Notes

Retraction recognize with regard to: "Long non-coding RNA HOTAIR stimulates UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes" [Braz L Mediterranean Biol Ers (2018) Fifty one(8): e6896].
Story insights into the device regarding mobile period kinases Mec1(ATR) and also Tel1(Bank).
Persistent anticoagulation is not connected with a decreased chance of serious kidney harm in hospitalised Covid-19 sufferers.
A sensor with an improved dynamic range was obtained, and insights from the screening provided evidence for a dual regulator function of C. glutamicum Lrp.Molecular separation of carbon dioxide (CO2) and methane (CH4) is of growing interest for biogas upgrading, carbon capture and utilization, methane synthesis and for purification of natural gas. Here, we report a new zeolitic-imidazolate framework (ZIF), coined COK-17, with exceptionally high affinity for the adsorption of CO2 by London dispersion forces, mediated by chlorine substituents of the imidazolate linkers. COK-17 is a new type of flexible zeolitic-imidazolate framework Zn(4,5-dichloroimidazolate)2 with the SOD framework topology. Below 200 K it displays a metastable closed-pore phase next to its stable open-pore phase. At temperatures above 200 K, COK-17 always adopts its open-pore structure, providing unique adsorption sites for selective CO2 adsorption and packing through van der Waals interactions with the chlorine groups, lining the walls of the micropores. Localization of the adsorbed CO2 molecules by Rietveld refinement of X-ray diffraction data and periodic density functional theory calculations revealed the presence and nature of different adsorption sites. In agreement with experimental data, grand canonical Monte Carlo simulations of adsorption isotherms of CO2 and CH4 in COK-17 confirmed the role of the chlorine functions of the linkers and demonstrated the superiority of COK-17 compared to other adsorbents such as ZIF-8 and ZIF-71.Raspberry ketone (RK), the main aroma compound of raspberry fruit, has applications in cosmetics, food industry, and pharmaceutics. In this study, we biosynthesized RK via the catalytic reduction of 4-hydroxybenzylidenacetone using a whole-cell biocatalyst. Reductase RiRZS1 from Rubus idaeus and glucose dehydrogenase SyGDH from Thermoplasma acidophilum were expressed in Escherichia coli to regenerate NADPH for the whole-cell catalytic reaction. Following the optimization of balancing the coexpression of two enzymes in pRSFDuet-1, we obtained 9.89 g/L RK with a conversion rate of 98% and a space-time yield of 4.94 g/(L·h). The optimum conditions are 40 °C, pH 5.5, and a molar ratio of substrate to auxiliary substrate of 12.5. Our study findings provide a promising method of biosynthesizing RK.Fabrication of spherical lignin nanoparticles (LNPs) is opening more application opportunities for lignin. However, dissolution of LNPs at a strongly alkaline pH or in common organic solvent systems has prevented their surface functionalization in a dispersion state as well as processing and applications that require maintaining the particle morphology under harsh conditions. link= click here Here, we report a simple method to stabilize LNPs through intraparticle cross-linking. Bisphenol A diglycidyl ether (BADGE), a cross-linker that, like lignin, contains substituted benzene rings, is coprecipitated with softwood Kraft lignin to form hybrid LNPs (hy-LNPs). The hy-LNPs with a BADGE content ≤20 wt % could be intraparticle cross-linked in the dispersion state without altering their colloidal stability. Atomic force microscopy and quartz crystal microbalance with dissipation monitoring were used to show that the internally cross-linked particles were resistant to dissolution under strongly alkaline conditions and in acetone-water binary solvent that dissolved unmodified LNPs entirely. click here We further demonstrated covalent surface functionalization of the internally cross-linked particles at pH 12 through an epoxy ring-opening reaction to obtain particles with pH-switchable surface charge. Moreover, the hy-LNPs with BADGE content ≥30% allowed both inter- and intraparticle cross-linking at >150 °C, which enabled their application as waterborne wood adhesives with competitive dry/wet adhesive strength (5.4/3.5 MPa).Coral-like lanthanum manganese oxides (LayMnOx) with a hierarchical structure nanosphere were successfully prepared using a simple method, which presented a high-efficiency catalytic performance for toluene combustion. Among them, La0.08MnOx with the Mn3O4 phase exhibits superior catalytic activity, such as a lower T95 value (218 °C), excellent H2O resistance, and catalytic stability. The effects of La addition on the bulk and surface physicochemical properties of LayMnOx were investigated by sorts of characterization including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, N2 adsorption-desorption, temperature-programmed reduction with H2, temperature-programmed desorption of O2, X-ray photoelectron spectroscopy, and so forth. The results demonstrate that the doping of La can induce the variation of physicochemical properties and the formation of more surface oxygen species and high valence state amorphous manganese oxides, improving low-temperature reducibility, which facilitates good catalytic activity for La0.08MnOx. A series of in situ diffuse reflectance infrared Fourier transform spectroscopy experiments for toluene adsorption were performed on the La0.08MnOx catalyst pretreated under different atmosphere conditions to investigate the role of oxygen species and the reaction processes. The results indicate that the abundant surface oxygen species over La0.08MnOx can make the rapid formation of benzoic acid species, further transfer into CO2 and H2O, which is considered as the key factor in the activation and oxidation of toluene.Interfacial reconstruction, emanating from the symmetry breaking at the interface, plays a key role in modulating the microstructures and properties of heterostructures. The appeal of revealing such a reconstruction resides in the underlying mechanism connected to the function of heterostructures and new insights into designing a new interface device. Here, we demonstrate an interfacial reconstruction in a large lattice-mismatch system, h-LuFeO3/α-Al2O3 heterostructure. Combining the atomic-resolution imaging and spectroscopy of scanning transmission electron microscopy, the periodic variation of FeO immediate coordination and charge ordering of iron are revealed, indicating a strong lattice-charge coupling in the reconstruction. click here Such a reconstruction reported here suggests that polyhedral and electronic flexibility is important for the reconstruction formation and presents possibilities for further construction of more functional heterostructures.Effective strategies are needed to deal with invasive fungal infections caused by drug-resistant fungi. Previously, we designed a series of antifungal benzocyclane derivatives based on the drug repurposing of haloperidol. Herein, further structural optimization and antifungal mechanism studies were performed, leading to the discovery of new piperidol derivative B2 with improved synergistic antifungal potency, selectivity, and water solubility. In particular, the combination of compound B2 and fluconazole showed potent in vitro and in vivo antifungal activity against azole-resistant Candida albicans. Compound B2 inhibited important virulence factors by regulating virulence-associated genes and improved the efficacy of fluconazole by down-regulating the CYP51-coding gene and efflux pump gene. Taken together, the piperidol derivative B2 represents a promising lead compound for the combinational treatment of azole-resistant candidiasis.An innovative theoretical method to describe the microscopic dynamics of chemi-ionization reactions as prototype oxidation processes driven by selective electronic rearrangements has been recently published. It was developed and applied to reactions of Ne* atoms excited in their metastable 3PJ state, and here, its physical background is extensively described in order to provide a clear description of the microscopic phenomenon underlying the chemical reactivity of the oxidative processes under study. link2 It overcomes theoretical models previously proposed and reproduces experimental results obtained in different laboratories. Two basic reaction mechanisms have been identified (i) at low collision energies, a weakly bounded transition state is formed which spontaneously ionizes through a radiative physical mechanism (photoionization); (ii) in the hyperthermal regime, an elementary oxidation process occurs. In this paper, the selectivity of the electronic rearrangements triggering the two mechanisms has been related to the angular momentum couplings by Hund's cases, casting further light on fundamental aspects of the reaction stereodynamics of general interest. The obtained results allow peculiar characteristics and differences of the terrestrial oxidizing chemistry compared to that of astrochemical environments to be highlighted.Tropolonate complexes of Ru(II), Ru(III), and Os(II) with hinokitiol, also termed β-thuljaplicin, or 4-isopropyltropolone, readily formed by chloride and triarylphosphine substitution in RuCl2(PPh3)3 and MHCl(CO)(PR3)3 (M = Ru, R = Ph; M = Os, R = Ph and p-tolyl). The resulting colorful complexes have variable and strong charge transfer bands and also have a surprising combination of stereochemical selectivity and lability. For the Os(II) d6 examples, the tropolone chelate has a fluxionality with a barrier of only 90 kJ/mol for the R = aryl examples, as determined by variable-temperature 31P NMR. link2 Chlorination with N-chlorosuccinimide results in MCl(CO)(hino)(PPh3)2 (M = Ru and Os). Together these results quantify the fluxionality of this important chelate which in turn has consequences for its biochemistry.Although quantum mechanical/molecular mechanics (QM/MM) methods are now routinely applied to the studies of chemical reactions in condensed phases and enzymatic reactions, they may experience technical difficulties when the reactive region is varying over time. link3 For instance, when the solvent molecules are directly participating in the reaction, the exchange of water molecules between the QM and MM regions may occur on a time scale comparable to the reaction time. To cope with this situation, several adaptive QM/MM schemes have been proposed. However, these methods either add significantly to the computational cost or introduce artificial restraints to the system. In this work, we developed a novel adaptive QM/MM scheme and applied it to the study of a nucleophilic addition reaction. In this scheme, the configuration sampling was performed with a small QM region (without solvent molecules), and the thermodynamic properties under another potential energy function with a larger QM region (with a certain number of solvent molecules and/or different levels of QM theory) are computed via extrapolation using the reference-potential method. Our simulation results show that this adaptive QM/MM scheme is numerically stable, at least for the case studied in this work. Furthermore, this method also offers an inexpensive way to examine the convergence of the QM/MM calculation with respect to the size of the QM region.Biomass as a sustainable and abundant carbon source has attracted considerable attention as a potential alternative to petroleum resources. link3 The selective oxidation of 5-hydroxymethylfurfural (HMF), a versatile platform molecule, to value-added 2,5-diformylfuran (DFF) provides an efficient pathway for biomass valorization. Herein, three discrete imidazole-functionalized polyoxometalates (POMs), HPMo8VVI4O40(VVO)2[(VIVO)(IM)4]2·nH2O·(IM)m (IM = 1-methylimidazole, n = 4, m = 8 for 1; IM = 1-ethylimidazole, n = 4, m = 9 for 2; IM = 1-propylimidazole, n = 0, m = 4 for 3), have been successfully synthesized by a facile solvothermal method and thoroughly characterized by routine techniques. Compounds 1-3 contain a bi-capped pseudo-Keggin HPMo8V4O40(VO)2 and two imidazole-functionalized (VO)(IM)4 groups, which, to our knowledge, represent the first examples of organic-functionalized Mo-V clusters. Compounds 1-3 as heterogeneous catalysts can effectively promote the transformation of HMF to DFF using atmospheric O2 as oxidant.
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