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We want to evaluate the influence of the size of the osteotomy on the postsurgical outcomes.

A retrospective study was performed in patients who underwent TCL-DCR from January 1, 2008, to March 1, 2019. The patients were divided into two groups the patients in one group were subjected to LP surgery with an osteotomy diameter equal to 9mm±1mm (group A), and the patients in the other group were subjected to surgery with an osteotomy diameter equal to 14mm±1mm (group B).

A total of 159 lacrimal pathways (LPs) were operated on in group A with a success rate (SR) of 66.6%. Thirty-three LPs were operated on in group B with an SR of 81.8%.

An osteotomy diameter equal to 14mm±1mm achieved better postoperative results than an osteotomy diameter equal to 9mm±1mm.
An osteotomy diameter equal to 14 mm ± 1 mm achieved better postoperative results than an osteotomy diameter equal to 9 mm ± 1 mm.
To evaluate the effects of increased endogenous Antisecretory Factor (AF) synthesis using specially processed cereals (SPC) in a sample of patients with defined unilateral Meniere's disease (MD), compared to the results of a treatment protocol of intravenous glycerol and dexamethasone.

Twenty-six patients with unilateral MD were divided in 2 groups and treated with SPC and with intravenous glycerol and dexamethasone for 24months. Audio-vestibular evaluation was performed before (T0) and every six months. The number of vertigo spells were evaluated before and after therapy and the Efficacy Index (EI) was calculated. Questionnaires for hearing loss, tinnitus and quality of life were administered.

EI decreased in the SPC group after 18 (T18) (p=.0017) and 24 (T24) months of therapy (p=.0111). There was a significant reduction for tinnitus score in the SPC group at T24 (p=.0131). No significant differences were found between the two groups at T0 (p=.4723), while a significant difference was found at T24 (p=.0027). Quality of life showed a significant improvement in daily activities in the SPC group (p=.0033) compared to the infusion therapy group. No statistically significant changes in PTA thresholds were found in both groups between T0 and T24.

The preliminary results of our study show a significant reduction of vertigo spells and a positive effect on tinnitus severity and on quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.
The preliminary results of our study show a significant reduction of vertigo spells and a positive effect on tinnitus severity and on quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.
Individuals routinely perform cognitive tasks concurrent to balance functions. The attention is one of the most important cognitive functions and it has effects on vestibular system. This study aims to investigate the connection between balance and cognitive tasks under different conditions.

Visual attention tasks (VAT) and auditory attention tasks (AAT) were given to 30 healthy adults (40.42 ± 11.22 years) during functional balance tasks. Sensory Organization Test (SOT) and Adaptation Test (ADT) were used for the evaluation of postural stability and adaptation. The sounds were presented from the computer speakers in AATs, and VATs were presented in the virtual reality (VR) environment.

The first SOT condition had a statistically significant difference between all dual VAT (DT-VAT) and single task (ST) (p < 0.001), but there was no statistically significant difference between ST and DT-AAT (p = 1.00). Lazertinib In the fourth SOT condition, there was a statistically significant difference between all DT-VATs versus ST and DT-VA (p < 0.001); there was no statistically significant difference between ST and DT-AA scores (p = 0.80). While there was a significant difference between DT-VA and ST and DT-AA (p < 0.001), no statistically significant difference was observed between ST and DT-AA in the ADT (p = 0.321).

Balance performance gets worse with VAT in a VR environment. VR technology can be used to effectively evaluate balance and cognitive performance. The use of experimental environments in standard postural evaluations increases the efficiency of the postural stability tests.
Balance performance gets worse with VAT in a VR environment. VR technology can be used to effectively evaluate balance and cognitive performance. The use of experimental environments in standard postural evaluations increases the efficiency of the postural stability tests.
Tonsillotomy with radiofrequency (RF) is one of the newest treatments for chronic tonsillitis, but the mechanism of RF effects and complications are still pending. The aim of this study was to evaluate the effects of RF on the histological and bacteriological characteristics of the tonsils (Case-control study).

In fifty-two patients with chronic tonsillitis in 2017-2018, immediately after tonsillectomy, the tonsils were divided into 2sections; one sample treated with RF, and the other one considered as control, without intervention. All tonsil samples sent for histological and bacteriological study morphometric assays made by Digitizer software, and type of bacterial colonies identified by microbiological and biochemical tests. Willcoxon and McNemar tests were used for statistical analysis and level of significance was p≤.05.

Tonsil mucosal thickness (2202.98±323.09 vs. 2463.94±357.61μm) and size of the tonsil nodule (28,000.42±9608.75 vs. 36,692.81±7040.74μm
) were significantly lower in the RF+ group than other group (p=.001 and p=.01, respectively). There was no significant differences in thickness of the tonsil epithelium (p=.075), number of lymphoid nodules (p=.860), and the number of reticular tonsil epithelium (p=.813) between the two groups. link2 Bacterial growth in RF- and RF+ groups had no statistically significant difference (p=.06), however, the average colony count of S. aureus in RF+ tonsils were significantly lower, and total number of bacterial colonies were significantly lower in RF+ group(1405±156 vs. 2471±156), (p=.001).

RF surgery has significant effects on size of the nodules, thickness of the mucous layer and bacteriological characteristics of tonsil tissue. Especially S. aureus seems to be more sensitive to RF effects.
RF surgery has significant effects on size of the nodules, thickness of the mucous layer and bacteriological characteristics of tonsil tissue. Especially S. link3 aureus seems to be more sensitive to RF effects.
Extracts of several Asteraceae species in Brazil are popularly used as anti-inflammatory. Some of these species are popularly recognizes as "arnica" because of the morphological and sensorial analogy with the traditional European Arnica montana. These used species in Brazil were identified as Calea uniflora Less, Chaptalia nutans (L.) Polák, Lychnophora ericoides Mart. Lychnophora pinaster Mart. Lychnophora salicifolia Mart. Porophyllum ruderale (Jacq.) Cass, Pseudobrickellia brasiliensis (Spreng.) R. M. King & H. Rob. Sphagneticola trilobata (L.) Pruski and Solidago chilensis Meyen. However, the comparative chemical profile of these so-called "arnicas" has never been reported in the literature.

This work aimed to compare the main plants recognized as "arnica" in Brazil by using metabolomic analysis, based on UPLC-ESI-QTof-MS
data and multivariate statistical analysis.

The metabolites profiling of 10 "arnica" species were established by UPLC-ESI-QTof-MS
. Three tinctures of each species (dry leav, as well as to verify the chemical similarity among evaluated species. This methodology was successfully used to establish important correlations in medicinal preparations of so-called "arnicas" used in Brazil.
Traditionally plant-based remedies such as Commiphora myrrha (CM) have been used as an ayurvedic medicine to treat diabetes mellitus in some region of Arabia and Africa. Previous reports have shown that CM reduced blood glucose levels and increased insulin concentrations in animal models of diabetes in vivo. However, the exact mechanisms by which CM improved glycemic control in these animals are not fully understood. We hypothesized that CM may have a direct insulinotropic activity on β-cells to increase insulin secretion.

The direct effects of CM were investigated using MIN6 β-cells and isolated mouse and human islets in static and perifusion insulin secretion experiments. Isolated mouse and human islets were used to investigate the rate and pattern of CM-induced insulin secretion.

The effect of CM on insulin secretion was assessed by static and perifusion experiments using MIN6 cells, a mouse-derived β-cell line, and primary mouse and human islets. The effects of CM on cell viability and membrane intetion of insulin granules release rather than insulin synthesis.
Qingganjiuwei powder (QGJWS) is a well-known traditional drug containing nine kinds of medicinal materials. This drug is commonly used in the Inner Mongolia region and exerts remarkable clinical effects on hepatic protection.

To investigate whether QGJWS inhibits liver fibrosis in rats and to reveal its potential mechanisms.

Liver fibrosis model was induced by CCl
for 8 weeks in SD rats. Next, rats were intragastrically administered quantum satis doses of QGJWS (0.525, 1.575, 4.725g/kg per day) or Silymarin (SIL; 120mg/kg per day) for 8 weeks. Afterwards, the rats were sacrificed, and serum aminotransferase (ALT and AST) levels, histopathological changes as well as the mRNA and protein expression of matrix metalloproteinase 2 (MMP2), MMP9, tissue inhibitor of metalloproteinase1 (TIMP1), collagen type Ⅰ(COL1), α-smooth muscle actin (α-SMA), combined with phosphorylation levels of extracellular signal-regulated kinase (ERK), C-Jun amino-terminal kinases (JNKs) and stress-activated protein kinase-2 (p38)tection against CCl
-induced liver fibrosis in rats, which may be due to its ability to inhibited the MAPKs signaling pathway.
QGJWS offers notable protection against CCl4-induced liver fibrosis in rats, which may be due to its ability to inhibited the MAPKs signaling pathway.The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in Wuhan, Hubei Province, China, has rapidly spread to produce a global pandemic. It is now clear that person-to-person transmission of SARS-CoV-2 has been occurring and that the virus has been dramatically growing in recent months. Early, rapid and accurate diagnosis is of great significance for curtailing the spread of SARS-CoV-2. There are currently several diagnostic techniques (e.g. viral culture and nucleic acid amplification test) being used to detect the virus. However, the sensitivity and specificity of these methods are quite different, with the sample source and detection limit varying greatly. This study reviewed all types and characteristics of the currently available laboratory diagnostic assays for detecting SARS-CoV-2 infection and summarized the selection strategies of testing and sampling sites at different disease stages to improve the diagnostic accuracy of Coronavirus Disease 2019 (COVID-19).
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