Notes

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Bone is a dynamic organ under constant metabolism (or remodeling), where a delicate balance between bone resorption and bone formation is maintained. Disruption of this coordinated bone remodeling results in bone diseases, such as osteoporosis, the most common bone disorder characterized by decreased bone mineral density and microarchitectural deterioration. Epidemiological and clinical evidence support that consumption of dairy products is beneficial for bone health; this benefit is often attributed to the presence of calcium, the physiological contributions of milk proteins on bone metabolism, however, are underestimated. Emerging evidence highlighted that not only milk proteins (including individual milk proteins) but also their derived peptides positively regulate bone remodeling and attenuate bone loss, via the regulation of cellular markers and signaling of osteoblasts and osteoclasts. This article aims to review current knowledge about the roles of milk proteins, with an emphasis on individual milk proteins, bioactive peptides derived from milk proteins, and effect of milk processing in particular fermentation, on bone metabolism, to highlight the potential uses of milk proteins in the prevention and treatment of osteoporosis, and, to discuss the knowledge gap and to recommend future research directions.Plant-based diets exclude or substantially limit the consumption of meat and animal products and are of growing interest to many due to their sustainability and health benefits (Eshel et al, 2016). Veganism is an extreme type of plant-based diet which excludes the consumption of all animal-derived foods such as meat, eggs, and dairy, as well as foods containing animal-derived ingredients. In adults, for example, certain observational studies have suggested lower body mass index, total cholesterol, LDL-cholesterol, decreased incidence and mortality from ischemic heart disease, and decreased incidence of cancer in vegans and vegetarians versus omnivores (Dinu et al, 2017). The mechanistic basis for these observations and their generality are unclear.Breast cancer is the most common malignant disease in women all over the world and its chemotherapy outcome is restricted by multidrug resistance. Here, a nanostructure by functional larotaxel liposomes decorated with guanine-rich quadruplex nucleotide-lipid derivative for treatment of resistant breast cancer is developed. The studies are performed on the resistant breast cancer cells and the cancer-bearing mice. The nucleotide-lipid derivative (DSPE-PEG2000 -C6 -GT28nt) is synthesized by introducing a hydrophobic hexyl linkage between GT-28nt (containing 17 guanines and 11 thymidines) and DSPE-PEG2000 -NHS, and is incorporated on the functional larotaxel liposomes for specific binding with nucleolin receptor on the resistant cancer cells. The studies demonstrate that the liposomes had long circulatory effect, targeted capability, and significant anticancer efficacy in resistant cancer-bearing mice. The studies further reveal their action mechanism, consisting of blocking depolymerization of microtubules, arresting cell cycle, blocking JAK-STAT signaling pathway, and inhibiting activity of antiapoptotic proteins. In conclusion, the functional larotaxel liposomes can be used for effective treatment of drug-resistant breast cancer, and this study also offers a novel targeted nanomedicine based on nucleotide-lipid derivative.Transient lymphocytopenia is frequently observed in acute phase of coronavirus disease 2019 (COVID-19). It remains a concern whether impairment of cellular immunity may be retained after COVID-19. Here, we demonstrate by extensive lymphocyte profiling in 44 adults after mild COVID-19 that cellular immunity is not fundamentally altered in convalescent patients. Except for increased activated CD8+ lymphocytes, total counts of B, T, and NK cells and their subsets did not differ significantly between patients after COVID-19 and healthy controls after a median of 27 days (range 13-45) suggesting no residual cellular immune deficiency after recovery from mild COVID-19.Efficient light-stimulated hydrogen generation from top-down produced highly doped n-type silicon nanowires (SiNWs) with silver nanoparticles (AgNPs) in water-containing medium under white light irradiation is reported. It is observed that SiNWs with AgNPs generate at least 2.5 times more hydrogen than SiNWs without AgNPs. The authors' results, based on vibrational, UV-vis, and X-ray spectroscopy studies, strongly suggest that the sidewalls of the SiNWs are covered by silicon suboxides, by up to a thickness of 120 nm, with wide bandgap semiconductor properties that are similar to those of titanium dioxide and remain stable during hydrogen evolution in a water-containing medium for at least 3 h of irradiation. Based on synchrotron studies, it is found that the increase in the silicon bandgap is related to the energetically beneficial position of the valence band in nanostructured silicon, which renders these promising structures for efficient hydrogen generation.Ethylene glycol is a super commodity chemical and it has vital roles in various applications. Its co-production with other chemicals, such as ethylene carbonate and glycerol carbonate, has promised cheaper production cost. Its quantification presents a challenge as its contaminants, such as ethylene carbonate, produce a signal-reducing effect in flame ionized detector. The aim of this study is to evaluate external standard to quantify the composition of glycol mixture. Measurement system analysis was employed on the external standard method. Reliability of the external standard is statistically significant with low p-values, excellent capability indices, and high F-values. The external standard is found to have remarkable precision and trueness as both capability indices are mirroring each other. Furthermore, the capability analysis has a strong correlation with quality measurement. Based on capability indices, the limit of detection is recommended at S/N = 25 and the limit of quantification is recommended at S/N = 100 for a reliable measurement. A high degree of reliability is achieved coherently as almost all uncertainties of coefficients of variations are less than 5%. The established method was validated and successfully applied to glycol mixture at azeotropic distillation pilot plant.Several valuable scientific investigations have been conducted these last few years in materials design and device engineering for perovskite solar cells (PSCs) to make them competitive compared to traditional silicon-based photovoltaic technologies. Consequently, high power conversion efficiency beyond 25% is nowadays reported. However, their long-term stability remains a significant challenge to overcome. Herein, the influence of fluorinated compounds on each layer of PSCs devices and their impact on the resulted device performances and stability is spotlighted. The fluorinated compounds exhibit attractive properties due to their very high electronegativity attributed to the fluorine atom, and their strong hydrophobicity. Thus, the introduction of these compounds is found to be a successful strategy to positively suppress the surface trap states, enhancing charge collection and reducing interfacial charge recombination. LY 3200882 Besides, a better film quality and better energy level alignment is obtained, resulting in the improvement of device photovoltaic parameters such as the open-circuit voltage (Voc ), short-circuit current (Jsc ), and fill factor (FF), and then, the device's overall power conversion efficiency (PCE). Their long-term stability is also found to further be improved.
To characterize academic and adaptive skill outcomes in survivors of high-risk B-lineage acute lymphoblastic leukemia (HR B-ALL).

Participants were 178 patients enrolled on a nontherapeutic clinical trial that aimed to characterize neurocognitive and functional outcomes (ie, academic achievement and adaptive skills) following treatment for childhood HR B-ALL. Eligible patients were treated on Children's Oncology Group AALL0232 clinical trial that included two treatment randomizations methotrexate delivery (high or escalating dose) and corticosteroid (dexamethasone or prednisone). Academic achievement and adaptive skills were evaluated at one time point, 8-24months after completing treatment.

Multivariable logistic regression showed no significant association between treatment variables and outcomes after accounting for age at diagnosis, sex, and insurance status. In multivariable analyses accounting for sex and insurance status, survivors <10years old at diagnosis had significantly lower scores in Man for patients at highest risk, particularly young patients and lower resourced families, should be prioritized.The author should give careful consideration to the study eligibility criteria of systematic reviews (SRs) and follow it after review protocol development to reduce the possibility of manipulation of inclusion. Our aim was to investigate the prevalence of differences in study eligibility criteria between non-Cochrane SRs and their pre-registered protocols on PROSPERO, and determined what changes were involved as well as whether those changes were explained. We searched the protocols registered on PROSPERO platform in the year of 2018 and then selected these protocols which full-text have been published up to June 9, 2020. A random sample (n = 100) was included. Published full-texts were identified through the protocol's final publication citation. The following five key components of study eligibility criteria were compared participants, intervention(s)/exposure(s), comparator(s), types of study design, and outcome(s). A total of 90% of included SRs exhibited differences in study eligibility criteria, and 59/90 altered in no less than two key components. Only one SR reported and explained the rationale for changes to the individual key component (the definition of exposure). The "Outcome(s)" exhibited the greatest variation, with changes in 61% of the SRs. The "Comparator(s)/control" exhibited the smallest variation, with changes in 20% of the SRs. Differences in study eligibility criteria between the non-Cochrane SRs and their protocols registered on PROSPERO were widespread but were seldom explained. Authors themselves, PROSPERO platform, as well as peer-review journals and their peer-reviewers should play a role in further improving transparency.
Oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera Tortricidae) is a cosmopolitan pests of fruit trees in temperate regions. Control of G. molesta is challenging because larvae feed in concealed locations and have evolved resistance to many pesticides. We compared three commercially available species of Trichogramma for efficacy against G. molesta in the laboratory assays and tested releases of the promising species in a pear orchard.

Laboratory assays indicated that Trichogramma dendrolimi parasitized G. molesta at the highest rate. Parasitoids took longer to oviposit in older host eggs, and fewer eggs were parasitized when they were more than 3 days old. Field tests produced ca 60% cumulative parasitism of sentinel G. molesta eggs with one release of Trichogramma dendrolimi, with most parasitism occurring within 24 h. Female wasps dispersed up to 12 m from release points with a bias toward upwind movement.

We calculated that, for each generation of G. molesta, 900000 wasps per hectare, in three releases 3 days apart, each distributed among release points 10m apart, would reduce fruit damage by half in an orchard where 50% of fruit would otherwise be damaged.
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