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Pyruvate kinase M2 (PKM2) interacts with causing transcribing factor 2 (ATF2) for you to bridge glycolysis and also pyroptosis inside microglia.
Chronic and/or excessive consumption of alcohol followed by reduced consumption or abstention can result in Alcohol Withdrawal Syndrome. A number of behavioral changes and neurological damage result from ethanol (EtOH) withdrawal. Ceftriaxone (Cef) modulates the activity of excitatory amino acid transporters by increasing their gene expression. Zebrafish are commonly used to study alcohol exposure. The aim of this study was to evaluate the influence of Cef (100 µM) on behavior patterns, glutamate transport activity, and oxidative stress in zebrafish brains subjected to EtOH (0.3% v/v) withdrawal. The exploratory tests using Novel tank showed that EtOH withdrawal promoted a decrease in the time spent and number of entries of in the bottom displaying an anxiety-like behavior. In contrast, treatment with Cef resulted in recovery of exploratory behavioral patterns. Ceftriaxone treatment resulted in increased glutamate uptake in zebrafish subjected to EtOH withdrawal. Furthermore, EtOH withdrawal increased reactive species, as determined using thiobarbituric acid and dichlorodihydrofluorescein assays. Treatment with Cef reversed these effects. Ceftriaxone promoted a significant reduction in brain sulfhydryl content in zebrafish subjected to EtOH withdrawal. Therefore, Cef treatment in conjunction with EtOH withdrawal induced anxiolytic-like effects due to possible neuromodulation of glutamatergic transporters, potentially through mitigation of oxidative stress.INTRODUCTION Bronchial artery embolisation (BAE) is an established treatment method for massive haemoptysis. The aim of this study is to evaluate the impact of BAE on in-hospital outcomes and long-term survival in patients with massive haemoptysis. METHODS Retrospective review of all cases of acute massive haemoptysis treated by BAE between April 2000 and April 2012 with at least a 5 year follow up of each patient. Targeted BAE was performed in cases with lateralising symptoms, bronchoscopic sites of bleeding or angiographic unilateral abnormal vasculature. In the absence of lateralising symptoms or signs, bilateral BAE was performed. RESULTS 96 BAEs were performed in 68 patients. The majority (64 cases, 67%) underwent unilateral procedures. 83 (86.5%) procedures resulted in immediate/short term control of haemoptysis which lasted for longer than a month. The mean duration of haemoptysis free period after embolisation was 96 months. There were three major complications (cardio-pulmonary arrest, paraparesis and stroke). 38 (56%) patients were still alive at least 5 years following their BAE. Benign causes were associated with significantly longer haemoptysis free periods, mean survival 108 months compared to 32 months in patients with an underlying malignant cause (p = 0.005). An episode of haemoptysis within a month of the initial embolisation was associated reduced overall survival (p = 0.033). CONCLUSION BAE is effective in controlling massive haemoptysis. Long-term survival depends on the underlying pulmonary pathology. Strategies are required to avoid incomplete initial embolisation, which is associated with ongoing haemoptysis and high mortality despite further BAE.Perceived nose elongation resulting from vibratory stimulation to the bicep brachii tendon in the absence of visual input while the finger is touching the nose, known as the Pinocchio Illusion (PI), is used to investigate how afferent signals can contribute to aberrant top-down perception of body representation. The Pinocchio Illusion Questionnaire (PIQ) was developed to empirically quantify PI perception, allowing for external validation of the PI with psychologically relevant phenomenon. The current study (N = 60) examined the PIQ's test-retest reliability, internal consistency, factor structure, and correlations with self-reported interoceptive awareness and schizotypal traits. The PIQ demonstrated strong test-retest reliability and internal validity; however, a Principal Component Analysis did not yield a latent variable structure that distinguished PI-specific perceptual aberrations from unrelated or contradictory perceptual experiences. Additionally, decreased reports of PI-specific perceptual aberrations during two elicitations of the PI on the PIQ's open-ended free-response section (percent of sample endorsement = 5% (first elicitation); 8.3% (second elicitation)) compared to its 11-item section (endorsement of PI-specific items ranging 30-53.33% (first)]; 31.67-46.67% (second)) suggest that these responses may be heavily influenced by demand characteristics rather than accurately capturing PI perception. Therefore, further psychometric development of the PIQ and standardization of procedures to elicit the illusion are recommended.Sleeve gastrectomy is currently the most frequently performed bariatric surgery. Postoperative leaks represent the main cause of morbidity in up to 8% of patients with a mortality rate ranging between 0.1 and 5%. However, management of these leaks remains controversial. We report the case of a patient presenting with sepsis 2 weeks after surgery. A subphrenic collection and a leak were found on CT. Despite medical treatment, the patient did not show clinical improvement. Hence, we considered a transgastric endosonographic-guided drainage of the collection using an electrocautery-enhanced lumen-apposing metal stent (LAMS). The procedure underwent uneventfully, and the patient status improved rapidly. Two weeks later, the stent was withdrawn. A follow-up endoscopy 6 weeks later showed closure of the gastric wall defect.Many studies use manual action verbs to test whether people use neural systems for controlling manual actions to understand language about those actions. Yet, few of these studies empirically establish how people use their hands to perform the actions described by those verbs, relying instead on explicit self-report measures. Here, participants pantomimed the manual actions described by a large set of Dutch (N = 251) and English (N = 250) verbs, allowing us to approximate the extent to which people use each of their hands to perform these actions. After the pantomime task, participants also provided explicit ratings of each of these actions. click here The results from the pantomime task showed that most manual actions cannot be described accurately as either "unimanual" or "bimanual." With a few exceptions, unimanual action verbs do not describe actions that are performed with only one hand, and bimanual verbs do not describe actions that are performed by using both hands equally. Instead, individual actions vary continuously in the extent to which people use their non-dominant hand to perform them, and in the extent to which people consistently prefer one hand or the other to perform them. Finally, by comparing participants' implicit behavior to their explicit ratings, we found that participants' self-report showed only limited correspondence with their observed motor behavior. We provide all of our measures in both raw and summary format, offering researchers a precision tool for constructing stimulus sets for experiments on embodied cognition.Non-randomized response techniques (NRRTs) such as the crosswise model and the triangular model (CWM and TRM; Yu et al. Metrika, 67, 251-263, 2008) have been developed to control for socially desirable responding in surveys on sensitive personal attributes. We present the first study to directly compare the validity of the CWM and TRM and contrast their performance with a conventional direct questioning (DQ) approach. In a paper-pencil survey of 1382 students, we obtained prevalence estimates for two sensitive attributes (xenophobia and rejection of further refugee admissions) and one nonsensitive control attribute with a known prevalence (the first letter of respondents' surnames). Both NRRTs yielded descriptively higher prevalence estimates for the sensitive attributes than DQ; however, only the CWM estimates were significantly higher. We attribute the higher prevalence estimates for the CWM to its response symmetry, which is lacking in the TRM. Only the CWM provides symmetric answer options, meaning that there is no "safe" alternative respondents can choose to distance themselves from being carriers of the sensitive attribute. Prevalence estimates for the nonsensitive control attribute with known prevalence confirmed that neither method suffered from method-specific bias towards over- or underestimation. Exploratory moderator analyses further suggested that the sensitive attributes were perceived as more sensitive among politically left-oriented than among politically right-oriented respondents. Based on our results, we recommend using the CWM over the TRM in future studies on sensitive personal attributes.PURPOSE Corynebacterium spp. (C. spp.) is commonly considered as a contaminant in respiratory specimens. No study has ever focused on its clinical relevance in the lower respiratory tract of patients admitted to the intensive care unit (ICU) and requiring mechanical ventilation. The aims were to describe the characteristics of ICU patients with a C. spp. positive deep respiratory specimen, to investigate the impact of C. spp. on the occurrence of pneumonia, and to evaluate the outcomes of these pneumonia. METHODS We retrospectively included all adult patients admitted to ICU in a 1000-bed University Hospital (2007-2017) who had a C. spp. positive lower respiratory tract specimen at a significant quantitative level. We used clinical, radiological, and microbiological criteria to classify the likelihood of such pneumonia. RESULTS Among the 31 patients included, acute respiratory failure and postoperative care after major surgery were the main reasons of admission. SAPS II was 47 [34-60]. C. spp. pneumonia was considered as probable, possible and unlikely in 10, 14, and 7 patients, respectively. Fifty-two and 94% of C. spp. strains were sensitive to amoxicillin, and vancomycin/linezolid, respectively. Seventeen patients had a complete course of antibiotic against C. spp. The overall ICU mortality was 58%. CONCLUSION Corynebacterium spp seems to be responsible for authentic pneumonia in mechanically ventilated patients. It should be considered as clinically relevant when predominantly present in respiratory specimen from patients suspected with pneumonia in ICU, and empirically treated.AIM The present study aims to comparatively evaluate the instrumentation time and obturation quality using paediatric manual (Kedo-SH) and rotary (Kedo-S and Kedo-SG Blue) with conventional manual (Hand K-files) instrumentation technique for pulpectomy in primary mandibular molars. MATERIALS AND METHODS A double-blinded randomized controlled trial was designed, recruiting participants with pulpally involved primary mandibular molars requiring pulpectomy in the age group of 6-9 years old. Sixty primary mandibular molars were randomly allocated to either of the four intervention groups Group I 15 teeth were instrumented using hand K-files (control group); Group II 15 teeth were instrumented with paediatric rotary files (Kedo-S); Group III 15 teeth were instrumented with paediatric hand files Kedo-SH (experimental group) and Group IV 15 teeth were instrumented with paediatric rotary file system Kedo-SG Blue. Instrumentation time was recorded during root canal preparation and post-operative quality of obturation in each group was also assessed.
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