symptom resolution time, reduce calprotectin, and regulate intestinal flora.
To investigate the therapeutic effect and specific mechanism of self-designed Xiaoban Huoxue Prescription on chloasma derived from liver stagnation and blood stasis.

This study retrospectively analyzed the clinical data of 94 patients with chloasma derived from liver stagnation and blood stasis. The patients were divided into a control group (treated with tranexamic acid tablets) and an experimental group (treated with self-designed Xiaoban Huoxue Prescription), with 47 cases in each group. Both groups were treated for 3 months, and the clinical efficacy was compared between the two groups.

The total response rate of the experimental group was higher than that of the control group (P<0.05). Compared with before treatment, the traditional Chinese medicine syndrome scores and Melasma area severity index scores in the two groups were lower 1, 2 and 3 months after treatment, and lower scores were seen in the experimental group than in the control group (all P<0.001); there was an opposite trend in thed to the downregulation of serum sex hormone expressions and tyrosinase absorbance.
To compare the therapeutic effect of transumbilical single-port laparoscopic surgery (TSPLS) and three-port laparoscopic surgery (TPLS) on ovarian cyst.

Clinical data of 60 patients with ovarian cyst admitted to our hospital were respectively analyzed. The patients were divided into a TPLS group (n=30) and a TSPLS group (n=30) according to surgical methods. Clinical indicators, visual analogue scale (VAS), self-rating anxiety scale (SAS), self-rating depression scale (SDS) and satisfaction regarding aesthetic appearance of the incision were compared between the two groups.

The operation time, time to anal exhaust and hospital stay in the TSPLS group were shorter than those in the TPLS group, and lower postoperative VAS, SAS and SDS scores and higher quality-of-life score were seen in the TSPLS group (all P<0.05). The incidence of postoperative complications in the TSPLS group was lower than that in the TPLS group (P<0.05). The overall satisfaction in the TSPLS group was significantly higher than that in the TPLS group (93.33% vs. see more 66.67%; χ
=51.526, P=0.001).

Compared with TPLS, TSPLS has better therapeutic effect on ovarian cyst. TSPLS can improve the clinical indications of patients with higher safety.
Compared with TPLS, TSPLS has better therapeutic effect on ovarian cyst. see more TSPLS can improve the clinical indications of patients with higher safety.This study aimed to investigate the effect of high-quality nursing and health education on glucose and lipid metabolism and quality of life in elderly patients with diabetes. A total of 99 elderly patients with diabetes admitted to our hospital from December 2016 to April 2019 were enrolled and divided into an observation group (57 cases) and a control group (42 cases) according to different nursing methods. The nursing satisfaction, self-management ability, blood lipid index, and negative emotions of the two groups of patients before and after nurse intervention were evaluated. After nursing, the fasting blood glucose level of the two groups of patients decreased 2 hours after a meal, and the level in the observation group was lower than that of the control group. After nursing, the Self-Rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) scores of the two groups of patients decreased, and the scores of the observation group were lower than those of the control group. Before nursing intervention, there was no significant difference in the quality of life scores between the two groups, while after it, the quality of life scores of the two groups increased, and the scores of the observation group were higher than those of the control group. Moreover, after nursing, serum triglyceride (TG), cholesterol (TC), and low density lipoprotein cholesterol (LDL-C) in the observation group were significantly lower than those of the control group, while serum high density lipoprotein cholesterol (HDL-C) in the observation group was significantly higher than that of the control group. Furthermore, the nursing satisfaction and the self-management score were also significantly higher in the observation group. High quality nursing can significantly improve glucose and lipid metabolism levels and quality of life in elderly patients with diabetes, and is worthy of clinical application.
Acute cerebral infarction (ACI) can lead to death or disability, posing a serious threat to human health. This study aimed to investigate the effects of cerebral artery thrombectomy on the efficacy, safety, cognitive function and peripheral blood amyloid-β (Aβ), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in patients with ACI.

The clinical data of 169 patients with ACI admitted to our hospital from April 2019 to September 2020 were analyzed retrospectively. Among them, 100 patients were treated with cerebral artery thrombectomy and assigned to the research group, and the other 69 patients were intervened by conventional treatment and assigned to the control group. The clinical effects in the two groups were observed and compared. The cognitive function was evaluated by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA), the neurological dysfunction was assessed by the National Institutes of Health Stroke Scale (NIHSS), and the prognosis was determintwo scores in the research group were statistically higher than those in the control group after treatment. In addition, lower NIHSS and mRS scores were determined in the research group compared with the control group after treatment. Moreover, except for the statistically significant difference in the number of cases with cognitive dysfunction (P<0.05), there was no significant difference in the incidence of other adverse reactions between the research group and the control group (P>0.05).

Cerebral artery thrombectomy is effective in the treatment of ACI, which can improve the cognitive function of patients and alleviate the high Aβ accumulation and inflammation in the central nervous system, with a high safety profile.
Cerebral artery thrombectomy is effective in the treatment of ACI, which can improve the cognitive function of patients and alleviate the high Aβ accumulation and inflammation in the central nervous system, with a high safety profile.Despite the high rate of maternal and child health disparities among the Marshallese, there are no studies documenting gestational weight gain influences, beliefs, and goals among the Marshallese. From March 2019 to March 2020, a purposive sample of 33 participants took part in the mixed methods study. Two themes emerged (1) Gestational Weight Gain Influences and (2) Excessive Gestational Weight Gain Perceptions. In the first theme there were three subthemes (a) Church and Familial Influence on Gestational Weight Gain; (b) Healthy Gestational Weight Gain; and (c) Lack of Healthcare Provider Influence on Gestational Weight Gain. In the second theme there were three subthemes (a) Excessive Weight Gain and Pregnancy; (b) Excessive Gestational Weight Gain and Labor; and (c) Gestational Weight Gain Goals. This study will be used to culturally tailor interventions to help Marshallese women reduce maternal and infant health disparities in Marshallese communities.The clinical course of Pneumocystis pneumonia in liver transplant recipients has not been well investigated. Therefore, we collected and analyzed the clinical, epidemiological, and molecular data from patients with Pneumocystis pneumonia as well as paired controls (Chinese Clinical Trial Registry, ChiCTR2100046028; www.chictr.org.cn). There were a total of ten patients diagnosed with Pneumocystis pneumonia containing prospectively included six patients and retrospectively collected four patients, of which seven were transferred to the surgical intensive care unit and four died. The transmission map revealed that inter-patient transmission of Pneumocystis jirovecii was impossible; P. jirovecii detection was negative in all air samples. It was positive only in one sample from the twelve healthcare workers who had close contact with diseased patients. Five out of 79 liver transplant recipients during the outbreak were colonized with Pneumocystis jirovecii compared to 2 out of 94 after the outbreak upon admission (P>0.05). Liver transplant recipients with Pneumocystis pneumonia had totally different genotypes based on multilocus sequence typing. Additionally, we found an unreported mutation in the cytochrome b gene. The absolute CD19+ B-cell counts (odds ratio 1.028; 95% confidence interval 1.000-1.057; P=0.049) were defined to be the only significant independent risk factor. At a cut-off value of 117.16/µL, the sensitivity and specificity were 100% and 70%, respectively. Pneumocystis pneumonia is a severe complication following liver transplantation. The outbreak may not be caused by nosocomial transmission. A decrease in absolute CD19+ B-cell counts may be associated with the development of Pneumocystis pneumonia.
To explore the clinical efficacy of laparoscopic radical resection combined with neoadjuvant chemotherapy (NACT) in the treatment of colorectal cancer and its influence on postoperative complications.

The clinical data of 90 patients with colorectal cancer admitted to our hospital from June 2019 to June 2021 were retrospectively analyzed. According to different treatment methods, patients were divided into a control group (laparoscopic radical resection) and a study group (combined NACT before radical resection), with 45 cases in each group. The efficacy and complications were compared between the two groups after treatment.

Postoperatively, the early oral feeding, anal exhaust time, and hospitalization time of the patients in the study group were significantly shorter than those in the control group (P<0.05). The study group had significantly lower cancer metastasis rate, recurrence rate, infection rate, and smaller tumor diameters than the control group (P<0.05). The levels of tumor markers (CEAolongs the average survival time, without obvious complications.
To analyze the factors influencing the clinical effect of using respiratory humidifier in patients with AIDS complicated with severe Pneumocystis jiroveci pneumonia (PCP).

According to the treatment results, AIDS patients with severe PCP were divided into two groups, successful group (n=68) and failure group (n=94), to compare the early ventilation changes between the two groups.

The ICU ratio of the successful group was lower than that of the failure group (
<0.05). The respiratory frequency, heart rate, PaO
, C-reactive protein and SOFA score of the successful group were lower than those in the failure group (
<0.05), while SpO
, FiO
, PaO
/FiO
, SpO
/FiO
, Rox index and IL-10 levels were increased in the successful group (
<0.05). The successful group had higher IL-6 and IL-1β level than that of the failure group. The levels of IL-8 were decreased (
<0.05). The success of respiratory humidifier was negatively correlated with the score of SOFA (
<0.05).

The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO
/FiO
, PaO
, ROX index, SOFA score, and IL-6 and IL-8 levels.
The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO2/FiO2, PaO2, ROX index, SOFA score, and IL-6 and IL-8 levels.
The incidence of adolescent idiopathic scoliosis is higher in girls, but spine deformities are more severe in boys. We aimed to identify gender differences of mechanical factors involved in adult degenerative scoliosis (DS).

20 male (60.35±6.77 years) and 19 female (58.89±9.15 years) specimens of cadaveric lumbar spines were divided into 3 groups comprised of a Cobb angle >10° (DS), a Cobb angle <10° but >3° (pre-degenerative scoliosis (PS)) and intervertebral disc angles <3° in which the Cobb angle could not be measured (non-degenerative scoliosis (NS)), respectively. Spine data were collected for flexion/extension (FE), lateral bending (LB), axial torsion (AT), range of motion (ROM), neutral zone (NZ) and the neutral zone ratio (NZR).

There was no significant difference regarding the severity of DS between male and female specimens. Only in males were ROM
(
=0.001), NZ
(
<0.001), NZ
(
=0.045), NZ
(
=0.002) as well as NZR
(
<0.001) and NZR
(
=0.001) values significantly lower in right compared to left scoliosis. With the exception of ROM
in DS specimens, ROM
, ROM
and ROM
values were significantly higher in females than those in males for the DS, PS and NS specimens. NZ
, NZ
and NZ
values were significantly higher in PS and NS female specimens. NZR
was significantly lower in female DS specimens (
=0.031) and significantly higher in female PS specimens (
=0.031) compared to that in male specimens.

In lumbar scoliosis specimens, the rigidness of spines was higher in males than in females and more pronounced in right than in left scoliosis, but only in males.
In lumbar scoliosis specimens, the rigidness of spines was higher in males than in females and more pronounced in right than in left scoliosis, but only in males.
To evaluate the effects of targeted nursing intervention plus psychological counseling on the life quality, negative emotions, and complications in patients with extensively drug-resistant tuberculosis (XDR-TB).

In this prospective study, 88 patients with XDR-TB admitted to Hebei Chest Hospital from Jan 2017 to Dec 2020 were enrolled. All patients were grouped according to RANDBETWEEN (1, 2) function in Excel, assigning 1 to the control group (n=41) for every 2 in the research group (n=44). The control group received routine nursing, while the research group received targeted nursing intervention plus psychological counseling. link= see more The self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, self-management ability score, treatment compliance, sputum negative conversion rate, re-examination rate, life quality, complications, and nursing satisfaction of the two groups were compared before and after intervention.

After intervention, the research group had significantly higher SAS, SDS, self-management ability scores, compliance rate, sputum negative conversion rate, re-examination rate, and life quality compared to the control group (all P<0.05). The research group showed a lower incidence of complications and higher nursing satisfaction than the control group (both P<0.05).

Compared to routine nursing, targeted nursing intervention combined with psychological counseling substantially ameliorates the life quality and negative emotions of patients with XDR-TB and lowers the incidence of complications.
Compared to routine nursing, targeted nursing intervention combined with psychological counseling substantially ameliorates the life quality and negative emotions of patients with XDR-TB and lowers the incidence of complications.
Breast cancer is one of the most common malignant tumors in women and shows a rising incidence at younger ages. Therefore, early diagnosis is of great significance for treatment and prognosis. This study aimed to compare the value of ultrasound elastography (UE) combined with contrast-enhanced ultrasound (CEUS) and micro-flow imaging (MFI) in differential diagnosis of benign and malignant lesions of the breast.

The sonographic characteristics of UE and CEUS as well as the vascular characteristics of MFI of 109 breast lesions categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4, confirmed by surgical or biopsy pathology were retrospectively analyzed. Receiver operating characteristic (ROC) curves were used to compare the diagnostic efficacy of the three examination modalities, either alone or in combination.

Of the 109 breast lesions, 78 lesions were pathologically diagnosed as malignant and 31 as benign. At diagnosis, the area under the ROC curve (AUC), sensitivity, specificity, and accuracy of UE were 0.8495, 65.38%, 83.87% and 83.34%, respectively. The AUC, sensitivity, specificity and accuracy of MFI were 86.29%, 70.51%, 87.10% and 85.56%, respectively. The AUC, sensitivity, specificity and accuracy of CEUS were 90.84%, 88.46%, 74.19% and 89.16%, respectively. The AUC, sensitivity, specificity and accuracy of the combined diagnosis of UE, MFI, and CEUS were 93.90%, 85.90%, 90.32%, and 92.07%, respectively.

The combination of UE, CEUS and MFI has the highest specificity and accuracy in the differential diagnosis of benign and malignant breast lesions compared to any one used singly.
The combination of UE, CEUS and MFI has the highest specificity and accuracy in the differential diagnosis of benign and malignant breast lesions compared to any one used singly.
To explore the clinical efficacy and safety of CalliSpheres
microspheres drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with sorafenib in the treatment of large liver cancer.

The study retrospectively analyzed 90 patients with large liver cancer. 42 patients who received DEB-TACE and sorafenib were included in the experimental group and 48 patients who received only DEB-TACE were included in the control group. The efficacy, TTP, OS and ARs were evaluated and further analysis was conducted on factors which might affect the prognosis.

As of June 2020. The median OS of the experimental group was significantly longer than that of the control group (18.6 months vs. 12.7 months), and the TTP was also longer in the experimental group (8.3 months vs. 6.9 months). Three months after the intervention, the ORR and DCR of the experimental group were significantly higher than those of the control group. The main ARs of the experimental group taking sorafenib included hand-foot syndrome, skin rash, diarrhea, fatigue, hypertension, and anorexia. And they could be alleviated through treatment of the symptoms. TACE-related ARs for both groups were fever, pain, nausea, and vomiting, and there was no significant difference. Logistic regression analysis showed that the combined sorafenib treatment was a protective factor improving the prognosis of patients with large liver cancer, and risk factors were the number of tumors and vascular invasion.

DEB-TACE combined with sorafenib is safe and well tolerated in the treatment of large liver cancer. It can improve the tumor control rate and prolong the survival time.
DEB-TACE combined with sorafenib is safe and well tolerated in the treatment of large liver cancer. It can improve the tumor control rate and prolong the survival time.Inflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and are usually diagnosed as Crohn's disease or ulcerative colitis. link2 As these diseases do not have a cure, the goal of treatment is to induce and maintain remission. Monoclonal antibodies have been recognized as the most advanced therapy to avoid complications and reduce the need for surgical approaches. However, although their effectiveness has been proven by several studies, they can trigger the immune system, induce the occurrence of immunogenicity, which may lead to the loss of response and treatment failure. The purpose of this review is to determine what are the main mechanisms involved in IBD; to assess the recommended treatments; to explore the mechanisms of immunogenicity. We also try to explain the detection and describe the existing advances that make possible the clinical application of these approaches.
To determine the clinical efficacy and safety of urinary Kallindinogenase (HUK) combined with butylphthalide (NBP) in the treatment of progressive cerebral infarction (PCI), to provide more choices for the clinical treatment of PCI.

The clinical data of 94 with PCI admitted to our hospital from July 2015 to March 2017 were retrospectively analyzed in this study. link3 In addition to basic treatment, the control group (n = 52) was treated with NBP and edaravone. The research group (n = 42) was treated with NBP and HUK. After 14 days of treatment, the clinical efficacy on the two groups was evaluated according to their neurological function deficit using the National Institutes of Health Stroke Scale (NIHSS). The functional recovery results after the stroke were measured using the Modified Rankin Scale (MRS). The independence rate of the two groups was compared. The activities of daily living (ADL) scale was adopted to evaluate the patients' life quality. The two groups were compared in the incidence of complications during treatment and the recurrence within 12 months.

The two groups of patients were not greatly different in basic data. After 14 days of treatment, the improvements in NIHSS, MRS, and ADL scores in the research group were more obvious than those in the control group. After 12 months of treatment, the research group showed a significantly higher independence rate than the control group. No serious adverse reactions were found in the two groups. There was no death during the treatment. After 12 months of treatment, the two groups were not greatly different in recurrence rate.

HUK combined with NBP can reduce the neurological dysfunction and disability rate of patients and improve their independence rate and life quality. link2 It is a safe and effective method for the treatment of PCI.
HUK combined with NBP can reduce the neurological dysfunction and disability rate of patients and improve their independence rate and life quality. It is a safe and effective method for the treatment of PCI.
To investigate the therapeutic effect and safety of different doses of apatinib mesylate combined with chemotherapy in the treatment of advanced oral cancer.

Totally 100 patients with advanced oral cancer admitted to our hospital from January 2019 to July 2020 were retrospectively analyzed and divided into a control group (500 mg apatinib mesylate combined with chemotherapy) and an experimental group (250 mg apatinib mesylate combined with chemotherapy). The two groups were compared in terms of the incidence of adverse reactions, treatment effective rate, disease control rate, objective response rate, Karnofsky performance status (KPS) score (quality of life), score of the mental status scale in non-psychiatric settings (MSSNS), survival rates and vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) after treatment. In addition, logistic regression was used to analyze the influencing factors for KPS<85 after oral cancer treatment.

The treatment effectil cancer.
To investigate the effect of vincristine and cisplatin combined with intensity-modulated radiation therapy (IMRT) on the treatment of patients with advanced cervical cancer and its influence on adverse reactions.

In this retrospective clinical trial, 90 patients with advanced cervical cancer admitted to our hospital from January 2019 to January 2020 were collected as research subjects and were divided into two groups according to different treatment methods. The control group received IMRT, and the experimental group was treated with a triple therapy of vincristine, cisplatin, and IMRT. The clinical efficacy, incidence of adverse reactions, immune function indexes, serum indexes, and 3-year survival were compared between the two groups. The Generic Quality of Life Inventory-74 (GQOLI-74) questionnaire was used to assess the quality of life, and the Karnofsky Performance Scale (KPS) was used to evaluate the health status.

The experimental group exhibited a significantly higher total clinical treatment efficacy in comparison with the control group (P<0.05). Patients in the experimental group experienced fewer adverse reactions and better immune indexes as compared to those in the control group (all P>0.05). The serum indexes of the experimental group were significantly lower than those of the control group (P<0.05). Significantly higher GQOLI-74 scores and KPS scores were obtained in the experimental group than the control group after treatment (all P<0.05). The 3-year overall survival rate of the experimental group was significantly higher than that of the control group (P<0.05).

Vincristine and cisplatin combined with IMRT for patients with advanced cervical cancer can effectively optimize the clinical indicators of patients and improve their quality of life, with a high safety.
Vincristine and cisplatin combined with IMRT for patients with advanced cervical cancer can effectively optimize the clinical indicators of patients and improve their quality of life, with a high safety.
To determine the efficacy and safety of bevacizumab (Bz) combined with temozolomide (TMZ) in the treatment of recurrent malignant gliomas and its influence on serum tumor markers (STMs).

The clinical data of 73 patients with recurrent malignant gliomas admitted to the First People's Hospital of Shuangliu District from April 2016 to June 2018 were analyzed retrospectively. Patients were divided into two groups according to different therapies the control group (n=33) treated with TMZ, and the research group (n=40) treated with Bz combined with TMZ (Bz+TMZ). The overall response rate (ORR), disease control rate (DCR) and incidence of adverse reactions (ARs) were observed after 4 courses of treatment. The levels of STMs were detected. Additionally, the Karnofsky Performance Scale (KPS) score and quality of life (QoL) before and after treatment were compared between the two groups. The 1-year and 2-year survival rates as well as median survival time (MST) were also compared after 2-year follow-up. Treatment satisfaction was recorded and compared.

After treatment, the research group exhibited better ORR and DCR than the control group; The incidence of ARs differed insignificantly between the two arms; The serum levels of Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and transforming growth factor β (TGF-β) in the research group were statistically lower than those in the control group; The KPS score and QoL score increased significantly in both arms, and were higher in the research group compared with the control group; the research group was also superior to the control group in treatment satisfaction. The research group showed higher 1-year and 2-year survival rates than the control group.

BZ+TMZ is effective in treating recurrent malignant gliomas, which can improve the QoL and survival of patients.
BZ+TMZ is effective in treating recurrent malignant gliomas, which can improve the QoL and survival of patients.This study compared the clinical efficacy and complications of autogenous rib cartilage stent and Medpor stent auricle reconstruction in patients with congenital microtia. A total of 300 patients with congenital microtia were selected as the research objects. 150 patients in the auricle reconstruction group with autologous rib cartilage stent and 150 patients in the auricle reconstruction group with Medpor stent were selected. Postoperative follow-up was conducted to observe whether the shape, color, size, and position of the reconstructed auricle were good, and to compare whether the cranial auricle Angle was consistent with the healthy lateral auricle, so as to judge whether the reconstructed auricle was successful. The incidence of postoperative complications, such as infection and stent exposure was recorded. The postoperative satisfaction and quality of life scores were compared between the two groups. Two operation methods of the auricle reconstruction effect showed no obvious difference (P>0.05), but the incidence of auricle reconstruction scaffold exposing Medpor stenting was significantly higher than those of autologous rib cartilage auricle reconstruction. The satisfaction and quality of life scores of patients in the autologous rib cartilage group were significantly higher than those in the Medpor stent group (P less then 0.05). Although there was no significant difference between auricle reconstruction with autologous rib cartilage scaffold and Medpor stent implantation in the improvement rate of microtia, there were fewer complications after autologous rib cartilage stent implantation, but higher patient satisfaction and quality of life. link3 (The registry of clinical trial is Chinese Clinical Trial Register, ChiCTR2100052010, https//www.chictr.org.cn/).
Non-ST-segment elevation myocardial infarction (NSTEMI) is prevalent in patients with diabetes mellitus (DM). The long-term follow-up outcomes of this group of patients remain misunderstood. This study was aimed at investigating long-term follow-up outcomes of diabetic patients discharged with NSTEMI.

All diabetic patients discharged with MI were recruited and followed up in this study. Patients who had elevated serum troponin, but no ST segment elevation were considered as NSTEMI. A structured follow-up was conducted at 3 months, 6 months, 12 months, and 24 months. Independent risk factors for all-cause and cardiovascular mortality were analyzed.

A total of 743 diabetic patients with MI enrolled for analysis, with 132 patients being recognized as NSTEMI. The mean age was 70.4±8.3 years. The mean follow-up was 21.3±6.1 months. NSTEMI (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.08-2.23), age ≥75 years (HR 1.17, 95% CI 1.04-1.31), hypertension (HR 1.51, 95% CI 1.03-2.21), heart failure (HF) (HR 3.23, 95% CI 2.28-4.57), and previous MI (HR 2.01, 95% CI 1.44-2.79) were independent risk factors for all-cause mortality. Administration of beta-blocker (HR 0.62, 95% CI 0.45-0.85) was associated with a lower incidence of all-cause mortality. Predictors for cardiovascular mortality included elderly, hypertension, HF, previous MI, and MI with atypical chest pain.

Multiple risk factors contribute to a higher incidence of composite outcomes in diabetic patients with MI. STEMI poses a greater threat to adverse events, which warrants more investigations.
Multiple risk factors contribute to a higher incidence of composite outcomes in diabetic patients with MI. STEMI poses a greater threat to adverse events, which warrants more investigations.
Torque steadiness can be impaired in people with Huntington's disease (HD) and worsen with disease advancement. However, existing studies have several methodological oversights. Studies have used absolute torque targets, which do not account for differences in maximal torque capacity between people. Furthermore, despite its known influence on torque steadiness, previous studies in HD have not controlled for visual feedback. This study evaluated torque variability at relative intensities with and without visual feedback between people with prodromal HD and healthy controls.

Twenty-four people with prodromal HD and twenty-seven age- and sex-matched healthy controls were recruited for this study. Torque variability was evaluated, with and without visual feedback, in the right plantar flexors at 10% and 30% of each participant's maximum voluntary isometric contraction (MVIC). Measures of disease burden included the CAG age product, diagnostic confidence level and Unified Huntington's Disease Rating Scale - Toability measurements as markers of disease progression in people with prodromal HD.
To investigate the clinical efficacy of coenzyme Q10 (CoQ10) plus trimetazidine (TMZ) in treating acute viral myocarditis (AVMC) and the combination's influence on the oxidative stress markers and the patients' quality of life (QoL).

This retrospective analysis enrolled 156 patients with AVMC admitted to the Department of Cardiology of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine between February 2018 and February 2019. Based on the treatment method each patient was administered, the patients were classified into a control group (n=72, CoQ10 therapy) and a combination group (n=84, CoQ10+TMZ therapy). The clinical effectiveness was observed in the two groups two weeks after the treatment, and the changes in the patients' serum inflammatory factor levels, oxidative stress indexes, myocardial enzyme levels, and cardiac function were compared.

The combination group had a far superior total effective rate than the control group (90.5%
77.8%, P<0.05). After the treatmentress and inflammatory reactions, and bolster patients' QoL.
CoQ10 plus TMZ yields a favorable clinical effectiveness in the treatment of AVMC, and it can effectively promote cardiac function recovery, alleviate oxidative stress and inflammatory reactions, and bolster patients' QoL.
To explore the efficiency of radical cystectomy combined with GC chemotherapy in the treatment of invasive bladder cancer and its influence on the incidence of adverse reactions.

The clinical data of 120 patients with invasive bladder cancer admitted to our hospital from February 2015 to February 2016 were retrospectively analyzed. According to different treatment methods, they were equally divided into two groups. The experimental group (n=60) was treated with radical cystectomy combined with GC chemotherapy. The control group (n=60) was treated with bladder-preserving comprehensive treatment (transurethral bladder tumor resection + internal iliac artery infusion chemotherapy + intravesical infusion chemotherapy). The short-term efficiency, adverse reactions, long-term treatment indicators, survival, surgical indicators, and quality of life were compared between the two groups.

The two groups showed similar objective remission rate and disease control rate (P>0.05). Both groups of patients had diffesurvival of patients, with a promising long-term efficiency.
Radical cystectomy combined with GC for the treatment of invasive bladder cancer reduces the incidence of adverse reactions and enhances the 5-year survival of patients, with a promising long-term efficiency.
To investigate the effect of individualized positive end-expiratory pressure (PEEP) titration on intraoperative respiration and circulation in elderly patients undergoing spinal surgery in prone position under general anesthesia.

We prospectively selected 80 elderly patients (39 males and 41 females) aged over 65 years old, at American Society of Anesthesiologists (ASA) grade II or III, who underwent elective prone spinal surgery under general anesthesia, for this study. These patients were randomly divided into titration group and control group, with 40 cases in each group. PEEP of the titration group was increased from 0 to 20 cmH
O by steps of 2 cmH
O. For the control group, PEEP was constantly at 5 cmH
O and ventilation was maintained throughout the surgery. Dynamic pulmonary compliance (Cdyn) measurements were recorded when each PEEP level was kept for 1 min during titration, and individualized PEEP was determined by maximal Cdyn. MAP (mean arterial pressure), heart rate (HR), and CVP (Central ven, reduce intrapulmonary shunt and postoperative pulmonary complications. (Chinese Clinical Trial Registry, registration number ChiCTR2000040722, https//www.chictr.org.cn).
This study aimed to explore the impacts of comfort nursing on postoperative quality of life, negative emotions and nursing satisfaction of patients undergoing laparoscopic surgery.

Eighty-four patients who underwent laparoscopic cholecystectomy (LC) in Shengjing Hospital of China Medical University from September 2018 to November 2019 were analyzed retrospectively. Among them, 37 patients with routine nursing were assigned to the control group, while 47 patients receiving comfort nursing were assigned to the research group. The postoperative rehabilitation indexes, complication rate, pain degree at 12 h after surgery, postoperative quality of life, negative emotions and nursing satisfaction were compared between the two groups.

After nursing, compared with the control group, the research group experienced notably earlier first time of food intake, first defecation time, first time for ambulation, first anal exhaust time, and recovery time of gurgling sound, shorter length of stay, considerably lower incidence of postoperative complications and Visual Analogue Scale score at 12 h after surgery, and evidently higher scores of quality of life and nursing satisfaction. Moreover, Self-rating Depression Scale and Self-rating Anxiety Scale scores of the research group were significantly lower than those of the control group.

For patients undergoing laparoscopic surgery, comfort nursing can relieve their negative emotions, improve their quality of life and nursing satisfaction, reduce postoperative pain, and thus promote postoperative rehabilitation. Hence, it is worthy of clinical promotion.
For patients undergoing laparoscopic surgery, comfort nursing can relieve their negative emotions, improve their quality of life and nursing satisfaction, reduce postoperative pain, and thus promote postoperative rehabilitation. Hence, it is worthy of clinical promotion.
To explore the efficacy of tiotropium bromide combined with different doses of fluticasone plus salmeterol DPI (dry powder for inhalation) in treating stable moderate to severe chronic obstructive pulmonary disease (COPD) and its influence on pulmonary function.

From August 2017 to November 2019, 105 patients with stable moderate to severe COPD in our hospital were enrolled and divided into three groups group A (GA), group B (GB) and group C (GC). In GA, patients received tiotropium bromide combined with low dose of fluticasone plus salmeterol. In GB, patients received tiotropium bromide combined with medium dose of fluticasone plus salmeterol. In GC, patients received tiotropium bromide combined with high dose of fluticasone plus salmeterol. The baseline data and adverse reactions were observed in each group. After therapy, the improvement of clinical symptoms, quality of life, pulmonary function index and therapeutic effect were observed in each group.

There was no difference in the general data of paients with moderate to severe stable COPD.
Tiotropium bromide combined with high dose of salmeterol xinafoate (SX) and fluticasone propionate (FP) powder for inhalation can effectively improve the pulmonary function of patients with moderate to severe stable COPD.Consensus guidelines to protect airway managers during COVID-19 were developed to encourage safe, accurate and swift performance in intubation and extubation, but reintubation was not considered. With the massive surge of patients requiring mechanical ventilation in this COVID-19 pandemic, great incidence of difficult airways may necessitate reintubation. Equipments could be used now in extubation and reintubation are either too expensive and time-consuming in decontamination, or have not gained wide acceptance. Here, we adapted an extubation device from an intubating stylet, which is provided as accessory of endotracheal tube. Such stylet could provide safe access for expediting reintubation both during and after the COVID-19 pandemic, which is inexpensive, single-use, readily available, straightforward to handle, and well-tolerated, thereby benefiting both the patients and healthcare providers.
To explore the effect of butylphthalide soft capsules combined with modified tonic exercise therapy on neurologic function and the abilities of daily living in patients with stroke hemiplegia.

In this retrospective trial, a total of 90 patients with stroke hemiplegia admitted to our hospital from January 2019 to January 2020 were enrolled and divided into a control group and an experimental group according to different treatment methods. The two groups were both treated with butylphthalide soft capsules, and the experimental group was additionally treated by modified tonic exercise therapy. The clinical efficacy, endothelial injury indicators, molecular indicators of oxidative stress, and adverse reactions of the two groups were compared. Generic Quality of Life Inventory-74 (GQOLI-74) was used to assess the quality of life of patients after treatment. The Fugl-Meyer Upper Extremity Assessment (FMA) was used to evaluate their limb function before and after treatment, the National Institute of Health Strokstroke hemiplegia, butylphthalide soft capsule combined with modified tonic exercise therapy effectively improves their neurologic function, abilities of daily living, and quality of life.We conducted a single-center, single-arm, open-label, dose-escalation phase 1 clinical trial to evaluate the tolerability of a single intravenous injection of ciprofol emulsion for the induction of short-term general anesthesia. Four doses of ciprofol (0.15 mg/kg, n = 2; 0.4 mg/kg, n = 10; 0.6 mg/kg, n = 6; 0.9 mg/kg, n = 6) were administered. Twenty-four subjects were enrolled, with 18 subjects in the 0.4 to 0.9 mg/kg dosage groups included in the data analysis. In total, 37 mild and 4 moderate adverse events (AEs), including 9 abnormal limb movements (3 moderate cases), 8 cases of sinus bradycardia, 11 cases of prolonged QTcF interval (including 1 moderate case), and 1 case of hypotension, were found, but no serious AEs were reported. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scores rapidly decreased after ciprofol administration. The duration of recovery of the verbal response, loss of verbal response duration, the duration of MOAA/S ≤1 and the duration until the return of responsiveness were all increased in a dose-dependent manner. The durations of bispectral index values less then 60 (6, 8 and 12 min) were similar to the durations of loss of verbal response (6, 8 and 14 min) and MOAA/S ≤1 (5, 5.5 and 13.5 min) in the 0.4, 0.6 and 0.9 mg/kg dose groups, respectively. The plasma concentration reached a peak value approximately 2 min after injection in the 0.4-0.9 mg/kg groups and all subjects fully recovered after ciprofol administration, with the shortest time being 9.2 min in the 0.4 mg/kg group. A ciprofol dosing regimen of 0.4-0.9 mg/kg was well-tolerated and exhibited rapid onset and recovery properties.
This study aimed to investigate the expression of Survivin, inhibitor of growth 4 (ING4), CXC chemokine ligand 8 (CXCL8), vascular endothelial growth factor (VEGF), and the correlation between Survivin, ING4, CXCL8 and VEGF in prostate cancer (PCa) tissues.

From January 2019 to December 2019, 51 patients from Chengwu People's Hospital and The First People's Hospital of Taian, with PCa were selected as the PCa group and 47 patients with benign prostatic hyperplasia (BPH) were included as the BPH group. The expression of Survivin, ING4, CXCL8 and VEGF in both groups and among patients with different clinical stages in the PCa group were compared, and the correlation between Survivin, ING4, CXCL8 and VEGF expression in PCa tissues was analyzed.

Survivin, ING4, CXCL8, and VEGF expression differed significantly between the two groups (
<0.05). The Survivin positive expression rate, CXCL8 positive expression rate, and VEGF positive expression rate in the PCa group were significantly higher than those in tl stage; additionally, Survivin, ING4, CXCL8, and VEGF played a synergistic role with each other in the development and progression of PCa.
Salt-inducible kinase 1 (SIK1) plays an important role in lipid metabolism, which inhibits lipid synthesis by directly phosphorylating multiple serine residue sites of sterol regulatory element-binding protein 1c (SREBP-1c). This study examined potential therapeutic effect of a Chinese herbal medicine Zhenqing Recipe (ZQR) and metformin on diabetic nephropathy and investigated whether the SIK1/SREBP-1c axis is involved.

The rat model of type 2 diabetes was developed by high-sucrose plus high fat diet for one month combined with low-dose Streptozocin intraperitoneal injection for three days, after which the presence of hyperglycemia and hyperlipidemia was examined to validate the model. The diabetic rats were then randomly allocated to diabetic groups treated by either ZQR or metformin, and normal rats receiving normal diet were included as a control group. Metabolic parameters, renal function, and renal triglyceride were examined and compared between groups.

After a treatment of 12 weeks, ZQR and metformin significantly reduced serum glucose and triglyceride, inhibited diabetic nephropathy and improved renal function.
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