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For the background-to-sphere ratio of 110 with low activity concentration, the SUVmean metric showed an underestimation of about 38% from the actual SUV, and SUVmax exhibited an overestimation of about 24% for the largest sphere diameter. Meanwhile, the bias reductions of as much as -6% and 7% for SUV0.6 max and SUV0.75 max were observed, respectively. SUVmax indicated the most accurate reading compared with the others, although points that exceeded the actual value were detected. At 14 and 110 background, the low activity concentration attained a value close to the actual ratio. Using two iterations, 10 subsets (2i10s) without post-filtering had the best parameter in terms of the most accurate values for reconstruction and provided the best image overall. Conclusion SUVmax is the best metric in high- or low-contrast ratio phantom with adequate iteration number of at least 2i10s without any post-filtering.The emergence of PET and MRI as a hybrid modality has generated widespread interest in the technology and techniques. Although adoption and use are unlikely to be as expansive as for PET and CT hybrid systems, PET/MRI is an important modality that requires broad insight for nuclear medicine professions generally and deeper insight for those engaged in PET/MRI practice. This article provides insight into the considerations and challenges associated with establishing a PET/MRI facility. Each clinical site will present unique requisites for establishing a PET/MRI facility, and indeed, each PET/MRI vendor will have specific site requirements. Nonetheless, this article provides general insight into common considerations but should not be considered exhaustive. Here, development of the facility, staffing of the facility, and implications of both radiation and MRI safety are considered from the context of facility design. Given that the nature of PET is well established among the readership of this journal, the article provides an emphasis on MRI factors. This article is the first in a 4-part integrated series sponsored by the PET/MR and Publication Committees of the Society of Nuclear Medicine and Molecular Imaging-Technologist Section. In the subsequent 3 parts, PET/MRI will be explored on the basis of technology principles (part 2), protocols and procedures (part 3), and applications and clinical cases (part 4).The challenges of hybridizing position emission tomography (PET) and magnetic resonance imaging (MRI) as a simultaneous modality have been largely overcome in recent times. PET hybridized with magnetic resonance (MR) has seen the emergence of PET/MR imaging systems in the clinical setting and with it comes a responsibility to adapt appropriate facility design, safety practices, protocols and procedures, and clinical opportunity. This manuscript provides an insight into the considerations and challenges associated with PET/MR technology. Given the nature of PET is well established amongst the readership of this journal, the manuscript provides an introduction to the foundations of MRI instrumentation and emphasis on specific technological aspects of PET/MR systems. This manuscript is the second in a four-part integrated series sponsored by the SNMMI-TS PET/MR Task Force in conjunction with the SNMMI-TS Publication Committee; building on the previous article on establishing a facility (part 1). In subsequent editions, PET/MRI will be explored based on protocols and procedures (part 3), and applications and clinical cases (part 4).Rotor syndrome (RS) is a benign, inherited, commonly misdiagnosed cause of conjugated hyperbilirubinemia whose identification prevents unnecessary invasive investigations. We present the case of a 3-y-old boy with phenotypic and laboratory findings of RS but negative genetic test results, whose diagnosis was confirmed by hepatobiliary scintigraphy.Breast is unusual site for metastasis from malignant tumors though may be the first manifestation of extra-mammary malignancy with primary typically arising from lung, melanoma, ovary and lymphoma. Breast metastasis is extremely rare from thyroid carcinoma and may take years to develop as differentiated thyroid carcinoma are usually indolent, slow growing and metastasize to lymph nodes, lungs and bones. Here is a middle-aged woman (post-subtotal thyroidectomy for multi-nodular goitre 24 years ago) showing discordant FDG and iodine avidity in proven metastatic disease involving lymph nodes, bones, spleen and breast on whole-body radioiodine and FDG-PET/CT due to tumor heterogeneity.Lung cancer is the number one cause of cancer deaths in the United States. Prognosis is quite grim at the exception of stage 1. Bleomycin nmr When faced with failure of several therapeutic regimens and rapid progression of disease, considering alternative therapies such as radiopharmaceutical therapies may be an option. We describe the case of a 36 yo young gentleman with lung adenocarcinoma whom had imaging molecular characterization of his disease with 18F-Fluorodeoxyglucose(18F-FDG), 68Ga-DOTATATE and 18F-Fluoride PET scans which were able to shed some light on molecular characterization of his disease and serve as a guide to potential targeted/personalized radiopharmaceutical therapeutic options.Formal and informal lifelong learning allows nuclear medicine professionals to grow and change over time within this dynamic field. Over the past 2 decades, Internet-based websites have provided instantaneous access to informal learning opportunities, including nuclear medicine reference articles, videos and webinars, and case-based learning. More recently, medical educators have explored social media platforms such as Instagram, Facebook, and Twitter to provide nuclear medicine education. This article discusses the use of Instagram as a platform for lifelong learning in nuclear medicine. Several nuclear medicine Instagram sites are introduced and user characteristics and participation for a representative site are presented in an effort to learn more about this educational forum, which is increasingly being recognized among academic educators.Altered biodistribution can be a source of diagnostic error in the interpretation of nuclear medicine studies. We report a case of increased liver and spleen uptake with 99mTc-dimercaptosuccinic acid (DMSA) believed to be a result of chlorhexidine-mediated colloid labeling. This finding underscores the principle that certain constituents of antiseptics may adversely affect the purity of radiopharmaceuticals during their preparation.A 67-year-old man presented with progressive diplopia. On evaluation, he was noted to have bilateral palsies of cranial nerves III, IV and VI as well as a unilateral right true vocal fold paralysis. CT and MRI studies demonstrated a T2-bright left ethmoid mass with no evidence of bony erosion. Direct visualisation demonstrated a polypoid appearing mass of the left sphenoethmoid recess. Operative biopsy was pursued with final pathology demonstrating benign seromucinous hamartoma. Subsequent blood work demonstrated high titres of anti-acetylcholine receptor antibodies consistent with myasthenia gravis. The patient was started on pyridostigmine with improvement in his ocular cranial neuropathies.Recreational nitrous oxide (N2O) is commonly used among young people partly due to its low cost and accessibility, and awareness of its potential adverse effects is poor in this group. One such adverse effect is degeneration of the spinal cord due to its disruption of DNA synthesis by inactivating cobalamin (B12).A 19-year-old man presented to the emergency department with a 4-week history of worsening paraesthesia in his fingers and lower limbs, and weakness in the hands and lower limbs for 2 weeks. On examination, he had an ataxic gait, reduced power of grip strength and ankle movements, and impaired sensation in the lower limbs. An MRI brain and spine revealed myelopathy of the cervical and thoracic cord.On further questioning, he reported recreational N2O inhalation. His symptoms improved after stopping this and he was treated with supplementation of B vitamins. Education strategies regarding the risks of N2O misuse are indicated.Isolated dissection of one of the mesenteric arteries without concurrent involvement of the aorta is a rare clinical entity and an unusual cause of abdominal pain. It usually involves one artery, most commonly the superior mesenteric artery (SMA) followed by the coeliac artery. We are reporting a rare case where both coeliac and SMA were showing dissection. We are reporting a case of 60-year-old hypertensive male who came with worsening abdominal pain for 5 days; CT scan showed coeliac and SMA dissection without any imaging evidence of intestinal ischaemia. He was successfully managed medically with bowel rest and anticoagulation. Two weeks of follow-up CT scan showed no progression or thrombus formation. For complicated cases, percutaneous transluminal angioplasty of a visceral artery or open surgical exploration or hybrid approach is required. However, for stable uncomplicated cases, medical therapy alone is sufficient.Giant chorioangiomas are benign placental tumours, which can have potential severe fetal consequences. Complications in pregnancy include polyhydramnios, fetal hydrops and growth restriction. Such pregnancies can carry a significant risk of poor perinatal outcome and require close monitoring. Therapeutic options include fetoscopic or interstitial vessel ablation, chemosclerosis and embolisation. Where there is no evidence of fetal compromise, such pregnancies can successfully be managed conservatively.A 40-year-old man presented to a local hospital with a 2-day history of dyspnoea having been started on adjuvant chemotherapy consisting of oxaliplatin and capecitabine for mucinous adenocarcinoma of the colon. During his admission, he develops chest pain, worsening shortness of breath, and intermittent dysarthria and disorientation. Investigations reveal severely impaired left ventricular function on echocardiogram, bilateral acute pulmonary embolisms on CT pulmonary angiogragraphy, and diffused subcortical and callosal white matter signal change and restricted diffusion consistent with a toxic leukoencephalopathy on MRI of brain. This case highlights the pivotal role of the multidisciplinary cardio-oncology approach which enabled these challenging diagnoses to be made and ensured optimal patient outcome.Decidualisation of the endometrium is a progesterone-mediated reaction that naturally occurs during a woman's menstrual cycle. The hyperproliferated tissue is then usually dissolved and passed in a menstrual period. Occasionally, the natural dissolution does not happen, and the tissue maintains the shape of the endometrium, forming a decidual cast. These casts are known to be formed secondary to the use and/or cessation of various contraceptive methods. Here, we report a case of a patient presenting with passage of a decidual cast secondary to cessation of the Depo medroxyprogesterone acetate injection. This is the first reported case of the cast becoming infected, and also the first case of a decidual cast containing old products of conception.Diabetes insipidus (DI) is characterised by thirst and polydipsia with hypotonic polyuria. Several forms exist, namely, central or pituitary, nephrogenic and gestational and must be differentiated for adequate treatment. We describe the case of a 41-year-old woman chronically infected with HIV who had been recently medicated with a tenofovir-based antiretroviral treatment and who, at 22 weeks of pregnancy, presented with transient gestational DI. Obstetric ultrasound revealed oligohydramnios and foetal growth restriction that did not improve despite serum sodium correction. The severity of the case suggested the presence of an underlying disorder and elevated copeptin levels indicated that an underlying subclinical form of nephrogenic DI, possibly induced by HIV-related nephropathy or tenofovir use, was present and rendered clinically overt during pregnancy.
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