Notes

HER2 overexpression can be a putative analytic and prognostic biomarker for late-stage colorectal cancer malignancy throughout Northern African people.
Integration of the graft, implant survival rates and complications were recorded. Results Overall, 24 patients with 35 sites who were included were followed for (7.1±1.9) years. Graft integration (24/24) and implant survival rates (35/35) were determined as 100%. The average horizontal and vertical bone gain was (6.47±2.46) and (5.01±1.12) mm with resorption rates of 9.0% and 10.9%, respectively. One patient showed soft-tissue dehiscence with peri-implant mucositis were observed 9 years after surgery. More than 1.5 mm of buccal bone plate were observed using cone beam computed tomography. Conclusions This technique was effective and reliable for three-dimensional reconstruction of severely atrophic alveolar ridges in anterior maxillae. Autogenous graft combined with coverage by allogeneic bone graft and collagen membrane provided successful augmentation with low bone resorption.Objective To compare and evaluate the clinical outcome of immediate implant therapy in patients with limited buccal bone wall dehiscence and in patients with intact buccal bone wall. Methods This prospective cohort study included patients intended to receive immediate implant treatment in upper anterior esthetic region in the Department of Implantology, Hospital of Stomatology, Wuhan University from August to December, 2018. Patients with buccal bone wall dehiscence limited to the coronal half were attributed to experimental group to conduct flap implant surgery (indicating to less than coronal half of the buccal bone wall length from the alveolar bone crest to the implant tip), whereas patients with intact buccal bone wall were attributed to control group to conduct flapless implant surgery. Buccal bone wall resorptions in height and thickness were evaluated 6 months after implant placement. Implant survival rate, pink/white esthetic score and post-operation complications were also analyzed 12 months after iConclusions Clinical results of immediate implant to patients with buccal bone wall dehiscence limited to the coronal half are comparable to the results of patients with intact buccal bone wall.Passive fit is a key prerequisite for successful implant-supported restorations, especially for full-arch implant-supported fixed restoration. The precise passive fit comes from the fine control of the entire manufacturing process of resorations. Intraoral welding directly connects the metal framework and the upper abutment in the mouth, which can ensure precise and stable passive fit. This article will explain the definition, necessity, influencing factors and clinical control methods of passive fit, in order to provide guidance for achieving precise passive fit in implant-supported full-arch prostheses.In addition to restoring oral function, stable aesthetic outcome has become the goal of oral implant therapy. To ensure the harmonious appearance of the restoration and the natural tooth and to obtain the ideal hard and soft tissue structure, clinicians should have a clear understanding of the factors that influence the success of aesthetics and apply different technique accordingly. In view of the recent progress in the field of oral implant, the factors affecting the aesthetic outcome of implant treatment were discussed including neck design of implant, design of customized abutment, tissue regeneration and gingival papilla height, so as to provide clinical reference to improving the aesthetic outcome of oral implant treatment.Due to the highly predictable long-term clinical outcomes, modern implant dentistry has become one of the most preferred treatment modalities for restoring missing teeth. However, the complications of implant therapy compromise the long-term implant success and remain a great challenge to clinicians. Hardware complications include the mechanical complications which are related to the manufacturer-fabricated components of the prosthesis, such as abutment/screw loosening, fracture and implant fracture; and the technical complication which are related to laboratory-fabricated components of the prosthesis, such as veneer chipping. The biological complications mainly include peri-implant mucositis and peri-implantitis. It is crucial to figure out how to effectively avoid and manage the complications of implant therapy. This article reported the definitions, incidences, risk factors, prevention and treatment of both mechanical and biological complications of implant therapy.With the development of dental implant prosthodontic technique, many new concepts and methods have emerged. In the light of present situation, implant prosthodontic technique is developing towards precision, comfortability, immediacy and digitization. selleck products Meanwhile, the research area is focusing on expanding immediate restoration indications, clinical selection strategies of different prosthodontic materials and the accuracy of digitalized prosthodontics. The paper aims to discuss the developing trend in prosthodontics of dental implantology for clinical reference.Oral implantology has experienced more than half a century of development, the theoretical foundation and clinical technology are becoming more mature. This article elaborates on the establishment of implant timing, implant-related bone augmentation technology, surgical alternatives to bone augmentation technology, implant-related soft tissue augmentation technology, and computer-guided surgery. Provide a reference for a comprehensive understanding of dental implant surgery technology and its new developments.
Falling is one of the most common problems in older adults and can lead to additional health problems. This study aimed to determine the effects of a multicomponent program on fall incidence and quality of life in older adult nursing home residents.

This was a quasi-experimental study with a pretest and post-test design. The study population comprised 55 older adults residing in nursing homes. The intervention was a multicomponent program including physical activities, training sessions, and physical environment modifications in nursing homes that was conducted for 8 weeks. The data collection tools included a socio-demographic characteristics form and questionnaires pertaining to the quality of life and fear of falls, which were completed by the participants before and after the intervention.

The mean age of the participants was 68.48 years, and most (90%) were illiterate. We observed a significant difference between the mean number of falls and the scores for fear of falling before and after the intervention (p<0.001). We also observed a significant difference between the total quality of life scores and all of the related dimensions before and after the intervention, indicating that the quality of life of the older adults had improved after the intervention (p<0.001).

The results of this study indicated that the multicomponent fall prevention program was effective in improving the quality of life, fall rate, and fear of falling among older residents in nursing homes. Further studies are needed to explore the long-term effects of these interventions.
The results of this study indicated that the multicomponent fall prevention program was effective in improving the quality of life, fall rate, and fear of falling among older residents in nursing homes. Further studies are needed to explore the long-term effects of these interventions.Trachypithecus, which currently contains 20 species divided into four groups, is the most speciose and geographically dispersed genus among Asian colobines. Despite several morphological and molecular studies, however, its evolutionary history and phylogeography remain poorly understood. Phayre's langur ( Trachypithecus phayrei) is one of the most widespread members of the genus, but details on its actual distribution and intraspecific taxonomy are limited and controversial. Thus, to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T. phayrei, we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens, including two holotypes. Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus, suggesting that the T. pileatus group branched first, followed by the T. francoisi group, and the T. cristatus and T. obscurus groups most recently. The four species groups diverged from each other 4.5-3.1 million years ago (Ma), while speciation events within these groups occurred much more recently (1.6-0.3 Ma). Within T. phayrei, we found three clades that diverged 1.0-0.9 Ma, indicating the existence of three rather than two taxa. Following the phylogenetic species concept and based on genetic, morphological, and ecological differences, we elevate the T. phayrei subspecies to species level, describe a new species from central Myanmar, and refine the distribution of the three taxa. Overall, our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T. phayrei but the entire Trachypithecus genus as well.
Foot and leg pain in complex regional pain syndrome (CRPS) presents a challenge even with neuromodulation techniques such as spinal cord stimulation (SCS). We report our experience with a novo technique of direct sciatic nerve electrical stimulation (DISNES) for intractable foot and leg pain in CRPS I.

Following Research Ethics Board (REB) approval, data were gathered for 16 patients (10 women and 6 men, age 26-61 years) who had been subjected to ipsilateral DISNES. All 16 patients had failed conventional medical management. As well, seven subjects were previously treated with SCS for CRPS I pain. These subjects reported pain relief in the thigh and leg, however the SCS was unable to alleviate the disabling foot pain despite varied and multiple programming techniques. The remaining nine subjects were treated primarily with DISNES. Evaluation was done using visual analog scale (VAS), Oswestry Disability Index version 2 (ODI), and quality of life (EQ-5D and SF-36) scores done both pre-DISNES and at two follnd dystonia in CRPS I. Further studies are needed to determine long-term efficacy as this study pool is limited in size and follow-up period.
Increased acute postoperative pain intensity has been associated with the development of persistent postsurgical pain (PPP) in mechanistic and clinical investigations, but it remains unclear which aspects of acute pain explain this linkage.

We analysed clinical postoperative pain intensity assessments using symbolic aggregate approximations (SAX), a graphical way of representing changes between pain states from one patient evaluation to the next, to visualize and understand how pain intensity changes across sequential assessments are associated with the intensity of postoperative pain at 1 (M1) and 6 (M6) months after surgery. SAX-based acute pain transition patterns were compared using cosine similarity, which indicates the degree to which patterns mirror each other.

This single-centre prospective cohort study included 364 subjects. Patterns of acute postoperative pain sequential transitions differed between the 'None' and 'Severe' outcomes at M1 (cosine similarity 0.44) and M6 (cosine similarity 0.49).
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