Notes

Hygienic Problems, Civilizational Crisis.
However, substantial heterogeneity exists, since multiple large-scale studies yielded neutral findings. Differences in gender-related VC risk may result from variations in VC assessment methods, the anatomical segments of interest, study sample size, and even the ethnic origins of participants. From a biological perspective, plausible mediators of gender-related VC differences include body composition discrepancies, alterations involving lipid profiles, inflammatory severity, diversities in matrix Gla protein (MGP), soluble Klotho, vitamin D, sclerostin, parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), and osteoprotegerin levels. Based on our findings, it may be inappropriate to monotonously assume that male patients with CKD are at risk of VC compared to females, and we should consider more background in context before result interpretation.
pancreatic cancer is one of the most lethal malignancies and a leading cause of cancer-related death worldwide. The only chance to improve the long-term outcomes of patients with pancreatic cancer is surgery with radical intent.

in the present paper, we aim to describe a case series of 9 patients submitted to radical surgery for borderline resectable pancreatic cancer.

in all cases, negative resection margins were achieved. The types of venous resection consisted of tangential portal vein resection in four cases, circumferential portal vein resection with direct reanastomosis in one case and circumferential resection with graft placement in another four cases; postoperatively, one patient developed a vascular surgery-related complication consisting of graft thrombosis and thus necessitated prolonged anticoagulant therapy.

extended venous resections can be a safe and efficient way to maximize the benefits of radical surgery in locally advanced, borderline resectable pancreatic cancer.
extended venous resections can be a safe and efficient way to maximize the benefits of radical surgery in locally advanced, borderline resectable pancreatic cancer.
The main purpose of the current study was to compare the within-season variations of workload, training duration, acute/chronic workload ratio (ACWR), training monotony ™, and training strain (TS) through session rating perceived exertion (s-RPE) between starters and non-starters.

Seventeen under-17 European male soccer players (age, 16.2 ± 0.3 y, height, 1.8 ± 0.1 m; body mass, 66.5 ± 4.0 kg) divided in two groups nine starters and eight non-starters, were evaluated over 50 weeks throughout the season.

In general, there were load variations for all players during the full-season. RPE tended to decrease during in-season and RPE, training duration and s-RPE did not present significant differences between starters and non-starters. TM and TS presented lower values for starters in mesocycle (M) 4 and M11 compared to non-starters. TS presented lower values for starters in M4 and M11 compared to non-starters, while in M10 a higher value was found for starters when compared to non-starters. ACWR showed differences between starters and non-starters in two of the mesocycles.

This study showed that some mesocycles provided higher load for non-starters. This information can alert coaches that non-starter players are likely to try too hard in training to demonstrate their abilities, leading to non-functional overreaching, overtraining syndrome, and then poor performance.
This study showed that some mesocycles provided higher load for non-starters. selleck compound This information can alert coaches that non-starter players are likely to try too hard in training to demonstrate their abilities, leading to non-functional overreaching, overtraining syndrome, and then poor performance.Importance Medication non-adherence is highly costly and leads to worse disease control and outcomes. However, knowledge about medication adherence is often disconnected from prescribing decisions, and this disconnect may lead to inappropriate increases in medications and higher risks of adverse events. Objectives To evaluate the association between medication non-adherence and the likelihood of increases in the intensity of medication regimens for two chronic conditions, hypertension and type 2 diabetes. Design Cohort Study. Setting and Participants This study used US national pharmacy claims data for Medicare Part D (ages ≥ 65) and commercial (ages 50-64) plans to evaluate medication adherence and its association with the likelihood of receiving an increase in medication intensity for patients with hypertension and/or oral diabetes medication fills. Patients had an index fill for hypertension (N = 2,536,638) and/or oral diabetes (N = 701,376) medications in January 2015. Medication fills in the follow-up peable prescribers to have more targeted discussions with patients about their adherence and overall treatment plan. Additionally, it can increase safe medication prescribing and plausibly reduce adverse drug events and healthcare costs while improving patient health outcomes.This study examined the relationship between empathy and mobile phone dependence levels of the nursing staff in a public hospital in the island of Crete, using a cross-sectional study design. Data from 109 staff nurses and healthcare assistants (HCAs) were collected via the Greek version of the Mobile Phone Dependence Questionnaire (MPDQ) and the Toronto Empathy Questionnaire (TEQ). Multiple linear regression was used to determine the correlation between empathy and mobile phone dependency. The total mean score for TEQ was 33.9 (±5.7). Accordingly, the total mean score for MPDQ was 22.9 (±6.1). High mobile phone dependence was found in 4.7% of the participants. A statistically significant difference was found between HCAs and staff nurses, with HCAs presenting a higher mean empathy levels (TEQ) (36.5 vs. 32.6) and lower dependence levels (MPDQ) (18.9 vs. 24.5) than staff nurses. A significant correlation between empathy and dependence was found between dependence and the altruism empathy subscale, with higher dependence being correlated with lower altruism. The participants' levels of empathy do not seem to be affected by mobile phone dependence. However, empathy appears to be strongly determined by increased age and professional status. Nurses' dependence on mobile phones is a complex phenomenon that requires attention. Educational programs on empathy and information on the proper use of mobile phones by the nursing staff should be provided.
Female genital mutilation (FGM) is any process that injures female genitals for non-medical reasons and is a violation of women's human rights. An important number of women from countries where FGM is performed are arriving to Western countries. Health professionals are important for detecting cases of FGM. No surveys to assess knowledge, attitudes and practices on FGM among healthcare professionals has been conducted in Castilla la Mancha (Spain) until now.

The main goal of the study is assessing knowledge, attitudes and perceptions of healthcare professionals in relation to FGM. A cross-sectional descriptive study was conducted based on self-administered online surveys to nurses, midwives, family doctors, pediatricians, obstetrics and gynecologists.

In total, 1168 professionals answered the surveys. Just 13.9% indicated that they had received training in FGM, however just 10.7% correctly identified the three types of FGM, 10.7% the countries where it is usually practiced, 33.9% knew the legislation in Spain and only 4.4% found a case of FGM during their professional practice. Regarding the knowledge about protocols, 8.64% of the sample indicated to know one of them.

The present study demonstrate that it is necessary to improve the training and awareness of healthcare professionals related to FGM in Castilla la Mancha.
The present study demonstrate that it is necessary to improve the training and awareness of healthcare professionals related to FGM in Castilla la Mancha.Breast cancer is the most prevalent malignancy among women. Conservative and operative treatment methods are associated with a risk of side effects pertaining to the shoulder complex. The surgery complications including chronic pain, upper limb and chest lymphedema, range of motion limitations, and motor control deficiencies may lead to upper limb function impairment and affect the quality of life negatively. Twenty-three women were examined in the tested group and twenty-two women in the control group. The motor control was assessed with dissociation tests as defined by Comerford and Mottram. In order to assess patient-perceived upper limb disability, the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire was used. The test of glenohumeral (GH) abduction control in frontal plane and in scapular plane and medial rotation control outcomes were found to be statistically significant. It pertains to both Comparison between groups and analysis within the tested group-body sides comparison. The DASH questionnaire results analysis indicates that there was a higher degree of subjectively perceived disability of upper limb in the tested group. Surgical interventions in the breast cancer treatment and other medical procedures affect the level of motor control and perceived disability of upper limb negatively in this group of patients. Movement faults are statistically more prevalent in the tested group. Movement faults are more prevalent on the operated side in the tested group.Polydrug use is a frequent pattern of consumption in Europe. This behavior has mainly been analyzed within restricted groups; more rarely in large populations. Current polydrug use is less studied than simultaneous use. This study focused on the concurrent assumption of polydrug among drivers using hair matrix. Hair matrix, for its biological characteristics, allows to identify illicit drug use more often than other matrices, i.e., urine, and it provides information on the long-term use of them. Hair samples of subjects positive for opiates, cocaine and delta-9-tetrahydrocannabinol (Δ9-THC) collected by the forensic toxicology laboratory of the University of Macerata in the period 2010-2020, were analyzed using a gas chromatography-mass spectrometry method. Our results evidenced that a significant part of the examined population (12.15%) used polydrug. A strong predominance of males over females was evident. Polydrug users were more frequently young people. The abuse of two substances was predominant. Cocaine and Δ9-THC was the most common combination, followed by cocaine and morphine, and morphine and Δ9-THC. The timeframe of polydrug use was also analyzed. Our study shows that polydrug use is a very frequent behavior, and that hair analysis may be a powerful tool to obtain objective biological information of this complex phenomenon.Alzheimer's disease (AD) is a neurodegenerative disease that mainly affects older adults. Currently, AD is associated with certain hypometabolic biomarkers, beta-amyloid peptides, hyperphosphorylated tau protein, and changes in brain morphology. Accurate diagnosis of AD, as well as mild cognitive impairment (MCI) (prodromal stage of AD), is essential for early care of the disease. As a result, machine learning techniques have been used in recent years for the diagnosis of AD. In this research, we propose a novel methodology to generate a multivariate model that combines different types of features for the detection of AD. In order to obtain a robust biomarker, ADNI baseline data, clinical and neuropsychological assessments (1024 features) of 106 patients were used. The data were normalized, and a genetic algorithm was implemented for the selection of the most significant features. Subsequently, for the development and validation of the multivariate classification model, a support vector machine model was created, and a five-fold cross-validation with an AUC of 87.
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