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Cytotoxic and Genotoxic Evaluation of the actual Aqueous and also Hydroalcoholic Leaf as well as Bark Concentrated amounts associated with Crataegus oxyacantha inside Murine Style.
Developing a convenient and rapid detection method for water is greatly desirable in the field of chemical industry. Herein, we present a simple and effective strategy combining a fluorescence sensor and a one-to-two fluorescence colorimetric logic operation to monitor water in a wide range of organic media and classify aprotic/protic polar solvents. The dual-emitting luminescent detector was prepared by incorporating a fluorescent dye Rhodamine 6G (R6G) with strong green light emission within a red light-emitting Eu-metal-organic framework (MOF) through the "bottle around ship" method. R6G@Eu-MOF displays completely different fluorescence response behaviors to various organic solvents. Thus, when one made use of the intensity ratio of different fluorescence emission centers, a 3D decoded map was proposed to reliably and effectively distinguish different aprotic/protic polar solvents. Moreover, R6G@Eu-MOF exhibited two different ratiometric sensing modes when detecting water in aprotic/protic polar solvents due to the hydrogen bonding interaction, that is ratiometry with one reference signal or two reversible signal changes. Furthermore, using water content as the input signal and two kinds of fluorescence emission as the output signals, a one-to-two logic gate system was constructed, making it possible to develop an intelligence system for water detection. Overall, we demonstrated for the first time that R6G@Eu-MOF could serve as an efficient platform for tracing water in organic media and distinguishing protic/aprotic polar organic solvents.Solar-driven water evaporation provides a promising solution to the energy crisis and environmental issues. Capitalizing on the high photothermal conversion efficiency and excellent resistance to strong acids or strong alkalis of Pt3Ni-S nanowires, we strategically design and prepare a flexible Pt3Ni-S-deposited Teflon (PTFE) membrane for achieving efficient strong acid/alkaline water evaporation under simulated sunlight irradiation (1 sun). By comparing the surface morphology, mechanical properties, and water evaporation performance of the as-prepared three different membranes, we have screened out a high-performance photothermal membrane that has good hydrophobicity (water contact angle = 106°), strong mechanical properties, high light-to-heat conversion efficiency (η = 80%), and excellent durability (10 cycles in a range of pH = 1.2-12). In particular, we explore the mechanism of high surface mechanical properties of the as-prepared membrane using density functional theory. The results demonstrate that the related mechanism can be ascribed to two main reasons (1) hydrogen bonds can be formed between the 2-pyrrolidone ring and PTFE-3 and (2) the O atom in PTFE-3 carries more negative charge (-0.19 |e|) than PTFE-1 (-0.16 |e|) and PTFE-2 (-0.15 |e|). Our work highlights the great potentials of a Pt3Ni-S-deposited PTFE membrane as a device for implementing solar energy-driven evaporation of industrial wastewater with strong acidity or alkalinity and provides a new strategy for improving the surface mechanical properties of a photothermal membrane.Activatable magnetic resonance imaging (MRI) contrast agents that can be selectively stimulated at a tumor region are urgently demanded to realize the efficient and accurate diagnosis of cancers. Here, extremely small iron oxide nanoparticles (ESIONPs) modified with citric acid (ESIONPs-CA) are encapsulated in disulfide-cross-linked poly(carboxybetaine methacrylate) (poly(CBMA)) nanogels, and a cyclo[Arg-Gly-Asp-d-Tyr-Lys] (c(RGD)) ligand is further introduced to obtain ESIONP-packaged poly(CBMA) nanogels equipped with tumor-targeted c(RGD) (ICNs-RGD). On the basis of the transformation of the clustered ESIONPs into dispersed ones induced by the reducing glutathione (GSH), ICNs-RGD can complete the conversion from a T2 contrast agent to a T1 one, realizing the selective activation of the T1 contrasting effect. The GSH-dependent MRI signal conversion of ICNs-RGD is feasible in the tumor cell and tissue. Moreover, ICNs-RGD exhibits obvious targeting specificity and favorable biocompatibility. In the MRI experiments of tumor-bearing mice, benefiting from the stimuli-responsiveness toward GSH and targeting specificity, the T1 contrasting effect of tumor tissues can be selectively enhanced after the intravenous injection of ICNs-RGD. Therefore, tumor-targeted ICNs-RGD with a switchable MRI signal derived from the activation of GSH is a potential contrast agent for the efficient and precise tumor diagnosis in the clinic.Background Despite the wide body of research on the properties of the Oswestry Disability Index (ODI), only a few studies have investigated whether ODI scores can be interpreted similarly in both genders. A few previous studies suggested that the ODI may behave differently in different populations, e.g. in different age groups. Aim The objective was to investigate gender-related differences in the psychometric properties of the ODI amongst patients with chronic low back pain. Design Observational cross-sectional cohort study. Settings University outpatient Physical and Rehabilitation Medicine clinic. ODM208 in vitro Population Consecutive patients seen in an outpatient Physical and Rehabilitation Medicine clinic at a university hospital between April 2014 and February 2017. Methods Internal consistency was evaluated using Cronbach's alpha. Factor structure was investigated using exploratory factor analysis. Gender-related differences in psychometric properties of ODI items were assessed using item response theory analysis. Results 912 patients, 579 women (63%), with an average age of 45.8 (SD 14.2) years old, were included in the study. The Cronbach's alpha for both genders was good at 0.88. The discrimination abilities of all 10 ODI items were mostly high to perfect for both men and women with only small fluctuations. The item information function curves were similar for most of the items. Exploratory factor analysis resulted in a unidimensional one-factor structure for both genders. Conclusions The ODI appears to be a similarly unidimensional and internally consistent questionnaire in both genders without any substantial variability in the items' difficulty and discrimination. Clinical rehabilitation impact The ODI produces psychometrically similar results in both genders. Small and clinically hardly significant gender-related differences in the properties of ODI can be neglected.Background Dorsiflexion-restricting ankle-foot orthoses (DR-AFOs) are often prescribed in polio survivors with calf muscle weakness to reduce or solve gait problems. However, orthoses are sometimes not being used and/or users are dissatisfied with the usability. Aim To compare the usability of custom-made DR-AFOs provided in clinical care between users and discontinued users who have calf muscle weakness due to polio. Design Cross-sectional survey. Setting Outpatient post-polio university hospital clinic in the Netherlands. Population All polio survivors with calf muscle weakness, provided with a DR-AFO between 2004 and 2015 in our outpatient clinic. Methods DR-AFO use and usability according to the ISO 9241-11 standard were evaluated with a questionnaire sent out by postal mail. Results Forty of 57 questionnaires were returned. Five respondents did not fulfil the eligibility criteria. DR-AFO use among the 35 eligible respondents was 74%. Compared to discontinued users, users were significantly more often mald to pay extra attention to females and should particularly take care that the experienced fit and comfort are satisfactory. Incorporating these suggestions in clinical practice may further improve DR-AFO use among polio survivors with calf muscle weakness.When a patient dies, it is important that nurses understand their role in the verification of death. This article explains the steps required to verify the death of an adult patient. Verification of death is not a mechanistic task, but one that requires sensitivity and compassion. It is also crucial that nurses understand the legal implications of verifying a patient's death. With the development of the current coronavirus disease 2019 (COVID-19) pandemic, nurses must also understand any changes in their role when verifying the death of a patient. Verification or confirmation of death is the process of ascertaining whether a patient is deceased, based on a physical assessment. Nurses can only verify a death if the patient is expected to die and has a do not attempt cardiopulmonary resuscitation (DNACPR) order in place. A DNACPR order is essential because it allows the nurse to verify the death without being concerned with the need to resuscitate the patient. Nurses should ensure they act in accordance with local and national guidance regarding the verification of a patient's death. REFLECTIVE ACTIVITY How to articles can help to update your practice and ensure it remains evidence based. Apply this article to your practice. Reflect on and write a short account of How this article might inform your practice when verifying a patient's death. How you could use this information to educate your colleagues on the appropriate steps required when verifying a patient's death.Background Clinical trial reports often emphasize efficacy over harms, leading to misinterpretation of the risk-to-benefit ratio of new therapies. Clear and sufficiently detailed reporting of methods and results is especially important in the abstracts of trial reports, as readers often base their assessment of a trial on such information. In this study, we evaluated the quality of adverse event (AE) reporting and abstract quality in phase III randomized controlled trials (RCTs) of systemic therapies in breast and colorectal cancer. Methods Medline, EMBASE, Cochrane Database of RCTs, and Cochrane Database of Systematic Reviews were searched from November 2005 to September 2018. Phase III RCTs evaluating systemic therapies in breast or colorectal cancer were included. Each article was independently reviewed by two investigators using a standardized data extraction form based on guidelines developed by the Consolidated Standards of Reporting Trials (CONSORT) group. Descriptive statistics, bivariate analysis, and multivariable linear regression were used to analyze data. All statistical tests were two-sided. Results Of 166 RCTs identified, 99.4% reported harms in the manuscript body, and 59.6% reported harms in the abstract. Reporting was restricted to severe harms in 15.6% of RCTs. Statistical comparison of AE rates went unreported in 59.0% of studies. Information regarding AEs leading to dose reductions, treatment discontinuations, or study withdrawals went unreported in 59.3%, 18.7%, and 86.8% of studies, respectively. Recently published RCTs (P = .009) and those sponsored at least partially by for-profit companies (P = .003) had higher abstract quality scores. Conclusions Breast and colorectal cancer phase III RCTs inadequately report CONSORT-compliant AE data. Improved guideline adherence and abstract reporting is required to properly weigh benefits and harms of new oncologic therapies. Systematic review registration number CRD42019140673.Clopidogrel is an antiplatelet drug with high intraindividual variability in systemic exposure and efficacy. It has been used for treating atherosclerosis and acute coronary syndrome and in preventing stent restenosis and thrombotic complications after stent implantation in clinical practice for nearly 20 years. In this study we aimed to evaluate the bioequivalence of 2 clopidogrel hydrogen sulfate formulations (75-mg tablets) under fed (n = 66) and fasted (n = 66) conditions by using the reference-scaled average bioequivalence method. An open-label, randomized, 3-sequence and 3-period crossover (3×3), semireplicated study was designed and conducted. Clopidogrel concentration of plasma samples was measured by high-precision liquid chromatography and tandem mass spectrometry. The pharmacokinetic parameters were derived by a noncompartmental model. In the fed condition the geometric least-squares mean ratios of peak concentration (Cmax ) and area under the concentration-time curve (AUC0-t ) were, respectively, 103.
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