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INTRODUCTION To demonstrate the broad utility of the remotely supervised transcranial direct current stimulation (RS-tDCS) protocol developed to deliver at-home rehabilitation for individuals with multiple sclerosis (MS). METHODS Stimulation delivered with the RS-tDCS protocol and paired with adaptive cognitive training was delivered to three different study groups of MS patients to determine the feasibility and tolerability of the protocol. The three studies each used consecutively increasing amounts of stimulation amperage (1.5, 2.0, and 2.5 mA, respectively) and session numbers (10, 20, and 40 sessions, respectively). find more RESULTS High feasibility and tolerability of the stimulation were observed for n = 99 participants across three tDCS pilot studies. CONCLUSIONS RS-tDCS is feasible and tolerable for MS participants. The RS-tDCS protocol can be used to reach those in locations without clinic access and be paired with training or rehabilitation in locations away from the clinic. This protocol could be used to deliver tDCS paired with training or rehabilitation activities remotely to service members and veterans. © Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail [email protected] First responders and those who work with organophosphate (OP) compounds can experience ocular symptoms similar to those caused by exposure to low levels of nerve agents. This study was designed to examine the efficacy of a safe, clinically available, simulant that reproduces ocular symptoms associated with low-level OP exposure. Among these ocular symptoms are a constriction of the pupils (miosis), decreased visual acuity, and changes in accommodation. MATERIALS AND METHODS Volunteers aged 18-40 were assigned to groups receiving either a two-drop or three-drop dose of FDA approved 2% pilocarpine ophthalmic solution. Baseline visual performance measurements were taken before eye drop instillation and a timer was started following the first drop of pilocarpine. Once eye drops were administered, visual performance including distant and near vision, pupil size, and accommodation were measured every 5 minutes for 2 hours. RESULTS Both groups experienced significant miosis in excess of 90 minutes. Visual acuity was significantly reduced because of accommodative changes. The three-drop group experienced longer lasting combined effects when compared to the two-drop group. CONCLUSIONS 2% pilocarpine ophthalmic solution can safely simulate major ocular symptoms of OP exposure for behavioral research studies for at least 60 minutes. © Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail [email protected] Over the past three decades, a growing research base has emerged around the role of adverse childhood experiences (ACEs) in the biological, psychological, social, and relational health and development of children and adults. More recently, the role of ACEs has been researched with military service members. The purpose of this article was to provide a brief description of ACEs and an overview of the key tenets of the theory of toxic stress as well as a snapshot of ACEs and protective and compensatory experiences (PACEs) research with active duty personnel. METHODS Ninety-seven active duty personnel completed the study including questions pertaining to demographics, adverse childhood experiences, adult adverse experiences, and PACEs survey. RESULTS Significant findings pertaining to ACEs and PACEs were found by service member's sex and rank, with higher ACE scores for men and enlisted service members. CONCLUSIONS The contrast by rank and sex in relation to ACEs punctuates the need for attention to ACEs and protective factors among early career service members in order to promote sustainable careers in the military. © Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail [email protected] Musculoskeletal overuse injuries are a serious problem in the military, particularly in basic combat training, resulting in hundreds of millions of dollars lost because of limited duty days, medical treatment, and high rates of reinjury. Injury risk models have been developed using peripheral computed tomography (pQCT)-based injury correlates. However, pQCT image capture on large number of recruits is not practical for military settings. Thus, this article presents a method to derive spatial density pQCT images from much lower resolution but more accessible dual-energy X-ray absorptiometry (DXA). MATERIALS AND METHODS Whole-body DXA images and lower leg pQCT images for 51 male military recruits were collected before a 40-day School of Infantry. An artificial neural network model was constructed to relate the DXA density profiles to spatial pQCT density at the 38% and 66% tibial locations. RESULTS Strong correlation, R2 = 0.993 and R2 = 0.990 for the 38% and 66% pQCT slices, respectively, was shown between spatial density predicted by the artificial neural network model and raw data. CONCLUSIONS High potential exists to create a practical protocol using DXA in place of pQCT to assess stress fracture risk and aid in mitigating musculoskeletal injuries seen in military recruits. © Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail [email protected] There is no dose-response model available for the assessment of the risk of tympanic membrane rupture (TMR), commonly known as eardrum rupture, from exposures to blast from nonlethal flashbangs, which can occur concurrently with temporary threshold shift. Therefore, the objective of this work was to develop a fast-running, lumped parameter model of the tympanic membrane (TM) with probabilistic dose-dependent prediction of injury risk. MATERIALS AND METHODS The lumped parameter model was first benchmarked with a finite element model of the middle ear. To develop the dose-response curves, TMR data from a historic cadaver study were utilized. From these data, the binary probability response was constructed and logistic regression was applied to generate the respective dose-response curves at moderate and severe eardrum rupture severity. RESULTS Hosmer-Lemeshow statistical and receiver operation characteristic analyses showed that maximum stored TM energy was the overall best dose metric or injury correlate when compared with total work and peak TM pressure.
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