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What type from the cold weather methods (heating system Genetic or tissues) enhances the gene appearance in mammalian tissue?
Climate change will create numerous risks for human health, including impacts associated with temperature extremes, diarrheal diseases, and undernutrition. Such risks, along with other socioeconomic and development trends, will affect cause-of-death patterns experienced in the coming decades. this website This study explores future mortality trends using the shared socioeconomic pathways (SSP) framework, a widely utilized tool for understanding socioeconomic development trends in a world with climate change. Existing projections for GDP, urbanization, and demographic trends based on SSP narratives are incorporated into an integrated assessment model, International Futures (IFs), in order to project mortality levels by cause of death for all countries from 2020 to 2100. Under more optimistic SSPs, non-communicable diseases (NCDs) rise as a proportion of all deaths, particularly in low- and middle-income countries, while more pessimistic SSPs suggest a continued high burden of largely preventable communicable diseases. In high-income countries, significant continued burdens of NCDs are projected for the remainder of the century under all SSPs. Comparisons are also made to recent cause-of-death projections from the Institute for Health Metrics and Evaluation (IHME) to assess how the IFs and IHME models vary.This paper argues that the concept of affordance, which captures the relations between one's abilities and the properties of one's environment, can help in aligning the elements of a tourism service with intended service experiences. We start with a general review of its conceptual basis in ecological psychology and design research, and then elaborate on the concept's potential applications in the context of tourism service design. The application of an affordance-centred framework is illustrated through a case study which examined a group of tourists with and without visual impairment on a holiday to an international destination. Finally, we offer four propositions to guide the use of the affordance concept in tourism service design.Although prior theory suggests that rumination contributes to cognitive impairments associated with depression, recent work suggests that rumination is associated with higher levels of intelligence. The present study examined the relations between two ruminative subtypes (brooding and reflective pondering) and multiple measures and types of intelligence (verbal and performance) after controlling for rumination's overlapping variance with depression. Participants were 751 individuals from the Colorado Longitudinal Twin Study who completed the Ruminative Response Scale; the Center for Epidemiological Studies-Depression Scale and a fully structured clinical interview as measures of depression; and verbal and performance intelligence tasks at age 16 and the Raven's Advanced Progressive Matrices at age 23. Reflective pondering was positively associated with all measures of intelligence, whereas brooding was not associated with intelligence. Our findings indicate that any negative associations between rumination and intelligence are attributable to shared variance with depression, and that examination of rumination as a multifaceted construct may provide new insights into the relations between rumination and cognition.A primary cause of simulator sickness in head-mounted displays (HMDs) is conflict between the visual scene displayed to the user and the visual scene expected by the brain when the user's head is in motion. It is useful to measure perceptual sensitivity to visual speed modulation in HMDs because conditions that minimize this sensitivity may prove less likely to elicit simulator sickness. In prior research, we measured sensitivity to visual gain modulation during slow, passive, full-body yaw rotations and observed that sensitivity was reduced when subjects fixated a head-fixed target compared with when they fixated a scene-fixed target. In the current study, we investigated whether this pattern of results persists when (1) movements are faster, active head turns, and (2) visual stimuli are presented on an HMD rather than on a monitor. Subjects wore an Oculus Rift CV1 HMD and viewed a 3D scene of white points on a black background. On each trial, subjects moved their head from a central position to face a 15° eccentric target. During the head movement they fixated a point that was either head-fixed or scene-fixed, depending on condition. link2 They then reported if the visual scene motion was too fast or too slow. Visual speed on subsequent trials was modulated according to a staircase procedure to find the speed increment that was just noticeable. Sensitivity to speed modulation during active head movement was reduced during head-fixed fixation, similar to what we observed during passive whole-body rotation. We conclude that fixation of a head-fixed target is an effective way to reduce sensitivity to visual speed modulation in HMDs, and may also be an effective strategy to reduce susceptibility to simulator sickness.Daily energy intake of adult female mammals is influenced by environmental conditions and physiological requirements, including reproduction. We examined the effects of fruit availability on macronutrient and metabolisable energy intake by adult female chimpanzees (Pan troglodytes schweinfurthii) of the Kanyawara community in Kibale National Park, Uganda from January 2014 through June 2015. Drupe fruits were abundant for four months, whereas the other fourteen months were dominated by fig fruits. The mean daily intake of food (dry matter) and metabolisable energy, did not differ between drupe-months and fig-months. However, foraging costs were higher during fig-months, as indicated by a 20% increase in feeding time. Furthermore, during drupe-months female chimpanzees ingested more water-soluble carbohydrates and lipids, and less available protein and neutral detergent fibre. Although metabolisable energy intake did not differ consistently between drupe-months and fig-months, they consumed more on days when ripe fruit dominated the diet than when leaves and pithy stems dominated the diet. Our data suggest that differences in diet quality between drupes and figs can have important effects on frugivore foraging, and that they influence net energy gain more by their effects on macronutrient composition or foraging cost than by their direct impact on energy intake.A simulator for testing automatic control algorithms for nonlinear systems with time-varying parameters, variable time delays, and uncertainties is developed. It is based on simulation of virtual patients with Type 1 diabetes (T1D). link3 Nonlinear models are developed to describe glucose concentration (GC) variations based on user-defined scenarios for meal consumption, insulin administration, and physical activity. They compute GC values and physiological variables, such as heart rate, skin temperature, accelerometer, and energy expenditure, that are indicative of physical activities affecting GC dynamics. This is the first simulator designed for assessment of multivariable controllers that consider supplemental physiological variables in addition to GC measurements to improve glycemic control. Virtual patients are generated from distributions of identified model parameters using clinical data. The simulator will enable testing and evaluation of new control algorithms proposed for automated insulin delivery as well as various control algorithms for nonlinear systems with uncertainties, time-varying parameters and delays.In producing linguistic prominence, certain linguistic elements are highlighted relative to others in a given domain; focus is an instance of prominence in which speakers highlight new or important information. This study investigates prominence modulation at the sub-syllable level using a corrective focus task, examining acoustic duration and pitch with particular attention to the gestural composition of Korean tense and lax consonants. The results indicate that focus effects are manifested with systematic variations depending on the gestural structures, i.e. consonants, active during the domain of a focus gesture, that the patterns of focus modulation do not differ as a function of elicited focus positions within the syllable. The findings generally support the premise that the scope of the focus gesture is not (much) smaller than the interval of (CVC) syllable. Lastly, there is also some support for an interaction among prosodic gestures-focus gestures and pitch accentual gestures-at the phrase level. Overall, the current findings support the hypothesis that focus, implemented as a prosodic prominence gesture, modulates temporal characteristics of gestures, as well as possibly other prosodic gestures that are co-active in its the domain.
There is strong evidence that adverse childhood experiences (ACEs) negatively impact mental health. However, the association between ACEs and personality, emotions and affect are poorly understood. Therefore, we examined the association between composite ACE score and ACE type and personality, emotions and positive and negative affect.

Three waves of data from the Midlife Development in the United States (MIDUS) study were used. ACE was the primary independent correlate. Covariates included demographic variables and survey wave. Outcome variables included generativity, personality traits (agreeableness, conscientiousness, extraversion, neuroticism, openness, agency), and affect (positive, negative.) Statistical analyses included 3 approaches 1) treatment of ACE as dichotomous, 2) ordinal composite of ACE score, and 3) three individual ACE type components to assess the association between ACE and psychological constructs.

Of 6,323 adults in the sample, 53% were female, and 56% had a past ACE. In the adjuACEs are significantly associated with personality, emotions, and affect, with greater effect seen at higher ACE scores and with ACE abuse type, which helps support the cumulative risk hypothesis and our study hypothesis. There is a need for continued research to understand the mechanistic processes and the directionality of the association between ACEs, emotions, and behaviors to help continue to drive biopsychosocial interventions.Across two studies, the current research investigated how different dimensions of narcissism (grandiosity/agentic extraversion, entitlement/self-centered antagonism, vulnerability/narcissistic neuroticism) relate to social networking site (SNS) use and behaviors. Study 1 employed a community sample of young adults, whereas Study 2 examined college students. Participants completed assessments of narcissism and SNS use through an online survey. Grandiosity/agentic extraversion was generally associated with greater levels of downward social comparison relative to the other two dimensions. Entitlement/self-centered antagonism generally showed weak correlations with SNS outcomes. Vulnerability/narcissistic neuroticism was generally associated with greater upward social comparison and perceived social exclusion relative to the other two dimensions. Results suggest that SNS experiences may vary depending on the dimensions of narcissism.Personality is related to psychopathology and its higher-order structures, but there is little research regarding neurobiological associations of higher-order psychopathology factors. This study examined the factor structure of a wide range of psychopathology and its associations with both personality and emotional reactivity revealed through the late positive potential (LPP) in a sample of 275 undergraduates. A three-factor structure of psychopathology emerged comprising Internalizing (INT), Externalizing (EXT), and Aberrant Experiences (ABX). EXT predicted aggressive disconstraint, whereas both INT and ABX predicted Alienation and Stress Reaction. INT uniquely predicted low Well-Being, and ABX predicted a rigid absorption combined with interpersonal detachment. ABX correlated with reduced parietal emotional LPP reactivity, whereas INT correlated with stronger frontal LPP reactivity to emotional versus neutral pictures.
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