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Physical exercise, dietary consumption and excellence of living in the course of COVID-19 lockdown inside patients looking forward to transcatheter aortic control device implantation.
The gelled structure was validated by the rheological and textural characteristics. The results highlighted the potential use of red beetroot and sour cherry as food raw materials, due to their particular profile of bioactive compounds.An experimental printable γ'-strengthened nickel-based superalloy, MAD542, is proposed. By process optimization, a crack-free component with less than 0.06% defect was achieved by laser powder bed fusion (LPBF). After post-processing by solution heat treatment, a recrystallized structure was revealed, which was also associated with the formation of annealing twins. After the aging treatment, 60-65% γ' precipitates were obtained with a cuboidal morphology. The success of printing and post-processing the new MAD542 superalloy may give new insights into alloy design approaches for additive manufacturing.Wedelia chinensis (Asteraceae) is a wetland herb native to India, China, and Japan. It is a valuable medicinal plant recorded to have pharmaceutical properties. However, the phytotoxic potential of Wedelia chinensis has not yet been examined. Thus, we carried out this study to establish the allelopathic effects of Wedelia chinensis and to identify its phytotoxic substances. Extracts of Wedelia chinensis exhibited high inhibitory activity against the root and shoot growth of cress, alfalfa, rapeseed, lettuce, foxtail fescue, Italian ryegrass, timothy, and barnyard grass. The inhibition was varied with species and was dependent on concentrations. The extracts were separated through several purification steps, and the two effective substances were isolated and characterized as vanillic acid and gallic acid using spectral analysis. Vanillic acid and gallic acid significantly arrested the growth of cress and Italian ryegrass seedlings. The concentrations of vanillic acid and gallic acid needed for 50% inhibition (I50 values) of the seedling growth of the cress and Italian ryegrass were 0.04-15.4 and 0.45-6.6 mM, respectively. The findings suggest that vanillic acid and gallic acid may be required for the growth inhibitory activities of Wedelia chinensis.Fluorine is an essential nutrient, and excessive or deficient fluoride contents in water can be harmful to human health. The shallow groundwater of the Jiaolai Basin, China has a high fluoride content. This study aimed to (1) investigate the processes responsible for the formation of shallow high-fluoride groundwater (SHFGW); (2) identify appropriate methods for in situ treatment of SHFGW. A field investigation into the formation of SHFGW was conducted, and the results of experiments using soils from high-fluoride areas were examined to investigate the leaching and migration of fluoride. The results showed that the formation of SHFGW in the Jiaolai Basin is due to long-term geological and evaporation processes in the region. Stratums around and inside the basin act as the source of fluoride whereas the terrain promotes groundwater convergence. The hydrodynamic and hydrochemical conditions resulting from slow groundwater flow along with high evaporation and low rainfall all contribute to the enrichment of fluoride in groundwater. In situ treatment of SHFGW may be an effective approach to manage high SHFGW in the Jiaolai Basin. Aristolochic acid A Since soil fluoride in high-fluoride areas can leach into groundwater and migrate with runoff, the construction of ditches can shorten the runoff of shallow groundwater and accelerate groundwater loss, resulting in the loss of SHFGW from high-fluoride areas through river outflow. The groundwater level will be reduced, thereby lowering the influence of evaporation on fluoride enrichment in shallow groundwater. The results of this study can act a reference for further research on in situ treatment for high-fluoride groundwater.This study determined the maximum possible filtration time per filtration cycle and the cumulated number of operational hours per year as a function of the processing temperature during milk protein fractionation by 0.1 µm microfiltration (MF) of pasteurized skim milk. The main stopping criteria were the microbial count (max. 105 cfu/mL) and the slope of the pH change as a function of filtration time. A membrane system in a feed and bleed configuration with partial recirculation of the retentate was installed, resembling an industrial plants' operational mode. Filtration temperatures of 10, 14, 16, 20, and 55 °C were investigated to determine the flux, pH, and bacterial count. While the processing time was limited to 420 min at a 55 °C filtration temperature, it could exceed 1440 min at 10 °C. These data can help to minimize the use of cleaning agents or mixing phase losses by reducing the frequency of cleaning cycles, thus maximizing the active production time and reducing the environmental impact.Navigated transcranial magnetic stimulation (nTMS) is increasingly used for mapping of motor function prior to surgery in patients harboring motor-eloquent brain lesions. To date, single-pulse nTMS (sp-nTMS) has been predominantly used for this purpose, but novel paired-pulse nTMS (pp-nTMS) with biphasic pulse application has been made available recently. The purpose of this study was to systematically evaluate pp-nTMS with biphasic pulses in comparison to conventionally used sp-nTMS for preoperative motor mapping of lower extremity (lE) muscle representations. Thirty-nine patients (mean age 56.3 ± 13.5 years, 69.2% males) harboring motor-eloquent brain lesions of different entity underwent motor mapping of lE muscle representations in lesion-affected hemispheres and nTMS-based tractography of the corticospinal tract (CST) using data from sp-nTMS and pp-nTMS with biphasic pulses, respectively. Compared to sp-nTMS, pp-nTMS enabled motor mapping with lower stimulation intensities (61.8 ± 13.8% versus 50.7 ± 11.6% of maximum stimulator output, p less then 0.0001), and it provided reliable motor maps even in the most demanding cases where sp-nTMS failed (pp-nTMS was able to provide a motor map in five patients in whom sp-nTMS did not provide any motor-positive points, and pp-nTMS was the only modality to provide a motor map in one patient who also did not show motor-positive points during intraoperative stimulation). Fiber volumes of the tracked CST were slightly higher when motor maps of pp-nTMS were used, and CST tracking using pp-nTMS data was also possible in the five patients in whom sp-nTMS failed. In conclusion, application of pp-nTMS with biphasic pulses enables preoperative motor mapping of lE muscle representations even in the most challenging patients in whom the motor system is at high risk due to lesion location or resection.The prediction of springback angle for ultra-thin metallic sheets becomes extremely difficult with the existence of size effects. In this study, size effects on the springback behavior of CuZn20 foils are investigated by experiments and analytical methods. The experimental results reveal that the springback angle first decreases gradually and then increases markedly with the decrease of foil thickness, which cannot be analyzed by current theoretical models. Then, an analytical model based on the Taylor-based nonlocal theory of plasticity is developed, in which the drastic increases of both the proportion of surface grains and the strain gradient are taken into account. Moreover, the influence of strain gradient is modified by the grain-boundary blocking factor. The calculation results show that the springback angle of foils is determined by the intrinsic competition between the decrement angle caused by surface grains and the increment angle caused by the strain gradient. Besides, the relative error of predicted springback angle by the model is less than 15%, which means that the developed model is very useful for improving the quality of micro sheet parts with high accuracy of springback prediction.In this study, pure Y2O3, La0.1Y1.9O3 and La0.1Nd0.12Y1.78O3 nanosized powders were successfully synthesized by a modified sol-gel method. Pure and rare-earth ions doped yttria powders were characterized by X-ray diffraction, scanning electron microscopy and Brunauer-Emmett-Teller methods. The powders were sintered by the hot isostatic pressing process. The highest in-line transmittance of 56% was obtained at 800 nm and increased in the IR region. The influence of the lanthanum and neodymium ions on the physicochemical properties of yttria were discussed. The La-Nd-doped material exhibited a Verdet constant over 4000 deg/T·m at 400 nm and low thermal dependence. An interesting evolution of the Verdet constant across the absorption band with high resolution was studied. A study of the optical and magneto-optical properties of yttria doped with Nd3+ and La3+ is discussed in this paper.Porcine epidemic diarrhea (PED) is a devastating disease that causes considerable economic damage to the global pig industry. Although the causative agent, the porcine epidemic diarrhea virus (PEDV), was identified about a half century ago, there is still much debate on the preventive measures against the disease, especially regarding the PED vaccine. Recent reports on PEDV variants make the vaccination for PEDV more confusing. Therefore, we systematically reviewed published articles on PED and vaccines against the disease and performed a meta-analysis of vaccine efficacy based on the clinical signs, fecal score and survival rates. A total of 299 articles on the efficacy of PED vaccines were found online, and 21 articles were selected that fulfilled all the criteria. A meta-analysis was performed on the 21 articles based on the fecal scores and survival rates. This analysis showed the efficacy of PED vaccines, and no significant differences in the efficacy depending on vaccine type (killed vs. live) or administration route (intramuscular vs. oral) were found. The results from our study suggest that any vaccination against PED is a useful strategy to control the disease regardless of the type of vaccine and administration route.Amyloid beta (Aβ) peptide, one of the most important pathogenic traits of Alzheimer's disease (AD), invokes a cascade of oxidative damage and eventually leads to neuronal death. In the present study, baicalein, wogonin, and oroxylin A, main active flavones in Scutellaria baicalensis, were evaluated for their neuroprotective effects against Aβ25-35-stimulated damage. All tested compounds decreased Aβ25-35-induced ROS generation and cell cycle arrest. In particular, baicalein exhibited the strongest antioxidant activity. In addition, these compounds suppressed apoptosis by attenuating mitochondrial dysfunction such as loss of membrane potential, Ca2+ accumulation and Bax/Bcl-2 ratio. Furthermore, all tested flavones inhibited the expression of iNOS and COX-2, which resulted in suppressing inflammatory cytokines including TNF-α, NO, and PGE2. Noticeably, all compounds exhibited the anti-inflammatory effects through downregulating NF-κB/MAPK pathway. Especially, oroxylin A was effective against both p65 and IκBα, while wogonin and baicalein were suppressed phospho-p65 and phospho-IκBα, respectively. Taken together, baicalein, wogonin, and oroxylin A can effectively relieve Aβ25-35-stimulated neuronal apoptosis and inflammation in PC12 cells via downregulating NF-κB/MAPK signaling pathway.
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