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mize celiotomy healing and timely return to function. Horses compete in many disciplines with incisional hernias. © Veterinary Emergency and Critical Care Society 2020.An Egyptian fruit bat (Rousettus aegyptiacus) from the Zoological Gardens, at Tel Aviv, Israel, showed pox-like clinical signs including vesicular and nodular skin lesions on the wings. Cell culture isolation, histopathology, electron microscopy and molecular analysis, revealed the presence of a novel bat poxvirus. Future research is needed to determine whether this virus can affect human health. © 2020 Kimron Veterinary Institute. Veterinary Medicine and Science Published by John Wiley & Sons Ltd.AIM The aim of this study was to translate and adapt the Mouth Handicap in Systemic Sclerosis (MHISS) Questionnaire into the Turkish language and evaluate its validity and reliability in Turkish systemic sclerosis (SSc) patients. METHOD The MHISS was translated according to Beaton guidelines. Patients being diagnosed with SSc, being between 18-65 years old and receiving no treatment between test-retest assessments were included to study. Test-retest reliability was evaluated, comparing the results of two administrations, with Spearman's correlation. Internal consistency was assessed by Cronbach's α. Validity of the questionnaire was assessed by comparison with mouth opening, total scores of Disabilities of Arm, Shoulder and Hand Questionnaire (DASH) and Health Assessment Questionnaire (HAQ). Construct validity was tested by factor analysis. RESULTS Forty-five SSc patients were included in the study. The Turkish version of the MHISS (MHISS-T) met set criteria of reliability and validity. Internal consistency (Cronbach's α = 0.863) and test-retest reliability were excellent (r = .88). The correlations between MHISS-T and inter-incisor distance, MHISS-T and HAQ and MHISS-T and DASH were negatively and statistically significant (r = -0.739, P less then .001), very good and statistically significant (r = .664, P less then .001), good and statistically significant (r = .570, P less then .001), respectively. Regarding factor analysis, MHISS-T has three subscales. https://www.selleckchem.com/products/tideglusib.html CONCLUSION Our results demonstrated that the Turkish version of the MHISS-T has excellent test-retest reliability and very good validity. As a result of this study we determined that MHISS-T is a valid and reliable instrument to measure mouth disabilities in Turkish-speaking SSc patients. © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.Transmission electron microscopy (TEM) and rock magnetic study of ferromanganese nodule sample JC120-104B collected from Clarion-Clipperton zone (CCZ) in the eastern Pacific Ocean indicate the presence of biogenic magnetite (magnetofossils). First-order reversal curves (FORCs) and decomposition of isothermal remanent magnetization (IRM) curves were used as the main tool for the characterization of magnetic properties of the bulk magnetic minerals present in the sample. TEM was performed for the direct identification of biogenic magnetic minerals (magnetofossils). The nodule sample has distinctive alternating Mn and Fe-rich layers per micro-X-ray fluorescence data. While diagenetic precipitation of Mn is known for the less oxygenated environment, the presence of biogenic magnetite is also common in the environments where the supply of oxygen is limited. Moreover, the increase in magnetic properties is consistent with the increase in Mn-content, which is related to favourable conditions for Mn precipitation as well as magnetite biomineralization in oxic-suboxic transition zone. Investigations on magnetofossil fingerprints lead to a better understanding of paleoenvironmental conditions involved in the formation and growth of deep-sea ferromanganese nodules. © 2020 Society for Applied Microbiology and John Wiley & Sons Ltd.The aldehyde derivatives of 1,3-dipropyl xanthines as described in this paper, constitutes a new series of selective adenosine ligands displaying bronchospasmolytic activity. The effect of substitution at third- and fourth-position of 8-phenyl xanthine has also been taken into consideration. The synthesized compounds showed varying binding affinities at different adenosine receptor subtypes (A1 , A2A , A2B , and A3 ) and also good in vivo bronchospasmolytic activity against histamine aerosol-induced asthma in guinea pigs. Most of the compounds showed maximum affinity toward the A2A receptor subtype. The monosubstituted 3-aminoalkoxyl 8-phenyl xanthine with a aminodiethyl moiety (compound 12e) was found to be most potent A2A adenosine receptor ligand (Ki = 0.036 µM) followed by disubstituted 4-aminoalkoxyl-3-methoxy-8-phenyl xanthine (Ki = 0.050 µM) (compound 10a). © 2020 John Wiley & Sons Ltd.Homozygosity for nonsense variants in CEP55 has been associated with a lethal condition characterized by multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly (MARCH syndrome) also known as Meckel-like syndrome. Missense variants in CEP55 have not previously been reported in association with disease. Here we describe seven living individuals from five families with biallelic CEP55 variants. Four unrelated individuals with microcephaly, speech delays, and bilateral toe syndactyly all have a common CEP55 variant c.70G>A p.(Glu24Lys) in trans with nonsense variants. Three siblings are homozygous for a consensus splice site variant near the end of the gene. These affected girls all have severely delayed development, microcephaly, and varying degrees of lissencephaly/pachygyria. Here we compare our seven patients with three previously reported families with a prenatal lethal phenotype (MARCH syndrome/Meckel-like syndrome) due to homozygous CEP55 nonsense variants. Our series suggests that individuals with compound heterozygosity for nonsense and missense variants in CEP55 have a different viable phenotype. We show that homozygosity for a splice variant near the end of the CEP55 gene is also compatible with life. © 2020 Wiley Periodicals, Inc.AIM Gut microbiota play an important role in rheumatoid arthritis (RA). Biological therapies targeting tumor necrosis factor-α (TNF-α) have been used for treatment in RA patients. However, whether TNF-α antagonist has some influence on gut microbiota is still unknown. This study aims to investigate the distribution of gut microbiota in collagen-induced arthritis (CIA) mice treated with the TNF-α antagonist etanercept. METHODS Collagen-induced arthritis mice were induced by type II collagen. Cytokine expression was detected by real-time polymerase chain reaction. 16S ribosomal RNA sequencing was performed to characterize the gut microbiota in CIA mice treated with vehicle or etanercept. Sequencing reads were processed by Microbial Ecology software program. RESULTS Compared with vehicle-treated mice, we showed that CIA mice treated with etanercept led to attenuation of inflammation and reduced expression of TNF-α, interferon (IFN)-γ, interleukin (IL)-6 and IL-21. Meanwhile, results showed operational taxonomic units, richness estimators and the diversity indices of gut microbiota in etanercept-treated mice were lower than that in vehicle-treated mice.
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