Notes

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We generated an Immuno-Clinic score (ICS) model to evaluate T cell immunity based on the clustering of antiviral cytokines and inhibitory molecules in 229 naïve chronic hepatitis B (CHB) patients. 126 patients receiving antiviral therapy were used to validate the model for predicting antiviral therapy effectiveness. Through receiver-operator characteristic curve analysis, the area under the curve, sensitivity, and specificity of the ICS model were 0.801 (95%CI 0.703-0.900), 0.727, and 0.722, respectively. The cut-off value was 0.442. Re-evaluation of T cell immunity in different phases of CHB showed that patients in the immune tolerant phase had the lowest percentage of ICS-high (15%), while patients in the inactive carrier phase had the highest percentage of ICS-high (92%). Patients in the immune active and gray zone phases had 17% and 56% ICS-high, respectively. Elevation of ICS as early as four weeks after treatment could predict the effectiveness of hepatitis B virus (HBV) DNA loss and normalization of alanine aminotransferase, while eight weeks after treatment could predict HBV surface antigen decline. Thus, this ICS model helps clinicians choose an optimal time for initiating antiviral therapy and predicting its efficacy.
This study examined the maintenance of passing performance following soccer-specific high-intensity intermittent exercise in elite (n = 9) and subelite (n = 11) Western Australian female soccer players (19.5 [2.5]y).

A total of 20 participants completed the Loughborough Soccer Passing Test (LSPT) prior to, during, and following 90 minutes of a modified, female-specific, individualized exercise protocol (Loughborough Intermittent Shuttle Test [LIST]) to simulate 2 halves of a soccer match. Performance in the LSPT was calculated by adding "raw time" to the accumulated "penalty time" for each test.

Elite players recorded greater distances (t58 = 4.671, P < .001, effect size [ES] = 1.21) and higher derived VO2max values (t58 = 4.715, P < .001, ES = 1.20) for the LIST exercise protocol over the subelite players. The total performance times for each LSPT were longer in the subelites in comparison with the elites, with a very large ES difference seen in post-LIST1 (t18 = -6.64, P < .001, ES = 2.99) an players through sustained passing performance. Coaches may also use this information to better inform best-practice training methods through modification of male soccer-specific high-intensity intermittent exercise to a female cohort.
To examine the relationship between the maximal power output (MPO) in an individualized 7 × 2-minute incremental (INCR) test, average power in a 2k (W2k) rowing ergometer test, and maximal oxygen uptake (V˙O2max) and to develop a regression equation to predict V˙O2max.

A total of 34 male club rowers (age 18-30y) performed a 2k and an INCR test in a Concept2 rowing ergometer to determine and compare MPO, W2k, and V˙O2max.

No significant difference was found between V˙O2max measured during INCR or 2k test (P = .73). A very high correlation coefficient (r = .96) was found between MPO and V˙O2max and between W2k and V˙O2max (r = .93). Linear regression analyses were developed for predicting V˙O2max from MPO (1)V˙O2max (mL·min-1) = 11.49 × MPO + 810 and V˙O2max from W2k (2)V˙O2max = 10.96 × W2k + 1168. Cross-validation analyses were performed using an independent sample of 14 rowers. There was no difference between the mean predicted V˙O2max in the INCR test (4.41L·min-1) or the 2k test (4.39L·min-1) and the observed V˙O2max (4.40L·min-1). Technical error of measurement was 3.1% and 3.6%, standard error of estimate was 0.136 and 0.157mL·min-1, and validation coefficients (r) were .95 and .94 using Equation(1) and (2), respectively.

A prediction model only including MPO or W2k explains 88% to 90% of the variability in V˙O2max and is suggested for practical use in male club rowers.
A prediction model only including MPO or W2k explains 88% to 90% of the variability in V˙O2max and is suggested for practical use in male club rowers.Basic psychological needs theory is limited by variable-centered studies focused on linear relationships between perceived needs-supportive/controlling coach behaviors. Therefore, latent profile analysis was used to determine if heterogenous profiles emerged from the interactive effects of needs-supportive and -controlling coach behaviors and the subsequent association with sport-specific mental health outcomes (i.e., burnout and subjective vitality). A total of 685 athletes took part (age = 23.39 years, male = 71%), and the latent profile analysis revealed five novel, diverse profiles, labeled as "supportive-developmental," "needs-indifferent," "overly critical," "harsh-controlling," and "distant-controlling" coaches. The profiles predicted significant mental health variance (adjusted R2 = .15-.24), wherein the "supportive-developmental" profile scored most favorably on 90% of the outcomes. The largest mean differences were observed against the "harsh-controlling" (n = 5), "overly critical" (n = 3), and "distant controlling" (n = 2) profiles. Overall, latent profile analysis revealed substantial nuance in athletes' social contexts, predicting variance in mental health. Cloperastine fendizoate cell line Needs-supportive interventions are needed for "overly critical," "harsh controlling," and "distant controlling" athlete profiles.
To compare the effects of different modalities of morning priming exercise on afternoon physical performance with the associated hormonal and psychophysiological responses in young soccer players.

In a randomized counterbalanced crossover design, 12 young soccer players completed 3 different morning conditions on 3 different days repeated-sprint running (6 × 40m), easy exercise (4 × 12 fast half squats, 6 speed ladder drills, and 20-m sprints), and control (no exercise). Blood testosterone and cortisol concentrations were assessed upon arrival (approximately 830AM) and approximately 5hours and 30minutes later. Body temperature, self-reported mood, quadriceps neuromuscular function (maximal voluntary contraction, voluntary activation, rate of torque development, and twitch contractile properties), jump, and sprint performance were evaluated twice per day, while rating of perceived exertion, motivation, and the Yo-Yo Intermittent Recovery level 2 (IR2) tests were assessed once per day.

Compared with the control, repeated-sprint running induced a possible positive effect on testosterone (+11.
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