Notes

Dynein stops incorrect kinetochore-microtubule parts in mitosis.
americanum populations that are in frequent contact with humans and their companion animals. © The Author(s) 2020. Published by Oxford University Press on behalf of Entomological Society of America.All rights reserved. For permissions, please e-mail [email protected] class of conjugating green algae, Zygnematophyceae (Conjugatophyceae), is extremely rich in species and has attracted interest of phycologists for a long time. It is now widely accepted that this class of Charophyte algae holds a key position in the phylogenetic tree of streptophytes where they represent the closest relatives to all land plants (embryophytes). In order to better understand the process of terrestrialization and the related molecular, cellular and physiological adaptations, the necessity of robust model plants allowing easy cultivation and genetic transformation becomes more and more evident. Living algae collections play an important role, not only for the phylogenomic-based taxonomy but also for the screening for suitable model organisms. For this review we screened six major public algae collections for Zygnematophyceae strains and established a cumulative list comprising 738 different taxa (including species, subspecies, varieties and forms). From the described biodiversity with 8883 registered taxa (Algaebase) the cultured Zygnematophyceae taxa worldwide cover only ca. 8.3%.. The past research on this clade of algae is reviewed and discussed under the perspective of model organism establishment. For the genera of Micrasterias and Spirogyra, representing the orders of Desmidiales and Zygnematales, we exemplarily present data on the life cycle. The current status of genetic transformation of Zygnematophyceae algae and future research perspectives are outlined. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email [email protected] Clinical provision of intensive behavioral therapy for obesity (IBTO) has been a reimbursable treatment for obesity since 2012. However, gaps remain in the literature regarding its impact on patient outcomes. OBJECTIVES The primary objective of this study was to examine the integration of registered dietitian nutritionist provided IBTO into a primary care setting and evaluate clinic outcomes for Medicare Part B beneficiaries. FRAX597 cost A secondary objective was to examine intensity of IBTO (quantity of IBTO visits) versus clinical outcomes and influence of socioeconomic factors. METHODS A case-control retrospective chart review was conducted at a rural, Academic Family Medicine Clinic in Eastern North Carolina for patients seen between 1 January 2016 and 1 January 2019. In order to be included in the treatment group, patients had to be female, white or black race, have Medicare insurance and a body mass index ≥ 30 kg/m2. RESULTS Mixed model analysis showed statistically significant improvements in clinical outcomes from IBTO treatment. Weight decreased by nearly 3 pounds, while body mass index was half a point lower. A1C was 0.1 units lower for IBTO patients, and they took prescription medication and average of 6 days less than the control group. Minorities and older respondents experienced smaller, all else constant, and annual fixed effects suggest that differentials widen over time. CONCLUSIONS Registered dietitian nutritionist (RDN) provision of IBTO has demonstrated benefit in improving clinical outcomes including weight, A1C, and reduced medication duration (use) as demonstrated by the IBTO treatment group versus control. IBTO intensity was not predictive of success, and its impact was reduced with older and African American patients. IBTO is beneficial and can be delivered within the primary care setting by a RDN. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail [email protected] previously reported durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) patients treated with CD19-targeted chimeric antigen receptor-engineered T (CD19 CAR-T) cell immunotherapy after ibrutinib failure. Since pre-clinical studies showed that ibrutinib could improve CAR-T cell antitumor efficacy and reduce cytokine release syndrome (CRS), we conducted a pilot study to evaluate the safety and feasibility of administering ibrutinib concurrently with CD19 CAR-T cell immunotherapy. Nineteen CLL patients were included. The median number of prior therapies was 5, and 17 patients (89%) had high-risk cytogenetics (17p deletion and/or complex karyotype). Ibrutinib was planned to begin at least 2 weeks before leukapheresis and continue at least 3 months after CAR-T cell infusion. CD19 CAR-T cell immunotherapy with concurrent ibrutinib was well tolerated; 13 patients (68%) received ibrutinib as planned without dose reduction. The 4-week overall response rate by iwCLL criteria was 83%, and 61% achieved minimal residual disease (MRD)-negative marrow response by IGH sequencing. In this subset, the 1-year OS and PFS probabilities were 86% and 59%, respectively. Compared to CLL patients treated with CAR-T cells without ibrutinib, CAR-T cells with concurrent ibrutinib were associated with lower CRS severity and lower serum concentrations of CRS-associated cytokines despite equivalent in vivo CAR-T cell expansion. The 1-year PFS probabilities in all evaluable patients were 38% and 50% after CD19 CAR-T therapy with and without concurrent ibrutinib, respectively (p=0.91). CD19 CAR-T cells with concurrent ibrutinib for R/R CLL were well tolerated, with low CRS severity, and led to high rates of MRD-negative response by IGH sequencing. Copyright © 2020 American Society of Hematology.Despite impressive success in molecular physiological understanding of photosynthesis, and preliminary evidence on its potential for quantum shifts in agricultural productivity, the question remains if increased photosynthesis, without parallel fine-tuning of the associated processes is enough. There is a distinct lack of formal socio-economic impact studies that address the critical questions on product profiling, cost-benefit analysis, environmental trade-offs, and technological and market forces in product acceptability. When a relatively well understood process gains enough traction for translational value, its broader scientific and technical gap assessment, in conjunction with its socio-economic impact assessment for success, should be a prerequisite. The successes in the upstream basic understanding of photosynthesis should be integrated with a gap analysis for downstream translational applications to impact the farmers' and customers' lifestyles and livelihoods. The purpose of this review is to assess how the laboratory, the field and the societal demands from photosynthesis could generate a transformative product.
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