Notes

The Persistence in the Effect of COVID-19-Related Hardship, Feelings Inertia, along with Being lonely on Emotional Wellness After a Postlockdown Period of time throughout Indonesia: The Environmentally friendly Brief Evaluation Study.
ed. With the inadequate objective assessment of adverse events, especially long-term adverse events, associated with adhesiolysis or LUNA for CPPS, there is currently little to support these interventions for CPPS.
Online searches about anxiety and depression are recorded every 3-5s. As such, information and communication technologies (ICT) have enormous potential to enable or impair help-seeking and patient-professional interactions. Youth studies indicate that ICT searches are undertaken before initial mental health consultations, but no publications have considered how this online activity affects the first steps of the patient journey in youth mental health settings.

State-of-the-art review using an iterative, evidence mapping approach to identify key literature and expert consensus to synthesize and prioritise clinical and research issues.

Adolescents and young adults are more likely to seek health advice via online search engines or social media platforms than from a health professional. Young people not only search user-generated content and social media to obtain advice and support from online communities but increasingly contribute personal information online.

A major clinical challenge is to raise professional awareness of the likely impact of this activity on mental health consultations. Potential strategies range from modifying the structure of clinical consultations to ensure young people are able to disclose ICT activities related to mental health, through to the development and implementation of 'internet prescriptions' and a youth-focused 'toolkit'.
A major clinical challenge is to raise professional awareness of the likely impact of this activity on mental health consultations. Potential strategies range from modifying the structure of clinical consultations to ensure young people are able to disclose ICT activities related to mental health, through to the development and implementation of 'internet prescriptions' and a youth-focused 'toolkit'.
The CAT-CAD trial showed that coronary computed tomography angiography (CTA) in patients with a high prevalence of coronary artery disease (CAD) and indications for invasive coronary angiography (ICA) reduces the number of patients undergoing ICA by two-thirds and nearly eradicates non-actionable ICAs. However, the long-term benefits of this non-invasive strategy remain unknown.

To evaluate the long-term efficacy and safety of a non-invasive strategy employing coronary CTA vs. ICA as the first-line imaging test in stable patients with a high clinical likelihood of obstruc-tive CAD.

The long-term outcomes were evaluated for 36 months following randomization and included the efficacy outcome (analyzed as the composite of major adverse cardiovascular events (MACE) all-cause death, acute coronary syndrome, unplanned coronary revascularization, urgent hospitalization for a cardiovascular reason, a stroke) and the safety outcome (analyzed as a cumulative incidence of serious adverse events).

One hundred and twenty participants at a mean age of 60.6 (7.9) years (female, 35.0%) were randomized with an allocation ratio of 11 to coronary CTA and direct ICA as the first-line anatomical test for suspected obstructive CAD. There were no significant differences between both diagnostic strategies neither in terms of the long-term efficacy (MACE occurrence 15.5% in coronary CTA group vs. 16.7% in ICA group; log-rank P = 0.89) nor the long-term safety (cumulative number of serious adverse events 36 vs. 38; P = 0.79, respectively).

Long-term follow-up of the randomized CAT-CAD trial confirms that the strategy employing coronary CTA is an effective and safe, non-invasive, outpatient-based alternative to ICA for patients with a high clinical likelihood of obstructive CAD.
Long-term follow-up of the randomized CAT-CAD trial confirms that the strategy employing coronary CTA is an effective and safe, non-invasive, outpatient-based alternative to ICA for patients with a high clinical likelihood of obstructive CAD.In ecological systems, the hydra effect is an increase in population size caused by an increase in mortality. This seemingly counterintuitive effect has been observed in several populations, including fish, blowflies, snails and plants, and has been modeled in both continuous and discrete time. A similar effect induced by disease has recently been observed empirically. Here we present theoretical and simulation results for an infectious disease-induced hydra effect, namely conditions under which the total population size, composed of those that are infectious as well as those that are susceptible, at an endemic equilibrium is greater than the population size at the disease-free equilibrium. (For an endemic k-cycle, this can be similarly defined using the average population.) We find this disease-induced hydra effect occurs when the intra-specific competition is strong and disease infection sufficiently inhibits the reproductive output of infected individuals. For our continuous time model, we give a necessary and sufficient condition for a disease-induced hydra effect. This condition requires overcompensatory recruitment. With a discrete time model, we show there is no disease-induced hydra effect without overcompensatory recruitment. We illustrate by simulations that a disease-induced hydra effect may occur with Ricker recruitment when the endemic system converges to either a fixed equilibrium or a 2-cycle.
Australian Football is a fast paced, intermittent sport, played by both male and female populations. The aim of this systematic review was to compare male and female Australian Football players, competing at elite and sub-elite levels, for running performance during Australian Football matches based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Medline, SPORTDiscus, and Web of Science searches, using search terms inclusive of Australian Football, movement demands and microsensor technology, returned 2535 potential manuscripts, of which 33 were included in the final analyses.

Results indicated that male athletes performed approximately twice the total running distances of their female counterparts, which was likely due to the differences in quarter length (male elite = 20min, female elite = 15min (plus time-on). When expressed relative to playing time, the differences between males and females somewhat diminished. However, high-speed running distances covered at velocities > 14.4km·h
(> 4m·s
) were substantially greater (≥ 50%) for male than female players. Male and female players recorded similar running intensities during peak periods of play of shorter duration (e.g., around 1min), but when the analysis window was lengthened, females showed a greater decrement in running performance.

These results suggest that male players should be exposed to greater training volumes, whereas training intensities should be reasonably comparable across male and female athletes.
These results suggest that male players should be exposed to greater training volumes, whereas training intensities should be reasonably comparable across male and female athletes.The heavy metal(loid)s concentrations in water and sediments were analyzed in the Hashilan wetland to assess the spatial distribution, pollution status, fate, partitioning, and ecological risk and also to identify the heavy metal(loid)s sources in sediments using PMF (Positive Matrix Factorization) and APCs-MLR (absolute principal component score-multiple linear regression) receptor models. According to the pollution indices, (Ni, Cu, Cr, Mo), and (Zn, Cr, and Cu) are considered the most important pollutants in sediments and water, respectively. Ni, Cr, and Cu are the main contributors to ecological risks in sediments of some stations. The potential ecological risk assessment proposed low ecological risk in water of the study area. Higher distribution coefficient (Kp) values of Ni, Cr, Mn, Cu, Co, Pb, As, and Zn indicated the majority of these heavy metals present in the sediments; whereas, the majority of Cd concentration occurs in water. PMF and APCs-MLR results indicated the natural sources were the main factors affecting the concentrations of Ni, Cr, Zn, Al, Co, Fe, Pb, As, Cd and somewhat Cu. Mixed natural and agricultural activities are the main sources of Mo, and somewhat Cu. According to the results, there is low pollution of TPH (total petroleum hydrocarbons) in the sediment samples. Also, phosphate (PO42-) and nitrate (NO3-) concentrations were below the recommended permissible limits at all sampling sites except the S8 station for NO3-.
Despite hip and groin pain being commonly reported in elite youth football players, little evidence on risk factors exists. Risk factors in adult football players include reduced hip adductor strength and hip adductor/abductor strength ratios, and lower Copenhagen Hip and Groin Outcome Score (HAGOS) subscale scores. It is unknown if these factors are also predictive of pain development in youth football players.

To identify whether preseason hip adductor and abductor strength and HAGOS subscale scores of male and female elite youth football players are associated with in-season or historical (lifetime) hip and groin pain.

Preseason hip adductor and abductor strength testing and the HAGOS were undertaken by 105 elite male (n = 58) and female (n = 47) football players aged 11-15years. Medical staff documented both players' self-reported historical and in-season hip and groin pain. Univariate and multivariate logistic regression models were undertaken with main outcome measures in-season hip and groin painseason higher hip abductor strength and lower HAGOS scores were retrospectively associated with historical hip and groin pain.
Pre-season hip adductor and abductor strength and HAGOS subscale scores did not predict subsequent in-season hip and groin pain in elite youth football players. However, pre-season higher hip abductor strength and lower HAGOS scores were retrospectively associated with historical hip and groin pain.
To address the focused question in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?

After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included.

66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1-3days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8-15weeks but not after 6months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing.

Based on the analyzed studies, PRF is most effective in the early healing period of 2-3months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
Based on the analyzed studies, PRF is most effective in the early healing period of 2-3 months after tooth extraction. Recilisib A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
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