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Erythropoietin promotes hippocampal mitochondrial perform as well as boosts understanding within rodents.
The purpose of this article is the assessment of energy efficiency and indoor air quality for a single-family house located in Cluj-Napoca County, Romania. The studied house is meant to be an energy-efficient building with thermal insulation, low U-value windows, and a high efficiency boiler. Increasing the energy efficiency of the house leads to lower indoor air quality, due to lack of natural ventilation. As the experimental campaign regarding indoor air quality revealed, there is a need to find a balance between energy consumption and the quality of the indoor air. To achieve superior indoor air quality, the proposed mitigation systems (decentralized mechanical ventilation with heat recovery combined with a minimally invasive active sub-slab depressurization) have been installed to reduce the high radon level in the dwelling, achieving an energy reduction loss of up to 86%, compared to the traditional natural ventilation of the house. The sub-slab depressurization system was installed in the room with the highest radon level, while the local ventilation system with heat recovery has been installed in the exterior walls of the house. The results have shown significant improvement in the level of radon decreasing the average concentration from 425 to 70 Bq/m3, respectively the carbon dioxide average of the measurements being around 760 ppm. The thermal comfort improves significantly also, by stabilizing the indoor temperature at 21 °C, without any important fluctuations. The installation of this system has led to higher indoor air quality, with low energy costs and significant energy savings compared to conventional ventilation (by opening windows).Pollutant source apportionment is of great significance for water environmental protection. However, it is still challenging to accurately quantify pollutant loads at basin-scale. Refined analytical methods combined the pollution discharge coefficient method (PDCM), field observation, and numerical model (Soil & Water Assessment Tool, SWAT) to make quantitative source appointment in the Tuojiang River, a key tributary of the upper Yangtze River. The chemical oxygen demand (COD), total nitrogen (TN), total phosphorus (TP), and ammonia nitrogen (N-NH4+) were analyzed. Results showed that the urban sewage treatment plant point source has the largest contribution to COD, TN, and N-NH4+, while TP is mostly from the agricultural sources throughout the year. The total inflowing loads of pollution sources are significantly affected by rainfall. The overall pollution characteristics showed that pollutant loads present in different seasons are as follows wet season > normal season > dry season. The month with the highest levels of pollutants is July in the wet season. Among the nine cities, the city that contributes the most COD, TN and N-NH4+, is Neijiang, accounting for about 25%, and the city that contributes the most TP is Deyang, accounting for 23%. Among the sub-basins, the Fuxi River subbasin and Qiuxihe River subbasin contribute the most pollutant loads. The technical framework adopted in this paper can be used to accurately identify the types, administrative regions and sub-basins of the main pollution sources in the watershed, which is conducive to management and governance of the environment.The practice of slow-paced breathing (SPB) has been linked to a range of positive outcomes, such as decreasing symptoms of depression, anxiety, and stress, as well as increasing well-being. Among the suggested mechanisms of action, SPB has been shown to increase cardiac vagal activity (CVA). The present study aimed to investigate whether there is a dose-response relationship modulating the effects of SPB on CVA. A total of 59 participants were involved in this study. In a within-subject design, participants attended the lab five times, and realized SPB at six cycles per minute with different durations (5, 10, 15, and 20 min), as well as a control condition without SPB. CVA was indexed via the root mean square of successive differences (RMSSD). During SPB, findings showed an increase in RMSSD in all conditions compared to the control condition. However, no differences were found in RMSSD among the different session durations, during SPB or during the resting measurement completed immediately after SPB. Noteworthily, session duration showed an influence on the spontaneous respiratory frequency in the resting measurement occurring immediately after SPB. Specifically, respiratory frequency appears to decrease with session duration, thus potentially contributing to additional relaxing effects.
The sun is a natural source of UV radiation. It can be divided into three bands, UVA (315-400 nm), UVB (280-315 nm) and UVC (100-280 nm), where the radiation up to 290 nm is very effectively eliminated by the stratospheric ozone. Although UV radiation can have a beneficial effect on our organism and can be used in the treatment of several skin diseases, it must primarily be considered harmful.

In the presented work, we focused on the study of the longer-wavelength UV components (UVA and UVB) on the human epidermal keratinocyte line HaCaT. As UVA and UVB radiation sources, we used commercially available UVA and UVB tubes from Philips (Philips, Amsterdam, The Netherlands), which are commonly employed in photochemotherapy. We compared their effects on cell viability and proliferation, changes in ROS production, mitochondrial function and the degree of DNA damage.

Our results revealed that UVB irradiation, even with significantly lower irradiance, caused greater ROS production, depolarization of mitochondrial membrane potential and greater DNA fragmentation, along with significantly lowering cell viability and proliferative capacity.

These results confirm that UV radiation causes severe damages in skin cells, and they need to be protected from it, or it needs to be applied more cautiously, especially if the component used is UVB.
These results confirm that UV radiation causes severe damages in skin cells, and they need to be protected from it, or it needs to be applied more cautiously, especially if the component used is UVB.The COVID-19 pandemic has forced general practices to search for possibilities to provide healthcare remotely (e.g., e-health). In this study, the impact of the pandemic on the use of e-health in general practices in the Netherlands was investigated. In addition, the intention of practices to continue using e-health more intensively and differences in the use of e-health between practice types were investigated. For this purpose, web surveys were sent to general practices in April and July 2020. Descriptive data analysis was performed and differences in the use of e-health between practice types were tested using one-way ANOVA. Response rates were 34% (n = 1433) in April and 17% (n = 719) in July. The pandemic invoked an increased use of several (new) e-health applications. A minority of practices indicated the intention to maintain this increased use. In addition, small differences in the use of e-health between the different practice types were found. This study showed that although there was an increased uptake of e-health in Dutch general practice during the COVID-19 pandemic, only a minority of practices intends to maintain this increased use in the future. This may point towards a temporary uptake of digital healthcare delivery rather than accelerated implementation of digital processes.Several indicators are strongly related to health and well-being in university students, such as emotional intelligence and physical activity. At the same time, some qualities threaten it and are incompatible with students' adaptation to society in general, such as aggressive behaviours. The aim of this research is to analyse the relationship established between emotional intelligence using TMMS-24, physical activity, using IPAQ, and aggression behaviours in university students. For this purpose, a descriptive, cross-sectional and non-experimental study was developed with 932 undergraduates (M = 20.55; SD = 3.673). The findings highlight how emotional intelligence and physical activity practice decrease violent behaviour in university students. In addition, men tend to have more aggressive behaviours than women as well as the relation between physical activity and emotional intelligence is stronger in all its dimensions. Results highlight the importance of including emotional intelligence programs in order to enable undergraduate well-being.Improving productivity within health systems using limited resources is a matter of great concern. see more The objectives of the paper were to evaluate the productivity, efficiency, and impact of environmental factors on efficiency in Serbian hospitals from 2015-2019. Data envelopment analysis, Malmquist index and Tobit regression were applied to hospital data from this period, and public hospitals in Serbia exhibited a great variation regarding their capacity and performance. Between five and eight hospitals ran efficiently from 2015 to 2019, and the productivity of public hospitals increased whereas technical efficiency decreased in the same period. Tobit regression indicated that the proportion of elderly patients and small hospital size (below 200 beds) had a negative correlation with technical efficiency, while large hospital size (between 400 and 600 beds), the ratio of outpatient episodes to inpatient days, bed turnover rate and the bed occupation rate had a positive correlation with technical efficiency. Serbian public hospitals have considerable space for technical efficiency improvement and public action must be taken to improve resource utilization.Potentially toxic elements (PTEs) have attracted substantial attention because of their widespread sources, long residue time and easy accumulation. PTEs in the surface sediments of inshore waters are strongly affected by human activities because these waters are a zone of interaction between the ocean and land. In the present study, to explore the environmental geochemical behaviour and source of PTEs in the surface sediments of coastal waters, the contents and spatial distributions of copper (Cu), lead (Pb), zinc (Zn), cadmium (Cd), chromium (Cr), mercury (Hg) and arsenic (As) in different regions of Xiamen Bay were investigated. The data were processed by multivariate statistical methods, and the distribution characteristics of PTEs in the surface sediments of Xiamen Bay were analysed. In addition, the pollution load index (PLI), geo-accumulation index (Igeo) and potential ecological index(RI) were used to evaluate the pollution degree and potential risk in the surface sediments of Xiamen Bay, and the positive matrix factorisation (PMF) model was used to analyse the source. The results show that Zn had the highest mean concentration, followed by Pb, Cr, Cu, As, Cd and Hg, among the seven PTEs. The mean contents of Pb, Zn, Cd, Cu and Hg, and especially Hg and Cd, were higher than the corresponding environmental background values. The average PLI value indicated that the Xiamen Bay sediment was moderately contaminated by PTEs. The Igeo results showed that Xiamen Bay was moderately to strongly polluted by Cd and Hg. The proportions of samples with low, medium and strong risk levels were 11.63%, 74.42%, and 13.95% in surface sediments, respectively. PMF models showed that the input of chemical fertilizer and medication, anthropogenic atmospheric components and terrestrial detritus were the main sources of PTEs in the surface sediment of Xiamen Bay.
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