Notes

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This investigation confirms that both models are sufficiently accurate to investigate stress distribution in the TMJ disc, and, particularly, the model with the region-specific disc material properties ensure better simulations of the TMJ disc behaviour.
Pictorial warning labels and standardized "plain" packaging are policy interventions to reduce smoking, in part, by making cigarette packs and smoking less appealing. To inform potential policy decisions, this study examined the relative effects of message text framing (gain vs. loss) and cigarette packaging (standardized vs. branded) on appeal in a sample of young adult cigarette smokers.

Cigarette smokers (N=339) ages 18-30 completed two within-subjects experimental tasks. Tasks assessed the effects of message text framing (gain vs. loss) and packaging (standardized vs. branded) on cigarette packaging appeal. Task 1 was a 2×2 discrete choice experiment, where participants chose between each experimental pack and a standard branded cigarette pack without a pictorial warning label. Task 2 was a ranking task where participants ranked all packs on measures of appeal.

In Task 1, there were no significant differences in measures of appeal between packs displaying gain- vs. loss-framed message text, but all packs with pictorial warning labels significantly decreased appeal relative to standard branded packs without pictorial warning labels. Standardized packs with pictorial warning labels significantly reduced appeal relative to branded packs with pictorial warning labels and standard branded packs without pictorial warning labels. Task 2 pack rankings showed similar effects of pictorial warning labels and standardized packaging on appeal.

Pictorial warning labels with gain- and loss-framed text were equally powerful at reducing appeal of cigarette packs in young adult smokers relative to branded packs without pictorial warning labels, especially when combined with standardized packaging.
Pictorial warning labels with gain- and loss-framed text were equally powerful at reducing appeal of cigarette packs in young adult smokers relative to branded packs without pictorial warning labels, especially when combined with standardized packaging.Alcohol consumption in adolescence is widespread. Several studies have investigated alcohol use in minors and its consequences in adulthood, but prospective findings on psychosocial predictors for problematic alcohol use (PAU) already in youth are still limited. Next to genetic aspects, psychosocial predictors appear to be particularly relevant. The objective of the present longitudinal survey was to explore psychosocial influences on PAU in adolescence. At baseline, 1,444 adolescents (52.1% girls, average age 14.65 years) were surveyed. Two years later (at follow-up), we were able to re-assess 515 adolescents (mean age 16.60 years). Both times, a standardized questionnaire was applied to explore PAU and various psychosocial aspects. We conducted multiple imputation, created 100 datasets with a Markov Chain Monte Carlo algorithm and calculated regression analyses to identify predictors for PAU. In a multivariable analysis, we found that female gender (protective factor), school-type 'Gymnasium' (highest level of school education, protective factor), PAU, more conduct problems and lower psychological well-being (all at baseline) predicted adolescent PAU at follow-up. In supplementary analyses for frequent alcohol use (regardless of quantity) and high alcohol consumption quantity (regardless of frequency), these predictors could only partially be found again. According to the findings of the present study, psychosocial aspects are relevant for PAU in adolescence, and particularly psychological well-being should be given more attention in primary prevention measures and treatment approaches.
Foetal occipto-posterior position during labour can contribute to negative outcomes. Encouraging women to adopt positions utilising thigh flexion with the aim of increasing pelvic diameters and promoting foetal rotation to the occpito-anterior position are often used. However, the efficacy of these strategies has not yet been determined.

To compare the effects of maternal hands and knees or lateral positions with flexed thighs versus control in rotating foetal occipito-posterior to occipito-anterior in the first stage of labour.

The databases such as MEDLINE/PubMed, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase were searched with dates ranging from 1947 to 2019. We included randomised controlled trials (RCTs) that compared maternal hands and knees, and lateral positions incorporating flexed thighs (spine-femur angle of ≥ 90°) versus control to rotate foetal malposition in the first stage of labour and published in English. Methodological quality was assessed based on Cochrar and birth outcomes. Given that the majority of fetuses will rotate spontaneously to an occipito-anterior position it may be that maternal posturing facilitates earlier rotation in this group but has no effect on the subset of infants that would otherwise persist in the occipito-posterior position to birth.
This systematic review reports no significant correlation between maternal positioning with flexed thighs and foetal rotation from occipito-posterior to occipito-anterior position during first stage labour. The specific maternal positions tested did not impact on the majority of other labour and birth outcomes. Given that the majority of fetuses will rotate spontaneously to an occipito-anterior position it may be that maternal posturing facilitates earlier rotation in this group but has no effect on the subset of infants that would otherwise persist in the occipito-posterior position to birth.Venovenous extracorporeal membrane oxygenation (VV-ECMO) is the preferred surgical intervention for patients suffering from severe cardiorespiratory failure, also encountered in SARS-Cov-2 management. The key component of VV-ECMO is the double-lumen cannula (DLC) that enables single-site access. The biofluid dynamics of this compact device is particularly challenging for neonatal patients due to high Reynolds numbers, tricuspid valve location and right-atrium hemodynamics. Tamoxifen concentration In this paper we present detailed findings of our comparative analysis of the right-atrial hemodynamics and salient design features of the 13Fr Avalon Elite DLC (as the clinically preferred neonatal cannula) with the alternate Origen DLC design, using experimentally validated computational fluid dynamics. Highly accurate 3D-reconstructions of both devices were obtained through an integrated optical coherence tomography and micro-CT imaging approach. Both cannula configurations displayed complex flow structures inside the atrium, superimposed over predominant recirculation regimes.
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