Notes

Mobile immunotherapy with regard to hematological metastasizing cancer: recent development as well as future perspectives.
There is a need for research that extends beyond functional communication into how AAC can promote access to these key aspects of school education.
Research into students requiring or using AAC has focused on teaching communication skills and far less on academic learning and social activities of classrooms and schools. There is a need for research that extends beyond functional communication into how AAC can promote access to these key aspects of school education.
We examined the relation between spelling ability and word-reading ability in children with Williams syndrome (WS).

Eighty 9-17-year-olds with genetically-confirmed WS completed standardized tests of spelling, word reading, and intellectual ability; 45 also completed tests of phonological awareness and vocabulary. Reading instruction method was classified as Phonics or Other.

Spelling ability varied widely. Although at the group level, spelling standard scores (SSs) were significantly lower than word-reading SSs, at the individual level, this difference was significant for fewer than half the participants. Spelling and reading SSs were highly correlated, even after controlling for intellectual ability. Students taught to read using systematic phonics instruction had significantly higher spelling SSs than those taught to read using other approaches, even after controlling for intellectual ability. Spelling ability contributed significant unique variance to word-reading ability, beyond the effects of phonological awareness, vocabulary, and reading instruction method.

Our findings are consistent with Ehri's Word Identity Amalgamation Theory. In combination with previous meta-analytic findings for typically developing children (Graham & Santangelo, 2014) our results suggest that children with WS are likely to benefit from the inclusion of systematic spelling instruction as part of a systematic phonics approach to teaching word reading.
Our findings are consistent with Ehri's Word Identity Amalgamation Theory. In combination with previous meta-analytic findings for typically developing children (Graham & Santangelo, 2014) our results suggest that children with WS are likely to benefit from the inclusion of systematic spelling instruction as part of a systematic phonics approach to teaching word reading.
The scientific study of young children with a significant cognitive and motor developmental delay is challenging due to the children's complex disabilities and high demands on family life and professional support. We aim to critically reflect on the measurement and analysis of child- and contextual variables within an ongoing research project on these children's developmental trajectories.

The OJKO-project tracked the development of a sample of children (n = 45) between the age of 6 months and 4 years with a significant cognitive and motor developmental delay, in Belgium and the Netherlands.

The complexity of the children's disabilities and daily life context, and subsequent challenges in measurement and analysis of variables, were confirmed and reflected upon.

Due to the uniqueness and complexity of this target group, research should be characterized by creativity, perseverance and substantial modesty in the immediate generalization of results.
Due to the uniqueness and complexity of this target group, research should be characterized by creativity, perseverance and substantial modesty in the immediate generalization of results.
Adolescents with Mild Intellectual Disability (MID) or Borderline Intellectual Functioning (BIF) are highly susceptible to negative peer influence. However, research in typically developing adolescents shows that peers can also promote prosocial behavior, which is an opportunity for positive development.

The current study aimed to investigate the effect of peer influence on prosocial behavior in adolescents with MID or BIF.

In an experimental donation task, 40 adolescents with MID or BIF (M
= 14.0, 40 % boys) were repeatedly asked how many of five coins they would like to donate to the group. The task had four consecutive within-subject conditions alone, with virtual peers present, with virtual peer feedback, and alone again.

Results showed that adolescents made larger donations with virtual peers present, and even larger with peer feedback. This increase in donations sustained for subsequent decisions made alone. Finally, adolescents with BIF made larger donations with peer feedback compared to adolescents with MID.

Adolescents with MID or BIF are susceptible to peer influence on prosocial behavior, demonstrating the potential effect social context can have on promoting positive development.
Adolescents with MID or BIF are susceptible to peer influence on prosocial behavior, demonstrating the potential effect social context can have on promoting positive development.Prime editing uses the Cas9 nickase fused to a reverse transcriptase to copy a DNA sequence into a specific locus from a 'prime editing' guide RNA (pegRNA), eliminating the need for double-stranded DNA breaks and donor DNA templates. To facilitate prime editing in human induced pluripotent stem cells (iPSCs), we integrated a doxycycline-inducible Prime Editor protein (PE2) into the AAVS1 genomic safe harbor locus. Prime editing of iPSCs resulted in precise insertion of three nucleotides in HEK3 locus with high efficiency, demonstrating the utility of this approach. This engineered cell line can be used to edit a single or multiple genomic loci by introducing a target-specific pegRNA for precise and effective genome editing to facilitate disease modeling and functional genetics studies.The role of infectious diseases including coxiellosis in causing poorer reproductive performance of primiparous ewes are not well studied. The aims of this study were to determine if natural exposure to Coxiella burnetii is widespread in breeding ewes and whether seropositivity is associated with poor reproductive performance of primiparous ewes. Seropositivity to Coxiella burnetii was 0.08% (CI95% 0.01, 0.36) in primiparous ewes and 0.36% (CI95% 0.07, 1.14) in mature ewes. Coxiella burnetii was not detected in aborted or stillborn lambs using qPCR. These findings suggest C. burnetii infection was unlikely to be an important contributor to abortion and perinatal mortalities observed for primiparous ewe flocks, and exposure to C. burnetii was not widespread in ewes on farms located over wide geographical region of southern Australia. Whilst ewes on these farms were not an important reservoir for C. burnetii, sporadic zoonotic transmission from sheep is reported and has public health implications.Phosphorus (P) is an essential element for the growth and reproduction of organisms. Unfortunately, the natural P cycle has been broken by the overexploitation of P ores and the associated discharge of P into water bodies, which may trigger the eutrophication of water bodies in the short term and possible P shortage soon. Consequently, technologies emerged to recover P from wastewater to mitigate pollution and exploit secondary P resources. Electrochemically induced phosphate precipitation has the merit of achieving P recovery without dosing additional chemicals via creating a localized high pH environment near the cathode. We critically reviewed the development of electrochemically induced precipitation systems toward P removal and recovery over the past ten years. We summarized and discussed the effects of pH, current density, electrode configuration, and water matrix on the performance of electrochemical systems. Next to ortho P, we identified the potential and illustrated the mechanism of electrochemical P removal and recovery from non-ortho P compounds by combined anodic or anode-mediated oxidation and cathodic reduction (precipitation). Furthermore, we assessed the economic feasibility of electrochemical methods and concluded that they are more suitable for treating acidic P-rich waste streams. Despite promising potentials and significant progress in recent years, the application of electrochemical systems toward P recovery at a larger scale requires further research and development. Future work should focus on evaluating the system's performance under long-term operation, developing an automatic process for harvesting P deposits, and performing a detailed economic and life-cycle assessment.Systemic insecticides like neonicotinoids and the phenylpyrazole insecticide fipronil are the most widely applied insecticides around the world. Multiple studies analyzed insecticide residues in freshwater systems, but data on seawater contamination levels are scarce. Veliparib cost This study investigates the spatiotemporal distribution and ecological risk assessment of fipronil, neonicotinoids, sulfoxaflor and selected transformation products (TPs) in the Chinese Bohai Sea and its surrounding rivers. Well-established neonicotinoids (acetamiprid, clothianidin, imidacloprid, thiacloprid and thiamethoxam) and TPs of fipronil and imidacloprid were frequently detected (detection frequency (DF) 42-100%) in freshwater. The median total insecticide concentration in freshwater was significantly higher in summer (72.4 ng•L-1) than in fall (23.4 ng•L-1), with major contributions from neonicotinoids, suggesting that pollution originates mostly from diffuse sources. In 2018, acetamiprid, desnitro-imidacloprid, fipronil-desulfinyl and stal seas.
Young adult patients may suffer from poststroke depression (PSD) and anxiety. Few studies have evaluated these important psychiatric conditions that may lead to adverse outcomes in young adults. We aimed to determine the prevalence of PSD and anxiety as well as to identify their predictors in a population of young Filipino adults (18-49 years old).

We performed a cross-sectional epidemiologic study in the largest tertiary hospital in the Philippines. The study involved the administration of a structured survey tool and review of medical records. The Hospital Anxiety and Depression Score - Pilipino version (HADS-P) was used to screen for anxiety and depression. Multivariable logistic regression analysis was performed to determine significant socio-economic and clinical risk factors of PSD and anxiety.

114 young adult stroke patients were included. The prevalence of depression was 20.2% while that of anxiety was 34.2%. Significant predictors of PSD were the presence of anxiety (OR 1.84; CI 1.05-3.22), lower mRS scores (mRS 3-5 OR 5.52; 95% CI 1.09-8.03) and diabetes (OR 2.09; 95% CI 1.67-6.26). Meanwhile, significant predictors of poststroke anxiety included depression (OR 7.5; 95% CI 5.02-21.94) and dependency (Barthel Index scores 95-100; OR 0.94; 95% CI 0.89-0.99). Relationship status, educational attainment, stroke subtype and location were not found to be significant predictors of PSD and anxiety.

A significant proportion of young adults suffered from depression and anxiety after stroke. Clinicians should be aware of these psychiatric conditions that influence outcomes and quality of life of young adults with stroke.
A significant proportion of young adults suffered from depression and anxiety after stroke. Clinicians should be aware of these psychiatric conditions that influence outcomes and quality of life of young adults with stroke.
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