Notes

All-Electronic Emitter-Detector Frames regarding 300 GHz throughout Rubber.
In order to provide insights into the evolutionary and epidemiological viral dynamics during the current COVID-19 pandemic in South Eastern Italy, a total of 298 genomes of SARS-CoV-2 strains collected in the Apulia and Basilicata regions, between March 2020 and January 2021, were sequenced. The genomic analysis performed on the draft genomes allowed us to assign the genetic clades and lineages of belonging to each sample and provide an overview of the main circulating viral variants. Our data showed the spread in Apulia and Basilicata of SARS-CoV-2 variants which have emerged during the second wave of infections and are being currently monitored worldwide for their increased transmission rate and their possible impact on vaccines and therapies. These results emphasize the importance of genome sequencing for the epidemiological surveillance of the new SARS-CoV-2 variants' spread.Hepatocellular carcinoma (HCC) biomarkers are lacking in clinical practice. We therefore explored the pattern and composition of urinary volatile organic compounds (VOCs) in HCC patients. This was done in order to assess the feasibility of a potential non-invasive test for HCC, and to enhance our understanding of the disease. This pilot study recruited 58 participants, of whom 20 were HCC cases and 38 were non-HCC cases. The non-HCC cases included healthy individuals and patients with various stages of non-alcoholic fatty liver disease (NAFLD), including those with and without fibrosis. Urine was analysed using gas chromatography-ion mobility spectrometry (GC-IMS) and gas chromatography-time-of-flight mass spectrometry (GC-TOF-MS). GC-IMS was able to separate HCC from fibrotic cases with an area under the curve (AUC) of 0.97 (0.91-1.00), and from non-fibrotic cases with an AUC of 0.62 (0.48-0.76). For GC-TOF-MS, a subset of samples was analysed in which seven chemicals were identified and tentatively linked with HCC. These include 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (2TMS derivative), 2-butanone, 2-hexanone, benzene, 1-ethyl-2-methyl-, 3-butene-1,2-diol, 1-(2-furanyl)-, bicyclo(4.1.0)heptane, 3,7,7-trimethyl-, [1S-(1a,3β,6a)]-, and sulpiride. Urinary VOC analysis using both GC-IMS and GC-TOF-MS proved to be a feasible method of identifying HCC cases, and was also able to enhance our understanding of HCC pathogenesis.This paper deals with the description, measurement, and use of electromagnetic properties of ferromagnetic fibres used as dispersed fibre reinforcement in composite mixtures. Firstly, the fibres' magnetic properties are shown, and a method of measuring the hysteresis loop of fibres is proposed. The results from the measurements are presented and a discussion of the influence of measured parameters on the fibres' orientation in a magnetic field is performed. Furthermore, methods of non-destructive estimation, of their amount and orientation in the composite specimens, are discussed. The main experimental goal of this paper is to show the relationship between this non-destructive method's results and the destructive flexural strength measurements. The method is sensitive enough to provide information related to fibre reinforcement.This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics. More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values). The scientists involved in chitosan to date have focused mainly on acetic acid solutions. Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt. were used in this research. The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation. Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days). The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis. The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing. Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.Determining the optimal endotracheal tube (ETT) depth in neonates remains challenging for neonatologists. The guideline for optimal ETT depth is based on the patients' weight or gestational age. However, there is a discrepancy in the suggested ETT depth between these two parameters. The aim of this retrospective study was to compare the recommended weight-based and age-based formulas for optimal ETT depth and obtain the optimal reference before intubation. Participants were assigned to group 1 if the recommended ETT insertion depth based on weight was concordant with the recommended depth based on gestational age, and to group 2 if the weight and age-based depth recommendations were discordant. After exclusion, 180 patients were included in the analysis. Results indicated that the predicted ETT depth suggested by age required more adjustment than by weight (p less then 0.05). Furthermore, the required adjustment in the weight-based formula was smaller than the age-based formula (p less then 0.05). Multivariate linear regression analysis revealed that weight was the key factor affecting the optimal depth (p less then 0.001). These results imply that when there is a discrepancy in ETT depth between the weight-based and age-based recommendation, the weight-based one will be more accurate than the age-based one.Vaccination against foot-and-mouth disease is the most common method for preventing the spread of the disease; the negative effects include miscarriage, early embryo death, lower milk production, and decreased growth of fattening cattle. Therefore, in this study, we analyze the side effects of vaccination by determining the acute immune response and ovulation rate after vaccinating cows for foot-and-mouth disease. The test axis was synchronized with ovulation using 100 Hanwoo (Bos taurus coreanae) cows from the Gyeongsangbuk-do Livestock Research Institute; only individuals with estrus confirmed by ovarian ultrasound were used for the test. All test axes were artificially inseminated 21 days after the previous estrus date. The control group was administered 0.9% normal saline, the negative control was injected intramuscularly with lipopolysaccharide (LPS; 0.5 µg/kg), and the test group was administered a foot-and-mouth disease virus vaccine (FMDV vaccine; bioaftogen, O and A serotypes, inactivated vaccine) 2, 9, and 16 days before artificial insemination. White blood cells and neutrophils increased significantly 1 day after vaccination, and body temperature in the rumen increased for 16 h after vaccination. Ovulation was detected 1 day after artificial fertilization by ovarian ultrasound. The ovulation rates were as follows control 89%, LPS 60%, FMDV vaccine (-2 d) 50%, FMDV vaccine (-9 d) 75%, and FMDV vaccine (-16 d) 75%. In particular, the FMDV vaccine (-2 d) test group confirmed that ovulation was delayed for 4 days after artificial insemination. In addition, it was confirmed that it took 9 days after inoculation for the plasma contents of haptoglobin and serum amyloid A to recover to the normal range as the main acute immune response factors. The conception rate of the FMDV vaccine (-2 d) group was 20%, which was significantly lower than that of the other test groups.Histone modifications are the main epigenetic mechanisms that regulate gene expression, chromatin structure, and plant development, among which histone acetylation is one of the most important and studied epigenetic modifications. Histone acetylation is believed to enhance DNA access and promote transcription. GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5), a well-known enzymatic protein responsible for the lysine acetylation of histone H3 and H4, is a universal and crucial histone acetyltransferase involved in gene transcription and plant development. Many studies have found that GCN5 plays important roles in the different development stages of Arabidopsis. In terms of exogenous stress conditions, GCN5 is also involved in the responses to heat stress, cold stress, and nutrient element deficiency by regulating the related gene expression to maintain the homeostasis of some key metabolites (e.g., cellulose) or ions (e.g., phosphate, iron); in addition, GCN5 is involved in the phytohormone pathways such as ethylene, auxin, and salicylic acid to play various roles during the plant lifecycle. Some of the pathways involved by GCN5 also interwind to regulate specific physiological processes or developmental stages. Dihydromyricetin Here, interactions between various developmental events and stress-resistant pathways mediated by GCN5 are comprehensively addressed and the underlying mechanisms are discussed in the plant. Studies with some interacting factors such as ADA2b provided valuable information for the complicated histone acetylation mechanisms. We also suggest the future focuses for GCN5 functions and mechanisms such as functions in seed development/germination stages, exploration of novel interaction factors, identification of more protein substrates, and application of advanced biotechnology-CRISPR in crop genetic improvement, which would be helpful for the complete illumination of roles and mechanisms of GCN5.This study aimed to analyze the correlations among weekly (w) acute workload (wAW), chronic workload (wCW), acute/chronic workload ratio (wACWR), training monotony (wTM), training strain (wTS), sleep quality (wSleep), delayed onset muscle soreness (wDOMS), fatigue (wFatigue), stress (wStress), and Hooper index (wHI) in pre-, early, mid-, and end-of-season. Twenty-one elite soccer players (age 16.1 ± 0.2 years) were monitored weekly on training load and well-being for 36 weeks. Higher variability in wAW (39.2%), wFatigue (84.4%), wStress (174.3%), and wHI (76.3%) at the end-of-season were reported. At mid-season, higher variations in wSleep (59.8%), TM (57.6%), and TS (111.1%) were observed. Moderate to very large correlations wAW with wDOMS (r = 0.617, p = 0.007), wFatigue, wStress, and wHI were presented. Similarly, wCW reported a meaningful large association with wDOMS (r = 0.526, p less then 0.001); moderate to very large associations with wFatigue (r = 0.649, p = 0.005), wStress, and wHI. Moreover, wTM presented a large correlation with wSleep (r = 0.515, p less then 0.001); and a negatively small association with wStress (r = -0.426, p = 0.003). wTS showed a small to large correlation with wSleep (r = 0.400, p = 0.005) and wHI; also, a large correlation with wDOMS (r = 0.556, p = 0.028) and a moderate correlation with wFatigue (r = 0.343, p = 0.017). Wellness status may be considered a useful tool to provide determinant elite players' information to coaches and to identify important variations in training responses.The purpose of this study is to suggest the optimum mix design with a high volume of GGBS (Ground Granulated Blast-furnace Slag) replacement and the procedure of the cryogenic test to consider mechanical and thermal properties, and durability performance. To decide the optimum mix design, four mix designs with high-volume of GGBS replacement were suggested, in terms of the slump and retention time. Based on the test results, with respect to the workability and compressive strength, the mixtures with 65% of GGBS (C40-2 and C40-4) were better than the mixtures with 50% and 60% of GGBS (C40-1 and C40-3). After selecting two mixtures, two types of cryogenic test methods were conducted under one-cycle cryogenic condition (Test A) and 50-cycles cryogenic condition (Test B). As a result, in Test A, the compressive strength and elastic modulus of the C40-2 and C40-4 mixtures tended to be decreased over time, because of the volume expansion of ice crystals contained in the capillary pores. In Test B, the mechanical properties of the C40-4 mixture were better than those of the C40-2 mixture, in terms of the reduction rate of compressive strength and elastic modulus.
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