Notes

Potential contradiction associated with flowing design depending on betweenness.
An important factor for the acceptance and thus the spread of automated and connected driving (ACD) is the degree of subjective uncertainty that users experience when interacting with automated vehicles. Subjective uncertainties always occur when people are not able to predict the further course of a situation or future events due to lack of experience or information. If such uncertainties occur during the use of automated vehicles, the development of trust and thus acceptance of this technology is impaired by the negative emotions accompanying subjective uncertainties. Within the AutoAkzept project (which full title translates to Automation without uncertainty to increase the acceptance of automated and connected driving), solutions for user-focused automation have been developed that put vehicle occupants at the center of system development. User-focused systems take into account two basic human needs in human-machine interaction, the need to understand and the need to be understood. For this purpose, user-focused systems use different sensors to detect subjective uncertainties and their influencing factors in real time, integrate this information with context data and make adjustments that reduce subjective uncertainties. The systemic adaptations of user-focused systems follow a holistic approach that includes the levels of vehicle guidance, interior adaptation and information presentation as well as target guidance are included. By reducing or avoiding subjective uncertainties, the project developments contribute to a positive, comfortable user experience and help to increase the acceptance of ACD. This paper presents research results of AutoAkzept on the topics of user state and activity modelling as well as needs-based adaptation strategies, which represent key components for the implementation of user-focused automation.This study examines COVID-19 pandemic effects on the stock market and exchange rate of South Korea. With daily data from January 2, 2019 to August 31, 2020, we show that a new infection spike increases stock price index volatility and decreases foreign investors' holdings of domestic stocks, and indirectly leads to the depreciation of the South Korean won. We indicate that investors may have repurchased the South Korean won seven days after an infection spike, thereby slightly increasing its value. We also find that the Bank of Korea's foreign exchange intervention had a short-run effect with a limited impact. The intervention did not have a significant effect on exchange rate volatility.Manufacturing has long been the center of industrialization strategies for poor developing countries. This article first investigates the effects of labor supply constraints on industrialization, which may have been caused by the coronavirus disease 2019 (COVID-19). Then, it examines how manufacturing automation could affect industrialized developing economies based on the premise that manufacturers may accelerate production automation in response to the COVID-19 pandemic. The model predicts declines in developing economies' manufacturing competitiveness and a heterogeneous pattern of recovery from the COVID-19 recession. In comparison, developing economies with large manufacturing bases would recover relatively quickly, whereas those with weaker manufacturing bases would suffer from a long-term decline and manufacturing contraction trends (undesirable deindustrialization). Manufacturing automation can enhance economic welfare, causing a contraction in the unproductive nontradable good (service) sector. However, with low labor mobility, the welfare effect is ambiguous, thereby widening the wage gap between skilled and unskilled labor.The impact of the COVID-19 Crisis on museums and galleries has been paramount, with the sector taking on long-term recovery plans. This paper examines this crisis in the context of temporary exhibition programmes of UK museums, studying online content for 21 museums with exhibitions due to open between March and June 2020. Analysis was conducted, noting how COVID was considered, how content was presented, and discussing the emerging themes of access, embodiment, and human connection. In considering these results in the context of wider digital heritage literature, several questions are raised in terms of how digital content is conceptualised, presented, and valued. At a crucial turning point in the sector, these aspects will need to be considered as museums and galleries continue to adapt in light of a post-COVID world where practices, both digital and physical, will undoubtedly shift.Small businesses experienced very sharp declines in activity, business sentiment, and expectations early in the pandemic. While there has been some recovery since then, multiple indicators of small business performance remained substantially in the negative range early in 2021. These findings are from a unique high frequency, real time, survey of small employer businesses, the Census Bureau's Small Business Pulse Survey (SBPS). In contrast, results from the high frequency, real time, Business Formation Statistics (BFS) show there has been a surge in new business applications following an initial decline. Most of these applications are for likely nonemployers; however, there has also been a surge in new applications for likely employers, especially in Retail Trade (and especially Non-store Retailers). We compare and contrast the patterns from these two new high frequency data products that provide novel insights into the distinct patterns of dynamics for existing small businesses relative to new business formations.We report on the lived experiences of faculty members during the early months of the COVID-19 pandemic, exploring the broader experiences of faculty members as individuals living multifaceted lives whose homes became their offices, their students scattered geographically and their home lives upended. Using a phenomenological approach for data collection and analysis, we conducted 20 in-depth interviews with faculty holding varied academic appointments at universities across Canada. Experiences during the early months of the pandemic were described as being overwhelming and exhausting, and participants described as being stuck in a cycle of never-ending repetitiveness, sadness and loss, or managing life, teaching and other professional responsibilities with little sense of direction. In keeping with phenomenological methods, this research paints a visceral picture of faculty experiences, seeking to contextualize teaching and learning during this time. Its unique contribution lies in portraying emergency remote teaching as an overlapping and tumultuous world of personal, professional and day-to-day responsibilities.The course of an infection was modeled as a controlled nonlinear process. Understanding the substantial differences observed in the trajectory of the disease caused by the new coronavirus SARS-CoV-2 is of critical importance at the moment. Numerous factors have been considered to explain the fact that symptoms vary highly among different people and the infection transmission rate varies among local populations. Virus replication within the host cell and the development of an immune response to virus antigens in the body are two interdependent processes, which have aftereffects and depend on the preexisting states of the cell and virus populations. Different scenarios with the same input parameters are necessary to consider for modeling the properties of the states. The efficiency of the immune response is the most important factor, including the time it takes to develop defense responses from three levels of the immune system, which is a complex system of the body. A computational description of infection sceis C virus (HCV) infection were used as a basis for model scenarios.We highlight the problem of loneliness, and argue that it is not only a public health issue but also an economic problem. We provide a brief review of findings from the key literature on the associations between loneliness, mental and physical health, and healthcare costs; and then present some evidence on its trends, the extent of socioeconomic inequalities and its links with health and healthcare usage, in Australia. We hope to encourage further economics research on loneliness, and related issues of social isolation and poor social support, to aid the design of policies and interventions to reduce loneliness.This article explores the impact of COVID-19 on the higher education crisis and its implications for workforce preparedness and the future of work. It takes an integrative look at the evolving role of three primary actors involved in higher education traditional universities, corporate universities, and educational technology companies, before, during, and after the pandemic. We conclude with recommendations for reframing discussions about higher education and workforce preparation to achieve a better balance between the workforce needs of the corporate world and those of society.This study explores higher education and the ways in which the shutdown caused by the COVID-19 pandemic have accelerated the evolution of online education. This movement from face-to-face (F2F) education to a virtual environment was forced and unplanned. It can be viewed as a stress test for digital teaching and learning in the higher education system. this website The study addresses course conversions and the progress of online education in response to the current crisis.Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the resolution of infection. Upon ligand engagement, immune receptors together with their downstream adaptors and effectors undergo substantial conformational changes and spatial reorganization. During this process, nanometre-to-micrometre-sized signalling clusters have been commonly observed that are believed to be hotspots for signal transduction. Because of their large size and heterogeneous composition, it remains a challenge to fully understand the mechanisms by which these signalling clusters form and their functional consequences. Recently, phase separation has emerged as a new biophysical principle for organizing biomolecules into large clusters with fluidic properties. Although the field is still in its infancy, studies of phase separation in immunology are expected to provide new perspectives for understanding immune responses. Here, we present an up-to-date view of how liquid-liquid phase separation drives the formation of signalling condensates and regulates immune signalling pathways, including those downstream of T cell receptor, B cell receptor and the innate immune receptors cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) and retinoic acid-inducible gene I protein (RIG-I). We conclude with a summary of the current challenges the field is facing and outstanding questions for future studies.Neutrophils are the most abundant myeloid cells in human blood and are emerging as important regulators of cancer. However, their functional importance has often been overlooked on the basis that they are short-lived, terminally differentiated and non-proliferative. Recent studies of their prominent roles in cancer have led to a paradigm shift in our appreciation of neutrophil functional diversity. This Review describes how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumour microenvironment as well as systemically. We compare neutrophil heterogeneity in cancer and in other pathophysiological contexts to provide an updated overview of our current knowledge of the functions of neutrophils in cancer.
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