Notes

Overexpression involving miR-195-5p lowers weakening of bones by way of activating BMP-2/SMAD/Akt/RUNX2 walkway by way of focusing on SMURF1.
The outbreak of new coronavirus disease (COVID-19) has triggered a global panic, affecting the mental well-being of people of all ages, including students. The aim of this study was to explore the relationship between self-reported mental health concerns and subjective sleep quality of the Bangladeshi university students during the COVID-19 pandemic. A web-based cross-sectional study was conducted to maintain the social distancing recommended by the World Health Organization. There were 1,317 student responses from 49 universities across Bangladesh. Data was analyzed by executing both bi-variate and multivariate analysis. Findings indicate that 27.1%, 51.0%, 45.9%, and 86.0% of students had poor subjective sleep quality, anxiety, depression, and fear of COVID-19, respectively. Anxiety (AOR = 1.09, 95% CI 1.06-1.12, p less then 0.001) was a risk factor for increasing the poor subjective sleep quality of university students. In contrast, the odds of poor subjective sleep quality were lower with increasing the score of depression (AOR = 0.88, 95% CI 0.86-0.90, p less then 0.001) and fear of COVID-19 (AOR = 0.97, 95% CI 0.94-0.99, p less then 0.05). Compared to public university students, private university students were more likely to report poor subjective sleep quality since the pandemic began. Therefore, it is strongly recommended that psychiatric conditions of university students should be monitored during the COVID-19 epidemic, and necessary strategies, such as allocation of resources, implementation of awareness programs, establishment of psychological counselling unit, should carefully be devised.Low soil moisture during dry season, poor soil properties and lack of adequate crop varieties are the major constraints for sustainable intensification of eastern Himalayas in changing climate. Suitable varieties, tillage alteration and integrated nutrient management with emphasis on locally available crop residues/plant biomass may help addressing these issues. The role of minimum tillage (MT) and no-till (NT), and organic matter substitution on conferring of favourable root environment, improvement in morpho-physiology and subsequent productivity of the crops are not objectively studied in Himalayan ecosystems. Thus, a six year field study was conducted for examining the residual effect of tillage and nutrient management (NM) practices applied to summer (rainy) rice (Oryza sativa L) on root growth-attributes and impact on morpho-physiology of succeeding winter pea (Pisums ativum L.) grown uniformly under NT. Higher root surface area, total root length, root volume, root length ratio (RLR) and root tissue deractices. Thus, adoption of MT/NT along with 50% NPK+WB/GLM in summer rice is recommended for inducing favourable root environment and optimised pea production in succeeding winter season in study region of the Eastern Himalayas, India and other similar agro-ecosystems.Recovery of nutrients from biogas slurry (BGS) as a soil amendment, on low input smallholder farms in sub-Saharan Africa, could improve agricultural production and minimize contribution of the agroecosystems to CO2 emissions. Comparative effects of BGS and cattle manure (CM) on maize dry matter, grain yield, uptake of nitrogen (N), phosphorus (P) and potassium (K), and soil total N, extractable P and exchangeable K after harvest were studied, relative to chemical fertiliser (CF). The field experiment was conducted in the 2016/2017 and 2017/2018 growing seasons and was arranged in a randomized complete block design replicated four times with (i) BGS, (ii) CM and (iii) CF as the treatments. Each treatment was applied at 40, 80 and 120 kg Nha-1. Additional P was added to BGS and CM to have the same added P as in the CF treatments. The CM treatment had higher dry matter than both BGS and CF in both seasons at each N rate. Maize grain yield from CF treatment was higher than the two organic fertilisers at each N rate, while the BGS treatment had higher grain yield than CM except at 40 kg Nha-1. When applied at the same N rate, BGS resulted in lower P and K than CF, and had higher extractable P with lower exchangeable K when compared with CM. The findings imply that while BGS provided nutrients, it resulted in lower maize dry matter than CM and lower grain yield than CF, but raised total N and available P, over time.Outcome-based Education is currently of much potential in the global educational landscape. In recent years, implementing outcome-based education and student-centered learning have also been prioritized at the policy level of the Ministry of Higher Education of Afghanistan. Thus, the current study aimed to investigate the attitudes of Afghan lecturers towards the recent paradigm shift in the educational system of Afghanistan. The researcher employed a mixed-method approach to collect both quantitative and qualitative data. The researcher used a questionnaire responded by 120 lecturers and interviewed 7 outcome-based education experts and Afghan lecturers. The quantitative findings reveal that teachers have positive attitudes towards outcome-based education, and they are ready and willing to implement the approach by mentioning some key challenges. However, the results also show that implementing this approach is currently at a low level of practice. The qualitative findings reveal that; content-based curriculum, policies of teaching, learning, and assessment, the lack of basic infrastructure and info-structure, lack of facilities, and teachers' workload are among the key challenges towards implementing this approach. The results will help the Ministry of Higher Education and Higher Education Development Program to develop applicable policies and to emphasize this recent paradigm shift in the future within addressing the key challenges to ensure the efficacy during implementation. It will also help lecturers to have an overall picture of outcome-based education and student-centered learning. Likewise, it will open a window for researchers to investigate this potential topic in more in-depth details in the higher education system of Afghanistan.This study investigates boundary layer flows with inhomogeneous material properties driven by natural convection using linear and quadratic Boussinesq approximations around a horizontal cylinder. The cylinder's surface was kept at a uniform temperature. The governing equations for the setup were formulated from the principles of mass continuity, momentum and energy under realistic assumptions. Four coupled partial differential equations were obtained and reduced using stream function to two. Using perturbation techniques with one spatial coordinate as the perturbation parameter, the partial differential equations were further reduced to a set of nonlinear coupled ordinary differential equations. The fluid's velocity, as well as the temperature distributions, were computed and analyzed using the Maple 17 platform. The results obtained were consistent with existing results from reference literature. Further analysis of the embedded flow parameters was also carried out and analyzed with relevant tables and graphical illustrations for the linear and quadratic Boussinesq approximations. The results of the study show a fundamental difference between the linear and quadratic Boussinesq approximation alongside an interconnection between constant and variable thermophysical properties.This study investigates the priorities of food preference attributes of Muslim travellers in Japan to identify Muslim consumers' willingness to pay for food at establishments that offer religion-related services and to divide Muslim travellers in Japan into consumer segments. A mixed methods approach combining a questionnaire survey (386 respondents) and semi-structured, in-depth interviews (12 respondents) was employed. Food preference priority attributes were examined using discrete-choice conjoint analysis, while willingness to pay was investigated via the incentive-compatible elicitation of a consumer's reservation price range, commonly known as ICERANGE, procedure. Muslim travellers were segmented via hierarchical clustering. The results indicate that Muslim travellers in Japan prioritise prayer room availability first and halalness second when dining out. Other attributes, which figure less strongly, include access, word of mouth, and price. Muslim travellers in Japan are willing to pay 1.4 to 1.7 times more than the average price of a meal when the establishment also offers a religion-related service such as a prayer room. Moreover, the study identifies four segments of Muslim travellers in Japan prayer-room oriented, halal-label oriented, low-budget oriented, and high-end oriented. The study's findings offer valuable insights for business owners and managers who seek to target Muslim travellers in Japan.Computational calculations of 5-bromo-3-nitropyridine-2-carbonitrile (5B3N2C) on molecular structure and on energy are implemented using the 6-311++G(d,p) basis set by DFT/B3LYP method. The UV-Vis spectrum of 5B3N2C was obtained by TD-DFT with chloroform as a solvent. The analysis of molecular electrostatic potential (MEP) and frontier molecular orbital (FMO) were used to evaluate, the entire electron density and organic reactive sites of 5B3N2C. The electron-hole conversions were conjointly deliberated. Donor-acceptor interactions (NBO) analysis examines the intra-and intermolecular charge transfer, hyper conjugate interaction of the compound. The orbital molecular contributions are evaluated by density of states (DOS and PDOS). To discern the reactivity of the molecule, topology analyses were done. The biological prominence of the 5B3N2C molecule was investigated in a pertinent study of molecular docking with target protein 3CEJ exhibiting the centromere associated protein inhibitor property. Molecular Dynamics simulations were done to assess the stability of the complex. 5B3N2C physiochemical parameters were also compared to those of widely viable medications Ispinesib and Lonafarnib.Leaf gas exchanges play a critical role in determining crop productivity as they control both CO2 gain and water loss. CO2 gain and water loss influence water use efficiency (WUE) and carbon isotope composition (δ13C). Responses in leaf gas exchanges to water stress are species-specific. However, the extent of this variation in C3 crops is less studied. A field study was carried out to investigate the influence of water stress on leaf gas exchanges of triticale and cowpea. Crops were grown under water stress and well-watered conditions and leaf gas exchanges were determined at flowering. The results showed that triticale maintained a higher stomatal conductance (gs), transpiration rate(E) and intercellular CO2 concentration (ci) compared to cowpea but did not differ in photosynthetic rate(A). As a result, triticale discriminated against 13C more than cowpea. These results suggest a higher influence of ci on δ13C than A. Despite triticale maintaining higher rates of ci, A and gs, it had lower WUE compared to cowpea. Uprosertib inhibitor Consequently, triticale grain yield was more sensitive to water stress than cowpea. The findings of this study showed significant variation in leaf gas exchanges and δ13C between two drought-tolerant C3 crops suggesting differences in their response mechanism to water stress.
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