Notes

Second-line therapy inside renal cellular carcinoma: clinical expertise and also selection.
Human infants can categorize objects at various category levels (e.g., as a dog, animal, or living thing). It is crucial to understand how infants learn about the relationships between objects. This study investigated whether 4- to 11-month-old infants can categorize modeled objects at superordinate and living/non-living levels. In this experiment, we presented modeled objects with a uniform texture constructed by a 3D printer in animal, vegetable/fruit, vehicle, and tool categories and measured the time taken to examine novel categories. We investigated infants' categorization abilities using familiarization/novelty-preference tasks and their pre-linguistic development based on information from their parents. The analyses examined whether infants dedicated more examination time to objects in the new category at superordinate and living/non-living levels for each month of age. The results revealed that the examination time among 4- and 5-month-olds was at chance levels for both superordinate and living/non-living levels, while at 7 months, they showed high preference for the novel category at both category levels. For the superordinate level, the strength of response to living objects increased with linguistic development, while the strength of response to non-living objects did not depend on linguistic development. This indicates that the superordinate-level categorization of living objects depends on both perceptual information and linguistic ability. For the living/non-living level, the examination time for non-living objects increased with linguistic development. This implies that the recognition of non-living objects may depend on the development of object knowledge. The current study suggests that infants can recognize categories at an abstract level before the acquisition of linguistic representations while the category levels that infants can categorize objects are different for living/non-living objects. This may imply that infants learn the concepts of living/non-living via different mechanisms.The purpose of this study was to investigate the effect on throwing performance (velocity and accuracy) of experienced female handball players when throwing at four different targets in a handball goal. Thirteen experienced female handball players (age 18.2 ± 1.7 years, height 1.7 ± 0.10 m, mass 68.1 ± 19.6 kg, and training experience 9.5 ± 3.7 years) performed 10 throws from a 7 m distance at each corner of the handball goal with maximal effort. Maximal ball velocity was recorded with a radar gun together with mean radial error, centroid error, and bivariate variable error, as measurements of accuracy. The main findings were that the ball velocity was higher when throwing at targets at the ipsilateral side, compared with the contralateral side, while throwing consistency (bivariate variable error) decreased when throwing at the contralateral side upper corner. No velocity-accuracy trade-off was found between the four targets. Based upon the findings, it is suggested that players throw to the (upper) ipsilateral side of the goal when performing a penalty throw, dependent on the goalkeepers' position, since the ball velocity is the highest here, without losing accuracy. This gives the goalkeeper less time to react and stop the ball, thereby giving the player the highest chance of scoring.
The identical sets of neurons - the mirror neuron system (MNS) - can be activated by simply observing specific, specific movements, decoded behaviors and even facial expressions performed by other people. The same neurons activated during observation are those recruited during the same movements and actions. Hence the mirror system plays a central role in observing and executing movements. Little is known about MNS in a neurodegenerative motor disorder, such as Parkinson's Disease (PD) is.

We explored the neural correlates potentially involved in empathy and embodiment in PD through complex action observation of complex behaviors like the choreutical arts. An integrated multidisciplinary assessment (neurological, neuropsychiatric, and neuropsychological) was used for the selection of the PD candidate for the neuroimaging experimental acquisition. For the first time in literature the famous Calvo-Merino's paradigm was administered to a PD subject.

Functional magnetic resonance imaging (fMRI) exploratory n complex action observation could be considered a promising target for neuro-rehabilitative intervention mediated by the elicitation of the MNS.The voluntary shift of responsibility from the producer to the consumer is one feature of self-design activities. Past research emphasizes the economic gains of such customer co-creation. However, the psychological mechanism underlying customer co-creation behavior is still not fully understood. Notably, the goal-driven self-congruence nature of customer co-creation is mostly ignored in the co-creation literature. The objective of this research is to firstly develop a conceptual understanding of how co-creation literature can be related to the self-congruence theory. Furthermore, this study also extends the original self-congruence theory by arguing the differential role of actual and ideal self-congruence on the relationship between self-congruence and customers' willingness to participate in the co-creation process. Two laboratory experiments were conducted to examine whether self-congruence plays a prominent role in motivating customers to participate in the self-design process. Specifically, both the actual self-congruence and ideal self-congruence are positively related to customers' willingness to participate in the self-design process is hypothesized. Moreover, it is expected that product styles and different consumption situations may strengthen the relationship between actual/ideal self-congruence and customers' willingness to participate in the self-design process. Theoretical and practical implications are also discussed.Many traditions in the East have proposed that consciousness without content is possible and could be achieved with mental training. However, it is not clear whether such a state is possible given that intentionality is a critical property of mentality and consciousness in many theories of consciousness. A prominent recent attempt to account for such states of "minimal phenomenal experience" is the ascending reticular arousal system (ARAS) model, which proposes a specific type of non-conceptual representational content to address such a state. Consciousness without content can also be understood by studying related or similar states of minimal phenomenal experience and this paper discusses such findings from such states including dreamless sleep experience and their implications. Resveratrol ic50 One way to argue for the need for proposing consciousness without content is to locate a property of consciousness that would necessitate postulating it. A continuous state of consciousness without content may be needed to understand continuity of conscious experience. Finally, I discuss the implications of consciousness without content for current theories of consciousness.Although the evidence for attentional bias to pain-related information among individuals with chronic pain has been well established, there are a number of inconsistencies in the research that have been observed due to sample characteristics. Therefore, the present study expanded upon previous studies by including patients with a variety of chronic pain conditions and compared a chronic pain patient sample with healthy community sample. We also investigated how pain catastrophizing and other psychological factors in chronic pain patients affected attentional patterns to pain-related information. Forty chronic pain patients from the departments of neurology and rheumatology of an academic medical center hospital and 40 participants without chronic pain from a university that is located in Seoul, South Korea were recruited for the present study. Patients observed pictures of faces displaying pain that were presented simultaneously with faces with neutral expressions, while their eye movements were measured using an eye-tracking system. Independent t-tests were conducted to investigate attentional preferences to pain stimuli between the chronic pain and control groups. No significant attentional differences in pain-neutral pairs were found for both chronic pain and control group. A one-way MANOVA was conducted to examine the role of pain catastrophizing on psychological factors and attentional engagement to pain stimuli. No significant results for the attentional bias to pain stimuli among chronic pain patients may indicate that chronic pain patients who have suffered from chronic pain for a long time and have been treated for their chronic pain in the hospital may interpret pain-related information not as threatening. Clinical implications related to use in pain treatment and future research suggestions are discussed.In the last decades, an increasingly prominent role has been given to the motivational factors that can promote pro-environmental behavior. In this contribution, we focus on the role of the individual's ability to shape the emotions originating from nature in engaging in pro-environmental behavior. In particular, we expect that an emotion regulation strategy as cognitive reappraisal should positively predict pro-environmental behavior, through enhanced perceived restorativeness attributed to the natural environment in terms of the experience of "being away." One-hundred and fifteen visitors to an urban park (Parco Nord Milano) filled out a questionnaire including measures of cognitive reappraisal, the experience of "being away," and pro-environmental behavior while in the park. Results confirmed that cognitive reappraisal was positively and significantly related to pro-environmental behavior. Importantly, the indirect effect of cognitive reappraisal on pro-environmental behavior through the experience of "being away" was significant. Findings suggest the importance of implementing interventions aimed at promoting the habitual use of cognitive reappraisal to enhance the experience of "being away" and, thus, sustain pro-environmental behavior.The COVID-19 pandemic is now a major global health issue, affecting world population and high-performance athlete too. The aim of the present research was to analyze the effect of psychological profile, academic schedule, and gender in the perception of personal and professional threat of Olympic and Paralympic athletes facing the 2021 Tokyo Olympiad in the actual COVID-19 crisis. We analyzed in 136 Olympic (26.4 ± 6.2 years) and 39 Paralympic athletes (31.8 ± 9.3 years) academic and sport variables, individual perceptions about COVID-19 crisis, personality, loneliness, psychological inflexibility, and anxiety. Paralympic athletes perceived higher negative impact in their training and performance by the confinement than Olympic athletes (+24.18, p less then 0.005, r = 0.60). Neuroticism and psychological inflexibility presented the greatest negative feelings for female athletes (+32.59, p less then 0.000, r = 0.13) and the perception that quarantine would negatively affect their sports performance. Finally professional athletes showed lower values in personality tests (Agreeableness factor) about COVID-19 crisis than non-professionals (-40.
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