Notes

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crest and floor were greater than those of the frontal sinus mucosa. There was a positive correlation between the tensile strength and the thickness of the mucosa.
The mucosal thickness and tensile strength of the maxillary sinus crest and floor were greater than those of the frontal sinus mucosa. There was a positive correlation between the tensile strength and the thickness of the mucosa.
Continuous care during the post-discharge transition period is necessary for convalescence in patients with chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the effect of group visits on the health of patients with COPD during the post-discharge transition period.

In this prospective randomized study, a total of 116 patients with COPD post-discharge were randomly assigned to either the control group (n = 57) or the group visit intervention group (GV; n = 59). A healthy lifestyle, quality of life, self-efficacy and lung function before and after the intervention and acute COPD exacerbation(s) during the intervention were recorded and analyzed.

Healthy lifestyle and self-efficacy scores were higher in the GV group after compared with before the intervention and the control group. Lung function was improved in both groups, with greater improvement in the GV group. In addition, the frequency of outpatient emergency services and hospitalizations due to acute COPD exacerbations was lower in the GV group compared with the control group.

Group visits are efficient administration models in patients with COPD. Through health education and companion support, group visits increase patients' self-efficacy, promote patients' transition to a healthy lifestyle, improve their quality of life, reduce acute exacerbations and lower medical costs during the post-discharge transition period.
Group visits are efficient administration models in patients with COPD. Through health education and companion support, group visits increase patients' self-efficacy, promote patients' transition to a healthy lifestyle, improve their quality of life, reduce acute exacerbations and lower medical costs during the post-discharge transition period.Psoriasis is a chronic inflammatory disease which has multisystem involvement, predominantly skin and joints. It affects quality of life and leads to psychological distress in patients leading to poor self-esteem and depression, ultimately affecting interpersonal relationships. Homoeopathy believes in a holistic approach and, when prescribed on a constitutional basis, helps to cure the condition from its root cause. A diagnosed case of psoriasis in a 23-year-old male came into the Homoeopathic OPD with complaints of psoriatic patches on the face and scalp. Routine investigations were done to rule out other disorders. In this case, Sulphur was prescribed on a constitutional basis and proved to be beneficial. Considering the extent of psoriasis in this patient, the Homoeopathic approach relieved the case in a short period of time with prolonged treatment response, suggesting that this may represent the ideal cure in Homoeopathy.
Pterygium, meaty eyes, is a disease that produces a triangular, conjunctival-epithelial, neovascularized overgrowth covering the cornea, which can cause vision loss. Histological characterization of Pterygium reveals the presence of proliferating fibroblasts (FBs) that remodel the extracellular matrix, with infiltration of immune cells, causing chronic inflammation. The fresh juice of Echeveria pallida E. Walther (Crassulaceae), mechanically extracted from the leaves, can be used to lubricate the eyes and remove Pterygium, even in advanced, degenerative ocular disease.

This study aimed to explore the healing mechanisms of an ethanolic extract of E. pallida on pterygium-derived FBs, lymphocytes, and neutrophils.

The research team designed an in-vitro study. Primary cultures of FBs were obtained from fresh, surgical pterygium tissues, and neutrophils and mononuclear cells were purified from the peripheral blood of healthy donors.

An ethanolic extract of E. pallida was evaluated at 30, 50, 80, 100, 200, activity, from 100 µg/mL, on FB adhesion and the production of NETs.

The study found scientific evidence that supports the effects of an extract of the medicinal plant E. pallida in inhibiting the adhesion of FBs derived from human pterygium and NET production.
The study found scientific evidence that supports the effects of an extract of the medicinal plant E. pallida in inhibiting the adhesion of FBs derived from human pterygium and NET production.Patients with type 1 diabetes mellitus (T1DM) are vulnerable to developing diabetic retinopathy even under insulin therapy. Thus, this study was designed to evaluate the efficacy of hesperidin and insulin in rats with T1DM compared with insulin alone in improving diabetic retinal changes. Eighty rats were divided into four equal groups group I, control rats without diabetes; group II, untreated rats with diabetes; group III, rats with diabetes treated daily with subcutaneous (SC) doses of long-acting insulin; and group IV, a rat with diabetes in which hesperidin was orally administered with SC insulin. The animals were assessed histologically, morphometrically, and biochemically. In group II, the thickness of all retinal layers decreased histologically. Ultrastructurally, degenerated retinal neurons and congested blood vessels were observed. Immunostaining detected elevated gene expression of advanced glycation end products. Gene expression of vascular endothelial growth factor, and glial fibrillary acidic protein were elevated. In this study, hesperidin supplementation with insulin significantly improved the retinal histological changes, supported by morphometric findings, compared with insulin alone. Moreover, treatment with hesperidin significantly reduced malondialdehyde and elevated serum antioxidant markers, including superoxide dismutase and catalase; furthermore, glutathione peroxidase decreased. Hesperidin might be an effective supplement for improving diabetic retinal complications occurring even with insulin treatment.Bleomycin (BLM) is one of anti-cancerous drugs. One of its limitation is the development of pulmonary fibrosis during therapy So, we proposed to examine the outcome of BLM take on the light and electron microscopic design of rat lung. Along with, assessment the probable protecting role of ginsenoside on BLM induced pulmonary changes. In this study, thirty adult male albino rats were comprised and were classified to four clusters; Negative & positive control group, BLM treated group and BLM& ginsenoside treated group. The lung was treated for histological and immunohistochemical (anti-p65) studies. Light microscopic examination of H&E stained sections of BLM treated group showed huge distortion of the lung building. Mallory trichrome stain of this group showed evident deposition of collagen fibers in the markedly thickened interalveolar septa and around intrapulmonary bronchi, bronchioles and blood vessels. Moreover, strong positive staining for nuclear factor (NF)-κB in the wall of bronchiole as well as the thickened interalveolar septa were observed. Ultrastructural inspection of lung of this group revealed muddled lung planning. Marked improvement of the lung structure and marked reduction in NF-κB immunoexpression was appeared in BLM and ginsenoside treated group. So, we concluded that co-administration of ginsenoside with BLM significantly enhanced the histological and morphometric image of the lung.
The aim of this study was 2-fold (1)to assess and compare the external and internal load of elite young soccer players during competitive microcycles and (2)to describe the training/match ratios (TMr) in elite male youth soccer players.

Twenty-one youth soccer players were monitored using a 10-Hz global positioning system. Total distance covered, running distance (RD), high-speed RD, sprint distance, number of accelerations and decelerations, player load, and rated perceived exertion were recorded during training sessions and matches. The TMr was calculated for each load measure. All variables were also normalized dividing the load per minute of activity.

The RD, high-speed running, and sprint distance were higher 3 days before the match and 2days before match compared with the rest of the training sessions. However, accelerations, decelerations, and player load were higher 4days before match than other sessions. Besides this, the TMr of RD, high-speed running, and sprint distance were associated with lower values than the TMr of total distance covered, accelerations, decelerations, and player load. The match constituted the highest load during competitive microcycle.

The present data support the idea that youth soccer coaches and practitioners must consider relative training load according to match demands to better manage and evaluate player periodization.
The present data support the idea that youth soccer coaches and practitioners must consider relative training load according to match demands to better manage and evaluate player periodization.
This study evaluated the effects of 12weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity.

Seventy adolescents were randomized into 2 groups control received nutritional and psychological interventions once a week for 12weeks, and treatment received nutritional and psychological interventions once a week, plus 3 karate sessions per week, for 12weeks. The main outcome measure was improvement in cardiometabolic parameters, oxidative stress, and inflammation.

After the intervention period, the treatment group showed a reduction in resting heart rate (77.86 [10.89]), high-density lipoprotein cholesterol (40.86 [8.31]), and triglycerides (75.18 [32.29]) and an increase in low-density lipoprotein cholesterol (95.64 [42.53]) in relation to pretraining. Regarding oxidative stress markers, there was a reduction in protein carbonylation (0.07 [0.06]) and nitric oxide (1.39 [1.11]) and an increase in superoxide dismutase (0.68 [0.31]) and glutathione (0.11 [0.08]) compared with pretraining. Ubiquitin inhibitor With respect to inflammation, adiponectin increased (14.54 [5.36]) after the intervention when compared with preintervention.

The study concluded that the intervention may improve cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Long-term effects need to be evaluated.
The study concluded that the intervention may improve cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Long-term effects need to be evaluated.
Modern pentathlon is a multidisciplinary sport that involves exhaustive training which can cause tissue damage and metabolic changes. However, few studies have evaluated the metabolic changes that occur in pentathletes. Accordingly, we aimed to evaluate the metabolomic profile of pentathletes during a 3-week training period before competition using nuclear magnetic resonance.

Blood samples from 6 members of a Brazilian modern pentathlon team were collected at the beginning (Pre1, Pre2, and Pre3) and end (Post1, Post2, and Post3) of each week. Low molecular-weight metabolite profiles were analyzed by nuclear magnetic resonance spectroscopy, and biochemical markers were assessed using enzyme-linked immunosorbent assays. Data were assessed using partial least-squares discriminant analysis and univariate statistical model.

Metabolic changes were observed between pre- and postdata of each week and over the 3weeks before the competition in the partial least-squares discriminant analysis. Creatine kinase concentration increased in the first 2 weeks (P = .
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