Notes

Physicochemical and microbiological look at antioxidant-rich conventional dark carrot cocktail: Kanji.
Microthermal perpetual motion meter test showed that PS-DZP-CHP nanoparticles have an affinity with apolipoprotein E, which may be vital for this nanoparticle targeting to brain tissue.
Cutaneous metastases of colorectal cancer (CRC) are rare, occurring in 0.7% to 5% of cancer patients. Furthermore, the molecular subtypes of cutaneous metastasis of CRC are unclear. Here, we present a rare case of cutaneous metastasis of high-frequency microsatellite instability (MSI-high)/BRAFV600E-mutant cecum cancer.

A 77-year-old woman presented at the outpatient clinic with a subcutaneous mass on her left back. An excisional biopsy was performed and metastatic cutaneous adenocarcinoma was diagnosed. A computed tomography scan of the thorax and abdomen showed thickening of the cecum wall, the presence of pericolic lymph nodes, multiple masses in the liver, and a single nodule in the right lung. Right colectomy with D2 lymphadenectomy and functional end-to-end anastomosis was performed because of the almost-complete intestinal obstruction. The expression of KRAS wild type, BRAFV600E mutation, and MSI-high was detected in the cecum cancer using molecular pathological examination. She received chemotherapy with XELOX + BEV regimen (capecitabine + oxaliplatin + bevacizumab). After four administrations, a computed tomography scan showed reduction of distant metastases, which suggested partial response.

We encountered a rare case of cutaneous metastasis of MSI-high and BRAFV600E-mutant cecum cancer. In the future, it will be necessary to accumulate more cases to identify clinical features and more effective treatments for CRCs with cutaneous metastasis.
We encountered a rare case of cutaneous metastasis of MSI-high and BRAFV600E-mutant cecum cancer. In the future, it will be necessary to accumulate more cases to identify clinical features and more effective treatments for CRCs with cutaneous metastasis.
Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced
Ac has been recently made available. Accelerator-produced
Ac via
Th irradiation (denoted
Ac) contains a low percentage (0.1-0.3%) of
Ac (21.77-year half-life) activity at end of bombardment. Using pharmacokinetic modeling, we have examined the dosimetric impact of
Ac on the use of accelerator-produced
Ac for radiopharmaceutical therapy. We examine the contribution of
Ac and its daughters to tissue absorbed doses. The dosimetric analysis was performed for antibody-conjugated
Ac administered intravenously to treat patients with hematological cancers. Published pharmacokinetic models are used to obtain the distribution of
Ac-labeled antibody and also the distribution of either free or antibody-conjugated
Th.

Based on our modeling, the tissue specific absorbed dose from
Ac would be negligible in the context of therapy, less than 0.02mGy/MBq for the top 6 highest absorbed tissues and less than 0.007mGy/MBq for all other tissues. Compared to that from
Ac, the absorbed dose from
Ac makes up a very small component (less than 0.04%) of the total absorbed dose delivered to the 6 highest dose tissues red marrow, spleen, endosteal cells, liver, lungs and kidneys when accelerator produced
Ac-conjugated anti-CD33 antibody is used to treat leukemia patients. For all tissues, the dominant contributor to the absorbed dose arising from the
Ac is
Th, the first daughter of
Ac which has the potential to deliver absorbed dose both while it is antibody-bound and while it is free.

These results suggest that the absorbed dose arising from
Ac to normal organs would be negligible for an
Ac-labeled antibody that targets hematological cancer.
These results suggest that the absorbed dose arising from 227Ac to normal organs would be negligible for an 225/7Ac-labeled antibody that targets hematological cancer.As one of the promising anode materials, iron selenide has received much attention for potassium-ion batteries (KIBs). Nevertheless, volume expansion and sluggish kinetics of iron selenide result in the poor reversibility and stability during potassiation-depotassiation process. In this work, we develop iron selenide composite matching ether-based electrolyte for KIBs, which presents a reversible specific capacity of 356 mAh g-1 at 200 mA g-1 after 75 cycles. According to the measurement of mechanical properties, it is found that iron selenide composite also exhibits robust and elastic solid electrolyte interphase layer in ether-based electrolyte, contributing to the improvement in reversibility and stability for KIBs. To further investigate the electrochemical enhancement mechanism of ether-based electrolyte in KIBs, we also utilize in situ visualization technique to monitor the potassiation-depotassiation process. For comparison, iron selenide composite matching carbonate-based electrolyte presents vast morphology change during potassiation-depotassiation process. When changing to ether-based electrolyte, a few minor morphology changes can be observed. This phenomenon indicates an occurrence of homogeneous electrochemical reaction in ether-based electrolyte, which results in a stable performance for potassium-ion (K-ion) storage. We believe that our work will provide a new perspective to visually monitor the potassium-ion storage process and guide the improvement in electrode material performance.This article presents a brief retrospective on the Haken-Kelso-Bunz (HKB) model of certain dynamical properties of human movement. Though unanticipated, HKB introduced, and demonstrated the power of, a new vocabulary for understanding behavior, cognition and the brain, revealed through a visually compelling mathematical picture that accommodated highly reproducible experimental facts and predicted new ones. HKB stands as a harbinger of paradigm change in several scientific fields, the effects of which are still being felt. In particular, HKB constitutes the foundation of a mechanistic science of coordination called Coordination Dynamics that extends from matter to movement to mind, and beyond.Polyvinyl alcohol (PVA) hydrogel has gained interest in cartilage repair because of its highly swollen, porosity, and viscoelastic properties. However, PVA has some deficiencies, such as its poor biocompatibility and microstructure. This research aimed to design novel hydroxyapatite (HA)-collagen (COL)-PVA hydrogels. COL was added to improve cell biocompatibility, and the microstructure of the hydrogels was controlled by fused deposition modeling (FDM). The feasibility of the COL-HA-PVA hydrogels in cartilage repair was evaluated by in vitro and in vivo experiments. The scanning electron microscopy results showed that the hybrid hydrogels had interconnected macropore structures that contained a COL reticular scaffold. The diameter of the macropore was 1.08-1.85 mm, which corresponds to the diameter of the denatured PVA column. The chondrocytes were then seeded in hydrogels to assess the cell viability and formation of the cartilage matrix. The in vitro results revealed excellent cellular biocompatibility. Osteochondral defects (8 mm in diameter and 8 mm in depth) were created in the femoral trochlear of goats, and the defects were implanted with cell-seeded hydrogels, cell-free hydrogels, or a blank control. The in vivo results showed that the COL-HA-PVA hydrogels effectively repaired cartilage defects, especially the conditions inoculated with chondrocyte in advance. This research suggests that the COL-HA-PVA hydrogels have promising application in cartilage repair.Interaction of cytoskeletal filaments, motor proteins, and crosslinking proteins drives important cellular processes such as cell division and cell movement. Cytoskeletal networks also exhibit nonequilibrium self-assembly in reconstituted systems. An emerging problem in cytoskeletal modeling and simulation is spatiotemporal alteration of the dynamics of filaments, motors, and associated proteins. This can occur due to motor crowding, obstacles along the filament, motor interactions and direction switching, and changes, defects, or heterogeneity in the filament binding lattice. How such spatiotemporally varying cytoskeletal filaments and motor interactions affect their collective properties is not fully understood. We developed the Cytoskeleton Lattice-based Kinetic Simulator (CyLaKS) to investigate such problems. The simulation model builds on previous work by incorporating motor mechanochemistry into a simulation with many interacting motors and/or associated proteins on a discretized lattice. CyLaKS also includes detailed balance in binding kinetics, movement, and lattice heterogeneity. The simulation framework is flexible and extensible for future modeling work and is available on GitHub for others to freely use or build upon. Here we illustrate the use of CyLaKS to study long-range motor interactions, microtubule lattice heterogeneity, motion of a heterodimeric motor, and how changing crosslinker number affects filament separation.
It is known that in uni-compartmental knee arthroplasty (UKA) low-volume surgeons have a higher complication and revision rate than high-volume surgeons. Further, robotic-assisted UKA leads to lower early revision rate as well as fewer limb and joint line outliers compared to conventional UKA. The purpose of this study was to retrospectively analyze the outliers' and revision rate of low-volume UKA surgeons with different robotic systems at short-term follow-up.

In this case-control study, 103 robotic-assisted UKAs were included. The procedures were performed between 2016 and 2019 from two low-volume UKA surgeons with an imageless (IL) (63 patients) and image-based (IB) (40 patients) robotic system. Alignment outliers, joint line (JL) reconstruction, complication and revision rates of the two different robotic systems were analyzed. The minimum follow-up was two years. Outliers were defined as a postoperative valgus malalignment greater than 182°. The surgery time for all procedures was evaluated.

The overall revision rate was 3.9% (4 of 103). Two occurred in the IB group (5.0%) and two in the IL group (3.2%). No valgus malalignment outliers were observed in both groups. The mean JL was not distalized by more than 2mm in both groups (IL 1.3 ± 1.6mm vs. IB 1.8 ± 0.9mm, p value 0.08). The IL procedures had a significant lower mean surgery time (55 ± 13min vs. 68 ± 14, p value 0.001).

Robotic-assisted UKA is a safe procedure in the hand of low-volume UKA surgeons. Robotic-assisted UKA minimizes overcorrection into valgus mal-alignment. Low revision rates are observed at short-term follow-up for robotic-assisted UKA. The choice of the different robotic systems has no impact on the outcome.
Robotic-assisted UKA is a safe procedure in the hand of low-volume UKA surgeons. Robotic-assisted UKA minimizes overcorrection into valgus mal-alignment. Low revision rates are observed at short-term follow-up for robotic-assisted UKA. The choice of the different robotic systems has no impact on the outcome.
The aim of this study was to compare the fixation stability and complications in patients undergoing periacetabular osteotomy (PAO) with either K-wire or screw fixation.

We performed a retrospective study to analyze a consecutive series of patients who underwent PAO with either screw or K-wire fixation. mTOR inhibitor Patients who were treated for acetabular retroversion or had previous surgery on the ipsilateral hip joint were excluded. 172 patients (191 hips 99K-wire/92 screw fixation) were included. The mean age at the time of PAO was 29.3years (16-48) in the K-wire group and 27.3 (15-45) in the screw group and 83.9% were female. Clinical parameters including duration of surgery, minor complications (soft tissue irritation and implant migration) and major complications (implant failure and non-union) were evaluated. Radiological parameters including LCE, TA and FHEI were measured preoperatively, postoperatively and at 3-months follow-up.

Duration of surgery was significantly reduced in the K-wire group with 88.2min (53-202) compared to the screw group with 119.
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