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Usefulness as well as security associated with poly (ADP-ribose) polymerase inhibitors in cancer treatment: A systematic evaluation and meta-analysis.
In the opposite direction, depressive symptoms directly led individuals to drift into poverty at baseline and at follow-up. CONCLUSIONS This study suggested that social causation and social selection may operate concurrently. Proactive interventions, especially ones focusing on modifiable protective factors that our findings identified as mediators in the link between poverty and depression, are urgently needed to break the vicious cycle of poverty and depression and create a virtuous cycle of increasing returns. While several studies find adverse birth outcomes among Latina mothers after discrete immigration enforcement events, it is unknown whether day-to-day enforcement activities precede adverse birth outcomes. This study examines birth outcomes among Latinas following local immigrant apprehensions-48-h holds on suspected undocumented immigrants by local law enforcement-over an 8-year period. County-level apprehensions, scaled to 1000 of the population, were averaged across the third trimester. We analyzed the association between county-level apprehensions and low birth weight (LBW) and preterm birth (PTB) between 2008 and 2015 in California using spline logistic regression models with knots at the quartiles of apprehensions and included covariates, county fixed-effects, and a time propensity variable to account for trend and seasonality in LBW and PTB. We performed these regressions for non-Hispanic White, all Latina, and foreign-born (FB) Latina mothers. There were no significant associations between apprehensions and LBW. selleck chemical For all Latina women, there were no differences in PTB between zero apprehensions and levels that were below the median. Latina mothers exposed to moderately high apprehensions had lower odds for PTB compared to zero apprehensions. At the highest levels of apprehensions, however, Latina women showed significantly elevated odds of PTB (at 0.71 apprehensions OR = 1.06, 95% CI 1.01-1.12). PTB responded differentially to localized enforcement threats. At lower and moderate levels, Latino communities may have mobilized in ways that reduced the risk for PTB. Risks emerged at the highest levels of enforcement, underlying the intense fear and anxiety in hyper-surveilled areas. Research on mental illness stigma tends to focus on the most severe diagnoses and settings, and it pays insufficient attention to how the treatment process itself relates to stigma. This study, calling on 28 interviews with providers treating a wide range of mental problems in varied settings, addresses these issues. Findings reveal that stigma is associated with treatment across settings and severity, although dynamics vary based on the intensity of setting. Mental illness stigma competes with other stigmas in presenting for treatment. Once in treatment, mental health care acts as a stigma-mitigating "stamp" of risk containment for other societal systems and institutions, signifying that risks posed by clients' problems are being officially contained. Reflecting the increasing relevance of quality outcomes for hospital payments, some hospital boards have promoted physicians into top-management positions. So far, however, the literature regarding the impact of physician leadership on care quality or cost is limited. The aim of this study is to examine the link between the educational background of a hospital's CEO and its performance in terms of medical quality and financial success. Examining data of 370 German hospitals for the year 2016, this study uses the second largest sample of its kind and the largest for a single country. Multivariate regression analysis with matching is used to model the effect of the CEO's education, controlling for tenure, competition, hospital size and ownership. We find that physician-led hospitals have lower in-hospital mortality rates for pneumonia and higher patient satisfaction (at the 5% and 1% significance level, respectively). In contrast, institutions led by managers with economics or business degrees have better financial performance (at the 10% significance level) and superior outcomes for hip and knee surgeries (at the 1% and 10% significance level). Our findings support prior results regarding financial outcomes and mortality. However, including a broad spectrum of measures for clinical quality, we draw a more nuanced picture that does not point to the straightforward interpretation that physician CEOs lead to superior medical quality. Many studies find a strong positive correlation between education and adult health. A subtler question is whether this correlation can be interpreted as a causal relationship. We combine multi-country data from two cross-sections of the European Union Statistics on Income and Living Conditions (EU-SILC) survey and use exogenous variation in compulsory years of schooling across countries and cohorts induced by compulsory schooling laws. We find no causal effect of education on any of our several health measures. This finding is extremely robust to different changes in our main specification and holds using other databases. We discuss different explanations for our results. BACKGROUND Environmental exposure to perfluorooctane sulfonate (PFOS) is associated with various adverse outcomes in humans. However, risk assessment for PFOS with the traditional risk estimation method is faced with multiple challenges because there are high variabilities and uncertainties in its toxicokinetics and toxicity between species and among different types of studies. OBJECTIVES This study aimed to develop a robust probabilistic risk assessment framework accounting for interspecies and inter-experiment variabilities and uncertainties to derive the human equivalent dose (HED) and reference dose for PFOS. METHODS A Bayesian dose-response model was developed to analyze selected 34 critical studies, including human epidemiological, animal in vivo, and ToxCast in vitro toxicity datasets. The dose-response results were incorporated into a multi-species physiologically based pharmacokinetic (PBPK) model to reduce the toxicokinetic/toxicodynamic variabilities. In addition, a population-based probabilistic risk assessment of PFOS was performed for Asian, Australian, European, and North American populations, respectively, based on reported environmental exposure levels.
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