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Greater ubiquitination as well as lowered plasma televisions membrane trafficking of placental protein transporter SNAT-2 in man IUGR.
Results The MT and PMR groups showed significant rates of decline in grief severity and yearning, though only the PMR group showed a greater rate of decline in grief severity than wait-list. All groups showed significant rates of decline in grief rumination. The PMR and wait-list groups showed significant rates of increase in decentering compared to the MT group. Conclusions Results support the feasibility and acceptability of MT and PMR for widow(er)s as well as the preliminary efficacy of PMR for improving grief severity in widow(er)s compared to a wait-list control condition. With replication, PMR could be a standalone intervention for non-disordered grief or a component of treatment for disordered grief. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Objective Sexual interest/arousal disorder (SIAD) is the most prevalent sexual dysfunction in women. selleck chemicals Our goal was to compare (a) group mindfulness-based cognitive therapy (MBCT) plus sex education with (b) group supportive sex education and therapy (STEP) for women with SIAD. Method Eight-session treatments were delivered weekly and participants completed the measures of sexual desire and arousal, sexual distress, relationship satisfaction, rumination, and global impressions of change, at baseline, immediately posttreatment, and at 6- and 12-month posttreatment. Of 148 women who consented, 70 were randomized to MBCT (mean age 39.3 ± 13.2 years) and 78 were randomized to STEP (mean age 37.9 ± 12.2 years). Results Sexual desire and arousal significantly improved at each time point relative to baseline, with large effect sizes (d = -1.29 to -1.60), and similarly for MBCT and STEP. Sexual distress also improved at each time point with large effect sizes (d = 0.83-1.17), and more so for MBCT relative to STEP. Relationship satisfaction significantly improved (d = -0.17 to -0.20), and rumination about sex improved significantly in both arms, with medium effect sizes (d = 0.42-0.69), with both outcomes responding more to MBCT. About half the participants across both treatments reported moderate or great improvements in global indicators of desire and overall sexuality. Conclusions Results support the efficacy of both group MBCT and group supportive sex education for improving symptoms of SIAD with 12-month retention of improvements. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Objective Although attention deficit hyperactivity disorder (ADHD) is associated with cognitive deficits, there is considerable heterogeneity and only a minority of individuals with the disorder demonstrate a deficit in any cognitive domain. Recent studies indicate that the relationships between ADHD symptoms and cognition are complex with a dissociation between medication responses across these two domains. Method We examined whether methylphenidate (MPH) differentially impacts on cognition in those with and without pretreatment cognitive deficits in a 4-week randomized controlled crossover of high (0.6 mg/kg/dose) and low (0.3 mg/kg/dose) dose MPH and placebo in 75 medication-naive boys with ADHD. Cognition was assessed using tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Confirmatory factor analysis (CFA) was used to form latent cognitive factors of executive functioning, visual memory, and reaction time, as well as a general cognition factor. Results Compared to placebo, both high and low MPH doses significantly improved performance on pattern recognition (PR), spatial recognition (SR), and simple reaction time. The low, but not the high, dose improved performance on the Stockings of Cambridge (SOC) and delayed matching-to-sample tasks. Both doses also significantly improved performance on the executive functioning, visual memory, reaction time skills, and general cognitive latent variables. There were however no differences in the effects of MPH on cognition between those with and without a baseline cognitive deficit, for either the observed task values or the latent cognitive factor scores. Conclusions We conclude that MPH can enhance executive functioning, visual memory, reaction time, and general cognitive function in boys with ADHD. These improvements are not dependent on baseline cognitive performance. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Objective The goal was to develop a universal and resource-efficient adaptive preventive intervention (API) for incoming first-year students as a bridge to indicated interventions to address alcohol-related risks. The aims were to examine (a) API versus assessment-only control, (b) the different APIs (i.e., 4 intervention sequences) embedded in the study design, and (c) moderators of intervention effects on binge drinking. Method A sequential multiple assignment randomized trial (SMART) included two randomizations timing (summer before vs. first semester) of universal personalized normative feedback and biweekly self-monitoring and, for heavy drinkers, bridging strategy (resource email vs. health coaching invitation). Participants (N = 891, 62.4% female, 76.8% White) were surveyed at the end of first and second semesters. The primary outcome was binge drinking frequency (4+/5+ drinks for females/males); secondary outcomes were alcohol consequences and health services utilization. Results API (vs. control) was not significantly associated with outcomes. There were no differences between embedded APIs. Among heavy drinkers, the resource email (vs. health coach invitation) led to greater health services utilization. Moderator analyses suggested students intending to pledge into Greek life benefited more from any API (vs. control; 42% smaller increase from precollege in binge drinking frequency). Conclusions Although overall effects were not significant, students at high risk (i.e., entering fraternities/sororities) did benefit more from the intervention. Furthermore, the resource email was effective for heavier drinkers. A technology-based strategy to deliver targeted resource-light interventions for heavy drinkers may be effective for reducing binge drinking during the transition to college. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Objective Generalized anxiety disorder (GAD) is a debilitating condition, characterized by negative interpretations about ambiguous situations. This study tested whether entirely internet-delivered interpretation training [cognitive bias modification (CBM)] versus control promotes positive interpretations and reduces worry and anxiety in individuals with GAD, with or without depression. Method A two-arm (CBM; control) parallel-group randomized controlled experiment. Assessments were preintervention (T0), postintervention (T1), 1-month (T2) postintervention, and 3-month (T3) postintervention. Participants with GAD (with or without comorbid depression) were randomly allocated to either CBM (n = 115) or control (n = 115). Participants, but not researchers, were blind to allocated condition. Participants completed up to 10 online CBM or control sessions across 1 month. Interpretation bias [coprimary outcomes scrambled sentence test (SST), recognition test (RT)], and number of negative thought intrusions during a without comorbid depression up to 3 months posttraining. (PsycInfo Database Record (c) 2021 APA, all rights reserved).To prevent mistakes in psychological assessment, the precision of test norms is important. This can be achieved by drawing a large normative sample and using regression-based norming. Based on that norming method, a procedure for sample size planning to make inference on Z-scores and percentile rank scores is proposed. Sampling variance formulas for these norm statistics are derived and used to obtain the optimal design, that is, the optimal predictor distribution, for the normative sample, thereby maximizing precision of estimation. This is done under five regression models with a quantitative and a categorical predictor, differing in whether they allow for interaction and nonlinearity. Efficient robust designs are given in case of uncertainty about the regression model. Furthermore, formulas are provided to compute the normative sample size such that individuals' positions relative to the derived norms can be assessed with prespecified power and precision. (PsycInfo Database Record (c) 2021 APA, all rights reserved).With the nationwide closures of educational institutions in the United States due to the novel coronavirus disease 2019 (COVID-19), many schools transitioned from face-to-face instruction to eLearning formats at the beginning of the pandemic, while many students and their families self-isolated at home. The literature has revealed that self-isolation has a negative effect on adolescents' psychological outcomes, and high social support buffers against these outcomes. The purpose of the present research was to examine the moderating effect of perceived teacher support in the relationships between self-isolation during the beginning of the pandemic and negative health outcomes. Teacher support, self-isolation during the beginning of the COVID-19 pandemic, and health outcomes (i.e., suicidal ideation, nonsuicidal self-harm, subjective health complaints, depression) were measured in mid-April 2020 and health outcomes were measured again in late-May 2020. Participants were 467 7th and 8th graders (51% female; Mage = 13.47; ages range from 12 to 15 years old) from the suburbs of a large Midwestern city in the United States. The findings revealed that greater perceived teacher support buffered against the negative outcomes associated with self-isolation during the beginning of the COVID-19 pandemic and lower perceived teacher support strengthened these relationships. The results might inform policy development regarding strategies to improve health outcomes for adolescents during the COVID-19 crisis and future pandemics. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Under the integrated model of General Strain Theory (GST), the present study sought to examine whether delinquent peer association, social control, and negative emotion moderated the relations of distinctive cyberbullying roles with delinquency, as well as whether the moderating effects varied by gender among a nationally representative sample of American adolescents. Based on the data from the 2009-2010 Health Behavior in School-Aged Children study in the U.S., hierarchical moderated tobit regressions were conducted to test the potential moderating effects and gender differences. Adolescents involved in cyberbullying as different roles were more likely to engage in physical fight and substance use than noninvolved peers. The relationships remained significant after controlling for delinquent peer association, social control, and negative emotion, except for the relation of being cyber-victims with substance use. In addition, delinquent peer association conditioned the relationships of three cyberbullying roles with physical fight, while negative emotion moderated the relations of being cyberbullies or cyberbully-victims with substance use. Certain gender differences were found for the moderating effects of social control/delinquent peer association on cyberbullying roles related to physical fight and substance use. The findings suggest that GST may be useful for explaining the relations of distinctive cyberbullying roles with delinquency. Differentiating such relationships and the relevant moderating effects can be important in understanding adolescent violence and substance use. Cyberbullying-involved boys and girls under certain conditions are more vulnerable to react with violence and substance use in response to strains derived from cyberbullying experiences. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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