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Building ways of increase the group willingness level in order to avoid drug abuse within young people: Based on the neighborhood preparedness model, Eghlid Town, Iran, 2019.
). To this end, we employed an approach based on deep learning. Specifically, the system combines character embeddings to cope with out-of-vocabulary (OOV) words, Long Short-Term Memory (LSTM) networks to model contextual representations and it makes use of Conditional Random Fields (CRF) to classify each medical entity as either negated or not given the contextual dense representation. Moreover, we explored both embeddings created from words and embeddings created from lemmas. The best results were obtained with the lemmatized embeddings. Apparently, this approach reinforced the capability of the LSTMs to cope with the high lexical variability. The f-measure for exact-match was 65.1 and 82.4 for the partial-match. OBJECTIVE This study aims to develop and evaluate effective methods that can normalize diagnosis and procedure terms written by physicians to standard concepts in International Classification of Diseases(ICD) in Chinese, with the goal to facilitate automated medical coding in China. METHODS We applied the entity-linking framework to normalize Chinese diagnosis and procedure terms, which consists of two steps - candidate concept generation and candidate concept ranking. For candidate concept generation, we implemented both the traditional BM25 algorithm and an extended version that integrates a synonym knowledgebase. For candidate concept ranking, we investigated a number of different algorithms (1) the BM25 algorithm, (2) ranking support vector machines (RankSVM), (3) a previously reported Convolutional Neural Network (CNN) approach, (4) 11 deep ranking-based methods from the MatchZoo toolkit, and (5) a new BERT (Bidirectional Encoder Representations from Transformers) based ranking method. Using two manually annotated datasets (8,547 diagnoses and 8,282 procedures) collected from a Tier 3A hospital in China, we evaluated above methods and reported their performance (i.e., accuracy) at different cutoffs. RESULTS The coverage of candidate concept generation was greatly improved after integrating the synonym knowledgebase, achieving 97.9% for diagnoses and 93.4% for procedures respectively. Overall the new BERT-based ranking method achieved the best performance on both diagnosis and procedure normalization, with the best accuracy of 92.1% for diagnosis and 80.1% for procedure, when the top one concept and exact match criteria were used. CONCLUSIONS This study developed and compared diverse entity-linking methods to normalize clinical terms in Chinese and our evaluation shows good performance on mapping disease terms to ICD codes, demonstrating the feasibility of automated encoding of clinical terms in Chinese. The architectonical organization of putatively higher auditory areas in the human superior temporal gyrus and sulcus is not yet well understood. To provide a coherent map of this part of the brain, which is involved in language and other functions, we examined the cytoarchitecture and cortical parcellation of this region in histological sections of ten human postmortem brains using an observer-independent mapping approach. Two new areas were identified in the temporo-insular region (areas TeI, TI). TeI is medially adjacent to the primary auditory cortex (area Te1). TI is located between TeI and the insular cortex. Laterally adjacent to previously mapped areas Te2 and Te3, two new areas (STS1, STS2) were identified in the superior temporal sulcus. All four areas were mapped over their whole extent in serial, cell-body stained sections, and their cytoarchitecture was analyzed using quantitative image analysis and multivariate statistics. Interestingly, area TeI, which is located between area Te1 and area TI at the transition to the insula, was more similar in cytoarchitecture to lateral area Te2.1 than to the directly adjacent areas TI and Te1. Such structural similarity of areas medially and laterally to Te1 would be in line with the core-belt-parabelt concept in macaques. The cytoarchitectonic probabilistic maps of all areas show the localization of the areas and their interindividual variability. The new maps are publicly available and provide a basis to further explore structural-functional relationship of the language network in the temporal cortex. BACKGROUND AND AIMS The mechanisms by which passive smoking leads to cardiometabolic risks, and the tissues involved still require elucidation. We aimed to evaluate the association of parental smoking exposure (PSE) with the secretion of adipocyte-derived hormones and cardiometabolic risk factors in Chinese children. METHODS We included 3150 school children aged 6-18 years from the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. Data on PSE and potential confounders were collected. Six adipokines related to insulin resistance and metabolic syndrome (MetS) were measured. RESULTS PSE was reported in nearly two-thirds of the children. After adjusting for covariates, including age, sex, pubertal stages, lifestyle factors, and family history, PSE was independently associated with increases of 39.2% in leptin and 3.9% in retinol binding protein-4 and decreases of 11.4% in fibroblast growth factor 21 and 4.6% in adiponectin levels (p less then 0.05 for all), plus risks for central obesity (OR 1.59, 95% CI 1.33-1.90), elevated blood pressure (1.22, 1.02-1.46) and MetS (1.43, 1.11-1.85). However, the associations of PSE with hypertension and MetS were abolished when adjusted for adiposity parameters or the above-mentioned adipokine profiles. CONCLUSIONS PSE was associated with dysregulation of adipokine levels, which might mediate the development of MetS in early life. OBJECTIVES Since 2010, the number of homeless people in the UK has increased, and homelessness in its different types has become a major public health problem. Housed older people with past experience of homelessness are an understudied population that can provide valuable insight into this problem. For this reason, we examined the lifetime prevalence of homelessness and its associations with childhood adversity and mortality in a national sample of older people. STUDY DESIGN This is a longitudinal cohort study. METHODS We studied 6649 housed individuals aged 55-79 years in 2007 from the English Longitudinal Study of Ageing (ELSA). We used logistic regression to model the association between adverse childhood experiences (ACE) and lifetime experience of homelessness (ever been homeless for ≥1 months) and Cox proportional hazards regression to model the prospective association between lifetime experience of homelessness and mortality. RESULTS We identified 107 participants with lifetime experience of homelessness. We found a strong graded association between the number of ACE and lifetime experience of homelessness; participants with two ACE had 5.35 (95% confidence interval [CI] 3.17-9.05) times greater odds of having experienced homelessness than those reporting none. Most ACE were individually associated with lifetime homelessness, but fewer remained so in the mutually adjusted model. Participants with lifetime experience of homelessness had 1.55 (95% CI 1.01-2.37) times greater risk of mortality over a 10-year follow-up and after adjustment for covariates. CONCLUSIONS Exposure to childhood adversity is associated with increased risk of experiencing homelessness. Older housed people with past experience of homelessness are at increased risk of mortality. We assessed the association of spatiotemporal hot spots of critically ill small for gestational age (ciSGA) newborns and industrial air emissions. Using neonatal admission data from the Canadian Neonatal Network between 2006 and 2010 (n = 32,836 infants), we aggregated maternal residential postal codes from nineteen census metropolitan areas (CMA) into space-time cubes and applied emerging hot spot analyses. Using National Pollutant Release Inventory data (n = 161 chemicals) and Environment Canada weather station data (n = 19 sites), we estimated monthly wind-dispersion of air emissions and calculated hot spots. We associated the patterns using logistic regression, with covariates for low socioeconomic status, NO2 pollution, and number of infants. A total of 5465 infants were identified as ciSGA and the larger CMAs had more and larger hot spots (i.e. accumulation of events in space and time). click here Seventy-eight industrial chemical hot spots were associated with ciSGA hot spots. The highest number of positive associations were for 28 different pollutants, which differed by CMA. Twenty-one were known or suspected developmental toxicants, such as particulate matter, carbon monoxide, heavy metals, and volatile organic compounds. Associations with hot spots of industrial chemical emissions were geographically specific and may help explain the space-time trends of ciSGA. OBJECTIVE Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (i.e. fission/fusion) to gut inflammation is unknown. We hypothesised that perturbed mitochondrial dynamics would contribute to colitis. DESIGN qPCR for markers of mitochondrial fission and fusion was applied to tissue from dextran sodium-sulphate (DSS)-treated mice. An inhibitor of mitochondrial fission, P110 (prevents dynamin related protein (Drp)-1 binding to mitochondrial fission 1 protein (Fis1)), was tested in the DSS and di-nitrobenzene sulphonic acid (DNBS) models of murine colitis and the impact of DSS ± P110 on intestinal epithelial and macrophage mitochondria assessed in vitro. RESULTS Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control. Systemic delivery of P110, in prophylactic or treatment regimens, reduced the severity of DSS- or DNBS-colitis, and the subsequent hyperalgesia in DNBS-mice. Application of DSS to epithelial cells or macrophages caused mitochondrial fragmentation. DSS-evoked perturbation of epithelial cell energetics and mitochondrial fragmentation, but not cell death, were ameliorated by in vitro co-treatment with P110. CONCLUSION We speculate that the anti-colitic effect of systemic delivery of the anti-fission drug, P110, works, at least partially, by maintaining enterocyte and macrophage mitochondrial networks. Perturbed mitochondrial dynamics can be a feature of intestinal inflammation, the suppression of which is a potential novel therapeutic direction in inflammatory bowel disease. INTRODUCTION We recently proposed a scale for assessment of patient-relevant functional limitations following an episode of venous thromboembolism (VTE). Further development of this post-VTE functional status (PVFS) scale is still needed. METHODS Guided by the input of VTE experts and patients, we refined the PVFS scale and its accompanying manual, and attempted to acquire broad consensus on its use. RESULTS A Delphi analysis was performed involving 53 international VTE experts with diverse scientific and clinical backgrounds. In this process, the number of scale grades of the originally proposed PVFS scale was reduced and descriptions of the grades were improved. After these changes, a consensus was reached on the number/definitions of the grades, and method/timing of the scale assessment. The relevance and potential impact of the scale was confirmed in three focus groups totaling 18 VTE patients, who suggested additional changes to the manual, but not to the scale itself. Using the improved manual, the κ-statistics between PVFS scale self-reporting and its assessment via the structured interview was 0.
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