Notes

Preparation regarding CeO2/Nanographite Blend Resources and also Electrochemical Deterioration of Phenol by CeO2/Nanographite Cathodes.
INTRODUCTION Blood-brain barrier (BBB) disruption and subsequent neuro-inflammation occur following traumatic brain injury (TBI), resulting in a spectrum of human nervous system disorders. [99mTc]Tc-tilmanocept is a receptor-binding radiopharmaceutical FDA-approved for sentinel lymph node mapping. We hypothesize that after an intravenous (i.v.) injection, [99mTc]Tc-tilmanocept, will traverse a disrupted BBB and bind to CD206-bearing microglial cells. METHODS Age-matched mice were divided into three groups 5-days post TBI (n = 4), and 5-days post sham (n = 4), and naïve controls (n = 4). IRDye800CW-labeled [99mTc]Tc-tilmanocept (0.15 nmol per gram body weight) and FITC-labeled bovine serum albumin (FITC-BSA) were injected (i.v.) into each mouse. Mice were imaged with a high-resolution gamma camera for 45 min. Immediately after imaging, the brains were perfused with fixative, excised, imaged with a fluorescence scanner, assayed for radioactivity, and prepared for histology. RESULTS In vivo nuclear imaging, ex vDVANCES IN KNOWLEDGE AND IMPLICATIONS FOR PATIENT CARE [99mTc]Tc-tilmanocept could serve as an imaging biomarker for TBI-associated neuroinflammation and any disease process that involves a disruption of the blood-brain barrier. AIMS Stereotactic body radiotherapy (SBRT) is a locally ablative therapy used for the treatment of patients with spine metastases. However, it is associated with higher rates of vertebral compression fractures (VCF) than conventionally fractionated palliative radiotherapy. The purpose of this study was to determine the rate of VCF following spine SBRT and to identify the risk factors associated with this outcome. MATERIALS AND METHODS We retrospectively reviewed patients treated at two Australian institutions from January 2015 to March 2019. Descriptive statistics were used to assess patient, tumour and treatment factors. The Log-rank test and Cox proportional hazards model were applied in univariate and multivariable analyses to identify factors associated with VCF, local control and overall survival. RESULTS We evaluated 113 spinal segments from 84 patients, with a median follow-up time of 11.9 months. The median dose and fractionation utilised was 30 Gy in three fractions (67.3%), with a single-fraction rate of 0.9%. The median Spinal Instability Neoplastic Score (SINS) of the lesions was 4/18, with most (84.1%) being SINS stable, scoring between 0 and 6. Five VCFs were observed (three progression of pre-existing fractures and two de novo), a cumulative VCF risk of 4.4%. Four of five fractures occurred within the first year after treatment, with a median time to VCF of 9.2 months. A pre-existing VCF (P = 0.011) was associated with subsequent fracture on multivariable analysis, whereas all VCF segments displayed lytic disease appearance. All fractures were managed conservatively with analgesia, without requirement for subsequent surgical intervention. CONCLUSION SBRT to spine metastases is safe with respect to VCF, with rates around the lower limit observed in similar studies. Knowledge of factors that predispose to post-treatment fracture, such as pre-existing compression, lytic vertebral disease and SINS >6 will aid in the counselling and selection of patients for this therapy. INTRODUCTION The need of iterative surgeries, the proximity of two anatomical areas, the combination of an aesthetic surgery with a surgery covered by health insurance are the reasons which motivated the authors to provide a simultaneous procedure on arms and breast in patients achieving massive weight loss. We propose a vertical continuation of the lateral mastopexy incision superiorly, in continuity with a simultaneous brachioplasty incision to treat the excess skin and subcutaneous tissue of the lateral chest wall, either by resection, or by increasing the breast with the patients own autologous tissue. METHODS Between 2010 and 2017, twelve patients aged between 31 and 56 years, with 42 being the average, have undergone a technique that utilises a vertical continuation of the lateral mastopexy incision superiorly, in continuity with a simultaneous brachioplasty incision transverse skin incisions and free nipple transplantation for correction of extreme gynaecomastia (2 cases), mastopexy with resection of the excess tissue of the lateral chest wall (8 cases), autologous breast augmentation by the use of intercostal artery perforator flaps (2 cases). Mean body mass index (BMI) was 24kg/m2 [23; 32] after average weight loss of 56kg [14; 112] following diet (3 cases) or bariatric surgery (9 cases). RESULTS Mean operative time was 4hours [3 6], mean length of hospital stay was 4 days [2; 9]. We observed one major complication (hematoma) and one minor complication (wound dehiscence). At a mean follow-up of 21 months (ranged from 15 days to 84 months), the lateral flank scarring was well tolerated, with the additional benefit of reducing flank fullness. CONCLUSION The extended lateral flank scar allows reducing the excess skin and subcutaneous tissue of the lateral chest wall, while being easily concealable. This technique offers an elegant solution to this excess that used to persist after multistage surgeries. BACKGROUND Potential agents that can effectively treat hepatocellular carcinoma (HCC) are being continuously explored. METHODS Celastrol extracted from roots of an ancient Chinese herb, Tripterygium wilfordii (Thunder god vine), has been identified as a potential anti-tumor agent. In this study, the molecular mechanisms underlying the action of celastrol on cell proliferation and chemokine CXCR4-related signal pathway associated with tumor growth were investigated. RESULTS The CXCR4 expression was diminished by celastrol treatment in a dose-dependent manner, and its downstream associated pathways, including PI3K and Akt were also downregulated. Celastrol also significantly attenuated proliferation and migration ability of HCC cells, and induced cell apoptosis in vitro. Additionally, significant inhibition of HCC growth was observed in the celastrol-treated group as compared with the control group in vivo as well. CONCLUSION Celastrol is capable of attenuating cell proliferation and inducing apoptosis, leading to inhibition of HCC growth through the suppression of CXCR4-related signal pathway. OBJECTIVES To evaluate the degree to which evidence from large clinical trials can be applied to patients treated in a local hospital cohort of COPD outpatients. METHODS The authors selected seventeen RCTs identified in a systematic way from GOLD 2019 consensus document, and applied their inclusion and exclusion criteria to a real-world cohort of a previous cross-sectional study of 303 COPD outpatients included consecutively. RESULTS When the inclusion criteria of the 17 RCTs were applied to a real-world cohort of COPD outpatients, only a small portion of them were eligible to participate in the referred trials, from 4.29% to 60.07%. However, when both the inclusion and the exclusion criteria were applied, only as little as 3.63% to as much as 40.59% of patients were eligible to participate. Hence, only a small fraction of patients from this cohort could benefit from the findings of these RCTs. CONCLUSIONS There is a need to complement the efficacy evidence provided by large RCTs according to the extent to which their results, designed to target significant patient populations, can be applied to typical patients treated in routine clinical practice. BACKGROUND Given the popularity of restaurants as a meal source in the United States, it is important to understand the healthiness of their offerings. OBJECTIVE This study's purpose was to examine the healthiness of meals at national US chain restaurants in 2017 using the American Heart Association's (AHA) Heart-Check meal certification criteria. DESIGN Data for this cross-sectional study were obtained from MenuStat, an online database that includes nutrition information for menu items from the 100 restaurant chains with the largest sales in the United States in 2017. this website All possible meal combinations (meals defined as including an entrée and side item) were created at the 73 restaurants that reported nutrition information aligning with the AHA criteria calories, total fat, saturated fat, trans fat, cholesterol, sodium, protein, and fiber. MAIN OUTCOMES MEASURE Healthy meal (0=did not meet AHA criteria; 1=did meet AHA criteria). STATISTICAL ANALYSES PERFORMED We used χ2 tests to compare the percent of restaurant meals and meal components compliant with each AHA criterion and the percent of restaurant meals and meal components meeting varying numbers of AHA criteria across restaurant service types (ie, fast food, full service, fast casual). RESULTS Among all restaurants, the median calories, total fat, saturated fat, cholesterol, and sodium of meals exceeded the AHA criteria. Fewer than 20% of meals met the saturated fat and sodium criteria; 22% of restaurant meals met zero to one AHA criteria, 50% met two to four AHA criteria, 20% met five to six AHA criteria, and 8% met all seven AHA criteria. CONCLUSIONS Given the popularity of restaurants as a source of meals, efforts are needed to improve the healthiness of restaurant meals. This paper examines two approaches in tuning fractional order proportional-integral-differential (FOPID) control named as neuro-based FOPID (NNFOPID) and particle swarm-based FOPID (PSOFOPID) for pitch control of a Twin Rotor Aerodynamic System (TRAS). For the neuro-based FOPID control, the innovations are the modification of output equation in the artificial neural network and the implementation of the Rectified Linear Unit (ReLU) activation function. The advantages of the proposed approach are a lighter network and the ability to tune more practical controller parameters without a deep knowledge of the system to achieve a satisfying pitch tracking response. As for the particle swarm-based FOPID control, the application of PSO with spreading factor algorithm is extended for tuning the FOPID controller gains and the innovation here is a new procedure in setting the initial search range. The important advantages of this proposed swarm-based algorithm are the avoidance of being trapped in local optima and reducness and energy consumption of both controllers in Case III. It is envisaged that the proposed control designs can be very useful in tuning FOPID controller gains for high performance, low energy, and robust aerodynamics systems. A Space Vector Pulse Width Modulation (SVPWM) control strategy is proposed for a three phase five level dual inverter fed open-end winding induction motor. This system includes 2 three level Neutral Point Clamped (NPC) inverters, which is supplied by two isolated dc power supplies. The conventional SVPWM has more complexity in reference vector identification and switching time calculation. The reference vector for proposed five level SVPWM scheme is tracked using three level voltage vector and offset voltage, where 5-level hexagonal region is divided into seven 3-level hexagonal regions. The proposed SVPWM leads to reduce the complexity in switching time calculation, Total Harmonic Distortion (THD) reduction, Minimization of Common Mode Voltage (CMV) and low voltage stresses across the switching devices. Also this system estimate the phase current of the five level dual inverter fed open-end winding induction motor. The results obtained using simulation and hardware are compared and verified using Digital Signal Processor.
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