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Focusing on KRAS within Reliable Tumors: Present Difficulties and Future Possibilities regarding Book KRAS Inhibitors.
7%-42.02%) and lowest for lung cancer (15.4%-23.1%) and respiratory disease (15.6%-23.4%). Majorities understood snus is addictive (77.7%-87.9%), quitting all tobacco is the best option for smokers (83.6%-93.1%), and non-users of tobacco should not use snus (80.4%-87.8%). Only 2.1%-5.8% indicated smokers would receive a health benefit if they continued to smoke while using snus. Conclusions The modified-risk information, conveying that snus presents less risk than cigarettes but is not completely safe, was understood by majorities of respondents. Differential risk beliefs across diseases suggest responses were shaped not only by the modified-risk information, but also by intuitions and pre-existing beliefs about tobacco products.Marijuana (MJ) is the most widely used illicit substance among adolescents and young adults. Frequent MJ use has been associated with impairments in cognitive flexibility and inhibition, both of which play important roles in decision-making. However, the impact of frequent MJ use on decision-making performance is mixed and not well understood. The current study examined the influence of frequent MJ use on risky decision-making in college students, 18-22 years old. Methods From 2017 to 2019, data was collected from young adult college students (n = 65) consisting of 32 healthy controls (HC) and 33 frequent marijuana users (MJ+). Participants completed the Iowa Gambling Task (IGT), a measure of risky decision-making, and net IGT scores (advantageous-disadvantageous decisions) were used as a measure of optimal decision-making. Results The main finding indicated there was a significant effect of group on net IGT scores (p = 0.018), which remained significant when sex was included in the model (p = 0.006), such that MJ+ had lower net IGT scores than HC. Conclusions These findings highlight potential differences in risky decision-making between MJ+ and HC, but it is uncertain whether these differences are pre-existing and increase vulnerability for frequent MJ use or if they are related to the effects of frequent MJ use on decision-making.Introduction The relationship between narcissism and social media use has been a topic of research since the advent of the first social media website. While numerous meta-analyses have been conducted to synthesize empirical evidence on the association between narcissism and typical online behaviors (e.g., uploading photos and usage frequency), evidence on the association between narcissism and Problematic Social Media Use (PSMU) has not yet been systematized. The current study represents the first systematic review on this topic. Methods Electronic literature databases, including the Web of Science, MEDLINE, PsychINFO, and EMBASE, were searched to identify studies that examined the relationship between narcissism and PSMU. We found 14 empirical studies on narcissism and PSMU. Additionally, seven studies focused on the association with Problematic Facebook Use (PFU). Results Consistent results were reported regarding the positive and significant association between grandiose narcissism and PFU (0.13 less then r less then 0.32). The only two studies that included a vulnerable narcissism measure reported a positive and significant correlation with PFU as well. Studies that did not distinguish between different online platforms (i.e., those measuring PSMU) reported less consistent results. Conclusions The results generally revealed that narcissism might be involved in PFU, but it might not have consistent effects across social media platforms. The assessment of problematic social media use without distinguishing different platforms might not individuate narcissists' preferences and risks. However, our findings need to be interpreted with caution not only due to the relatively small number of studies on this topic but also because 19 studies out 21 used a cross-sectional design.Online poker is considered more at-risk than land-based poker in terms of intense gambling behaviors and gambling problems. The development of many online gambling sites has raised public health concerns about the potential increase in online poker players. Longitudinal studies are useful to better understand the evolution of gambling behaviors; however, very few consider online poker players. Using a prospective design, this study aims to identify online and land-based trajectories over a two-year period and the factors influencing those trajectories. Results are based on data collected at three time-points over the course of a prospective cohort study conducted in Quebec (n = 304). selleck products A latent class growth analysis was performed to determine trajectories based on the main poker modality played, either online or land-based poker. Multinomial multivariable logistic regression analyses were conducted to determine the correlates of poker playing trajectories. Over two years, three poker playing trajectories were identified, comprising two stable trajectories [stable land-based (51.5%) and stable online (36.3%)] and an unstable trajectory [unstable online land-based (12.1%)]. The second trajectory included online poker players at baseline who transitioned to land-based poker. Number of gambling activities increased the odds of being in the first trajectory as compared to the others. Severity of gambling problems was a significant predictor of the second "unstable" or the third "stable online" trajectories, but not for the first "stable land-based" poker trajectory. The majority of poker players remained in either the land-based or online trajectories over two years. No poker players transitioned from land-based to online poker.Introduction Being constantly connected on social media is a "way of being" among adolescents. However, social media use can become "problematic" for some users and only a few studies have explored the concurrent contribution of social context and emotion regulation to problematic social media use. The current study aimed to test (i) the influence of friends (i.e., their social media use and group norms about social media use); and (ii) the effects of difficulties in emotion regulation and so-called "e-motions" on adolescents' problematic social media use. Methods A cross-sectional study was conducted in Italian secondary schools. An online questionnaire was administered to 761 adolescents (44.5% females; Mage = 15.49 years; SDage = 1.03). Results Path analysis showed that social norms were directly associated with problematic social media use and friends' social media use was associated with the frequency of social media use, which, in turn, was associated with problematic use. Difficulties in emotion regulation were directly and indirectly linked to problematic social media use via frequency of use and facilitating use of e-motions. Conclusions These findings provide support for the importance of both peer influence and emotion regulation in this context. Social norms and emotion regulation should be considered in prevention programs addressing problematic social media use in adolescents.Introduction To advance the use of alcohol metabolites as biomarkers in the context of alcohol research, the present study tested the sensitivity and specificity of a commercially available urinary ethyl glucuronide (uEtG) test (DrugConfirm Advanced 80hr EtG) in a clinical research context. Methods A community sample of heavy drinkers (N = 68) completed the 30-day Timeline Follow-Back (TLFB) interview and provided a urine sample for uEtG analysis. Analyses of sensitivity and specificity of the uEtG assay were conducted using the following outcomes (a) past day drinking, (b) past day binge drinking (defined as ≥4 drinks for women and ≥5 drinks for men), (c) past 3-day drinking, and (d) past 3-day binge drinking. Results The majority of participants reported past-3-day drinking (80.9%) and a sizeable minority reported past day drinking (33.8%). While uEtG-based detection of past day drinking and binge drinking was acceptable (sensitivity = 73.91%, and 83.33%; specificity = 80.00% and 66.13%, respectively), detection of any drinking and binge drinking in the past 3 days was poor (sensitivity and specificity of 43.64% and 84.62%, and 39.39% and 62.86%, respectively). Conclusions This study contributes to the mixed findings on the validity of EtG tests, which suggest that commercial uEtG tests with conservative detection thresholds are not a reliable alcohol biomarker without corroborating self-report data. Lower detection thresholds are recommended when using uEtG as an alcohol biomarker. Efforts to reach acceptable levels of sensitivity and specificity with commercial assays hold potential to advance the measurement of alcohol intake, overcoming the pitfalls of self-report data.Background Emergence of electronic cigarettes (e-cigarettes) in the past decade has the potential to undermine the global tobacco control efforts and undo the successes achieved to date. There are also concerns that e-cigarettes may become a gateway for future tobacco use and its use is increasing globally. There is no published evidence on this issue from Myanmar. Hence, we aimed to assess prevalence of e-cigarette use among tobacco smokers and its associated socio-demographic factors in six states and regions of Myanmar. Methods This was a secondary analysis of data collected as part of a programme evaluation conducted by the National Tobacco Control Programme of Myanmar in 2018, which involved sampling 100 smokers from each state/region. We used modified Poisson regression to measure associations. Results There were 629 tobacco smokers included in the programme evaluation. Among them, 246 (39.2%, 95% CI 24.0%-56.7%) smokers reported that they had heard of e-cigarettes and 73 (11.6%, 95% CI 5.1%-24.3%) reported having ever used e-cigarettes. There was no e-cigarette use among female smokers. The prevalence of e-cigarette use was significantly higher among males, students, young adults aged 18-29 years, heavy smokers (greater than 20 cigarettes per day) and those who lived in the Mandalay region. Conclusion Our study provides preliminary evidence about e-cigarette use in Myanmar and fills an important knowledge gap. One limitation was small sample size, which is reflected by wide confidence intervals around the estimate. We recommend a national survey to obtain precise and nationally representative information.Introduction In England, the use of electronic cigarettes as a smoking cessation aid has become more popular than any other aid. Previous research suggests that ex-smokers from lower social groups are more likely to use e-cigarettes compared to ex-smokers from more socially advantaged groups. The present study aimed to assess the association between baseline education, income and employment status and (1) baseline motivation to stop using e-cigarettes (2) attempts to stop using e-cigarettes during follow-up among current smokers, recent ex-smokers and long-term ex-smokers who use e-cigarettes. Methods UK online longitudinal survey of smokers, ex-smokers and e-cigarette users, May/June 2016 (baseline) and September 2017 (follow-up). In logistic regression models, motivation to stop using e-cigarettes at baseline (n = 994) and attempts to stop using e-cigarettes at follow-up (n = 416) among current smokers and ex-smokers were regressed onto baseline educational attainment, income, employment status while adjusting for baseline demographics, vaping status, smoking and e-cigarette dependence.
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