Notes

GhKNL1 regulates fibers elongation and second cell walls synthesis by repressing it's downstream family genes within cotton (Gossypium hirsutum).
to develop and test the effects of specific social capital interventions on the quality of health care services.When the production of reactive oxygen species (ROS) is overloaded surpassing the capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage termed oxidative stress (OS). This phenomenon is ubiquitously detected in many human pathological conditions. Wound healing program implicates continuous neovascularization, cell proliferation, and wound remodeling. Increasing evidence indicates that reactive oxygen species (ROS) have profound impacts on the wound healing process through regulating a series of the physiological and pathological program including inflammatory response, cell proliferation, angiogenesis, granulation as well as extracellular matrix formation. In most pathological wound healing processes, excessive ROS exerts a negative role on the wound healing process. Interestingly, the moderate increase of ROS levels is beneficial in killing bacteria at the wound site, which creates a sterile niche for revascularization. In this review, we discussed the physiological rhythms of wound healing and the role of ROS in this progress, aim to explore the potential manipulation of OS as a promising therapeutic avenue.Neuropathic pain is still a serious and unsolved health problem. Activation of α7 nicotinic acetylcholine receptor (α7nAChR) is known to modulate neuropathic pain by inhibiting microglial activation and BDNF/TrkB/KCC2 signaling. Selleck PR-619 We previously identified that trifluoro-icaritin (ICTF) has an attenuated effect on spared nerve injury (SNI)-induced neuropathic pain, but its potential mechanisms remain unknown. Here, the pain-related behaviors were determined by paw withdrawal threshold (PWT), CatWalk gait analysis, rotarod test, open field test and elevated plus maze test. The expression of pain-related signal molecules was evaluated by Western blot and immunofluorescence staining. The results showed that ICTF (5.0 mg/kg, i.p.) successfully relieved SNI-induced mechanical allodynia and anxiety-like behavior, we subsequently found there existed either positive or negative correlation between mechanical allodynia and gait parameters or rotating speed following ICTF treatment. Moreover, ICTF not only enhanced the expression of spinal α7nAChR, KCC2, CD206 and IL-10, but also decreased the levels of spinal BDNF, TrkB, CD11b, Iba-1, CD40 and IL-1β in SNI rats. Conversely, α7nAChR antagonist α-Bgtx (I.T.) effectively reversed the inhibitory effects of ICTF on SNI rats, resulting in a remarkable improvement of mechanical allodynia, activation of microglia. and suppression of α7nAChR-mediated BDNF/TrkB/KCC2 signaling. Additionally, exogenous BDNF (I.T.) dramatically abrogated both blockade of BDNF/TrkB/KCC2 cascade and alleviation of mechanical allodynia by ICTF treatment. Altogether, the study highlighted that ICTF could relieve SNI-induced neuropathic pain by suppressing microglial activation via α7nAChR-mediated inhibition of BDNF/TrkB/KCC2 signaling in the spinal cord, suggesting that ICTF may be served as a possible painkiller against neuropathic pain.
The correlation between treatment-emergent adverse events (TEAE) and antiseizure medication (ASM) drug load is a controversial topic. Previous studies used daily defined dosage (DDD) to measure drug load. We aim to assess if ASM adjusted to body weight and plasma levels were associated with TEAE.

We analyzed clinical visits of a trial on therapeutic drug monitoring in outpatients with epilepsy. TEAE, treatment, and its changes, as well as ASM plasma levels, were recorded at each visit. Each medication level was stratified according to its position in relation to its proposed reference range (below, in the lower half, upper half, or above).

We analyzed 424 visits (151 participants). Treatment-emergent adverse events were reported in 84 (20%) visits. There was no significant difference when comparing visits with TEAE with those without TEAE in terms of ASM drug load (calculated with DDD), corrected for body weight, their changes since the last visit, as well as summed plasma levels compared to reference ranges.

Actual drug load seems not to represent a major determinant of TEAE recorded during routine visits, even when accounting thoroughly for the patient's exposure to the treatment. The use of structured questionnaires and neuropsychometric tests may assess more accurately the potential consequences of drug loads.
Actual drug load seems not to represent a major determinant of TEAE recorded during routine visits, even when accounting thoroughly for the patient's exposure to the treatment. The use of structured questionnaires and neuropsychometric tests may assess more accurately the potential consequences of drug loads.
Status epilepticus (SE) continues to be a challenging neurological emergency with high morbidity and mortality. During treatment, different regimens are practiced encompassing all known seizure termination mechanisms. To our knowledge, this is the first case series report describing EEG patterns and clinical outcomes in patients treated with ketamine and perampanel (PER) concomitantly.

To assess clinical and electrographic outcomes in patients receiving dual antiglutamatergic therapy in SE.

Twenty-one out of twenty five patients were treated with ketamine, and four patients with ketamine were associated with PER. In the ketamine plus PER group, three out of four patients had convulsive SE, and one had non-convulsive status epilepticus (NCSE), whereas eight patients in the ketamine group had NCSE. The incidence of beta pattern appearance on EEG after starting patients on ketamine and PER was achieved in all four patients (100%) compared to (61.9%) in the other group. A burst suppression pattern was recorded in 75% of patients treated with ketamine and PER, in comparison to 28.5% of patients in patients treated with a different regimen. The time to resolution of SE was significantly shorter in the ketamine group (median 24 (24-64) h vs. 6 (05-144) h p>0.05). Moreover, the average number of days on IV anesthetic was slightly lower in a patient treated with PER concomitantly. In terms of morbidity, the average increase in mRS was also lower in the ketamine and PER group, although it was not statistically significant.

Dual anti-glutamatergic therapy could provide a favorable approach to treating SE, which yet needs to be further investigated through larger randomized control studies.
Dual anti-glutamatergic therapy could provide a favorable approach to treating SE, which yet needs to be further investigated through larger randomized control studies.
Patients with hematologic malignancies experience anxiety and depressive symptoms from diagnosis through survivorship. The aim of this systematic review is to determine if coping skill interventions can reduce anxiety and depressive symptoms for persons with hematologic cancer.

Databases including PubMed, Embase, CINAHL, APA PyschInfo, Scopus, and Cochrane were searched in June of 2021 for coping skill interventional studies with adult patients with hematologic cancer and outcomes of anxiety and depressive symptoms. Search terms, definitions, and inclusion/exclusion criteria were guided by the Transactional Model of Stress and Coping, and quality appraisal utilized the Johns Hopkins Evidence Based Practice Appraisal tool. The study was registered in PROSPERO under "CRD42021262967."

Eleven studies met inclusion criteria with ten studies evaluating anxiety symptoms and nine studies evaluating depressive symptoms. Of ten studies with 449 participants evaluating anxiety, five studies showed significant reduction (p<0.05), three found small to moderate effect size reductions not reaching statistical significance (p>0.05), and only two showed no reduction in anxiety symptoms. Of nine studies with 429 participants evaluating depressive symptoms, three had significant reductions (p<0.05), three reported small to moderate effect size reductions not reaching statistical significance (p>0.05), and three found no effect on depressive symptoms. Coping interventions that were problem-focused as opposed to emotion-focused were most effective for both anxiety and depressive symptoms.

This systematic review finds evidence that problem-focused coping interventions reduce anxiety symptoms among patients with hematologic malignancies, with mixed evidence for reduction of depressive symptoms. Nurses and other clinicians caring for patients with hematologic cancers may employ coping skill interventions as a potential way to mitigate anxiety and depressive symptoms.

CRD42021262967.
CRD42021262967.In this study, carboxymethyl chitosan (CMCS)-based double cross-linked network spheres, are constructed by an emulsion template method. The first crosslinking network comes from the chelation between the CMCS and zinc ions, while the second one is based on the covalent crosslinking of 2-acrylamido-2-methyl-1-propanesulfonicacid (AMPS); and the as-prepared spheres are termed as ECMCS@AMPSs. The emulsion template method endows the ECMCS@AMPSs with large pore area (58.3 m2/g) and ultra-high porosity (92.3 %). Thanks to the heparin-mimicking functional groups of -OH, -COO- and -SO3-, the ECMCS@AMPSs show excellent anticoagulant properties without the activation of the complement system, contact system and platelets. Compared with the spheres without emulsification, the porous structure of the ECMCS@AMPSs results in a 5.3-fold increase in low-density lipoprotein (LDL) adsorption capacity in hypercholesterolemia plasma. Most importantly, in vitro simulated hemoperfusion experiment shows that the cumulative adsorption capacity of LDL by the ECMCS@AMPSs is as high as 41.66 mg/g in 1 h, which is approximately 4.2 times that of high-density lipoprotein (HDL). In conclusion, the ECMCS@AMPSs with self-anticoagulant and high-efficiency adsorption of LDL fabricated via simple emulsion template method have great clinical application prospects in the field of lipoprotein apheresis.The metal ion etching induced transformation of zeolitic imidazolate frameworks (ZIFs) to layered double hydroxides (LDHs) is closely related to the etching conditions. Here, by tuning the Ni2+ etching conditions (e.g., initial Ni2+ concentration and etching time), Co-ZIF-L templated CoNi-LDH with diverse morphologies and tailorable compositions are obtained and their resultant electrochemical properties are optimized. Mechanism study reveals that the etching conditions significantly affect the disassembling rate of Co-ZIF-L as well as the formation rate of CoNi-LDH, leading to the morphological and compositional variance of etched samples, which further results in their distinct electrochemical activities. The resultant asymmetric supercapacitor assembled with Co-ZIF-L derived CoNi-LDH and activated carbon can achieve a maximum energy density of 77.3 Wh/kg at a power density of 700 W/kg with the capacity retention of 85.7 % after 2000 cycles, superior or comparable to other advanced CoNi-LDH based supercapacitors.Much effort has been devoted to improving the photocatalytic capacity of graphitic carbon nitride (g-C3N4). In this paper, we reported the successful synthesis of a hybrid photocatalyst with superb photocatalytic hydrogen production activity through decorating atomically precise Ni6(SC2H4Ph)12 nanoclusters on g-C3N4 nanosheets (labeled as Ni6/g-C3N4) at room temperature. Zeta potential experiments demonstrated that the electrostatic interaction between Ni6 and g-C3N4 led to the formation of Ni6/g-C3N4. The photocatalytic measurements revealed that the 5 %-Ni6/g-C3N4 prepared with the original mass ratio of m(Ni6)/m(g-C3N4) = 1/20 exhibited the strongest hydrogen production activity. In the system with triethanolamine (TEOA) as the sacrifice agent, the visible-light hydrogen production rate reached up to 5.87 mmol h-1 g-1, approximately 290 times higher than that of pure g-C3N4 (0.02 mmol h-1 g-1). Density functional theory (DFT) calculations testified that the above significant enhancement of photocatalytic hydrogen evolution of the hybrid photocatalyst arose from the photogenerated electrons transfer from Ni6 to g-C3N4.
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