Notes

LncGSEA: a versatile application to be able to infer lncRNA associated paths from large-scale cancer transcriptome sequencing info.
These increases in stability coincide with mean-level changes in the direction of greater maturity. In contrast to previous findings, we found little evidence for increasing rank-order stabilities after Age 25. Moreover, cumulative mean-level trait changes across the life span were slightly smaller than previously estimated. Emotional stability, however, increased consistently and more substantially across the life span than previously found. Moderator analyses indicated that narrow facet-level and maladaptive trait measures were less stable than broader domain and adaptive trait measures. learn more Overall, the present findings draw a more precise picture of the life span development of personality traits and highlight important gaps in the personality development literature. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Motivation is a barrier to physical activity (PA) among African American (AA) women, but past studies have implemented a "one-size-fits-all" approach and have not addressed differences in autonomous motivation. This pilot randomized controlled trial assessed the preliminary efficacy of "Developing Real Incentives and Volition for Exercise," a community- and theory-based intervention, which evaluated whether a motivationally matched (vs. a nonmatched) intervention increases daily total PA.

In total, 68 AA women (50.72 ± 13.66 years; 86.8% with obesity) were randomized to an 8-week challenge-focused program (targeted toward high autonomous motivation) or rewards-focused program (targeted toward low autonomous motivation). Randomization was stratified by baseline autonomous motivation. FitBits were used during the intervention to promote self-monitoring (both programs) and social connectedness (challenge program only).

Both programs retained ≥ 80% of participants. Process evaluation revealed high attendancach for promoting PA among AA women. These findings are used to guide a discussion on best practices for engaging AA women in future behavioral interventions. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Though much effort is often put into designing psychological studies, the measurement model and scoring approach employed are often an afterthought, especially when short survey scales are used (Flake & Fried, 2020). One possible reason that measurement gets downplayed is that there is generally little understanding of how calibration/scoring approaches could impact common estimands of interest, including treatment effect estimates, beyond random noise due to measurement error. Another possible reason is that the process of scoring is complicated, involving selecting a suitable measurement model, calibrating its parameters, then deciding how to generate a score, all steps that occur before the score is even used to examine the desired psychological phenomenon. In this study, we provide three motivating examples where surveys are used to understand individuals' underlying social emotional and/or personality constructs to demonstrate the potential consequences of measurement/scoring decisions. These examples also mean we can walk through the different measurement decision stages and, hopefully, begin to demystify them. As we show in our analyses, the decisions researchers make about how to calibrate and score the survey used has consequences that are often overlooked, with likely implications both for conclusions drawn from individual psychological studies and replications of studies. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Latent transition analysis (LTA), also referred to as latent Markov modeling, is an extension of latent class/profile analysis (LCA/LPA) used to model the interrelations of multiple latent class variables. LTA methods have become increasingly accessible and in-turn are being utilized in applied research. The current article provides an introduction to LTA by answering 10 questions commonly asked by applied researchers. Topics discussed include (1) an overview of LTA; (2) a comparison of LTA to other longitudinal models; (3) software used to run LTA; (4) sample size suggestions; (5) modeling steps in LTA; (6) measurement invariance; (7) the inclusion of auxiliary variables; (8) interpreting results of an LTA; (9) the nature of data (e.g., longitudinal, cross-sectional); and (10) extensions of LTA. An applied example of LTA is included to help understand how to build an LTA and interpret results. Finally, the article suggests future areas of research for LTA. This article provides an overview of LTA, highlighting key decisions researchers need to make to navigate and implement an LTA analysis from start to finish. (PsycInfo Database Record (c) 2022 APA, all rights reserved).A fuel cell, an energy transducer, can convert chemical energy into electrical energy. In this work, graphite felt (GF) loaded with polypyrrole (PPy) and carboxylic carbon nanotubes (CNTs-COOH) was used as a cathode (GF/PPy/CNTs-COOH) in a double-chamber nonbiofuel cell (D-nBFC) to remove Cr(VI) efficiently. Therein, Na2S2O3 in an alkaline solution and Cr(VI) in a strongly acidic solution were employed as anode and cathode solutions, respectively. An agar salt bridge, consisting of saturated KCl solution, was used to transport ions between the anode and cathode. This system suggested that the removal efficiency of Cr(VI) could reach 99.6%. The maximum current, power, and power density could achieve 136.8 μA, 18.7 μW, and 20.8 mW/m2 at 90 min, respectively. Additionally, GF/PPy/CNTs-COOH also had good electrocatalytic stability and reusability after four cycles, which played an important role in the development of the D-nBFC system. Therefore, this study provides an environmentally friendly and efficient method to remove Cr(VI) and generate electricity simultaneously.On average, it has taken approximately 10 years and $250 million to discover and develop one pesticide out of approximately 100 000 compounds. A successful pesticide researcher nowadays needs to be knowledgeable and skillful in multiple disciplines. As a result of the high costs and unique requirements, only a handful of companies in the world can afford to continue pesticide research and development (R/D) in the $70 billion pesticide market. Pesticide R/D is a high-risk yet high-reward business. In this perspective, pesticide R/D is briefly discussed and a case study is used to illustrate how spinosad was discovered and became a successful product, despite the many challenges facing pesticide R/D.The behavioral and neural mechanisms by which distracters delay interval timing behavior are currently unclear. Distracters delay timing in a considerable dynamic range Some distracters have no effect on timing ("run"), whereas others seem to "stop" timing; some distracters restart ("reset") the entire timing mechanisms at their offset, whereas others seem to capture attentional resources long after their termination ("over-reset"). While the run-reset range of delays is accounted for by the Time-Sharing Hypothesis (Buhusi, 2003, 2012), the behavioral and neural mechanisms of "over-resetting" are currently uncertain. We investigated the role of novelty (novel/familiar) and significance (consequential/inconsequential) in the time-delaying effect of distracters and the role of medial prefrontal cortex (mPFC) catecholamines by local infusion of norepinephrine-dopamine reuptake inhibitor (NDRI) nomifensine in a peak-interval (PI) procedure in rats. Results indicate differences in time delay between groups, suggesting a role for both novelty and significance inconsequential, familiar distracters "stopped" timing, novel distracters "reset" timing, whereas appetitively conditioned distracters "over-reset" timing. mPFC infusion of nomifensine modulated attentional capture by appetitive distracters in a "U"-shaped fashion, reduced the delay after novel distracters, but had no effects after inconsequential, familiar distracters. These results were not due to nomifensine affecting either timing accuracy, precision, or peak response rate. Results may help elucidate the behavioral and physiological mechanisms underlying interval timing and attention to time and may contribute to developing new treatment strategies for disorders of attention. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Theoretical models of foraging are based on the maximization of food intake rate. Remarkably, foragers often hew close to the predictions of rate maximization, except for a frequently observed bias to remain in patches for too long. By sticking with depleting options beyond the optimal patch residence time-a phenomenon referred to as overharvesting or overstaying-foragers miss out on food they could have earned had they sought a new option elsewhere. Here, we review potential causes of overstaying and consider the role that temporal cognition might play in this phenomenon. We first consider how an explicit, internal sense of time might inform foraging behaviors, and next examine patch-leaving choices from the perspective of intertemporal decision-making. Finally, we identify promising areas for future research that will provide a better understanding of how foraging decisions are made, and what factors drive the tendency to overharvest patches. (PsycInfo Database Record (c) 2022 APA, all rights reserved).There has been a long-standing debate on where on the time axis the transition between time perception and time estimation (i.e., the cognitive reconstruction of time) can be located. According to Fraisse (1984), time perception applies to intervals 1 s are subject to time estimation. While there is good empirical evidence for this notion, it might be possible to further pinpoint the threshold. In two experiments, an auditory temporal generalization (TG) task in the range of 400 ms was used to compare event-related potentials (ERPs) with findings from an analogous task using standard durations in the range of 200 ms. As an ERP correlate of actively processed durations around 400 ms, offset latency of a medial central/centroparietal contingent negative variation (CNV) was identified. Thus, durations of around 400 ms may be coded as the duration of mental processes and, hence, are cognitively reconstructed (time estimation). This contrasts with again replicated ERP correlates of TG in the 200-ms range, which involve amplitude modulations of stationary P300/P500 components and suggest an immediate evaluation of durations around 200 ms. It is concluded that the P300 span may denote the transition between time perception and time estimation. (PsycInfo Database Record (c) 2022 APA, all rights reserved).As the key player of a new restriction modification system, DNA phosphorothioate (PT) modification, which swaps oxygen for sulfur on the DNA backbone, protects the bacterial host from foreign DNA invasion. The identification of PT sites helps us understand its physiological defense mechanisms, but accurately quantifying this dynamic modification remains a challenge. Herein, we report a simple quantitative analysis method for optical mapping of PT sites in the single bacterial genome. DNA molecules are fully stretched and immobilized in a microfluidic chip by capillary flow and electrostatic interactions, improving the labeling efficiency by maximizing exposure of PT sites on DNA while avoiding DNA loss and damage. After screening 116 candidates, we identified a bifunctional chemical compound, iodoacetyl-polyethylene glycol-biotin, that can noninvasively and selectively biotinylate PT sites, enabling further labeling with streptavidin fluorescent nanoprobes. With this method, PT sites in PT+ DNA can be easily detected by fluorescence, while almost no detectable ones were found in PT- DNA, achieving real-time visualization of PT sites on a single DNA molecule.
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