Notes

Real-world protection along with performance of rivaroxaban using Japan-specific medication dosage during long-term follow-up in individuals along with atrial fibrillation: XAPASS.
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Trauma patients often have complex injuries treated by multidisciplinary providers with wide-ranging expertise. We hypothesized that trauma patients would frequently incorrectly identify both their injuries and care teams. We also hypothesized that low health literacy level would be correlated with low levels of comprehension about injuries or care teams.

We performed a prospective study of adult trauma inpatients >18 years. Participants were surveyed to report on 1) injured body regions 2) their care teams, and 3) health literacy via a validated survey. Self-reported injuries and care teams were compared to the patient's medical record. We also studied whether health literacy was associated with patient knowledge of injuries and care teams.

Fifty participants were surveyed; thirty-two percent could not identify ≥50% of their injuries. Patients reliably identified injuries to the head, but injuries to other body areas were often misidentified. Forty-two percent of patients were not able to identify ≥50% of their medical teams, and 28% could not identify ≥75% of their medical teams. Patients often did not recognize teams such as nutrition, physical/occupationalt, or social work as part of their care. Thirteen participants reported adequate health literacy. Health literacy was not related to participant knowledge of injuries or care teams (both P=0.9).

Many trauma inpatients were unable to correctly identify their injuries and care teams despite a range of self-reported health literacy scores.
Many trauma inpatients were unable to correctly identify their injuries and care teams despite a range of self-reported health literacy scores.Barriers preventing parents from accessing healthcare services affect the effectiveness of maternal care in mountainous areas of Vietnam.
This study aimed to examine the current knowledge, attitudes, and practice of parents about maternal care in a mountainous region of Cao Bang province.

With the participation of 18 individuals (mothers, fathers, and pregnant women), six semi-structured interviews and three group discussions were conducted at different commune health centers.

This study emerged three themes, including knowledge, attitude, and practice of parents. Overall, parental knowledge about maternal care was at a basic level. While they showed positive attitudes towards the importance of maternal healthcare, unexpected behaviors such as homebirth or poor attendance at maternal health visits were still evident. These behavior patterns reflect incorrect cultural beliefs about health along with geographical and economic barriers.
This study emerged three themes, including knowledge, attitude, and practice of parents. Overall, parental knowledge about maternal care was at a basic level. While they showed positive attitudes towards the importance of maternal healthcare, unexpected behaviors such as homebirth or poor attendance at maternal health visits were still evident. These behavior patterns reflect incorrect cultural beliefs about health along with geographical and economic barriers.Unintentional exposure to nitrite- or nitrate-containing toxic salts is a recognized cause of acquired methemoglobinemia (MetHb). This systemic alteration of the blood can be fatal if not recognized and treated promptly. The intentional ingestion of sodium nitrite (NaNO2) or sodium nitrate (NaNO3), causing MetHb, is an uncommon and recently identified method of suicide, with the first reported case in the literature occurring in New Zealand in 2010. In this case series we present 28 cases of sudden death of individuals with evidence of MetHb and/or toxic salt ingestion, occurring in the Province of Ontario, Canada, between the years 1980 and 2020, inclusive. Of the 28 deaths in our case series, 25 showed evidence of intentional ingestion of sodium nitrite or sodium nitrate salts. Our year-over-year data demonstrated this is an increasingly used method of suicide in our provincial population, with the majority of cases occurring in the final two years of our study. Postmortem detection of MetHb is typically established via screening techniques such as scene evidence suggesting fatal consumption of a toxic salt in addition to the characteristic grey-purple lividity observed upon the body. The diagnosis can be established via postmortem blood testing demonstrating elevated methemoglobin saturation. Additionally, we have confirmed that postmortem MRI in cases of MetHb demonstrates a T1-bright (hyperintense) signal of the blood; both within intracardiac blood on chest MRIs and postmortem blood samples in tubes.Arrest-related deaths in the context of Conducted Electrical Weapon (CEW) deployment are rare. The evaluation of such complex events is a challenge for the forensic scientist. We present a case of a 49-year old man, who was exposed to a Taser X26P during a confrontation with the police. He lost consciousness, vomited, aspirated and died after having been hospitalized for several days at the ICU. Based on the patient´s medical history, autopsy findings, witness testimonies, and reliable clinical and toxicological blood parameters, the most probable cause and mechanisms of his death are discussed. The present work demonstrates, based on one case report, the possibilities as well as limitations of forensic assessment in CEW-related deaths.Scanning transmission electron microscopy (STEM) has become the technique of choice for quantitative characterization of atomic structure of materials, where the minute displacements of atomic columns from high-symmetry positions can be used to map strain, polarization, octahedra tilts, and other physical and chemical order parameter fields. The latter can be used as inputs into mesoscopic and atomistic models, providing insight into the correlative relationships and generative physics of materials on the atomic level. However, these quantitative applications of STEM necessitate understanding the microscope induced image distortions and developing the pathways to compensate them both as part of a rapid calibration procedure for in situ imaging, and the post-experimental data analysis stage. Here, we explore the spatiotemporal structure of the microscopic distortions in STEM using multivariate analysis of the atomic trajectories in the image stacks. Based on the behavior of principal component analysis (PCA), we develop the Gaussian process (GP)-based regression method for quantification of the distortion function. The limitations of such an approach and possible strategies for implementation as a part of in-line data acquisition in STEM are discussed. The analysis workflow is summarized in a Jupyter notebook that can be used to retrace the analysis and analyze the reader's data.Inferring individuals' social rank-their position within a hierarchy-is central to many interactions. However, how do observers assess actors' social rank? The current article reviews three broad sources of social-rank cues physical characteristics, behaviors, and possessions. First, observers infer an actor's social rank from ancestral stereotypes tethered to physical characteristics. Second, observers ascribe social rank to an actor from behaviors that range from nonverbal communication to explicit acts.Finally, observers assume social rank from actors' possessions. The present review emphasizes recent developments in these areas and poses question for future research.This brief review article discusses marital dissolution and health with a focus on two specific themes. First, we introduce and discuss the search for plausible causal pathways that link the end of marriage to distal health outcomes. Second, we suggest that the socioeconomic status disruptions that follow divorce represent a plausible causal pathway and emphasize the need for more psychological science in this area of study. Although there is substantial literature that demonstrates that divorced adults, especially divorced women, experience significant financial disruptions, the research in this area remains broad and largely the province of family sociology and demography. Research is needed to better understand adults' psychological and behavioral responses to changes in their financial situation after the end of marriage.How people choose to spend money is often observable to others (e.g. based on their clothes, accessories, and social media pages), but there is a whole universe of financial decisions that are essentially unobservable (e.g. how people handle their debts, taxes, and retirement planning). We explore one context where people have an up-close-and-personal view of someone else's financial decision-making process romantic relationships. We discuss how the endless opportunities for financial observation in romantic relationships influence a range of behaviors, including spending habits, decisions about bank account structure, and financial infidelity. Our review highlights the need for more research on the ways in which financial decisions are made, communicated, and observed within romantic relationships.Many citizens distrust powerful societal institutions, and hold conspiracy theories about them. What are the implications of this suspicion of institutions for people's social relationships? The current paper proposes that institutions have at least two functions to regulate citizens' social relationships providing people with a sense of safety, and providing models for group norms and values. Suspicion of institutions undermines both of these functions, and therefore yields a range of negative societal outcomes by impacting people's interpersonal, within-group, and between-group relationships. More specifically, suspicion of institutions reduces trust between strangers, within-group cooperation, commitment, and prosocial behavior, and increases prejudice, intergroup conflict, polarization, and extremism. We conclude that institutional distrust and conspiracy theories erode the fabric of society.
Restenosis after vessel angioplastydue to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patients exhibiting more aggressive forms of vascular disease and poorer outcomes after surgery. Kv1.3 channels are critical players in VSMC proliferation. EGFR inhibitor drugs Kv1.3 blockers inhibit VSMCs MEK/ERK signalling and prevent vessel restenosis. We hypothesize that dysregulation of microRNAs (miR) play critical roles in adverse remodelling, contributing to Kv1.3 blockers efficacy in T2DM VSMCs.

We used clinically relevant in vivo models of vascular risk factors (VRF) and vessels and VSMCs from T2DM patients.

Human T2DM vessels showed increased remodelling, and changes persisted in culture, with augmented VSMCs migration and proliferation. Moreover, there were downregulation of PI3K/AKT/mTOR and upregulation of MEK/ERK pathways, with increased miR-126 expression. The inhibitory effects of Kv1.3 blockers on remodelling were significantly enhanced in T2DM VSMCs and in VRF model. Finally, miR-126 overexpression confered "diabetic" phenotype to non-T2DM VSMCs by downregulating PI3K/AKT axis.

miR-126 plays crucial roles in T2DM VSMC metabolic memory through activation of MEK/ERK pathway, enhancing the efficacy of Kv1.3 blockers in the prevention of restenosis in T2DM patients.
miR-126 plays crucial roles in T2DM VSMC metabolic memory through activation of MEK/ERK pathway, enhancing the efficacy of Kv1.3 blockers in the prevention of restenosis in T2DM patients.
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