Notes

Active reduction of digestive tract cellular material drives oncogenic increase in organoids.
Legerlotz, K, Kittelmann, J, Dietzel, M, Wolfarth, B, and Böhlke, N. Ice hockey-specific repeated shuttle sprint test performed on ice should not be replaced by off-ice testing. J Strength Cond Res XX(X) 000-000, 2020-Although the importance of sport-specific testing has been stated in various studies, the application of standard tests that are little related to the requirements in competition is still widespread in performance diagnostics. Furthermore, the actual exercise mode in testing often deviates from the exercise mode in competition. The aim of this study was therefore to investigate how the performance in an ice hockey mimicking repeated sprint shuttle test conducted off-ice (RSS) differs from the on-ice performance (RISS). The two performance tests were completed by 21 male junior ice hockey players within one week. Anaerobic fatigue was significantly larger in RISS and did not correlate with RSS, whereas best run, mean run, total run time, turn and fly time, and total times in all three shifts correlated moderately. Although the best and mean run times did not differ, these times were achieved with different strategies depending on the test condition, indicated by significantly different split times. Aerobic fatigue in shift 3 was the only parameter where the off-ice measurement correlated strongly with the on-ice measurement. Our results imply that an off-ice test does not predict on-ice performance with sufficient precision, strongly advocating performance testing in the exercise mode used in competition.Roberts, BM, Nuckols, G, and Krieger, JW. Sex differences in resistance training A systematic review and meta-analysis. J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study was to determine whether there are different responses to resistance training for strength or hypertrophy in young to middle-aged males and females using the same resistance training protocol. The protocol was pre-registered with PROSPERO (CRD42018094276). Meta-analyses were performed using robust variance random effects modeling for multilevel data structures, with adjustments for small samples using package robumeta in R. Statistical significance was set at P less then 0.05. The analysis of hypertrophy comprised 12 outcomes from 10 studies with no significant difference between males and females (effect size [ES] = 0.07 ± 0.06; P = 0.31; I = 0). The analysis of upper-body strength comprised 19 outcomes from 17 studies with a significant effect favoring females (ES = -0.60 ± 0.16; P = 0.002; I = 72.1). The analysis of lower-body strength comprised 23 outcomes from 23 studies with no significant difference between sexes (ES = -0.21 ± 0.16; P = 0.20; I = 74.7). We found that males and females adapted to resistance training with similar effect sizes for hypertrophy and lower-body strength, but females had a larger effect for relative upper-body strength. Given the moderate effect size favoring females in the upper-body strength analysis, it is possible that untrained females display a higher capacity to increase upper-body strength than males. Further research is required to clarify why this difference occurs only in the upper body and whether the differences are due to neural, muscular, motor learning, or are an artifact of the short duration of studies included.A badly injured young man and his family take an important step toward acceptance.How nursing's past holds back our present.Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog is a regular column to draw the attention of AJN readers to posts we think deserve a wider audience. To read more, please visit www.ajnoffthecharts.com.From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but they also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. To this end, From the AJN Archives highlights articles selected to fit today's topics and times.This month's article, from October 1969, is a classic piece by Virginia Henderson, known for her patient-focused theory of nursing practice and her extensive teaching and writing, including many thoughtful articles on the nature of nursing. Here, she illustrates her ideas about excellence in nursing by highlighting the accomplishments of several key nursing figures, from "Miss Nightingale" to 20th-century nursing innovators.Henderson's broad vision of nursing provides the framework for this discussion. She notes that "no one practices nursing except in relation to his or her times and in relation to the needs of a given society," and that nursing therefore calls for a social conscience and an interest in civic matters. "It seems hardly possible to me that an excellent nurse can be at the same time an indifferent or socially inexperienced citizen."Henderson's perspective seems more relevant and urgent today than even when it was written, during the turbulent 1960s. In this month's Viewpoint column, William E. Rosa builds upon her important work in his discussion of "Nurses as Global and Planetary Citizens."Type 2 diabetes mellitus is an increasingly urgent public health issue in the United States. Prevention through early detection and education can help decrease the prevalence and complications of the disease. A nursing faculty member and a postgraduate year one pharmacy resident collaborated to provide diabetes screening and education at a local festival in rural Alabama. The prevalence of diabetes in Alabama is approximately 1.6 times higher than the national average. A glycated hemoglobin (HbA1c) test is the gold standard for diabetes diagnosis and is relatively quick and inexpensive. At the event, 38 participants received point of care HbA1c testing, results, and counseling. Seven participants had an HbA1c level of 5.7% to 6.4%, which indicates prediabetes, and one participant had an HbA1c level of 6.5% or higher, which indicates possible diabetes mellitus. Many patients were surprised by their results and by the simplicity of the test. The purpose of this article is to describe a cost-effective interdisciplinary educational event to increase diabetes awareness in a rural community.Editor's note The mission of Cochrane Nursing is to provide an international evidence base for nurses involved in delivering, leading, or researching nursing care. Cochrane Corner provides summaries of recent systematic reviews from the Cochrane Library. For more information, see https//nursing.cochrane.org.Chicago NP Dwayne Dobschuetz makes house calls-often on bike-to improve his patients' health and well-being.Nurses' expertise, developed over time and through education, positions them to assume new careers such as independent nurse consultants. Although it's an exciting proposition, nurses may not understand what it means to be a consultant, know whether consulting is a good fit for them, or be familiar with how to establish and run a consulting business. This article defines consulting, discusses key competencies, and presents important considerations for starting and running a consulting business. Selected resources to assist in developing skills as a nurse consultant are also provided.Since the 1960s, plastic has been used in the production of medical equipment and products that improve patient comfort, safety, and treatment. Yet an unwelcome challenge has emerged in the years since how to safely dispose of this material without negatively affecting human health and the environment. Working with medical devices and supplies that are constructed using plastics, nurses are at the forefront of this issue and must identify solutions, collaborate with other health care workers, and lead efforts to establish more sustainable options. This series is in collaboration with the Alliance of Nurses for Healthy Environments (https//envirn.org).Among adults ages 65 and older, dementia doubles the risk of hospitalization. Roughly one in four hospitalized patients has dementia, and the prevalence of dementia in the United States is rising rapidly. Patients with dementia have significantly higher rates of hospital-acquired complications, including urinary tract infections, pressure injuries, pneumonia, and delirium, which when unrecognized and untreated can accelerate physical and cognitive decline, precipitating nursing home placement and death. The authors discuss the unique needs of patients with dementia who require acute care, highlighting evidence-based strategies for nurses to incorporate into practice.PURPOSE To explore whether burnout is an independent predictor of career choice regret among nurses. METHODS In November 2017 we invited a random sample of 89,995 members of the American Nurses Association to participate in an anonymous online survey. The survey collected demographic and professional information and included the Maslach Burnout Inventory-Human Services Survey for Medical Personnel (known as the MBI-HSS [MP]), as well as several items exploring career choice regret. Of the 86,858 nurses who received the e-mail invitation, 8,638 (9.9%) responded. Multivariable logistic regression analysis was conducted for the final sample of 6,933 nurses who provided complete responses to the MBI-HSS (MP) and the career choice regret survey items. RESULTS Fifteen percent of the 6,933 participating nurses had career choice regret. On multivariable analysis, experiencing burnout, working unplanned or mandatory overtime, being male, and having a higher academic degree related to nursing were independent predictors of career choice regret. Burnout was the strongest such predictor. CONCLUSION Career choice regret among U.S. nurses is relatively common. Of the independent predictors this study identified, burnout had the strongest relationship with career choice regret. Organizational strategies aimed at reducing burnout and supporting nurses' ongoing professional development should be pursued.Partnerships between tech companies and health systems challenge privacy expectations and laws.Treating parents reduces colonization rate in neonates by half.Nurses are the front line of protection.Updates on the coronavirus.Affected patients may not be aware of the impact on their care.A call for a vision of interconnectedness.We need to be vigilant against fake journals.BACKGROUND Although several trauma centers have developed "direct to OR" (DOR) trauma resuscitation programs, there is little published data on optimal patient selection, practices, and outcomes. We sought to analyze triage criteria and interventions associated with optimal DOR outcomes and resource utilization. METHODS Retrospective review of all adult DOR resuscitations over a 6-year period. Androgen Receptor Antagonist mw Triage criteria were analyzed individually, and grouped into categories mechanism, physiology, anatomy/injury, or other. The best univariate and multivariate predictors of requiring lifesaving interventions (LSI) or emergent surgery (ES) were analyzed. Actual and predicted mortality (pM) were compared for all patients and for pre-defined time-sensitive subgroups. RESULTS There were 628 DOR patients (5% of all admissions) identified; the majority were male (79%), penetrating mechanism (70%), severely injured (40% ISS>15), and 17% died. Half of patients required LSI and 23% required ES, with significantly greater need for ES and lower need for LSI after penetrating versus blunt injury (p less then 0.
Homepage: https://www.selleckchem.com/Androgen-Receptor.html