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2% (95% CI, -7.08 to -1.23) in April, -3.1% (95% CI, -5.79 to -0.47) in August, -3.7% (95% CI, -6.09 to -1.21) in October, and -1.9% (95% CI, -3.62 to -0.12) in December. The percentage change of evening PEFR significantly decreased by -3.3% (95% CI, -6.38 to -0.25) in April and by -3.3% (95% CI, -5.56 to -1.07) in October.
The PEFR in children with asthma was lower in autumn than in winter. In terms of monthly patterns, the PEFR was significantly reduced in April and October than in January. These results can serve as a basis for preventing asthma exacerbations by developing seasonal or monthly management strategies for children with asthma.
The PEFR in children with asthma was lower in autumn than in winter. read more In terms of monthly patterns, the PEFR was significantly reduced in April and October than in January. These results can serve as a basis for preventing asthma exacerbations by developing seasonal or monthly management strategies for children with asthma.Bortezomib, a highly selective reversible inhibitor of the proteasome complex, is used to the current standard of care in the treatment of multiple myeloma. Although its most commonly reported side effects are gastrointestinal symptoms, peripheral neuropathy, neuropathic pain, and thrombocytopenia, cutaneous adverse reactions are also frequently seen. However, severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS) occur very rarely. Here we report the first case of bortezomib-induced SJS with confirmed by patch test. In this case, we performed a patch test that proved bortezomib was the offensive drug in this patient, who had been treated with multiple drugs including antibiotics, allopurinol, and anticancer drugs. Although bortezomib-induced SCARs are generally very rare, we suggest that clinicians be aware of potential adverse reactions including SJS.
This year, pollen season coincided with the first wave of the coronavirus disease 2019 pandemic. Strict preventive measures have been implemented during April and May and then a normalization phase started in our country in June. Our aim is to evaluate the effect of preventive measures during the pandemic process on allergic airway disease symptoms.
A prospective questionnaire-based study was planned and a questionnaire form was sent to the cell-phones of the subjects with pollen allergy followed in our clinic. Number of airborne grass pollens was determined by Burkard volumetric 7-day spore trap.
A total of 222 pollen allergic patients were included in the study. At the beginning of the pandemic, majority of the subjects were spending time mostly indoors. The rate of home-office workers gradually decreased and the rate of office workers and the number of days at work increased from April to June, significantly. Nasal and ocular symptoms of the patients, also increased in June compared to April and May and, approximately one-third of the patients had less symptoms when compared to the same period of the previous year. The rates of using a face mask and taking a shower on return home were high among the subjects during all season.
Our study showed that spending less time outside during the pollen season and wearing a mask outdoors reduces exposure to pollens and causes a reduction in symptoms. Thus, strict application of measures that cannot be applied in daily practice can make a significant contribution to the management of seasonal allergic rhinitis.
Our study showed that spending less time outside during the pollen season and wearing a mask outdoors reduces exposure to pollens and causes a reduction in symptoms. Thus, strict application of measures that cannot be applied in daily practice can make a significant contribution to the management of seasonal allergic rhinitis.
Acute otitis media (AOM) is the most common bacterial infection in children. Some children with AOM tend to be otitis-prone, such as to have frequent recurrence of AOM (RAOM). The possible RAOM risk factors are widely debated.
The aim was to identify predictive factors, including clinical data and endoscopic findings, for RAOM in children.
The current study was performed in a real-life setting, such as an otorhinolaryngologic (ORL) clinic. In this study, 1,002 children (550 males, 452 females; mean age, 5.77 ± 1.84 years), complaining upper airway symptoms, were consecutively visited. Detailed clinical history and nasal endoscopy were performed.
Throughout the ORL visit, it was possible to define some factors involved in the recurrence of AOM, including female sex, artificial feeding, tonsillar and adenoid hypertrophy, whereas male sex and recurrent respiratory infections could protect from RAOM.
Allergy was not associated with RAOM. In addition, this real-life study identified some predictive factors of RAOM, thus also in a primary care setting it is possible to achieve important information that is relevant in clinical practice.
Allergy was not associated with RAOM. In addition, this real-life study identified some predictive factors of RAOM, thus also in a primary care setting it is possible to achieve important information that is relevant in clinical practice.An 8-year-old boy with poor control of atopic dermatitis could eat potato products such as French fries without restrictions until 21 months of age. However, he developed generalized urticaria after eating potato products at the same age. Therefore, potatoes were excluded from his diet; nevertheless, he continued to consume a very small amount of potato starch but was without symptoms until the age of 8 years. At this age, he developed anaphylaxis after consuming potato starch and required administration of intramuscular epinephrine. He tested positive for potato-specific immunoglobulin E, skin prick test, and basophil activation test. He developed severe eczema with dry skin and erosion. We later discovered that potato starch had been used for play clay at his nursery school. Although he discontinued using potato starch play clay, it remained present in his surroundings for 6 years. His potato allergy may have developed and continued to worsen as a result of making indirect contact with surfaces that had previously been exposed to the allergen. Two-dimensional Western blot analysis on potato starch revealed the presence of proteins binding to the immunoglobulin E of the patient. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis findings showed that 5 of the 6 protein bands had a similar molecular weight as that of potato proteins. Thus far, there are no reports of anaphylaxis due to potato starch. Children with atopic dermatitis or damaged skin may have sensitivity to potato starch and could develop anaphylaxis as noted in this case.Epicutaneous sensitization to food allergens is a recently recognised phenomenon. However, there is less understanding around necessary or sufficient cofactors that permit sensitization through this route. In this report, we describe the development of goat's milk allergy in members of a household with pre-existing atopic dermatitis, following use of a goat's milk soap marketed for sensitive skin. Soaps appear to be an effective vehicle for sensitization to food antigens and the risks are potentiated in those with compromised barrier function. Although such products may be marketed for atopic dermatitis, we would advocate for the avoidance of food-based skin care products in this patient group.
The study of HLA classes I and II in Brazilian psoriasis patients may contribute to a better understanding of their association with the disease.
To describe HLA classes I and II of Brazilian patients with psoriasis, with or without arthritis, compare them to controls and correlate HLA markers with epidemiological and evolutional aspects of psoriasis.
A total of 55 patients with more than 5 years of psoriasis, with or without arthritis, answered a questionnaire on ethnic background and disease severity. A total of 134 bone marrow donors were controls. HLA class I and II genotyping was determined by PCR-SSP.
Mean age was 42.4 years; 23 women and 32 men. HLA-B*57 was present in 23.6% patients and in 7.5% controls (p=0.00200, OR= 3.8381), and HLA-C*06 in 29.1% patients and in 16.4% controls (p= 0.04832, OR=2.0886). HLA-B*57 and HLA-C*18 were significantly present in patients with arthritis (p=0.00104, OR=6.6769 and p=0.00269, OR=16.50, respectively). HLA-B*57 was significantly present in patients with hised in the patients indicating risk for psoriasis. HLA-B*57 remained high in patients with history of erythroderma, hospital internment, systemic treatment, and psoriatic arthritis, showing association with disease severity. HLA-C*18 was significantly high only in patients with psoriatic arthritis. HLA-B*57 and HLA-C*06 and haplotype HLA-A*02B*57Cw*06DRB1*07 DQB1*03 seen in this study were already described before, associated with psoriasis. HLA-Cw*18 was not described in other populations in association with psoriasis.Footrot is one of the most important causes of lameness and economic losses in sheep and goat production worldwide. A 2-years-old ram was presented to the college of veterinary science teaching hospital, Mekelle University, with a history of non-weight bearing lameness of the left hindlimb. The hoof was damaged, split and the interdigital space was full of dirt and the scent of a rotten smell. On clinical examination, the sheep was suffering from depression, weight loss, with elevation in the physiological parameters such as a rectal temperature of 40.1°C, heart rate of 96 beats per minute, and respiratory rate of 40 breaths per minute. The hoof was carefully washed with isotonic saline solution and disinfected with hydrogen peroxide 3% and povidone-iodine 1%. Additionally, meloxicam (0.5mg/kg, IM) thrice daily for three days and oxytetracycline 10% (10mg/kg, IM) for successive 5 days were administered parenterally. The infected surface was also treated with topical oxytetracycline spray for five days. The sheep have recovered after 7 days of treatment with significant improvement in the hoof injury. Successful management of footrot in Abergele sheep is discussed in the current case report.
Trypanosomosis is the most prevalent disease and causes serious economic losses in Ethiopia. The disease is among the major constraint to camel production in the country. Hence, this study aimed to determine the occurrence and associated risk factors of camel trypanosomosis in the Borana zone, Ethiopia.
A cross-sectional study design was conducted from December 2018 to December 2019 using parasitological techniques in the Yabelo and Gomole districts of the Borana zone. A total of 384 camels were randomly selected and tested using wet blood film (thin) and the Giemsa-stained technique. The packed cell volume (PCV) of sampled camels was recorded using a hematocrit reader.
An overall 3.91% prevalence of camel trypanosomosis was observed in study areas.
-infected camel had significant (P=0.0001) lower mean PCV (20.73±1.91) than non-infected camel (27.07±4.35). The current study showed body condition of camel (OR=6.8, 95% CI 1.44-31.83) and season (OR=3.1, 95% CI 1.04-9.07) as risk factors for the occurrence of camel trypanosomosis. However, the sex, age, and origin (district) of camel did not affect the occurrence of camel trypanosomosis in the study areas.
Camel trypanosomosis impeded camel production in the study areas. Therefore, control and prevent methods considering seasonality, different ecology is necessary to design and implement. Moreover, a further study involving more sensitive molecular techniques should be conducted on camel trypanosomosis and their vectors.
Camel trypanosomosis impeded camel production in the study areas. Therefore, control and prevent methods considering seasonality, different ecology is necessary to design and implement. Moreover, a further study involving more sensitive molecular techniques should be conducted on camel trypanosomosis and their vectors.
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