Notes

Spin-valley combining in single-electron bilayer graphene quantum spots.
The recent growth of medicine sales online represents a major disruption to pharmacy markets, with COVID-19 encouraging this trend further. While e-pharmacy businesses were initially the preserve of high-income countries, in the past decade they have been growing rapidly in low-income and middle-income countries (LMICs). Public health concerns associated with e-pharmacy include the sale of prescription-only medicines without a prescription and the sale of substandard and falsified medicines. There are also non-health-related risks such as consumer fraud and lack of data privacy. However, e-pharmacy may also have the potential to improve access to medicines. Drawing on existing literature and a set of key informant interviews in Kenya, Nigeria and India, we examine the e-pharmacy regulatory systems in LMICs. None of the study countries had yet enacted a regulatory framework specific to e-pharmacy. Key regulatory challenges included the lack of consensus on regulatory models, lack of regulatory capacity, regulating sales across borders and risks of over-regulation. However, e-pharmacy also presents opportunities to enhance medicine regulation-through consolidation in the sector, and the traceability and transparency that online records offer. The regulatory process needs to be adapted to keep pace with this dynamic landscape and exploit these possibilities. This will require exploration of a range of innovative regulatory options, collaboration with larger, more compliant businesses, and engagement with global regulatory bodies. A key first step must be ensuring that national regulators are equipped with the necessary awareness and technical expertise to actively oversee this e-pharmacy activity.
Low high-density lipoprotein (HDL) is widely used as a marker of cardiovascular disease risk, although this relationship is not causal and is likely mediated through associations with other risk factors. Low HDL is extremely common in sub-Saharan African populations, and this has often been interpreted to indicate that these populations will have increased cardiovascular risk. We aimed to determine whether the association between HDL and other cardiovascular risk factors differed between populations in sub-Saharan Africa and the UK.

We compared data from adults living in Uganda and Malawi (n=26 216) and in the UK (n=8747). We examined unadjusted and adjusted levels of HDL and applied the WHO recommended cut-offs for prevalence estimates. We used spline and linear regression to assess the relationship between HDL and other cardiovascular risk factors.

HDL was substantially lower in the African than in the European studies (geometric mean 0.9-1.2 mmol/L vs 1.3-1.8 mmol/L), with African prevalence of low Hosity and non-HDL cholesterol in sub-Saharan Africa is different from European populations. In sub-Saharan Africans low HDL is a marker of low overall cholesterol and sex differences are markedly attenuated. Therefore low HDL in isolation is unlikely to indicate raised cardiovascular risk and the WHO sex-based cut-offs are inappropriate.
Identifying and treating children with latent tuberculosis infection (TB infection) is critical to prevent progression to TB disease and to eliminate TB globally. Diagnosis and treatment of TB infection requires completion of a sequence of steps, collectively termed the TB infection care cascade. There has been no systematic attempt to comprehensively summarise literature on the paediatric TB infection care cascade.

We performed a scoping review of the paediatric TB infection care cascade. We systematically searched PubMed, Cumulative Index to Nursing and Allied Health Literature, Cochrane and Embase databases. We reviewed articles and meeting abstracts that included children and adolescents ≤21 years old who were screened for or diagnosed with TB infection, and which described completion of at least one step of the cascade. We synthesised studies to identify facilitators and barriers to retention, interventions to mitigate attrition and knowledge gaps.

We identified 146 studies examining steps in the pde. Future research should examine cascade steps upstream of treatment initiation and focus on identification and testing of at-risk paediatric patients. Additionally, future studies should focus on modifiable health systems factors associated with attrition and may benefit from use of behavioural theory and implementation science methods to improve retention.
To investigate the optic disc and peripapillary vessel density, as well as its ocular and systemic associations, in healthy eyes among adult Chinese population.

A population-based cross-sectional eye survey was conducted on Chinese adults residing in Hong Kong. 1891 eyes from 1891 participants who completed 4.5×4.5 mm optical coherence tomography angiography scans were recruited. Among the 1891 eyes, 404 were excluded due to low scan quality, optic disc or retinal disorders and non-Chinese ethnicity. The vessel densities (VDs) at nerve fibre layer plexus (NFLP) at both optic disc and peripapillary were collected for analysis. Multiple linear regression analysis was performed to determine the ocular and systemic associations of NFLP VD.

The study included 1487 participants (men 41.2%) with a mean age of 48.8±15.4 years. The mean NFLP VD of the whole
, inside disc and peripapillary region was 53.8%, 42.7% and 60.3%, respectively. In the multivariable model, decreased NFLP VDs were significantly associated with older age, male gender, longer axial length (AL) and lower Signal Strength Index.

This large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD.
This large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD.
Defects on the dorsum of the foot remain a reconstructive challenge for plastic surgeons. There are very few pedicled flaps that have a reach up to the distal foot and those too with a threat of poor perfusion. Very often distal foot has to be resurfaced with free flap even with small defects. This study describes our experience with the reverse extensor digitorum brevis muscle (EDB) flap for small- to medium-sized defects on the dorsum of the foot.

The study was conducted on 12 patients between February 2018 and March 2020 who presented with defects on the dorsum of the foot. The mean age of the patients was 30.8 years and the mean defect size was 20.17cm
. The EDB was applied on 10 male and 2 female subjects and resurfaced with a split thickness skin graft. The donor site was closed primarily.

All flaps survived well. Two patients had small graft loss and 2 partial wound dehiscence of donor site, all of which healed on conservative treatment. PFK158 Three patients had temporary sensory disturbance which resolved in few weeks.

The reverse EDB flap is a reliable flap for the coverage of small- to medium-sized dorsal foot defects. The flap has the advantage of robust vascularity, expendable muscle with little donor site morbidity, an easy to learn technique, short operating time, and acceptable esthetic outcome, and it can be used as the primary option in cases of small to medium dorsal foot defects.
The reverse EDB flap is a reliable flap for the coverage of small- to medium-sized dorsal foot defects. The flap has the advantage of robust vascularity, expendable muscle with little donor site morbidity, an easy to learn technique, short operating time, and acceptable esthetic outcome, and it can be used as the primary option in cases of small to medium dorsal foot defects.
The aim of this study was to evaluate the immediate cytotoxic effects of orthodontic molar bands, on HGF-1 cell line, after multiple times of sterilization following size selection procedure.

48 stainless steel orthodontic molar bands were divided into 4 groups according to times of sterilization (1, 2, 4 and 8 times). A liquid extract containing the ions released from each band was prepared and the HGF-1 cell line was exposed to the extracts. 2 control groups (positive and negative) were designated. An MTT assay was performed, and the absorbance was read at 492nm in a microplate reader (Antos 2020, Austria).

There was no significant difference in pure optical density (OD) among the 4 groups (P=0.749) however a statistically significant difference was seen between the positive control group and other 4 groups (P<0.001).

The stainless-steel orthodontic bands used in this study were inert as manufactured and even multiple times of sterilization did not decrease the biocompatibility of these bands for clinical use. The present study shows that clinicians can sterilize the tried-in molar bands for at least 8 times without any risk of cytotoxicity for patients.
The stainless-steel orthodontic bands used in this study were inert as manufactured and even multiple times of sterilization did not decrease the biocompatibility of these bands for clinical use. The present study shows that clinicians can sterilize the tried-in molar bands for at least 8 times without any risk of cytotoxicity for patients.
Increased levels of heat shock proteins after several types of stress play a central role in cellular homeostasis allowing for continued cell survival. This study was aimed at quantitatively analysing the expression pattern of major damage associated molecular patterns (DAMPs)-HSP70, and the amount of nuclear damage incident in periodontal ligament compression side cells.

Sixteen subjects with bimaxillary dentoalveolar protrusion requiring extraction of all first premolars as part of orthodontic treatment were selected. Extractions were carried out pretreatment from control group. In the experimental group, a buccally directed spring, with force range of 70-120gms promoting bodily movement of maxillary first premolars was placed. Periodontal ligament was scraped from the middle third of the root from the compression side, the cells were isolated and cultured followed by HSP70 protein estimation with western blot analysis and the extend of nuclear damage was assessed with COMET assay.

Western Blot analysontrol group.
Burnout syndrome (BOS) affects all professional categories, particularly in the medical sector. Perceived deterioration of working conditions in university hospital centres impacts not only hospital doctors, but also and more generally, university hospital (UH) staff. The goal of this survey was to analyse workplace quality of life among French UH digestive surgeons.

An online questionnaire was addressed to all members of sub-section 52-02 (digestive and visceral surgery) of the national university council (CNU). It contained isolated questions, as well as the specific Copenhagen Burnout Inventory (CBI) questionnaire, which assesses three fields personal burnout (PBO), work-related burnout (WBO) and client-related burnout (CBO).

While 132 (85%) out of the 156 surgeons responded, only 110 (70%) filled out the CBI questionnaire. Their perceptions of quality of life were poor or very poor (57%), and progressively poorer; this was mainly due to a lack of human, logistical and financial means, and also to conflictual relations with administration.
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