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05). Multivariable linear regression analyses showed that increased neuroticism and decreased GHQ both had an independent effect on generic and CS OIDP scores when adjusted for tooth wear severity (p less then 0.05).Conclusion Quality of life perception is complex and was not only affected by worsening levels of tooth wear.Objectives To illustrate, identify and assess a contemporary model of the geographic distribution of specialist dentists in relation to population age groups and rurality.Methods All UK dental specialists registered with the General Dental Council were extracted and paired with publicly available locations of work. Geographic information system tools were used to map specialist locations against population and rural-urban classifications of England, Wales, Scotland and Northern Ireland. The latest 2019 population estimates and health board areas were superimposed to create a specialist map. All other data were collected at the smallest geographic statistical areas and corresponding population data from the latest census.Results A total of 4,439 specialist titles were held by 3,041 individuals, linked to 3,459 unique locations of work. Specialist locations were mapped against 135 Clinical Commissioning Groups (CCGs) of England, seven Local Health Boards of Wales, 14 Health Boards of Scotland and five Health anxist in the geographic distribution of UK specialist dentists and high disparities were found in accessing a specialist, especially for vulnerable populations.Introduction Dental core training posts within oral and maxillofacial surgery (OMFS) units often include on-call provision. There is a lack of current data demonstrating the variation of dental core trainee (DCT) involvement in on-call. This variation may influence trainees' experience of training.Aim To examine the provision of on-call cover in OMFS units across the United Kingdom, including trainee involvement, supervision and training.Method Online surveys were distributed in August 2019 to all DCTs, educational supervisors (ESs) and training programme directors (TPDs) in OMFS units to understand trainee involvement in on-call provision, including levels of supervision and perceived educational benefit.Results In total, 167 trainees responded from 69 OMFS units. Responses were received from 102 ESs/TPDs. All trainees experienced on call, with over 75% covering night shifts. Trainees reported minimal difference between support within hours and out of hours (OOH). Qualitative data from trainees and supervisors highlighted the educational value of on-call within normal hours. However, limited supervised training opportunities were reported OOH.Conclusion This survey highlights the educational value of on-call within hours. The perceived level of support does not vary significantly between normal hours and OOH. Some concerns were expressed regarding OOH supervision and prolonged on-call periods.Aim To investigate, firstly, research priorities for people with periodontitis and those with periodontitis and diabetes. Secondary aims were to explore disease self-management barriers, difficulties and enhancers for people with periodontitis and/or diabetes, mutual learning in patient groups regarding self-care and views of academic researchers on patient-derived research prioritisation.Materials and methods Research prioritisation and self-care management was based on the James Lind Alliance workshop methodology. Participants generated and ranked research priorities and enhancers and barriers to self-care management. Semi-structured interviews were undertaken to explore the views of academic staff about patient and public involvement (PPI) and the findings from this research.Results Periodontitis patients ranked preventive educational interventions highest, whereas the top priority for those with both periodontitis and diabetes was increasing public awareness about periodontitis and systemic health links. Regarding self-care, both periodontitis and diabetes groups highly ranked the importance of being able to self-assess their condition and efficacy of management. Important barriers for the diabetes patients were psychological issues, while for periodontitis patients, the main barrier was receiving conflicting or lacking information. Both groups reported that shared learning helped to develop a better understanding of their conditions and improved management. Academics believed it was essential to involve patients in developing research and most felt the findings would influence their institutions' research priorities; however, they would not change their own research only based on patients' perspectives.Conclusions The workshops led to new insights for research priorities and approaches for health self-management. PPI should be further investigated across oral health applications.Aims To investigate the reported clinical applications of rubber dam isolation by UK general dental practitioners (GDPs) using an internet-mediated approach.Methods The data were collected in 2019, using an online (SurveyMonkey) questionnaire that was distributed to GDPs in a private group on Facebook. The percentages are based on the number of respondents who answered each question.Results The response rate was 61% with 403 valid completed questionnaires. The majority (395; 98%) of respondents reported using rubber dam in clinical practice. Undergraduate training in rubber dam use was received by 382 (98%) respondents, with greater training reported by younger, more recently qualified graduates. The main clinical applications of rubber dam included its use for composite restorations, endodontic treatments and internal bleaching procedures, while for other clinical procedures, the majority of respondents did not use rubber dam. For posterior and anterior composites, 332 (82%) and 298 (74%) respondents, respectively, reported using rubber dam isolation at least rarely. At least 98% (395) of the respondents used rubber dam for endodontic procedures, irrespective of tooth type and position. Over 70% (281) of respondents reported using rubber dam at least rarely for internal bleaching. Rubber dam was used by 99% (392) and 67% (262) of respondents on adults and paediatric patients, respectively.Conclusions The main clinical applications agree with previous reports, but highlight an increase in rubber dam use. This study investigated a wider range of clinical applications compared to previous studies, adding to the literature surrounding rubber dam use.The objective of this study was to compare clinical outcomes between noninherited maternal antigen (NIMA)-mismatched and noninherited paternal antigen (NIPA)-mismatched haploidentical hematopoietic stem cell transplantation (haplo-HSCT) among patients with hematological malignancies and perform a subgroup analysis. We retrospectively analyzed 378 patients with hematological malignancies who received haplo-HSCT from NIMA-mismatched (n = 201) and NIPA-mismatched (n = 177) donors between January 2012 and December 2017. The cumulative incidence of 100-d grades II-IV acute graft-versus-host disease (aGVHD) (19.2% vs. 32.8%, P = 0.003) was significantly lower in NIMA mismatch. Multivariate analysis showed that NIMA mismatch was associated with lower incidence of grades II-IV aGVHD and better overall survival (OS) and disease-free survival (DFS). According to the subgroup analysis, the clinical outcomes of older and/or female NIMA mismatches were comparable to those of younger and/or male NIPA mismatches with respect to grades II-IV aGVHD, chronic GVHD (cGVHD), nonrelapse mortality (NRM), relapse, DFS, and OS. In conclusion, this study confirmed the NIMA effect on aGVHD and demonstrated that NIMA mismatch was associated with better survival. In the NIMA mismatch context, donor age and sex did not seem to influence haplo-HSCT, which provides a basis for the selection of sibling donors.Home blood pressure monitoring (HBPM) can improve hypertension management. Digital tools to facilitate routinized HBPM and patient self-care are underutilized and lack evidence of effectiveness. MyBP provides video-based education and automated text messaging to support continuous BP self-monitoring with recurring feedback. In this pragmatic trial, we sought to generate preliminary evidence of feasibility and efficacy in community-dwelling adults ≥55 y/o with hypertension recruited from primary care offices. Enrollees were provided a standard automatic BP cuff and randomized 21 to MyBP vs treatment-as-usual (control). Engagement with MyBP was defined as the proportion of BP reading prompts for which a reading was submitted, tracked over successive 2-week monitoring periods. Preliminary measures of efficacy included BP readings from phone-supervised home measurements and a self-efficacy questionnaire. Sixty-two participants (40 women, 33 Blacks, mean age 66, mean office BP 164/91) were randomized to MyBP (n = 41) or a control group (n = 21). Median follow-up was 22.9 (SD = 6.7) weeks. In the MyBP group, median engagement with HBPM was 82.7% (Q1 = 52.5, Q3 = 89.6) and sustained over time. The decline in systolic [12 mm Hg (SD = 17)] and diastolic BP [5 mm Hg (SD = 7)] did not differ between the two treatment groups. However, participants with higher baseline systolic BP assigned to MyBP had a greater decline compared to controls [interaction effect estimate -0.56 (-0.96, -0.17)]. Selleckchem NX-2127 Overall hypertension self-efficacy improved in the MyBP group. In conclusion, trial results show that older hypertensive adults with substantial minority representation had sustained engagement with this digital self-monitoring program and may benefit clinically.Autism spectrum disorder (ASD) is a common set of heterogeneous neurodevelopmental disorders resulting from a variety of genetic and environmental risk factors. A core feature of ASD is impairment in prosocial interactions. Current treatment options for individuals diagnosed with ASD are limited, with no current FDA-approved medications that effectively treat its core symptoms. We recently demonstrated that enhanced serotonin (5-HT) activity in the nucleus accumbens (NAc), via optogenetic activation of 5-HTergic inputs or direct infusion of a specific 5-HT1b receptor agonist, reverses social deficits in a genetic mouse model for ASD based on 16p11.2 copy number variation. Furthermore, the recreational drug MDMA, which is currently being evaluated in clinical trials, promotes sociability in mice due to its 5-HT releasing properties in the NAc. Here, we systematically evaluated the ability of MDMA and a selective 5-HT1b receptor agonist to rescue sociability deficits in multiple different mouse models for ASD. We find that MDMA administration enhances sociability in control mice and reverses sociability deficits in all four ASD mouse models examined, whereas administration of a 5-HT1b receptor agonist selectively rescued the sociability deficits in all six mouse models for ASD. These preclinical findings suggest that pharmacological enhancement of 5-HT release or direct 5-HT1b receptor activation may be therapeutically efficacious in ameliorating some of the core sociability deficits present across etiologically distinct presentations of ASD.
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